SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4pw5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TT0_A_ACTA4901_0
(PYRANOSE OXIDASE)		 4pw5 E3 UBIQUITIN-PROTEIN
LIGASE UHRF2
(Homo
sapiens) 		4 / 6 THR A 508
GLN A 528
PHE A 495
ASN A 534
 None
 1.26A 1tt0A-4pw5A:
undetectable		 1tt0A-4pw5A:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TT0_B_ACTB3901_0
(PYRANOSE OXIDASE)		 4pw5 E3 UBIQUITIN-PROTEIN
LIGASE UHRF2
(Homo
sapiens) 		4 / 6 THR A 508
GLN A 528
PHE A 495
ASN A 534
 None
 1.25A 1tt0B-4pw5A:
undetectable		 1tt0B-4pw5A:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TT0_C_ACTC6901_0
(PYRANOSE OXIDASE)		 4pw5 E3 UBIQUITIN-PROTEIN
LIGASE UHRF2
(Homo
sapiens) 		4 / 6 THR A 508
GLN A 528
PHE A 495
ASN A 534
 None
 1.29A 1tt0C-4pw5A:
undetectable		 1tt0C-4pw5A:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TT0_D_ACTD5901_0
(PYRANOSE OXIDASE)		 4pw5 E3 UBIQUITIN-PROTEIN
LIGASE UHRF2
(Homo
sapiens) 		4 / 6 THR A 508
GLN A 528
PHE A 495
ASN A 534
 None
 1.27A 1tt0D-4pw5A:
undetectable		 1tt0D-4pw5A:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARR_A_PNXA606_1
(CHITINASE A)		 4pw5 E3 UBIQUITIN-PROTEIN
LIGASE UHRF2
(Homo
sapiens) 		4 / 7 GLY A 586
ASP A 613
TYR A 588
ARG A 557
 None
 1.24A 3arrA-4pw5A:
undetectable		 3arrA-4pw5A:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARU_A_PNXA606_1
(CHITINASE A)		 4pw5 E3 UBIQUITIN-PROTEIN
LIGASE UHRF2
(Homo
sapiens) 		4 / 7 GLY A 586
ASP A 613
TYR A 588
ARG A 557
 None
 1.24A 3aruA-4pw5A:
undetectable		 3aruA-4pw5A:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_A_SAMA238_0
(N,N-DIMETHYLTRANSFER
ASE)		 4pw5 E3 UBIQUITIN-PROTEIN
LIGASE UHRF2
(Homo
sapiens) 		5 / 12 ALA A 486
GLY A 480
HIS A 471
LEU A 539
TYR A 608
 None
 1.28A 3bxoA-4pw5A:
undetectable		 3bxoA-4pw5A:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_B_SAMB238_0
(N,N-DIMETHYLTRANSFER
ASE)		 4pw5 E3 UBIQUITIN-PROTEIN
LIGASE UHRF2
(Homo
sapiens) 		5 / 12 ALA A 486
GLY A 480
HIS A 471
LEU A 539
TYR A 608
 None
 1.37A 3bxoB-4pw5A:
undetectable		 3bxoB-4pw5A:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OKX_B_SAMB201_1
(YAEB-LIKE PROTEIN
RPA0152)		 4pw5 E3 UBIQUITIN-PROTEIN
LIGASE UHRF2
(Homo
sapiens) 		5 / 12 LEU A 545
ARG A 535
GLY A 509
THR A 508
LEU A 539
 None
 1.29A 3okxB-4pw5A:
1.8		 3okxB-4pw5A:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_H_ACTH502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 4pw5 E3 UBIQUITIN-PROTEIN
LIGASE UHRF2
(Homo
sapiens) 		3 / 3 SER A 510
GLY A 511
GLN A 528
 None
 0.54A 3v4tH-4pw5A:
undetectable		 3v4tH-4pw5A:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7C_D_ACTD504_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 4pw5 E3 UBIQUITIN-PROTEIN
LIGASE UHRF2
(Homo
sapiens) 		3 / 3 GLY A 456
SER A 457
TRP A 459
 None
 0.76A 4e7cD-4pw5A:
undetectable		 4e7cD-4pw5A:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IFX_A_ACTA404_0
(THIAMINE
BIOSYNTHESIS
LIPOPROTEIN APBE)		 4pw5 E3 UBIQUITIN-PROTEIN
LIGASE UHRF2
(Homo
sapiens) 		4 / 5 SER A 574
LYS A 575
ARG A 566
LEU A 491
 None
 1.46A 4ifxA-4pw5A:
undetectable		 4ifxA-4pw5A:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IG1_A_ACTA504_0
(FAD:PROTEIN FMN
TRANSFERASE)		 4pw5 E3 UBIQUITIN-PROTEIN
LIGASE UHRF2
(Homo
sapiens) 		4 / 5 SER A 574
LYS A 575
ARG A 566
LEU A 491
 None
 1.48A 4ig1A-4pw5A:
undetectable		 4ig1A-4pw5A:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YOA_A_017A100_1
(HIV-1 PROTEASE)		 4pw5 E3 UBIQUITIN-PROTEIN
LIGASE UHRF2
(Homo
sapiens) 		4 / 6 ASN A 582
ASP A 585
PRO A 473
VAL A 465
 None
 1.11A 4yoaA-4pw5A:
undetectable		 4yoaA-4pw5A:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA310_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 4pw5 E3 UBIQUITIN-PROTEIN
LIGASE UHRF2
(Homo
sapiens) 		3 / 3 GLU A 467
HIS A 474
ARG A 462
 None
 0.86A 5uunA-4pw5A:
undetectable		 5uunA-4pw5A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JMJ_A_ASCA201_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 4pw5 E3 UBIQUITIN-PROTEIN
LIGASE UHRF2
(Homo
sapiens) 		4 / 5 GLY A 494
HIS A 601
SER A 599
SER A 598
 None
 1.10A 6jmjA-4pw5A:
undetectable		 6jmjA-4pw5A:
21.16