SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4pxj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1FBM_B_RTLB951_2 (PROTEIN (CARTILAGE OLIGOMERIC MATRIX PROTEIN))	4pxj	C-JUN-AMINO-TERMINAL KINASE-INTERACTING PROTEIN 3 (Homo sapiens)	4 / 4	THR A 433 LEU A 437 VAL A 440 LEU A 444	None	0.78A	1fbmD-4pxjA: undetectable	1fbmD-4pxjA: 22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1MZ9_D_VDYD1001_4 (CARTILAGE OLIGOMERIC MATRIX PROTEIN)	4pxj	C-JUN-AMINO-TERMINAL KINASE-INTERACTING PROTEIN 3 (Homo sapiens)	4 / 4	THR A 433 LEU A 437 VAL A 440 LEU A 444	None	0.80A	1mz9D-4pxjA: 4.7	1mz9D-4pxjA: 22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2P16_A_GG2A298_2 (COAGULATION FACTOR X (EC 3.4.21.6) (STUART FACTOR) (STUART-PROWER FACTOR))	4pxj	C-JUN-AMINO-TERMINAL KINASE-INTERACTING PROTEIN 3 (Homo sapiens)	3 / 3	ARG A 459 GLU A 456 GLN A 455	EDO A 504 ( 2.9A) None EDO A 504 (-3.2A)	1.08A	2p16A-4pxjA: undetectable	2p16A-4pxjA: 13.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3PGY_B_GLYB511_0 (SERINE HYDROXYMETHYLTRANSFE RASE)	4pxj	C-JUN-AMINO-TERMINAL KINASE-INTERACTING PROTEIN 3 (Homo sapiens)	4 / 5	GLU A 454 LEU A 451 GLN A 450 LYS A 447	None	1.15A	3pgyB-4pxjA: undetectable	3pgyB-4pxjA: 11.63

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1FBM_B_RTLB951_2","PROTEIN (CARTILAGE OLIGOMERIC MATRIX PROTEIN)","4pxj","C-JUN-AMINO-TERMINAL KINASE-INTERACTING PROTEIN 3","Homo sapiens",4,"THR A 433;LEU A 437;VAL A 440;LEU A 444","None","0.78A","1fbmD-4pxjA:undetectable","1fbmD-4pxjA:22.39"],["1MZ9_D_VDYD1001_4","CARTILAGE OLIGOMERIC MATRIX PROTEIN","4pxj","C-JUN-AMINO-TERMINAL KINASE-INTERACTING PROTEIN 3","Homo sapiens",4,"THR A 433;LEU A 437;VAL A 440;LEU A 444","None","0.80A","1mz9D-4pxjA:4.7","1mz9D-4pxjA:22.39"],["2P16_A_GG2A298_2","COAGULATION FACTOR X (EC 3.4.21.6) (STUART FACTOR) (STUART-PROWER FACTOR)","4pxj","C-JUN-AMINO-TERMINAL KINASE-INTERACTING PROTEIN 3","Homo sapiens",3,"ARG A 459;GLU A 456;GLN A 455","EDO A 504 ( 2.9A);None;EDO A 504 (-3.2A)","1.08A","2p16A-4pxjA:undetectable","2p16A-4pxjA:13.97"],["3PGY_B_GLYB511_0","SERINE HYDROXYMETHYLTRANSFERASE","4pxj","C-JUN-AMINO-TERMINAL KINASE-INTERACTING PROTEIN 3","Homo sapiens",4,"GLU A 454;LEU A 451;GLN A 450;LYS A 447","None","1.15A","3pgyB-4pxjA:undetectable","3pgyB-4pxjA:11.63"]]