SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4px1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DB1_A_VDXA428_1
(VITAMIN D NUCLEAR
RECEPTOR)		 4px1 MALEYLACETOACETATE
ISOMERASE
(GLUTATHIONE
S-TRANSFERASE)
(Methylobacterium
extorquens) 		5 / 12 LEU A 142
LEU A 146
VAL A 188
SER A 162
VAL A 100
 None
 1.20A 1db1A-4px1A:
undetectable		 1db1A-4px1A:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DFO_A_FFOA1002_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4px1 MALEYLACETOACETATE
ISOMERASE
(GLUTATHIONE
S-TRANSFERASE)
(Methylobacterium
extorquens) 		4 / 5 GLU A  28
TYR A  26
PHE A  30
PRO A 210
 None
 1.33A 1dfoB-4px1A:
undetectable		 1dfoB-4px1A:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DFO_B_FFOB2002_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4px1 MALEYLACETOACETATE
ISOMERASE
(GLUTATHIONE
S-TRANSFERASE)
(Methylobacterium
extorquens) 		4 / 5 GLU A  28
TYR A  26
PHE A  30
PRO A 210
 None
 1.32A 1dfoA-4px1A:
undetectable		 1dfoA-4px1A:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DFO_C_FFOC3002_2
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4px1 MALEYLACETOACETATE
ISOMERASE
(GLUTATHIONE
S-TRANSFERASE)
(Methylobacterium
extorquens) 		4 / 5 GLU A  28
TYR A  26
PHE A  30
PRO A 210
 None
 1.32A 1dfoD-4px1A:
undetectable		 1dfoD-4px1A:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DFO_D_FFOD4002_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4px1 MALEYLACETOACETATE
ISOMERASE
(GLUTATHIONE
S-TRANSFERASE)
(Methylobacterium
extorquens) 		4 / 5 GLU A  28
TYR A  26
PHE A  30
PRO A 210
 None
 1.32A 1dfoC-4px1A:
undetectable		 1dfoC-4px1A:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_B_CHDB1603_0
(FERROCHELATASE)		 4px1 MALEYLACETOACETATE
ISOMERASE
(GLUTATHIONE
S-TRANSFERASE)
(Methylobacterium
extorquens) 		4 / 5 MET A   3
ARG A  14
LEU A  70
PRO A  62
 None
 1.50A 2hrcB-4px1A:
undetectable		 2hrcB-4px1A:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KAW_A_SUZA91_1
(SEGMENT POLARITY
PROTEIN DISHEVELLED
HOMOLOG DVL-1)		 4px1 MALEYLACETOACETATE
ISOMERASE
(GLUTATHIONE
S-TRANSFERASE)
(Methylobacterium
extorquens) 		5 / 11 GLY A 174
SER A 170
ILE A 169
VAL A 195
LEU A 196
 None
 1.00A 2kawA-4px1A:
undetectable		 2kawA-4px1A:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_A_FFOA505_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4px1 MALEYLACETOACETATE
ISOMERASE
(GLUTATHIONE
S-TRANSFERASE)
(Methylobacterium
extorquens) 		4 / 6 GLU A  28
TYR A  26
PHE A  30
PRO A 210
 None
 1.31A 2vmyA-4px1A:
undetectable		 2vmyA-4px1A:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_D_2FAD500_2
(ADENOSYLHOMOCYSTEINA
SE)		 4px1 MALEYLACETOACETATE
ISOMERASE
(GLUTATHIONE
S-TRANSFERASE)
(Methylobacterium
extorquens) 		4 / 4 LEU A 146
GLN A 157
THR A 152
THR A 141
 None
 1.39A 2zj0D-4px1A:
undetectable		 2zj0D-4px1A:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJD_A_C2FA314_0
(UNCHARACTERIZED
PROTEIN)		 4px1 MALEYLACETOACETATE
ISOMERASE
(GLUTATHIONE
S-TRANSFERASE)
(Methylobacterium
extorquens) 		5 / 12 LEU A  82
GLY A 158
ILE A 191
LEU A 166
ILE A 169
 None
 1.10A 3ijdA-4px1A:
undetectable		 3ijdA-4px1A:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJD_B_C2FB314_0
(UNCHARACTERIZED
PROTEIN)		 4px1 MALEYLACETOACETATE
ISOMERASE
(GLUTATHIONE
S-TRANSFERASE)
(Methylobacterium
extorquens) 		5 / 12 LEU A  82
GLY A 158
ILE A 191
LEU A 166
ILE A 169
 None
 1.16A 3ijdB-4px1A:
undetectable		 3ijdB-4px1A:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_B_MXMB606_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4px1 MALEYLACETOACETATE
ISOMERASE
(GLUTATHIONE
S-TRANSFERASE)
(Methylobacterium
extorquens) 		5 / 12 ILE A 169
LEU A 166
ALA A 200
LEU A 198
LEU A 196
 None
 0.95A 4m11B-4px1A:
1.2		 4m11B-4px1A:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0P_A_TE4A201_1
(BETA-LACTOGLOBULIN)		 4px1 MALEYLACETOACETATE
ISOMERASE
(GLUTATHIONE
S-TRANSFERASE)
(Methylobacterium
extorquens) 		5 / 12 LEU A  82
VAL A 161
ILE A 169
VAL A 100
LEU A 142
 None
 1.24A 4y0pA-4px1A:
undetectable		 4y0pA-4px1A:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZVG_B_SAMB401_0
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)		 4px1 MALEYLACETOACETATE
ISOMERASE
(GLUTATHIONE
S-TRANSFERASE)
(Methylobacterium
extorquens) 		5 / 12 ALA A  18
PRO A  81
GLY A  79
SER A 162
ARG A  14
 None
 1.33A 5zvgB-4px1A:
undetectable		 5zvgB-4px1A:
19.95