SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4pwn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_T_NCTT1208_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 4pwn SERINE/THREONINE-PRO
TEIN KINASE WNK1
(Homo
sapiens) 		4 / 8 LEU A 313
MET A 319
THR A 417
CYH A 352
 None
 1.33A 1uw6P-4pwnA:
undetectable
1uw6T-4pwnA:
undetectable		 1uw6P-4pwnA:
21.58
1uw6T-4pwnA:
21.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UWH_A_BAXA1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 4pwn SERINE/THREONINE-PRO
TEIN KINASE WNK1
(Homo
sapiens) 		6 / 12 ALA A 248
THR A 301
LEU A 338
HIS A 347
GLY A 367
PHE A 356
 None
 1.45A 1uwhA-4pwnA:
3.6		 1uwhA-4pwnA:
32.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UWJ_A_BAXA1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 4pwn SERINE/THREONINE-PRO
TEIN KINASE WNK1
(Homo
sapiens) 		6 / 12 VAL A 235
ALA A 248
THR A 301
LEU A 338
HIS A 347
GLY A 367
 None
 0.80A 1uwjA-4pwnA:
10.2		 1uwjA-4pwnA:
33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UWJ_B_BAXB1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 4pwn SERINE/THREONINE-PRO
TEIN KINASE WNK1
(Homo
sapiens) 		6 / 12 ILE A 227
VAL A 235
ALA A 248
THR A 301
LEU A 338
GLY A 367
 None
 1.29A 1uwjB-4pwnA:
8.8		 1uwjB-4pwnA:
33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UWJ_B_BAXB1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 4pwn SERINE/THREONINE-PRO
TEIN KINASE WNK1
(Homo
sapiens) 		6 / 12 VAL A 235
ALA A 248
THR A 301
LEU A 338
HIS A 347
GLY A 367
 None
 0.80A 1uwjB-4pwnA:
8.8		 1uwjB-4pwnA:
33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ITZ_A_IREA2021_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4pwn SERINE/THREONINE-PRO
TEIN KINASE WNK1
(Homo
sapiens) 		3 / 3 LEU A 299
LEU A 303
MET A 304
 None
 0.41A 2itzA-4pwnA:
16.7		 2itzA-4pwnA:
30.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_A_ACHA1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4pwn SERINE/THREONINE-PRO
TEIN KINASE WNK1
(Homo
sapiens) 		4 / 7 TYR A 422
SER A 423
CYH A 425
SER A 443
 None
 1.15A 2xz5A-4pwnA:
undetectable
2xz5B-4pwnA:
undetectable		 2xz5A-4pwnA:
22.26
2xz5B-4pwnA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_B_ACHB1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4pwn SERINE/THREONINE-PRO
TEIN KINASE WNK1
(Homo
sapiens) 		4 / 8 TYR A 422
SER A 423
CYH A 425
SER A 443
 None
 1.13A 2xz5B-4pwnA:
undetectable
2xz5E-4pwnA:
undetectable		 2xz5B-4pwnA:
22.26
2xz5E-4pwnA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CKZ_A_ZMRA469_2
(NEURAMINIDASE)		 4pwn SERINE/THREONINE-PRO
TEIN KINASE WNK1
(Homo
sapiens) 		4 / 6 ASP A 400
ARG A 467
ILE A 346
ARG A 348
 None
 1.24A 3ckzA-4pwnA:
undetectable		 3ckzA-4pwnA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LFA_A_1N1A361_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 4pwn SERINE/THREONINE-PRO
TEIN KINASE WNK1
(Homo
sapiens) 		4 / 8 ALA A 248
THR A 301
LEU A 303
MET A 304
 None
 0.38A 3lfaA-4pwnA:
20.8		 3lfaA-4pwnA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WXO_A_NIZA804_1
(CATALASE-PEROXIDASE)		 4pwn SERINE/THREONINE-PRO
TEIN KINASE WNK1
(Homo
sapiens) 		3 / 3 ASN A 463
GLU A 466
ARG A 467
 None
 0.97A 3wxoA-4pwnA:
undetectable		 3wxoA-4pwnA:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_2
(SEPIAPTERIN
REDUCTASE)		 4pwn SERINE/THREONINE-PRO
TEIN KINASE WNK1
(Homo
sapiens) 		3 / 3 LEU A 324
MET A 319
ASP A 445
 None
 0.68A 4j7xB-4pwnA:
undetectable		 4j7xB-4pwnA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_A_ACTA506_0
(RNA POLYMERASE
3D-POL)		 4pwn SERINE/THREONINE-PRO
TEIN KINASE WNK1
(Homo
sapiens) 		3 / 3 VAL A 435
GLY A 438
LYS A 440
 None
 0.64A 4k50A-4pwnA:
undetectable		 4k50A-4pwnA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_E_ACTE504_0
(RNA POLYMERASE
3D-POL)		 4pwn SERINE/THREONINE-PRO
TEIN KINASE WNK1
(Homo
sapiens) 		3 / 3 VAL A 435
GLY A 438
LYS A 440
 None
 0.58A 4k50E-4pwnA:
0.7		 4k50E-4pwnA:
21.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RZV_A_032A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4pwn SERINE/THREONINE-PRO
TEIN KINASE WNK1
(Homo
sapiens) 		5 / 12 ALA A 248
THR A 301
PHE A 356
GLY A 367
GLY A 370
 None
 0.95A 4rzvA-4pwnA:
8.6		 4rzvA-4pwnA:
32.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_O_EVPO2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 4pwn SERINE/THREONINE-PRO
TEIN KINASE WNK1
(Homo
sapiens) 		4 / 6 GLU A 288
ASP A 240
ARG A 219
GLY A 218
 None
 0.68A 5cdnC-4pwnA:
2.9
5cdnD-4pwnA:
undetectable		 5cdnC-4pwnA:
20.50
5cdnD-4pwnA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_P_EVPP2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 4pwn SERINE/THREONINE-PRO
TEIN KINASE WNK1
(Homo
sapiens) 		4 / 6 GLU A 288
ASP A 240
ARG A 219
GLY A 218
 None
 0.72A 5cdnT-4pwnA:
2.9
5cdnU-4pwnA:
undetectable		 5cdnT-4pwnA:
20.50
5cdnU-4pwnA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CVT_B_ACTB200_0
(N5-CARBOXYAMINOIMIDA
ZOLE RIBONUCLEOTIDE
MUTASE)		 4pwn SERINE/THREONINE-PRO
TEIN KINASE WNK1
(Homo
sapiens) 		3 / 3 ASN A 427
ALA A 429
ARG A 433
 None
 0.68A 5cvtB-4pwnA:
undetectable		 5cvtB-4pwnA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZJ_F_AZ1F2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR-DAR)		 4pwn SERINE/THREONINE-PRO
TEIN KINASE WNK1
(Homo
sapiens) 		5 / 7 GLY A 228
GLY A 230
SER A 231
PHE A 232
LEU A 252
 None
 0.79A 5izjB-4pwnA:
22.6		 5izjB-4pwnA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZJ_F_AZ1F2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR-DAR)		 4pwn SERINE/THREONINE-PRO
TEIN KINASE WNK1
(Homo
sapiens) 		5 / 7 GLY A 228
GLY A 230
SER A 231
VAL A 235
LEU A 252
 None
 0.36A 5izjB-4pwnA:
22.6		 5izjB-4pwnA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZJ_G_AZ1G2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR)		 4pwn SERINE/THREONINE-PRO
TEIN KINASE WNK1
(Homo
sapiens) 		5 / 7 GLY A 228
GLY A 230
SER A 231
VAL A 235
LEU A 252
 None
 0.41A 5izjA-4pwnA:
22.3		 5izjA-4pwnA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J5X_B_AZ1B2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAL-DAR-DAR-
DAR-DAR)		 4pwn SERINE/THREONINE-PRO
TEIN KINASE WNK1
(Homo
sapiens) 		5 / 7 GLY A 228
GLY A 230
SER A 231
PHE A 232
VAL A 235
 None
 0.59A 5j5xA-4pwnA:
22.4		 5j5xA-4pwnA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LW1_B_ADNB401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 8)		 4pwn SERINE/THREONINE-PRO
TEIN KINASE WNK1
(Homo
sapiens) 		5 / 9 ILE A 227
GLY A 228
VAL A 235
ALA A 248
MET A 304
 None
 0.72A 5lw1B-4pwnA:
20.0		 5lw1B-4pwnA:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LW1_E_ADNE401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 8)		 4pwn SERINE/THREONINE-PRO
TEIN KINASE WNK1
(Homo
sapiens) 		5 / 10 GLY A 228
VAL A 235
ALA A 248
LEU A 303
MET A 304
 None
 0.60A 5lw1E-4pwnA:
19.9		 5lw1E-4pwnA:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LW1_H_ADNH401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 8)		 4pwn SERINE/THREONINE-PRO
TEIN KINASE WNK1
(Homo
sapiens) 		5 / 9 GLY A 228
VAL A 235
ALA A 248
LEU A 303
MET A 304
 None
 0.53A 5lw1H-4pwnA:
20.1		 5lw1H-4pwnA:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCV_A_1N1A404_1
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 4pwn SERINE/THREONINE-PRO
TEIN KINASE WNK1
(Homo
sapiens) 		6 / 12 ALA A 248
VAL A 281
LEU A 299
THR A 301
PHE A 356
GLY A 367
 None
 0.59A 5vcvA-4pwnA:
23.1		 5vcvA-4pwnA:
22.80