SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4pxb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7A_B_PFLB4001_1
(SERUM ALBUMIN)		 4pxb UREIDOGLYCOLATE
HYDROLASE
(Arabidopsis
thaliana) 		5 / 9 LEU A 179
ARG A  97
VAL A 151
GLY A 150
LEU A  73
 None
None
None
MN  A 501 ( 4.0A)
None
 1.14A 1e7aB-4pxbA:
undetectable		 1e7aB-4pxbA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FK6_A_LNLA1201_1
(NON-SPECIFIC LIPID
TRANSFER PROTEIN)		 4pxb UREIDOGLYCOLATE
HYDROLASE
(Arabidopsis
thaliana) 		5 / 12 VAL A 100
LEU A 103
ALA A 107
ILE A 139
ILE A 177
 None
 0.86A 1fk6A-4pxbA:
undetectable		 1fk6A-4pxbA:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FXH_B_PACB1001_0
(PENICILLIN ACYLASE)		 4pxb UREIDOGLYCOLATE
HYDROLASE
(Arabidopsis
thaliana) 		4 / 7 MET A 435
SER A 420
ALA A 273
ILE A 274
 None
 1.02A 1fxhA-4pxbA:
undetectable
1fxhB-4pxbA:
2.1		 1fxhA-4pxbA:
20.20
1fxhB-4pxbA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JIP_A_KTNA801_1
(CYTOCHROME P450
107A1)		 4pxb UREIDOGLYCOLATE
HYDROLASE
(Arabidopsis
thaliana) 		5 / 12 ALA A 224
TYR A  89
GLY A 194
THR A 181
ALA A 205
 None
 1.42A 1jipA-4pxbA:
undetectable		 1jipA-4pxbA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_B_SAMB1293_1
(GLYCINE
N-METHYLTRANSFERASE)		 4pxb UREIDOGLYCOLATE
HYDROLASE
(Arabidopsis
thaliana) 		4 / 5 ARG A 353
ASP A 425
ASN A 118
SER A 191
 UGC  A 503 (-2.8A)
None
None
None
 1.42A 1kiaB-4pxbA:
undetectable		 1kiaB-4pxbA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_B_SAMB1293_1
(GLYCINE
N-METHYLTRANSFERASE)		 4pxb UREIDOGLYCOLATE
HYDROLASE
(Arabidopsis
thaliana) 		4 / 5 ARG A 353
ASP A 425
SER A 137
ASN A 118
 UGC  A 503 (-2.8A)
None
None
None
 1.33A 1kiaB-4pxbA:
undetectable		 1kiaB-4pxbA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_C_SAMC2293_1
(GLYCINE
N-METHYLTRANSFERASE)		 4pxb UREIDOGLYCOLATE
HYDROLASE
(Arabidopsis
thaliana) 		4 / 6 ARG A 353
ASP A 425
ASN A 118
SER A 191
 UGC  A 503 (-2.8A)
None
None
None
 1.41A 1kiaC-4pxbA:
undetectable		 1kiaC-4pxbA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_C_SAMC2293_1
(GLYCINE
N-METHYLTRANSFERASE)		 4pxb UREIDOGLYCOLATE
HYDROLASE
(Arabidopsis
thaliana) 		4 / 6 ARG A 353
ASP A 425
SER A 137
ASN A 118
 UGC  A 503 (-2.8A)
None
None
None
 1.34A 1kiaC-4pxbA:
undetectable		 1kiaC-4pxbA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_A_RBFA501_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 4pxb UREIDOGLYCOLATE
HYDROLASE
(Arabidopsis
thaliana) 		5 / 12 GLY A 146
SER A 145
GLU A 452
HIS A 138
ILE A 255
 None
None
None
MN  A 501 (-3.5A)
None
 1.08A 1kyvA-4pxbA:
3.5
1kyvE-4pxbA:
3.7		 1kyvA-4pxbA:
18.46
1kyvE-4pxbA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_B_RBFB502_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 4pxb UREIDOGLYCOLATE
HYDROLASE
(Arabidopsis
thaliana) 		5 / 11 ILE A 255
GLY A 146
SER A 145
GLU A 452
HIS A 138
 None
None
None
None
MN  A 501 (-3.5A)
 1.07A 1kyvA-4pxbA:
3.5
1kyvB-4pxbA:
3.6		 1kyvA-4pxbA:
18.46
1kyvB-4pxbA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_C_RBFC503_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 4pxb UREIDOGLYCOLATE
HYDROLASE
(Arabidopsis
thaliana) 		5 / 12 ILE A 255
GLY A 146
SER A 145
GLU A 452
HIS A 138
 None
None
None
None
MN  A 501 (-3.5A)
 1.07A 1kyvB-4pxbA:
3.6
1kyvC-4pxbA:
undetectable		 1kyvB-4pxbA:
18.46
1kyvC-4pxbA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_D_RBFD504_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 4pxb UREIDOGLYCOLATE
HYDROLASE
(Arabidopsis
thaliana) 		5 / 12 ILE A 255
GLY A 146
SER A 145
GLU A 452
HIS A 138
 None
None
None
None
MN  A 501 (-3.5A)
 1.05A 1kyvC-4pxbA:
undetectable
1kyvD-4pxbA:
3.3		 1kyvC-4pxbA:
18.46
1kyvD-4pxbA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_E_RBFE505_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 4pxb UREIDOGLYCOLATE
HYDROLASE
(Arabidopsis
thaliana) 		5 / 12 ILE A 255
GLY A 146
SER A 145
GLU A 452
HIS A 138
 None
None
None
None
MN  A 501 (-3.5A)
 1.07A 1kyvD-4pxbA:
3.3
1kyvE-4pxbA:
3.7		 1kyvD-4pxbA:
18.46
1kyvE-4pxbA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_B_SAMB1293_1
(GLYCINE
N-METHYLTRANSFERASE)		 4pxb UREIDOGLYCOLATE
HYDROLASE
(Arabidopsis
thaliana) 		4 / 5 ARG A 353
ASP A 425
ASN A 118
SER A 191
 UGC  A 503 (-2.8A)
None
None
None
 1.41A 1nbhB-4pxbA:
0.0		 1nbhB-4pxbA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_B_URFB2011_1
(URIDINE
PHOSPHORYLASE)		 4pxb UREIDOGLYCOLATE
HYDROLASE
(Arabidopsis
thaliana) 		4 / 8 THR A 272
GLY A 436
ILE A 401
VAL A 400
 None
 0.96A 1rxcB-4pxbA:
10.5		 1rxcB-4pxbA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_E_URFE2031_1
(URIDINE
PHOSPHORYLASE)		 4pxb UREIDOGLYCOLATE
HYDROLASE
(Arabidopsis
thaliana) 		4 / 8 THR A 272
GLY A 436
ILE A 401
VAL A 400
 None
 0.97A 1rxcE-4pxbA:
10.4		 1rxcE-4pxbA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_I_URFI2041_1
(URIDINE
PHOSPHORYLASE)		 4pxb UREIDOGLYCOLATE
HYDROLASE
(Arabidopsis
thaliana) 		4 / 8 THR A 272
GLY A 436
ILE A 401
VAL A 400
 None
 0.97A 1rxcI-4pxbA:
6.2		 1rxcI-4pxbA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_K_URFK2061_1
(URIDINE
PHOSPHORYLASE)		 4pxb UREIDOGLYCOLATE
HYDROLASE
(Arabidopsis
thaliana) 		4 / 8 THR A 272
GLY A 436
ILE A 401
VAL A 400
 None
 0.95A 1rxcK-4pxbA:
8.5		 1rxcK-4pxbA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XIU_B_9CRB202_1
(RXR-LIKE PROTEIN)		 4pxb UREIDOGLYCOLATE
HYDROLASE
(Arabidopsis
thaliana) 		5 / 12 ALA A 305
ALA A 306
LEU A 348
HIS A 335
LEU A 334
 None
 1.06A 1xiuB-4pxbA:
undetectable		 1xiuB-4pxbA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ADM_B_SAMB500_0
(ADENINE-N6-DNA-METHY
LTRANSFERASE TAQI)		 4pxb UREIDOGLYCOLATE
HYDROLASE
(Arabidopsis
thaliana) 		5 / 11 VAL A 212
GLU A 222
ALA A 223
ALA A 230
ASP A  93
 None
 1.23A 2admB-4pxbA:
undetectable		 2admB-4pxbA:
24.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CIZ_A_ACTA1320_0
(CHLOROPEROXIDASE)		 4pxb UREIDOGLYCOLATE
HYDROLASE
(Arabidopsis
thaliana) 		4 / 6 ALA A 422
ILE A 419
VAL A 271
PHE A 439
 UGC  A 503 (-3.4A)
None
None
None
 0.94A 2cizA-4pxbA:
undetectable		 2cizA-4pxbA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7P_A_SALA1001_1
(LYSR-TYPE REGULATORY
PROTEIN)		 4pxb UREIDOGLYCOLATE
HYDROLASE
(Arabidopsis
thaliana) 		4 / 6 SER A 474
PRO A 128
GLY A 125
TRP A 123
 None
 1.47A 2y7pA-4pxbA:
undetectable		 2y7pA-4pxbA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3008_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 4pxb UREIDOGLYCOLATE
HYDROLASE
(Arabidopsis
thaliana) 		4 / 7 HIS A 347
VAL A 282
VAL A 329
ALA A 310
 None
 0.89A 3kp6B-4pxbA:
undetectable		 3kp6B-4pxbA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU1_G_SAMG226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 4pxb UREIDOGLYCOLATE
HYDROLASE
(Arabidopsis
thaliana) 		5 / 12 LEU A  73
GLY A 156
GLY A 462
GLY A 150
ILE A 440
 None
None
None
MN  A 501 ( 4.0A)
None
 0.93A 3ku1G-4pxbA:
undetectable		 3ku1G-4pxbA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_A_URFA1301_1
(URIDINE
PHOSPHORYLASE)		 4pxb UREIDOGLYCOLATE
HYDROLASE
(Arabidopsis
thaliana) 		4 / 8 THR A 272
GLY A 436
ILE A 401
VAL A 400
 None
 0.99A 4e1vA-4pxbA:
8.8		 4e1vA-4pxbA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_C_URFC1301_1
(URIDINE
PHOSPHORYLASE)		 4pxb UREIDOGLYCOLATE
HYDROLASE
(Arabidopsis
thaliana) 		4 / 8 THR A 272
GLY A 436
ILE A 401
VAL A 400
 None
 0.96A 4e1vC-4pxbA:
8.6		 4e1vC-4pxbA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_D_URFD1301_1
(URIDINE
PHOSPHORYLASE)		 4pxb UREIDOGLYCOLATE
HYDROLASE
(Arabidopsis
thaliana) 		4 / 8 THR A 272
GLY A 436
ILE A 401
VAL A 400
 None
 0.99A 4e1vD-4pxbA:
8.6		 4e1vD-4pxbA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_G_URFG1301_1
(URIDINE
PHOSPHORYLASE)		 4pxb UREIDOGLYCOLATE
HYDROLASE
(Arabidopsis
thaliana) 		4 / 8 THR A 272
GLY A 436
ILE A 401
VAL A 400
 None
 0.99A 4e1vG-4pxbA:
8.4		 4e1vG-4pxbA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLM_A_198A1001_1
(ANDROGEN RECEPTOR)		 4pxb UREIDOGLYCOLATE
HYDROLASE
(Arabidopsis
thaliana) 		5 / 12 LEU A 466
LEU A 253
GLY A 462
LEU A 413
VAL A 270
 None
 1.37A 4olmA-4pxbA:
undetectable		 4olmA-4pxbA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUM_A_IMNA502_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4pxb UREIDOGLYCOLATE
HYDROLASE
(Arabidopsis
thaliana) 		4 / 7 GLU A 176
ILE A 119
LEU A  73
MET A 104
 None
 0.99A 4xumA-4pxbA:
undetectable		 4xumA-4pxbA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YIA_B_IMNB401_2
(THYROXINE-BINDING
GLOBULIN)		 4pxb UREIDOGLYCOLATE
HYDROLASE
(Arabidopsis
thaliana) 		3 / 3 LEU A 427
ARG A 196
ARG A 431
 None
 0.81A 4yiaB-4pxbA:
undetectable		 4yiaB-4pxbA:
7.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U63_A_ACTA406_0
(THIOREDOXIN
REDUCTASE)		 4pxb UREIDOGLYCOLATE
HYDROLASE
(Arabidopsis
thaliana) 		3 / 3 HIS A 138
SER A 182
ARG A  86
 MN  A 501 (-3.5A)
None
None
 0.87A 5u63A-4pxbA:
1.5		 5u63A-4pxbA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X5Q_B_D16B402_1
(THYMIDYLATE SYNTHASE)		 4pxb UREIDOGLYCOLATE
HYDROLASE
(Arabidopsis
thaliana) 		5 / 12 GLU A 452
ILE A 255
LEU A 253
GLY A 153
ALA A 460
 None
 1.24A 5x5qB-4pxbA:
undetectable		 5x5qB-4pxbA:
21.23