SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4px9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DF7_A_MTXA501_1
(DIHYDROFOLATE
REDUCTASE)		 4px9 ATP-DEPENDENT RNA
HELICASE DDX3X
(Homo
sapiens) 		5 / 12 ILE A 214
ILE A 179
VAL A 168
LEU A 403
ILE A 213
 None
 0.94A 1df7A-4px9A:
undetectable		 1df7A-4px9A:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J8U_A_H4BA429_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 4px9 ATP-DEPENDENT RNA
HELICASE DDX3X
(Homo
sapiens) 		4 / 7 LEU A 150
SER A 290
PHE A 289
LEU A 239
 None
 0.82A 1j8uA-4px9A:
undetectable		 1j8uA-4px9A:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADS_B_IMNB3_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4px9 ATP-DEPENDENT RNA
HELICASE DDX3X
(Homo
sapiens) 		5 / 12 CYH A 223
SER A 382
ALA A 349
ILE A 389
LEU A 397
 None
 0.90A 3adsB-4px9A:
undetectable		 3adsB-4px9A:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADX_B_IMNB3_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4px9 ATP-DEPENDENT RNA
HELICASE DDX3X
(Homo
sapiens) 		5 / 12 CYH A 223
SER A 382
ALA A 349
ILE A 389
LEU A 397
 None
 0.93A 3adxB-4px9A:
undetectable		 3adxB-4px9A:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TIC_A_ZMRA1002_2
(NEURAMINIDASE)		 4px9 ATP-DEPENDENT RNA
HELICASE DDX3X
(Homo
sapiens) 		4 / 5 LEU A 320
ARG A 326
ILE A 306
ARG A 333
 None
 1.34A 3ticA-4px9A:
undetectable		 3ticA-4px9A:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW1_D_CVID301_0
(PUTATIVE REGULATORY
PROTEIN)		 4px9 ATP-DEPENDENT RNA
HELICASE DDX3X
(Homo
sapiens) 		5 / 12 LEU A 235
ILE A 214
ILE A 282
ALA A 273
PHE A 381
 None
 1.21A 3vw1D-4px9A:
undetectable		 3vw1D-4px9A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DRI_A_RAPA201_2
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP5
SERINE/THREONINE-PRO
TEIN KINASE MTOR)		 4px9 ATP-DEPENDENT RNA
HELICASE DDX3X
(Homo
sapiens) 		5 / 10 LEU A 403
THR A 378
ASP A 219
TYR A 400
PHE A 402
 None
 1.31A 4driB-4px9A:
0.0		 4driB-4px9A:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKX_A_198A1002_2
(ANDROGEN RECEPTOR)		 4px9 ATP-DEPENDENT RNA
HELICASE DDX3X
(Homo
sapiens) 		4 / 6 LEU A 346
MET A 370
LEU A 270
ILE A 282
 None
 0.89A 4okxA-4px9A:
undetectable		 4okxA-4px9A:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QN9_B_DXCB610_0
(N-ACYL-PHOSPHATIDYLE
THANOLAMINE-HYDROLYZ
ING PHOSPHOLIPASE D)		 4px9 ATP-DEPENDENT RNA
HELICASE DDX3X
(Homo
sapiens) 		3 / 3 GLY A 325
PRO A 324
ALA A 273
 None
 0.48A 4qn9B-4px9A:
undetectable		 4qn9B-4px9A:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V1F_A_BQ1A1087_0
(F0F1 ATP SYNTHASE
SUBUNIT C)		 4px9 ATP-DEPENDENT RNA
HELICASE DDX3X
(Homo
sapiens) 		3 / 3 GLU A 285
ALA A 286
PHE A 289
 ADP  A 601 ( 4.4A)
None
None
 0.63A 4v1fA-4px9A:
undetectable		 4v1fA-4px9A:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V1F_C_BQ1C1087_0
(F0F1 ATP SYNTHASE
SUBUNIT C)		 4px9 ATP-DEPENDENT RNA
HELICASE DDX3X
(Homo
sapiens) 		3 / 3 GLU A 285
ALA A 286
PHE A 289
 ADP  A 601 ( 4.4A)
None
None
 0.63A 4v1fC-4px9A:
undetectable		 4v1fC-4px9A:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUM_B_IMNB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4px9 ATP-DEPENDENT RNA
HELICASE DDX3X
(Homo
sapiens) 		5 / 11 CYH A 223
SER A 382
ALA A 349
ILE A 389
LEU A 397
 None
 0.92A 4xumB-4px9A:
undetectable		 4xumB-4px9A:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YGF_A_AZMA303_1
(ALPHA-CARBONIC
ANHYDRASE)		 4px9 ATP-DEPENDENT RNA
HELICASE DDX3X
(Homo
sapiens) 		5 / 11 VAL A 345
VAL A 271
LEU A 235
THR A 231
ALA A 232
 None
None
None
ADP  A 601 (-4.1A)
None
 1.48A 4ygfA-4px9A:
undetectable		 4ygfA-4px9A:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YGF_C_AZMC303_1
(ALPHA-CARBONIC
ANHYDRASE)		 4px9 ATP-DEPENDENT RNA
HELICASE DDX3X
(Homo
sapiens) 		5 / 11 VAL A 345
VAL A 271
LEU A 235
THR A 231
ALA A 232
 None
None
None
ADP  A 601 (-4.1A)
None
 1.48A 4ygfC-4px9A:
undetectable		 4ygfC-4px9A:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YHA_G_MZMG303_1
(ALPHA-CARBONIC
ANHYDRASE)		 4px9 ATP-DEPENDENT RNA
HELICASE DDX3X
(Homo
sapiens) 		5 / 12 VAL A 345
VAL A 271
LEU A 235
THR A 231
ALA A 232
 None
None
None
ADP  A 601 (-4.1A)
None
 1.47A 4yhaG-4px9A:
undetectable		 4yhaG-4px9A:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BS8_H_MFXH101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 4px9 ATP-DEPENDENT RNA
HELICASE DDX3X
(Homo
sapiens) 		4 / 7 ASP A 329
ARG A 333
GLY A 334
ARG A 363
 None
 1.03A 5bs8A-4px9A:
undetectable
5bs8B-4px9A:
undetectable
5bs8C-4px9A:
undetectable		 5bs8A-4px9A:
21.44
5bs8B-4px9A:
23.38
5bs8C-4px9A:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTA_G_MFXG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 4px9 ATP-DEPENDENT RNA
HELICASE DDX3X
(Homo
sapiens) 		4 / 7 ARG A 363
ASP A 329
ARG A 333
GLY A 334
 None
 0.96A 5btaA-4px9A:
undetectable
5btaC-4px9A:
undetectable
5btaD-4px9A:
2.1		 5btaA-4px9A:
21.44
5btaC-4px9A:
21.44
5btaD-4px9A:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTF_F_GFNF101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 4px9 ATP-DEPENDENT RNA
HELICASE DDX3X
(Homo
sapiens) 		4 / 7 ASP A 329
ARG A 333
GLY A 334
ARG A 363
 None
 0.97A 5btfA-4px9A:
undetectable
5btfB-4px9A:
undetectable
5btfC-4px9A:
undetectable		 5btfA-4px9A:
21.44
5btfB-4px9A:
23.38
5btfC-4px9A:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTF_G_GFNG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 4px9 ATP-DEPENDENT RNA
HELICASE DDX3X
(Homo
sapiens) 		4 / 7 ARG A 363
ASP A 329
ARG A 333
GLY A 334
 None
 0.96A 5btfA-4px9A:
undetectable
5btfC-4px9A:
undetectable
5btfD-4px9A:
2.2		 5btfA-4px9A:
21.44
5btfC-4px9A:
21.44
5btfD-4px9A:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDQ_F_MFXF2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 4px9 ATP-DEPENDENT RNA
HELICASE DDX3X
(Homo
sapiens) 		4 / 6 ARG A 363
ASP A 329
ARG A 333
GLY A 334
 None
 0.96A 5cdqA-4px9A:
undetectable
5cdqC-4px9A:
undetectable
5cdqD-4px9A:
undetectable		 5cdqA-4px9A:
20.88
5cdqC-4px9A:
20.88
5cdqD-4px9A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GPG_A_RAPA301_2
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP3
SERINE/THREONINE-PRO
TEIN KINASE MTOR)		 4px9 ATP-DEPENDENT RNA
HELICASE DDX3X
(Homo
sapiens) 		5 / 9 LEU A 403
THR A 378
ASP A 219
TYR A 400
PHE A 402
 None
 1.29A 5gpgB-4px9A:
0.0		 5gpgB-4px9A:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 4px9 ATP-DEPENDENT RNA
HELICASE DDX3X
(Homo
sapiens) 		4 / 6 GLU A 284
ALA A 232
LEU A 236
TYR A 291
 None
 1.07A 5igiA-4px9A:
undetectable		 5igiA-4px9A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OCS_A_ACTA402_0
(PUTATIVE
NADH-DEPENTDENT
FLAVIN
OXIDOREDUCTASE)		 4px9 ATP-DEPENDENT RNA
HELICASE DDX3X
(Homo
sapiens) 		4 / 5 CYH A 175
ILE A 213
HIS A 209
HIS A 178
 None
 1.25A 5ocsA-4px9A:
undetectable		 5ocsA-4px9A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OCS_C_ACTC402_0
(PUTATIVE
NADH-DEPENTDENT
FLAVIN
OXIDOREDUCTASE)		 4px9 ATP-DEPENDENT RNA
HELICASE DDX3X
(Homo
sapiens) 		4 / 5 CYH A 175
ILE A 213
HIS A 209
HIS A 178
 None
 1.25A 5ocsC-4px9A:
undetectable		 5ocsC-4px9A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TT3_E_EZLE303_1
(ALPHA-CARBONIC
ANHYDRASE)		 4px9 ATP-DEPENDENT RNA
HELICASE DDX3X
(Homo
sapiens) 		5 / 9 VAL A 345
VAL A 271
LEU A 235
THR A 231
ALA A 232
 None
None
None
ADP  A 601 (-4.1A)
None
 1.44A 5tt3E-4px9A:
undetectable		 5tt3E-4px9A:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TT3_G_EZLG303_1
(ALPHA-CARBONIC
ANHYDRASE)		 4px9 ATP-DEPENDENT RNA
HELICASE DDX3X
(Homo
sapiens) 		5 / 9 VAL A 345
VAL A 271
LEU A 235
THR A 231
ALA A 232
 None
None
None
ADP  A 601 (-4.1A)
None
 1.46A 5tt3G-4px9A:
undetectable		 5tt3G-4px9A:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA608_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 4px9 ATP-DEPENDENT RNA
HELICASE DDX3X
(Homo
sapiens) 		3 / 3 GLY A 229
THR A 231
GLU A 285
 ADP  A 601 (-3.4A)
ADP  A 601 (-4.1A)
ADP  A 601 ( 4.4A)
 0.66A 6b58A-4px9A:
undetectable		 6b58A-4px9A:
20.76