SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4pwy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_A_TFPA202_1
(PROTEIN S100-A4)		 4pwy CALMODULIN-LYSINE
N-METHYLTRANSFERASE
(Homo
sapiens) 		5 / 12 LEU A  70
SER A  67
ILE A 292
GLU A 132
PHE A  65
 None
UNX  A 420 ( 3.0A)
None
UNX  A 420 ( 3.3A)
UNX  A 408 ( 4.8A)
 1.17A 3ko0A-4pwyA:
undetectable
3ko0B-4pwyA:
undetectable
3ko0C-4pwyA:
undetectable
3ko0D-4pwyA:
undetectable		 3ko0A-4pwyA:
18.85
3ko0B-4pwyA:
18.85
3ko0C-4pwyA:
18.85
3ko0D-4pwyA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_C_TFPC202_1
(PROTEIN S100-A4)		 4pwy CALMODULIN-LYSINE
N-METHYLTRANSFERASE
(Homo
sapiens) 		5 / 11 PHE A  65
LEU A  70
SER A  67
ILE A 292
GLU A 132
 UNX  A 408 ( 4.8A)
None
UNX  A 420 ( 3.0A)
None
UNX  A 420 ( 3.3A)
 1.20A 3ko0A-4pwyA:
undetectable
3ko0B-4pwyA:
undetectable
3ko0C-4pwyA:
undetectable
3ko0D-4pwyA:
undetectable		 3ko0A-4pwyA:
18.85
3ko0B-4pwyA:
18.85
3ko0C-4pwyA:
18.85
3ko0D-4pwyA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_D_TFPD202_1
(PROTEIN S100-A4)		 4pwy CALMODULIN-LYSINE
N-METHYLTRANSFERASE
(Homo
sapiens) 		5 / 11 GLU A 132
LEU A  70
SER A  67
ILE A 292
PHE A  65
 UNX  A 420 ( 3.3A)
None
UNX  A 420 ( 3.0A)
None
UNX  A 408 ( 4.8A)
 1.20A 3ko0C-4pwyA:
undetectable
3ko0D-4pwyA:
undetectable
3ko0E-4pwyA:
undetectable
3ko0F-4pwyA:
undetectable		 3ko0C-4pwyA:
18.85
3ko0D-4pwyA:
18.85
3ko0E-4pwyA:
18.85
3ko0F-4pwyA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_E_TFPE202_1
(PROTEIN S100-A4)		 4pwy CALMODULIN-LYSINE
N-METHYLTRANSFERASE
(Homo
sapiens) 		5 / 11 PHE A  65
LEU A  70
SER A  67
ILE A 292
GLU A 132
 UNX  A 408 ( 4.8A)
None
UNX  A 420 ( 3.0A)
None
UNX  A 420 ( 3.3A)
 1.17A 3ko0C-4pwyA:
undetectable
3ko0D-4pwyA:
undetectable
3ko0E-4pwyA:
undetectable
3ko0F-4pwyA:
undetectable		 3ko0C-4pwyA:
18.85
3ko0D-4pwyA:
18.85
3ko0E-4pwyA:
18.85
3ko0F-4pwyA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_F_TFPF202_1
(PROTEIN S100-A4)		 4pwy CALMODULIN-LYSINE
N-METHYLTRANSFERASE
(Homo
sapiens) 		5 / 11 GLU A 132
LEU A  70
SER A  67
ILE A 292
PHE A  65
 UNX  A 420 ( 3.3A)
None
UNX  A 420 ( 3.0A)
None
UNX  A 408 ( 4.8A)
 1.27A 3ko0E-4pwyA:
undetectable
3ko0F-4pwyA:
undetectable
3ko0G-4pwyA:
undetectable
3ko0H-4pwyA:
undetectable		 3ko0E-4pwyA:
18.85
3ko0F-4pwyA:
18.85
3ko0G-4pwyA:
18.85
3ko0H-4pwyA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_H_TFPH202_1
(PROTEIN S100-A4)		 4pwy CALMODULIN-LYSINE
N-METHYLTRANSFERASE
(Homo
sapiens) 		5 / 12 GLU A 132
LEU A  70
SER A  67
ILE A 292
PHE A  65
 UNX  A 420 ( 3.3A)
None
UNX  A 420 ( 3.0A)
None
UNX  A 408 ( 4.8A)
 1.21A 3ko0G-4pwyA:
undetectable
3ko0H-4pwyA:
undetectable
3ko0I-4pwyA:
undetectable
3ko0J-4pwyA:
undetectable		 3ko0G-4pwyA:
18.85
3ko0H-4pwyA:
18.85
3ko0I-4pwyA:
18.85
3ko0J-4pwyA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_K_TFPK202_1
(PROTEIN S100-A4)		 4pwy CALMODULIN-LYSINE
N-METHYLTRANSFERASE
(Homo
sapiens) 		5 / 12 LEU A  70
SER A  67
ILE A 292
GLU A 132
PHE A  65
 None
UNX  A 420 ( 3.0A)
None
UNX  A 420 ( 3.3A)
UNX  A 408 ( 4.8A)
 1.17A 3ko0K-4pwyA:
undetectable
3ko0L-4pwyA:
undetectable
3ko0S-4pwyA:
undetectable
3ko0T-4pwyA:
undetectable		 3ko0K-4pwyA:
18.85
3ko0L-4pwyA:
18.85
3ko0S-4pwyA:
18.85
3ko0T-4pwyA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_L_TFPL202_1
(PROTEIN S100-A4)		 4pwy CALMODULIN-LYSINE
N-METHYLTRANSFERASE
(Homo
sapiens) 		5 / 12 GLU A 132
LEU A  70
SER A  67
ILE A 292
PHE A  65
 UNX  A 420 ( 3.3A)
None
UNX  A 420 ( 3.0A)
None
UNX  A 408 ( 4.8A)
 1.19A 3ko0K-4pwyA:
undetectable
3ko0L-4pwyA:
undetectable
3ko0M-4pwyA:
undetectable
3ko0N-4pwyA:
undetectable		 3ko0K-4pwyA:
18.85
3ko0L-4pwyA:
18.85
3ko0M-4pwyA:
18.85
3ko0N-4pwyA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_M_TFPM202_1
(PROTEIN S100-A4)		 4pwy CALMODULIN-LYSINE
N-METHYLTRANSFERASE
(Homo
sapiens) 		5 / 12 LEU A  70
SER A  67
ILE A 292
GLU A 132
PHE A  65
 None
UNX  A 420 ( 3.0A)
None
UNX  A 420 ( 3.3A)
UNX  A 408 ( 4.8A)
 1.18A 3ko0M-4pwyA:
undetectable
3ko0N-4pwyA:
undetectable
3ko0O-4pwyA:
undetectable
3ko0P-4pwyA:
undetectable		 3ko0M-4pwyA:
18.85
3ko0N-4pwyA:
18.85
3ko0O-4pwyA:
18.85
3ko0P-4pwyA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_N_TFPN202_1
(PROTEIN S100-A4)		 4pwy CALMODULIN-LYSINE
N-METHYLTRANSFERASE
(Homo
sapiens) 		5 / 11 PHE A  65
GLU A 132
LEU A  70
SER A  67
ILE A 292
 UNX  A 408 ( 4.8A)
UNX  A 420 ( 3.3A)
None
UNX  A 420 ( 3.0A)
None
 1.23A 3ko0K-4pwyA:
undetectable
3ko0L-4pwyA:
undetectable
3ko0M-4pwyA:
undetectable
3ko0N-4pwyA:
undetectable		 3ko0K-4pwyA:
18.85
3ko0L-4pwyA:
18.85
3ko0M-4pwyA:
18.85
3ko0N-4pwyA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_O_TFPO202_1
(PROTEIN S100-A4)		 4pwy CALMODULIN-LYSINE
N-METHYLTRANSFERASE
(Homo
sapiens) 		5 / 11 LEU A  70
SER A  67
ILE A 292
GLU A 132
PHE A  65
 None
UNX  A 420 ( 3.0A)
None
UNX  A 420 ( 3.3A)
UNX  A 408 ( 4.8A)
 1.16A 3ko0O-4pwyA:
undetectable
3ko0P-4pwyA:
undetectable
3ko0Q-4pwyA:
undetectable
3ko0R-4pwyA:
undetectable		 3ko0O-4pwyA:
18.85
3ko0P-4pwyA:
18.85
3ko0Q-4pwyA:
18.85
3ko0R-4pwyA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_P_TFPP202_1
(PROTEIN S100-A4)		 4pwy CALMODULIN-LYSINE
N-METHYLTRANSFERASE
(Homo
sapiens) 		5 / 12 PHE A  65
GLU A 132
LEU A  70
SER A  67
ILE A 292
 UNX  A 408 ( 4.8A)
UNX  A 420 ( 3.3A)
None
UNX  A 420 ( 3.0A)
None
 1.16A 3ko0M-4pwyA:
undetectable
3ko0N-4pwyA:
undetectable
3ko0O-4pwyA:
undetectable
3ko0P-4pwyA:
undetectable		 3ko0M-4pwyA:
18.85
3ko0N-4pwyA:
18.85
3ko0O-4pwyA:
18.85
3ko0P-4pwyA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_Q_TFPQ202_1
(PROTEIN S100-A4)		 4pwy CALMODULIN-LYSINE
N-METHYLTRANSFERASE
(Homo
sapiens) 		5 / 10 PHE A  65
LEU A  70
SER A  67
ILE A 292
GLU A 132
 UNX  A 408 ( 4.8A)
None
UNX  A 420 ( 3.0A)
None
UNX  A 420 ( 3.3A)
 1.19A 3ko0O-4pwyA:
undetectable
3ko0P-4pwyA:
undetectable
3ko0Q-4pwyA:
undetectable
3ko0R-4pwyA:
undetectable		 3ko0O-4pwyA:
18.85
3ko0P-4pwyA:
18.85
3ko0Q-4pwyA:
18.85
3ko0R-4pwyA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_T_TFPT202_1
(PROTEIN S100-A4)		 4pwy CALMODULIN-LYSINE
N-METHYLTRANSFERASE
(Homo
sapiens) 		5 / 11 PHE A  65
GLU A 132
LEU A  70
SER A  67
ILE A 292
 UNX  A 408 ( 4.8A)
UNX  A 420 ( 3.3A)
None
UNX  A 420 ( 3.0A)
None
 1.22A 3ko0Q-4pwyA:
undetectable
3ko0R-4pwyA:
undetectable
3ko0S-4pwyA:
undetectable
3ko0T-4pwyA:
undetectable		 3ko0Q-4pwyA:
18.85
3ko0R-4pwyA:
18.85
3ko0S-4pwyA:
18.85
3ko0T-4pwyA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BLV_A_SAMA1281_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 4pwy CALMODULIN-LYSINE
N-METHYLTRANSFERASE
(Homo
sapiens) 		5 / 12 LEU A 103
GLY A 156
GLY A 179
LEU A 160
GLY A 162
 None
SAH  A 401 ( 3.3A)
SAH  A 401 (-3.3A)
None
None
 0.96A 4blvA-4pwyA:
9.9		 4blvA-4pwyA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GRQ_C_AVLC203_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		 4pwy CALMODULIN-LYSINE
N-METHYLTRANSFERASE
(Homo
sapiens) 		4 / 7 TYR A 307
PRO A 314
TYR A 313
PHE A  68
 None
 1.46A 4grqA-4pwyA:
undetectable
4grqC-4pwyA:
undetectable		 4grqA-4pwyA:
16.29
4grqC-4pwyA:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LG1_A_SAMA301_0
(PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21D)		 4pwy CALMODULIN-LYSINE
N-METHYLTRANSFERASE
(Homo
sapiens) 		5 / 12 GLY A 154
GLY A 156
ASP A 178
TRP A 212
ALA A 231
 SAH  A 401 (-3.7A)
SAH  A 401 ( 3.3A)
SAH  A 401 (-2.8A)
SAH  A 401 (-3.3A)
SAH  A 401 (-3.6A)
 0.24A 4lg1A-4pwyA:
20.2		 4lg1A-4pwyA:
25.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LG1_C_SAMC301_0
(PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21D)		 4pwy CALMODULIN-LYSINE
N-METHYLTRANSFERASE
(Homo
sapiens) 		5 / 12 CYH A 233
ALA A 246
GLY A 179
GLY A 154
ASP A 178
 SAH  A 401 ( 3.8A)
None
SAH  A 401 (-3.3A)
SAH  A 401 (-3.7A)
SAH  A 401 (-2.8A)
 1.15A 4lg1C-4pwyA:
19.5		 4lg1C-4pwyA:
25.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LG1_C_SAMC301_0
(PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21D)		 4pwy CALMODULIN-LYSINE
N-METHYLTRANSFERASE
(Homo
sapiens) 		5 / 12 GLY A 154
GLY A 156
ASP A 178
TRP A 212
ALA A 231
 SAH  A 401 (-3.7A)
SAH  A 401 ( 3.3A)
SAH  A 401 (-2.8A)
SAH  A 401 (-3.3A)
SAH  A 401 (-3.6A)
 0.24A 4lg1C-4pwyA:
19.5		 4lg1C-4pwyA:
25.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FUK_A_SNPA1236_1
(MROUPO)		 4pwy CALMODULIN-LYSINE
N-METHYLTRANSFERASE
(Homo
sapiens) 		4 / 7 ILE A 247
ILE A 227
ILE A 318
PHE A 280
 None
 0.57A 5fukA-4pwyA:
undetectable
5fukB-4pwyA:
undetectable		 5fukA-4pwyA:
21.83
5fukB-4pwyA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQG_A_ERMA1201_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562)		 4pwy CALMODULIN-LYSINE
N-METHYLTRANSFERASE
(Homo
sapiens) 		5 / 12 VAL A 125
VAL A  89
GLY A  76
GLU A 132
ASN A  69
 None
None
UNX  A 418 ( 3.5A)
UNX  A 420 ( 3.3A)
UNX  A 421 ( 3.9A)
 1.14A 6bqgA-4pwyA:
undetectable		 6bqgA-4pwyA:
15.18