SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4pwv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_A_ADNA601_1
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 4pwv P450 MONOOXYGENASE
(Streptomyces
sp.
Acta
2897) 		5 / 12 LEU A 119
THR A 157
GLU A 366
LEU A 244
GLY A 248
 None
None
HEM  A 501 ( 4.9A)
HEM  A 501 (-4.8A)
HEM  A 501 (-3.4A)
 1.28A 1d4fA-4pwvA:
undetectable		 1d4fA-4pwvA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DMI_A_BHSA1610_1
(NITRIC OXIDE
SYNTHASE)		 4pwv P450 MONOOXYGENASE
(Streptomyces
sp.
Acta
2897) 		4 / 8 SER A 259
ARG A 289
ALA A 291
TRP A 290
 None
 1.10A 1dmiA-4pwvA:
undetectable
1dmiB-4pwvA:
undetectable		 1dmiA-4pwvA:
24.26
1dmiB-4pwvA:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HBP_A_RTLA184_0
(RETINOL BINDING
PROTEIN)		 4pwv P450 MONOOXYGENASE
(Streptomyces
sp.
Acta
2897) 		5 / 11 ALA A 314
ALA A 301
VAL A  56
LEU A 307
GLN A 310
 None
 1.30A 1hbpA-4pwvA:
undetectable		 1hbpA-4pwvA:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK3_A_T44A3003_1
(SERUM ALBUMIN)		 4pwv P450 MONOOXYGENASE
(Streptomyces
sp.
Acta
2897) 		3 / 4 LYS A  71
ALA A 301
MET A 305
 None
 1.01A 1hk3A-4pwvA:
4.1		 1hk3A-4pwvA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_D_FUAD705_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4pwv P450 MONOOXYGENASE
(Streptomyces
sp.
Acta
2897) 		5 / 12 THR A 378
PHE A 145
VAL A 287
PHE A 338
ALA A 283
 None
 1.40A 1q23D-4pwvA:
undetectable
1q23E-4pwvA:
undetectable		 1q23D-4pwvA:
16.52
1q23E-4pwvA:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKN_A_RALA600_2
(ESTROGEN RECEPTOR
BETA)		 4pwv P450 MONOOXYGENASE
(Streptomyces
sp.
Acta
2897) 		3 / 3 ASP A 249
LEU A 246
HIS A 391
 None
 0.78A 1qknA-4pwvA:
2.6		 1qknA-4pwvA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_C_STRC3001_1
(MINERALOCORTICOID
RECEPTOR)		 4pwv P450 MONOOXYGENASE
(Streptomyces
sp.
Acta
2897) 		5 / 12 LEU A 172
LEU A 175
ASN A 176
ALA A 179
LEU A 200
 None
 1.07A 1ya3C-4pwvA:
undetectable		 1ya3C-4pwvA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GVC_B_MMZB501_1
(MONOOXYGENASE)		 4pwv P450 MONOOXYGENASE
(Streptomyces
sp.
Acta
2897) 		3 / 3 ASN A 323
TYR A  31
SER A  57
 None
 0.93A 2gvcB-4pwvA:
undetectable		 2gvcB-4pwvA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GVC_E_MMZE501_1
(MONOOXYGENASE)		 4pwv P450 MONOOXYGENASE
(Streptomyces
sp.
Acta
2897) 		3 / 3 ASN A 323
TYR A  31
SER A  57
 None
 0.94A 2gvcE-4pwvA:
undetectable		 2gvcE-4pwvA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OC8_A_HU5A999_1
(HEPATITIS C VIRUS)		 4pwv P450 MONOOXYGENASE
(Streptomyces
sp.
Acta
2897) 		5 / 12 ILE A 312
LEU A 307
GLY A 309
ARG A  39
VAL A  55
 None
 0.97A 2oc8A-4pwvA:
undetectable		 2oc8A-4pwvA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V57_A_PRLA1188_0
(TETR FAMILY
TRANSCRIPTIONAL
REPRESSOR LFRR)		 4pwv P450 MONOOXYGENASE
(Streptomyces
sp.
Acta
2897) 		4 / 8 SER A 159
ILE A 158
ASP A 249
ARG A 253
 None
 1.09A 2v57A-4pwvA:
undetectable		 2v57A-4pwvA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V57_C_PRLC1187_0
(TETR FAMILY
TRANSCRIPTIONAL
REPRESSOR LFRR)		 4pwv P450 MONOOXYGENASE
(Streptomyces
sp.
Acta
2897) 		4 / 8 SER A 159
ILE A 158
ASP A 249
ARG A 253
 None
 1.09A 2v57C-4pwvA:
undetectable		 2v57C-4pwvA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FPJ_B_SAMB301_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 4pwv P450 MONOOXYGENASE
(Streptomyces
sp.
Acta
2897) 		5 / 12 TYR A 415
GLU A 366
ILE A 126
LEU A 133
VAL A 260
 None
HEM  A 501 ( 4.9A)
None
None
None
 1.22A 3fpjB-4pwvA:
undetectable		 3fpjB-4pwvA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9T_B_BEZB264_0
(ECHA1_1)		 4pwv P450 MONOOXYGENASE
(Streptomyces
sp.
Acta
2897) 		4 / 7 ILE A 390
LEU A 254
ALA A 146
ALA A 150
 None
 0.89A 3r9tB-4pwvA:
undetectable		 3r9tB-4pwvA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFG_B_LEUB289_0
(GLYCYL-TRNA
SYNTHETASE ALPHA
SUBUNIT)		 4pwv P450 MONOOXYGENASE
(Streptomyces
sp.
Acta
2897) 		3 / 3 PHE A 350
SER A 255
SER A 252
 HEM  A 501 (-4.6A)
HEM  A 501 (-3.5A)
HEM  A 501 (-3.7A)
 0.92A 3ufgB-4pwvA:
undetectable		 3ufgB-4pwvA:
24.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_B_ACHB301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 4pwv P450 MONOOXYGENASE
(Streptomyces
sp.
Acta
2897) 		4 / 8 THR A  37
TYR A  42
TRP A  32
ARG A  58
 None
 1.48A 3wipB-4pwvA:
undetectable
3wipC-4pwvA:
undetectable		 3wipB-4pwvA:
20.43
3wipC-4pwvA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I1N_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4pwv P450 MONOOXYGENASE
(Streptomyces
sp.
Acta
2897) 		5 / 11 ILE A 257
ALA A 147
ASP A 144
PHE A 145
LEU A 374
 None
 1.19A 4i1nA-4pwvA:
undetectable		 4i1nA-4pwvA:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JX1_E_CAME502_0
(CAMPHOR
5-MONOOXYGENASE)		 4pwv P450 MONOOXYGENASE
(Streptomyces
sp.
Acta
2897) 		4 / 5 PHE A 145
THR A 262
PHE A 381
ILE A 257
 None
 1.04A 4jx1E-4pwvA:
42.8		 4jx1E-4pwvA:
26.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L6V_A_PQNA2001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
FUSION PROTEIN OF
PHOTOSYSTEM I
SUBUNIT III AND
SUBUNIT IX)		 4pwv P450 MONOOXYGENASE
(Streptomyces
sp.
Acta
2897) 		5 / 9 PHE A 114
ALA A 365
LEU A 362
GLY A 359
ALA A 166
 HEM  A 501 (-4.3A)
None
HEM  A 501 ( 4.5A)
HEM  A 501 (-3.5A)
None
 1.47A 4l6va-4pwvA:
undetectable
4l6vf-4pwvA:
undetectable		 4l6va-4pwvA:
20.21
4l6vf-4pwvA:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_STRA301_1
(ANCESTRAL STEROID
RECEPTOR 2)		 4pwv P450 MONOOXYGENASE
(Streptomyces
sp.
Acta
2897) 		5 / 12 LEU A 172
LEU A 175
ASN A 176
ALA A 179
LEU A 200
 None
 0.96A 4ltwA-4pwvA:
2.7		 4ltwA-4pwvA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QLG_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4pwv P450 MONOOXYGENASE
(Streptomyces
sp.
Acta
2897) 		5 / 12 ILE A 257
ALA A 147
ASP A 144
PHE A 145
LEU A 374
 None
 1.18A 4qlgA-4pwvA:
undetectable		 4qlgA-4pwvA:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RGC_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4pwv P450 MONOOXYGENASE
(Streptomyces
sp.
Acta
2897) 		5 / 12 ILE A 257
ALA A 147
ASP A 144
PHE A 145
LEU A 374
 None
 1.17A 4rgcA-4pwvA:
undetectable		 4rgcA-4pwvA:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_E_FK5E201_1
(FK506-BINDING
PROTEIN 1)		 4pwv P450 MONOOXYGENASE
(Streptomyces
sp.
Acta
2897) 		5 / 11 ASP A 249
ARG A 253
TYR A 242
ILE A 199
ILE A 245
 None
 1.23A 5hw8E-4pwvA:
undetectable		 5hw8E-4pwvA:
12.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MWY_A_YNUA1101_0
(MINERALOCORTICOID
RECEPTOR)		 4pwv P450 MONOOXYGENASE
(Streptomyces
sp.
Acta
2897) 		5 / 12 LEU A 172
LEU A 175
ASN A 176
ALA A 179
LEU A 200
 None
 0.96A 5mwyA-4pwvA:
undetectable		 5mwyA-4pwvA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N4T_A_BEZA507_0
(BETA-LACTAMASE VIM-2)		 4pwv P450 MONOOXYGENASE
(Streptomyces
sp.
Acta
2897) 		3 / 3 THR A  98
HIS A 355
ASN A  78
 None
HEM  A 501 (-3.7A)
HEM  A 501 (-3.9A)
 0.80A 5n4tA-4pwvA:
undetectable		 5n4tA-4pwvA:
22.54