SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4pws'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_C_SC2C1289_1
(FICOLIN-2)		 4pws PROLINE-RICH 28 KDA
ANTIGEN
(Mycobacterium
tuberculosis) 		4 / 6 ASP A 257
SER A 164
LEU A 157
GLY A 158
 None
 0.93A 2j2pA-4pwsA:
undetectable
2j2pC-4pwsA:
undetectable		 2j2pA-4pwsA:
20.20
2j2pC-4pwsA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_F_SC2F1289_1
(FICOLIN-2)		 4pws PROLINE-RICH 28 KDA
ANTIGEN
(Mycobacterium
tuberculosis) 		4 / 6 ASP A 257
SER A 164
LEU A 157
GLY A 158
 None
 0.98A 2j2pD-4pwsA:
undetectable
2j2pF-4pwsA:
undetectable		 2j2pD-4pwsA:
20.20
2j2pF-4pwsA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_A_ACHA1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4pws PROLINE-RICH 28 KDA
ANTIGEN
(Mycobacterium
tuberculosis) 		4 / 7 TYR A 218
SER A 190
GLN A 167
SER A 246
 None
 1.14A 2xz5A-4pwsA:
undetectable
2xz5B-4pwsA:
undetectable		 2xz5A-4pwsA:
23.36
2xz5B-4pwsA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_B_ACHB1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4pws PROLINE-RICH 28 KDA
ANTIGEN
(Mycobacterium
tuberculosis) 		4 / 8 TYR A 218
SER A 190
GLN A 167
SER A 246
 None
 1.13A 2xz5B-4pwsA:
undetectable
2xz5E-4pwsA:
undetectable		 2xz5B-4pwsA:
23.36
2xz5E-4pwsA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQ7_B_DX2B271_1
(PTERIDINE REDUCTASE
1)		 4pws PROLINE-RICH 28 KDA
ANTIGEN
(Mycobacterium
tuberculosis) 		4 / 8 ARG A 229
SER A 244
ASP A 148
TYR A 171
 None
 1.19A 3jq7B-4pwsA:
undetectable		 3jq7B-4pwsA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQA_A_DX4A270_0
(PTERIDINE REDUCTASE
1)		 4pws PROLINE-RICH 28 KDA
ANTIGEN
(Mycobacterium
tuberculosis) 		4 / 6 ARG A 229
SER A 244
ASP A 148
TYR A 171
 None
 1.19A 3jqaA-4pwsA:
undetectable		 3jqaA-4pwsA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQA_B_DX4B270_0
(PTERIDINE REDUCTASE
1)		 4pws PROLINE-RICH 28 KDA
ANTIGEN
(Mycobacterium
tuberculosis) 		4 / 6 ARG A 229
SER A 244
ASP A 148
TYR A 171
 None
 1.19A 3jqaB-4pwsA:
undetectable		 3jqaB-4pwsA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQA_C_DX4C270_0
(PTERIDINE REDUCTASE
1)		 4pws PROLINE-RICH 28 KDA
ANTIGEN
(Mycobacterium
tuberculosis) 		4 / 6 ARG A 229
SER A 244
ASP A 148
TYR A 171
 None
 1.20A 3jqaC-4pwsA:
undetectable		 3jqaC-4pwsA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQA_D_DX4D270_0
(PTERIDINE REDUCTASE
1)		 4pws PROLINE-RICH 28 KDA
ANTIGEN
(Mycobacterium
tuberculosis) 		4 / 6 ARG A 229
SER A 244
ASP A 148
TYR A 171
 None
 1.19A 3jqaD-4pwsA:
undetectable		 3jqaD-4pwsA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O94_A_NCAA192_0
(NICOTINAMIDASE)		 4pws PROLINE-RICH 28 KDA
ANTIGEN
(Mycobacterium
tuberculosis) 		5 / 11 LEU A 110
PHE A 177
HIS A 109
LEU A 242
ILE A 233
 None
 1.25A 3o94A-4pwsA:
undetectable		 3o94A-4pwsA:
24.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O94_B_NCAB192_0
(NICOTINAMIDASE)		 4pws PROLINE-RICH 28 KDA
ANTIGEN
(Mycobacterium
tuberculosis) 		5 / 11 LEU A 110
PHE A 177
HIS A 109
LEU A 242
ILE A 233
 None
 1.32A 3o94B-4pwsA:
undetectable		 3o94B-4pwsA:
24.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O94_C_NCAC192_0
(NICOTINAMIDASE)		 4pws PROLINE-RICH 28 KDA
ANTIGEN
(Mycobacterium
tuberculosis) 		5 / 11 LEU A 110
PHE A 177
HIS A 109
LEU A 242
ILE A 233
 None
 1.28A 3o94C-4pwsA:
undetectable		 3o94C-4pwsA:
24.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O94_D_NCAD192_0
(NICOTINAMIDASE)		 4pws PROLINE-RICH 28 KDA
ANTIGEN
(Mycobacterium
tuberculosis) 		5 / 11 LEU A 110
PHE A 177
HIS A 109
LEU A 242
ILE A 233
 None
 1.27A 3o94D-4pwsA:
undetectable		 3o94D-4pwsA:
24.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O4D_A_ACTA406_0
(INOSITOL
HEXAKISPHOSPHATE
KINASE)		 4pws PROLINE-RICH 28 KDA
ANTIGEN
(Mycobacterium
tuberculosis) 		4 / 7 ASP A 207
ARG A 230
PHE A 209
SER A 211
 None
 1.39A 4o4dA-4pwsA:
undetectable		 4o4dA-4pwsA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_B_SAMB301_1
(PUTATIVE
METHYLTRANSFERASE
BUD23)		 4pws PROLINE-RICH 28 KDA
ANTIGEN
(Mycobacterium
tuberculosis) 		4 / 5 TYR A 218
SER A 246
ASP A 189
ASP A 108
 None
 1.22A 4qtuB-4pwsA:
undetectable		 4qtuB-4pwsA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_B_GCSB307_1
(CHITOSANASE)		 4pws PROLINE-RICH 28 KDA
ANTIGEN
(Mycobacterium
tuberculosis) 		4 / 7 GLU A 220
ARG A 229
THR A 248
THR A 227
 None
 0.81A 4qwpB-4pwsA:
undetectable		 4qwpB-4pwsA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UTU_H_ADNH503_2
(ADENOSYLHOMOCYSTEINA
SE)		 4pws PROLINE-RICH 28 KDA
ANTIGEN
(Mycobacterium
tuberculosis) 		4 / 5 THR A 261
GLU A 215
THR A 199
LEU A 251
 None
 1.34A 5utuH-4pwsA:
undetectable		 5utuH-4pwsA:
19.48