SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4pwt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1PXX_B_DIFB1701_1 (PROSTAGLANDIN G/H SYNTHASE 2)	4pwt	PEPTIDOGLYCAN-ASSOCI ATED LIPOPROTEIN (Yersinia pestis)	5 / 9	VAL A 133 LEU A 128 LEU A 60 TYR A 168 ALA A 88	None	1.23A	1pxxB-4pwtA: undetectable	1pxxB-4pwtA: 11.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1PXX_D_DIFD3701_1 (PROSTAGLANDIN G/H SYNTHASE 2)	4pwt	PEPTIDOGLYCAN-ASSOCI ATED LIPOPROTEIN (Yersinia pestis)	5 / 10	VAL A 133 LEU A 128 LEU A 60 TYR A 168 ALA A 88	None	1.24A	1pxxD-4pwtA: undetectable	1pxxD-4pwtA: 11.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3V4T_H_ACTH502_0 (UDP-N-ACETYLGLUCOSAM INE 1-CARBOXYVINYLTRANSF ERASE)	4pwt	PEPTIDOGLYCAN-ASSOCI ATED LIPOPROTEIN (Yersinia pestis)	3 / 3	SER A 45 GLY A 44 GLN A 52	None	0.55A	3v4tH-4pwtA: undetectable	3v4tH-4pwtA: 16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5ESG_A_1YNA701_1 (LANOSTEROL 14-ALPHA DEMETHYLASE)	4pwt	PEPTIDOGLYCAN-ASSOCI ATED LIPOPROTEIN (Yersinia pestis)	5 / 12	TYR A 168 PHE A 68 VAL A 141 GLY A 76 HIS A 86	None	1.32A	5esgA-4pwtA: undetectable	5esgA-4pwtA: 13.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6CI6_A_NBOA607_1 (SERUM ALBUMIN)	4pwt	PEPTIDOGLYCAN-ASSOCI ATED LIPOPROTEIN (Yersinia pestis)	4 / 7	ASP A 84 ALA A 88 LYS A 131 LEU A 128	None	0.91A	6ci6A-4pwtA: undetectable	6ci6A-4pwtA: 17.29

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1PXX_B_DIFB1701_1","PROSTAGLANDIN G\/H SYNTHASE 2","4pwt","PEPTIDOGLYCAN-ASSOCIATED LIPOPROTEIN","Yersinia pestis",5,"VAL A 133;LEU A 128;LEU A  60;TYR A 168;ALA A  88","None","1.23A","1pxxB-4pwtA:undetectable","1pxxB-4pwtA:11.30"],["1PXX_D_DIFD3701_1","PROSTAGLANDIN G\/H SYNTHASE 2","4pwt","PEPTIDOGLYCAN-ASSOCIATED LIPOPROTEIN","Yersinia pestis",5,"VAL A 133;LEU A 128;LEU A  60;TYR A 168;ALA A  88","None","1.24A","1pxxD-4pwtA:undetectable","1pxxD-4pwtA:11.30"],["3V4T_H_ACTH502_0","UDP-N-ACETYLGLUCOSAMINE 1-CARBOXYVINYLTRANSFERASE","4pwt","PEPTIDOGLYCAN-ASSOCIATED LIPOPROTEIN","Yersinia pestis",3,"SER A  45;GLY A  44;GLN A  52","None","0.55A","3v4tH-4pwtA:undetectable","3v4tH-4pwtA:16.54"],["5ESG_A_1YNA701_1","LANOSTEROL 14-ALPHA DEMETHYLASE","4pwt","PEPTIDOGLYCAN-ASSOCIATED LIPOPROTEIN","Yersinia pestis",5,"TYR A 168;PHE A  68;VAL A 141;GLY A  76;HIS A  86","None","1.32A","5esgA-4pwtA:undetectable","5esgA-4pwtA:13.36"],["6CI6_A_NBOA607_1","SERUM ALBUMIN","4pwt","PEPTIDOGLYCAN-ASSOCIATED LIPOPROTEIN","Yersinia pestis",4,"ASP A  84;ALA A  88;LYS A 131;LEU A 128","None","0.91A","6ci6A-4pwtA:undetectable","6ci6A-4pwtA:17.29"]]