SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4pwo'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_A_ACTA1871_0
(FPRA)		 4pwo DSBA
(Corynebacterium
diphtheriae) 		4 / 7 PHE A 183
ALA A 209
PHE A 220
PHE A 205
 None
 1.20A 1lqtA-4pwoA:
undetectable		 1lqtA-4pwoA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_A_ACTA1428_0
(FPRA)		 4pwo DSBA
(Corynebacterium
diphtheriae) 		4 / 7 PHE A 183
ALA A 209
PHE A 220
PHE A 205
 None
 1.20A 1lquA-4pwoA:
undetectable		 1lquA-4pwoA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E5D_A_NCAA1501_0
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 4pwo DSBA
(Corynebacterium
diphtheriae) 		4 / 7 ARG A 100
ALA A 175
ARG A 172
ASP A 105
 None
 1.13A 2e5dA-4pwoA:
undetectable
2e5dB-4pwoA:
undetectable		 2e5dA-4pwoA:
21.39
2e5dB-4pwoA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E5D_B_NCAB1502_0
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 4pwo DSBA
(Corynebacterium
diphtheriae) 		4 / 7 ASP A 105
ARG A 100
ALA A 175
ARG A 172
 None
 1.22A 2e5dA-4pwoA:
undetectable
2e5dB-4pwoA:
undetectable		 2e5dA-4pwoA:
21.39
2e5dB-4pwoA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q64_B_1UNB1001_4
(PROTEASE RETROPEPSIN)		 4pwo DSBA
(Corynebacterium
diphtheriae) 		3 / 3 ASP A 105
THR A 283
PRO A 284
 None
 0.43A 2q64B-4pwoA:
undetectable		 2q64B-4pwoA:
15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y00_B_Y00B601_2
(BETA-1 ADRENERGIC
RECEPTOR)		 4pwo DSBA
(Corynebacterium
diphtheriae) 		3 / 3 VAL A 252
ASN A 155
TRP A 154
 None
 1.06A 2y00B-4pwoA:
undetectable		 2y00B-4pwoA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DTU_C_DXCC576_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2)		 4pwo DSBA
(Corynebacterium
diphtheriae) 		4 / 8 ALA A 164
ALA A 168
PRO A 158
THR A 248
 None
 0.86A 3dtuC-4pwoA:
undetectable
3dtuD-4pwoA:
undetectable		 3dtuC-4pwoA:
17.49
3dtuD-4pwoA:
26.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKG_C_ROCC901_3
(PROTEASE)		 4pwo DSBA
(Corynebacterium
diphtheriae) 		3 / 3 ASP A 105
THR A 283
PRO A 284
 None
 0.42A 3tkgD-4pwoA:
undetectable		 3tkgD-4pwoA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		 4pwo DSBA
(Corynebacterium
diphtheriae) 		4 / 7 ILE A 258
GLU A 272
LEU A 140
VAL A 150
 None
 0.81A 3ua5B-4pwoA:
undetectable		 3ua5B-4pwoA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M93_B_ACTB303_0
(S25-26 FAB (IGG1K)
HEAVY CHAIN
S25-26 FAB (IGG1K)
LIGHT CHAIN)		 4pwo DSBA
(Corynebacterium
diphtheriae) 		4 / 5 GLY A 260
SER A 259
ALA A 250
PHE A 128
 None
 1.05A 4m93B-4pwoA:
undetectable
4m93C-4pwoA:
undetectable		 4m93B-4pwoA:
20.24
4m93C-4pwoA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BXN_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 4pwo DSBA
(Corynebacterium
diphtheriae) 		5 / 11 SER A 282
THR A 283
ALA A 114
GLY A  63
THR A  64
 None
 1.35A 5bxnV-4pwoA:
undetectable
5bxnW-4pwoA:
undetectable		 5bxnV-4pwoA:
21.35
5bxnW-4pwoA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDQ_F_MFXF2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 4pwo DSBA
(Corynebacterium
diphtheriae) 		4 / 6 SER A 133
ASP A 156
ARG A 172
GLY A 171
 None
 0.93A 5cdqA-4pwoA:
undetectable
5cdqC-4pwoA:
undetectable
5cdqD-4pwoA:
undetectable		 5cdqA-4pwoA:
20.00
5cdqC-4pwoA:
20.00
5cdqD-4pwoA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_B_CVIB301_1
(REGULATORY PROTEIN
TETR)		 4pwo DSBA
(Corynebacterium
diphtheriae) 		4 / 8 GLY A 110
ARG A 184
ASP A 181
ASP A 105
 None
 1.05A 5vlmB-4pwoA:
undetectable		 5vlmB-4pwoA:
23.57