SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4pxg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU2_A_MRCA1993_2
(ISOLEUCYL-TRNA
SYNTHETASE)		 4pxg TYPE-2 RESTRICTION
ENZYME SAU3AI
(Staphylococcus
aureus) 		3 / 3 GLU A 152
TRP A 151
LYS A 244
 None
 0.96A 1qu2A-4pxgA:
undetectable		 1qu2A-4pxgA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VE9_A_BEZA352_0
(D-AMINO ACID OXIDASE)		 4pxg TYPE-2 RESTRICTION
ENZYME SAU3AI
(Staphylococcus
aureus) 		4 / 5 TYR A 464
ILE A 416
ARG A 441
GLY A 442
 None
 1.24A 1ve9A-4pxgA:
undetectable		 1ve9A-4pxgA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XQL_A_4AXA605_1
(ALANINE RACEMASE)		 4pxg TYPE-2 RESTRICTION
ENZYME SAU3AI
(Staphylococcus
aureus) 		4 / 8 TYR A 215
LYS A 298
TYR A 207
TYR A 135
 None
 1.44A 1xqlA-4pxgA:
undetectable
1xqlB-4pxgA:
undetectable		 1xqlA-4pxgA:
23.94
1xqlB-4pxgA:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XQL_B_4AXB505_1
(ALANINE RACEMASE)		 4pxg TYPE-2 RESTRICTION
ENZYME SAU3AI
(Staphylococcus
aureus) 		4 / 8 LYS A 298
TYR A 207
TYR A 135
TYR A 215
 None
 1.47A 1xqlA-4pxgA:
undetectable
1xqlB-4pxgA:
undetectable		 1xqlA-4pxgA:
23.94
1xqlB-4pxgA:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA501_1
(CYTOCHROME P450 2B4)		 4pxg TYPE-2 RESTRICTION
ENZYME SAU3AI
(Staphylococcus
aureus) 		4 / 7 LEU A 349
GLY A 169
THR A 171
ILE A 154
 None
 1.11A 2bdmA-4pxgA:
undetectable		 2bdmA-4pxgA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJT_A_SAMA501_1
(N(2),N(2)-DIMETHYLGU
ANOSINE TRNA
METHYLTRANSFERASE)		 4pxg TYPE-2 RESTRICTION
ENZYME SAU3AI
(Staphylococcus
aureus) 		3 / 3 ARG A 199
ASP A 150
ASP A 143
 None
 0.82A 2ejtA-4pxgA:
undetectable		 2ejtA-4pxgA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L35_H_DHIH3_0
(GP41 N-PEPTIDE
HIV ENTRY INHIBITOR
PIE12)		 4pxg TYPE-2 RESTRICTION
ENZYME SAU3AI
(Staphylococcus
aureus) 		3 / 3 LEU A 449
TRP A 468
GLY A 442
 None
 0.72A 3l35A-4pxgA:
undetectable
3l35H-4pxgA:
undetectable		 3l35A-4pxgA:
6.48
3l35H-4pxgA:
2.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L35_K_DHIK3_0
(GP41 N-PEPTIDE
HIV ENTRY INHIBITOR
PIE12)		 4pxg TYPE-2 RESTRICTION
ENZYME SAU3AI
(Staphylococcus
aureus) 		3 / 3 LEU A 449
TRP A 468
GLY A 442
 None
 0.72A 3l35B-4pxgA:
undetectable
3l35K-4pxgA:
undetectable		 3l35B-4pxgA:
6.48
3l35K-4pxgA:
2.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIX_A_NIMA201_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 4pxg TYPE-2 RESTRICTION
ENZYME SAU3AI
(Staphylococcus
aureus) 		4 / 4 LEU A 256
ALA A 276
ILE A 277
LYS A 255
 None
 1.26A 4eixA-4pxgA:
undetectable		 4eixA-4pxgA:
14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJW_A_SRYA2001_2
(TRANSCRIPTIONAL
REGULATOR TCAR)		 4pxg TYPE-2 RESTRICTION
ENZYME SAU3AI
(Staphylococcus
aureus) 		4 / 6 GLU A 378
ILE A 381
ASN A 382
GLU A 332
 None
 1.11A 4ejwB-4pxgA:
undetectable		 4ejwB-4pxgA:
14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1E_B_C2FB4000_1
(DIHYDROPTEROATE
SYNTHASE DHPS)		 4pxg TYPE-2 RESTRICTION
ENZYME SAU3AI
(Staphylococcus
aureus) 		4 / 4 LYS A 386
ASN A 477
ASP A 422
ASP A 390
 None
 1.08A 4o1eB-4pxgA:
undetectable		 4o1eB-4pxgA:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_A_GCSA302_1
(CHITOSANASE)		 4pxg TYPE-2 RESTRICTION
ENZYME SAU3AI
(Staphylococcus
aureus) 		4 / 5 ARG A 415
THR A 410
ASP A 412
TYR A 464
 None
 1.34A 4oltA-4pxgA:
undetectable		 4oltA-4pxgA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_B_GCSB302_1
(CHITOSANASE)		 4pxg TYPE-2 RESTRICTION
ENZYME SAU3AI
(Staphylococcus
aureus) 		4 / 5 ARG A 415
THR A 410
ASP A 412
TYR A 464
 None
 1.29A 4oltB-4pxgA:
undetectable		 4oltB-4pxgA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUR_E_PFLE406_1
(PROTON-GATED ION
CHANNEL)		 4pxg TYPE-2 RESTRICTION
ENZYME SAU3AI
(Staphylococcus
aureus) 		5 / 10 ILE A 225
ILE A 240
ILE A 232
ILE A 142
ILE A 146
 None
 1.08A 5murE-4pxgA:
undetectable		 5murE-4pxgA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_A_ZITA501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		 4pxg TYPE-2 RESTRICTION
ENZYME SAU3AI
(Staphylococcus
aureus) 		4 / 7 GLU A 117
TYR A  78
PHE A  70
GLY A  19
 None
 1.07A 5uxdA-4pxgA:
undetectable		 5uxdA-4pxgA:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5Y_D_9CRD501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4pxg TYPE-2 RESTRICTION
ENZYME SAU3AI
(Staphylococcus
aureus) 		3 / 3 ASN A 478
VAL A 358
HIS A 307
 None
 0.83A 6a5yD-4pxgA:
undetectable		 6a5yD-4pxgA:
9.98