SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4pwu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2V0M_A_KLNA1500_1 (CYTOCHROME P450 3A4)	4pwu	MODULATOR PROTEIN MZRA (Klebsiella pneumoniae)	5 / 11	LEU A 94 ILE A 65 ALA A 89 GLU A 36 LEU A 106	None	0.99A	2v0mA-4pwuA: undetectable	2v0mA-4pwuA: 11.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2V0M_B_KLNB1498_1 (CYTOCHROME P450 3A4)	4pwu	MODULATOR PROTEIN MZRA (Klebsiella pneumoniae)	5 / 9	LEU A 94 ILE A 65 ALA A 89 GLU A 36 LEU A 106	None	1.02A	2v0mB-4pwuA: undetectable	2v0mB-4pwuA: 11.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2V0M_D_KLND1498_1 (CYTOCHROME P450 3A4)	4pwu	MODULATOR PROTEIN MZRA (Klebsiella pneumoniae)	5 / 11	LEU A 94 ILE A 65 ALA A 89 GLU A 36 LEU A 106	None	0.95A	2v0mD-4pwuA: undetectable	2v0mD-4pwuA: 11.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3FXR_A_ASCA3001_0 (LYSR TYPE REGULATOR OF TSAMBCD)	4pwu	MODULATOR PROTEIN MZRA (Klebsiella pneumoniae)	4 / 8	ARG A 42 ALA A 40 ILE A 41 PRO A 51	None	0.80A	3fxrA-4pwuA: undetectable	3fxrA-4pwuA: 15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5TWJ_C_SAMC201_0 (RIBOSOMAL RNA LARGE SUBUNIT METHYLTRANSFERASE H)	4pwu	MODULATOR PROTEIN MZRA (Klebsiella pneumoniae)	5 / 12	LEU A 60 ILE A 65 GLY A 64 LEU A 94 VAL A 93	None	1.15A	5twjC-4pwuA: undetectable	5twjC-4pwuA: 23.17

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["2V0M_A_KLNA1500_1","CYTOCHROME P450 3A4","4pwu","MODULATOR PROTEIN MZRA","Klebsiella pneumoniae",5,"LEU A  94;ILE A  65;ALA A  89;GLU A  36;LEU A 106","None","0.99A","2v0mA-4pwuA:undetectable","2v0mA-4pwuA:11.65"],["2V0M_B_KLNB1498_1","CYTOCHROME P450 3A4","4pwu","MODULATOR PROTEIN MZRA","Klebsiella pneumoniae",5,"LEU A  94;ILE A  65;ALA A  89;GLU A  36;LEU A 106","None","1.02A","2v0mB-4pwuA:undetectable","2v0mB-4pwuA:11.65"],["2V0M_D_KLND1498_1","CYTOCHROME P450 3A4","4pwu","MODULATOR PROTEIN MZRA","Klebsiella pneumoniae",5,"LEU A  94;ILE A  65;ALA A  89;GLU A  36;LEU A 106","None","0.95A","2v0mD-4pwuA:undetectable","2v0mD-4pwuA:11.65"],["3FXR_A_ASCA3001_0","LYSR TYPE REGULATOR OF TSAMBCD","4pwu","MODULATOR PROTEIN MZRA","Klebsiella pneumoniae",4,"ARG A  42;ALA A  40;ILE A  41;PRO A  51","None","0.80A","3fxrA-4pwuA:undetectable","3fxrA-4pwuA:15.08"],["5TWJ_C_SAMC201_0","RIBOSOMAL RNA LARGE SUBUNIT METHYLTRANSFERASE H","4pwu","MODULATOR PROTEIN MZRA","Klebsiella pneumoniae",5,"LEU A  60;ILE A  65;GLY A  64;LEU A  94;VAL A  93","None","1.15A","5twjC-4pwuA:undetectable","5twjC-4pwuA:23.17"]]