SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4pxd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT3_A_RTLA184_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 4pxd ALLANTOATE
AMIDOHYDROLASE
(Escherichia
coli) 		4 / 7 LEU A 341
LEU A 334
LEU A 404
GLN A 406
 None
 1.06A 1kt3A-4pxdA:
undetectable		 1kt3A-4pxdA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CDQ_B_SAMB1500_0
(ASPARTOKINASE)		 4pxd ALLANTOATE
AMIDOHYDROLASE
(Escherichia
coli) 		4 / 7 ASP A 359
ARG A 180
LEU A  77
GLU A 119
 None
 1.09A 2cdqB-4pxdA:
2.3		 2cdqB-4pxdA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_B_CHDB927_0
(FERROCHELATASE)		 4pxd ALLANTOATE
AMIDOHYDROLASE
(Escherichia
coli) 		3 / 3 LEU A  13
PRO A  14
ARG A   6
 None
 0.65A 2qd4B-4pxdA:
2.0		 2qd4B-4pxdA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_A_KLNA1501_1
(CYTOCHROME P450 3A4)		 4pxd ALLANTOATE
AMIDOHYDROLASE
(Escherichia
coli) 		5 / 10 SER A 138
ILE A 141
LEU A 102
ILE A 362
GLY A  93
 None
 1.33A 2v0mA-4pxdA:
undetectable		 2v0mA-4pxdA:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XF3_A_J01A500_1
(ORF12)		 4pxd ALLANTOATE
AMIDOHYDROLASE
(Escherichia
coli) 		5 / 10 VAL A  75
ILE A 183
LEU A 400
GLY A  79
ALA A 100
 None
 0.96A 2xf3A-4pxdA:
undetectable		 2xf3A-4pxdA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XF3_B_J01B500_1
(ORF12)		 4pxd ALLANTOATE
AMIDOHYDROLASE
(Escherichia
coli) 		5 / 9 VAL A  75
ILE A 183
LEU A 400
GLY A  79
ALA A 100
 None
 0.97A 2xf3B-4pxdA:
undetectable		 2xf3B-4pxdA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFS_A_J01A500_1
(ORF12)		 4pxd ALLANTOATE
AMIDOHYDROLASE
(Escherichia
coli) 		4 / 8 VAL A  75
LEU A 400
GLY A  79
ALA A 100
 None
 0.92A 2xfsA-4pxdA:
undetectable		 2xfsA-4pxdA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFS_B_J01B500_1
(ORF12)		 4pxd ALLANTOATE
AMIDOHYDROLASE
(Escherichia
coli) 		5 / 9 VAL A  75
ILE A 183
LEU A 400
GLY A  79
ALA A 100
 None
 0.96A 2xfsB-4pxdA:
undetectable		 2xfsB-4pxdA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XH9_A_J01A1436_1
(ORF12)		 4pxd ALLANTOATE
AMIDOHYDROLASE
(Escherichia
coli) 		4 / 8 VAL A  75
LEU A 400
GLY A  79
ALA A 100
 None
 0.93A 2xh9A-4pxdA:
undetectable		 2xh9A-4pxdA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XH9_B_J01B1436_1
(ORF12)		 4pxd ALLANTOATE
AMIDOHYDROLASE
(Escherichia
coli) 		5 / 9 VAL A  75
ILE A 183
LEU A 400
GLY A  79
ALA A 100
 None
 0.98A 2xh9B-4pxdA:
undetectable		 2xh9B-4pxdA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_B_REMB350_1
(RENIN)		 4pxd ALLANTOATE
AMIDOHYDROLASE
(Escherichia
coli) 		5 / 12 GLN A 110
GLY A 396
LEU A 189
ALA A 103
SER A  78
 None
 1.28A 3d91B-4pxdA:
undetectable		 3d91B-4pxdA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_P_TRPP1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4pxd ALLANTOATE
AMIDOHYDROLASE
(Escherichia
coli) 		4 / 7 GLY A  96
HIS A  81
ILE A 191
GLN A  94
 None
 0.91A 3fi0P-4pxdA:
undetectable		 3fi0P-4pxdA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_A_URFA254_1
(URIDINE
PHOSPHORYLASE)		 4pxd ALLANTOATE
AMIDOHYDROLASE
(Escherichia
coli) 		4 / 6 GLY A 212
MET A 323
ILE A 210
VAL A 211
 None
1AL  A 502 ( 4.7A)
None
None
 1.11A 3kvvA-4pxdA:
10.0		 3kvvA-4pxdA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_C_URFC254_1
(URIDINE
PHOSPHORYLASE)		 4pxd ALLANTOATE
AMIDOHYDROLASE
(Escherichia
coli) 		4 / 6 GLY A 212
MET A 323
ILE A 210
VAL A 211
 None
1AL  A 502 ( 4.7A)
None
None
 1.08A 3kvvC-4pxdA:
9.7		 3kvvC-4pxdA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_E_URFE254_1
(URIDINE
PHOSPHORYLASE)		 4pxd ALLANTOATE
AMIDOHYDROLASE
(Escherichia
coli) 		4 / 6 GLY A 212
MET A 323
ILE A 210
VAL A 211
 None
1AL  A 502 ( 4.7A)
None
None
 1.15A 3kvvE-4pxdA:
10.0		 3kvvE-4pxdA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_F_URFF254_1
(URIDINE
PHOSPHORYLASE)		 4pxd ALLANTOATE
AMIDOHYDROLASE
(Escherichia
coli) 		4 / 6 GLY A 212
MET A 323
ILE A 210
VAL A 211
 None
1AL  A 502 ( 4.7A)
None
None
 1.13A 3kvvF-4pxdA:
9.5		 3kvvF-4pxdA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LCV_B_SAMB301_1
(SISOMICIN-GENTAMICIN
RESISTANCE METHYLASE
SGM)		 4pxd ALLANTOATE
AMIDOHYDROLASE
(Escherichia
coli) 		3 / 3 ARG A 215
ASP A 359
GLN A  40
 1AL  A 502 (-3.9A)
None
None
 0.84A 3lcvB-4pxdA:
undetectable		 3lcvB-4pxdA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OWX_A_XRAA233_2
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4pxd ALLANTOATE
AMIDOHYDROLASE
(Escherichia
coli) 		4 / 5 VAL A 120
PHE A 363
ILE A 183
PHE A 142
 None
 1.12A 3owxB-4pxdA:
2.2		 3owxB-4pxdA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R55_A_PZAA598_0
(LACTOPEROXIDASE)		 4pxd ALLANTOATE
AMIDOHYDROLASE
(Escherichia
coli) 		3 / 3 GLU A 192
PHE A 373
GLN A 193
 None
None
1AL  A 502 ( 3.2A)
 1.02A 3r55A-4pxdA:
undetectable		 3r55A-4pxdA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VM4_A_IZPA1_1
(FATTY ACID
ALPHA-HYDROXYLASE)		 4pxd ALLANTOATE
AMIDOHYDROLASE
(Escherichia
coli) 		4 / 5 LEU A 144
PHE A 142
ARG A 366
PRO A 365
 None
 1.30A 3vm4A-4pxdA:
undetectable		 3vm4A-4pxdA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G19_D_ACTD302_0
(GLUTATHIONE
TRANSFERASE GTE1)		 4pxd ALLANTOATE
AMIDOHYDROLASE
(Escherichia
coli) 		3 / 3 TYR A  63
PHE A 142
ARG A 180
 None
 1.23A 4g19D-4pxdA:
undetectable		 4g19D-4pxdA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J4V_D_SVRD301_1
(NUCLEOCAPSID PROTEIN)		 4pxd ALLANTOATE
AMIDOHYDROLASE
(Escherichia
coli) 		5 / 11 ARG A 307
ALA A 308
GLN A 248
PHE A 264
ILE A 285
 None
 1.17A 4j4vD-4pxdA:
undetectable
4j4vE-4pxdA:
undetectable		 4j4vD-4pxdA:
20.19
4j4vE-4pxdA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MBS_A_MRVA1101_2
(CHIMERA PROTEIN OF
C-C CHEMOKINE
RECEPTOR TYPE 5 AND
RUBREDOXIN)		 4pxd ALLANTOATE
AMIDOHYDROLASE
(Escherichia
coli) 		4 / 7 GLN A   7
LEU A 102
THR A  12
THR A 399
 None
 1.14A 4mbsA-4pxdA:
undetectable		 4mbsA-4pxdA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLM_A_198A1001_2
(ANDROGEN RECEPTOR)		 4pxd ALLANTOATE
AMIDOHYDROLASE
(Escherichia
coli) 		4 / 6 ASN A 304
ILE A 317
ILE A 319
VAL A 218
 None
 1.01A 4olmA-4pxdA:
undetectable		 4olmA-4pxdA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PQA_A_X8ZA401_1
(SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE)		 4pxd ALLANTOATE
AMIDOHYDROLASE
(Escherichia
coli) 		5 / 11 HIS A  81
ASP A  92
GLU A 127
GLY A 355
HIS A 382
 None
MN  A 501 ( 2.2A)
MN  A 501 ( 2.0A)
None
MN  A 501 ( 3.3A)
 0.55A 4pqaA-4pxdA:
27.6		 4pqaA-4pxdA:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXL_A_SAMA401_0
(2-(3-AMINO-3-CARBOXY
PROPYL)HISTIDINE
SYNTHASE)		 4pxd ALLANTOATE
AMIDOHYDROLASE
(Escherichia
coli) 		5 / 12 GLY A  93
HIS A 190
GLN A  40
ASP A  57
VAL A 121
 None
1AL  A 502 (-4.3A)
None
None
None
 1.39A 6bxlA-4pxdA:
undetectable		 6bxlA-4pxdA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXN_B_SAMB901_0
(DIPHTHAMIDE
BIOSYNTHESIS ENZYME
DPH2)		 4pxd ALLANTOATE
AMIDOHYDROLASE
(Escherichia
coli) 		5 / 12 LEU A 189
GLY A  96
GLN A 193
VAL A  85
ASP A  83
 None
None
1AL  A 502 ( 3.2A)
None
None
 1.39A 6bxnB-4pxdA:
undetectable		 6bxnB-4pxdA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_A_QPSA602_1
(-)		 4pxd ALLANTOATE
AMIDOHYDROLASE
(Escherichia
coli) 		5 / 12 VAL A  59
ASP A 320
ASN A 146
PRO A 176
GLY A 143
 None
 1.45A 6gnfA-4pxdA:
3.2		 6gnfA-4pxdA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_C_QPSC602_2
(-)		 4pxd ALLANTOATE
AMIDOHYDROLASE
(Escherichia
coli) 		5 / 12 VAL A  59
ASP A 320
ASN A 146
PRO A 176
GLY A 143
 None
 1.47A 6gnfC-4pxdA:
undetectable		 6gnfC-4pxdA:
21.64