SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4pxl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q97_B_ADNB486_1
(SR PROTEIN KINASE)		 4pxl CYTOSOLIC ALDEHYDE
DEHYDROGENASE RF2C
(Zea
mays) 		4 / 4 VAL A 214
ALA A 212
LEU A 130
PHE A  92
 None
 1.15A 1q97B-4pxlA:
undetectable		 1q97B-4pxlA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RA8_A_FOLA161_1
(DIHYDROFOLATE
REDUCTASE)		 4pxl CYTOSOLIC ALDEHYDE
DEHYDROGENASE RF2C
(Zea
mays) 		3 / 3 ASP A 347
LYS A 353
ARG A 356
 None
NAD  A 601 (-3.2A)
None
 1.20A 1ra8A-4pxlA:
undetectable		 1ra8A-4pxlA:
13.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VPO_H_TESH1010_1
(ANTI-TESTOSTERONE
(HEAVY CHAIN)
ANTI-TESTOSTERONE
(LIGHT CHAIN))		 4pxl CYTOSOLIC ALDEHYDE
DEHYDROGENASE RF2C
(Zea
mays) 		5 / 12 SER A 274
ALA A 449
GLY A 450
LEU A 428
PHE A 466
 EDO  A 604 (-3.1A)
EDO  A 604 ( 3.7A)
None
CSO  A 303 (-4.5A)
None
 1.29A 1vpoH-4pxlA:
undetectable
1vpoL-4pxlA:
undetectable		 1vpoH-4pxlA:
19.36
1vpoL-4pxlA:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOU_A_CQAA403_0
(HISTAMINE
N-METHYLTRANSFERASE)		 4pxl CYTOSOLIC ALDEHYDE
DEHYDROGENASE RF2C
(Zea
mays) 		4 / 8 ASP A  62
LYS A  58
GLY A  56
ASP A  32
 None
 1.02A 2aouA-4pxlA:
3.1		 2aouA-4pxlA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2COJ_A_GBNA420_1
(BRANCHED CHAIN
AMINOTRANSFERASE 1,
CYTOSOLIC)		 4pxl CYTOSOLIC ALDEHYDE
DEHYDROGENASE RF2C
(Zea
mays) 		5 / 11 PHE A 319
GLY A 306
THR A 295
ALA A 294
VAL A 433
 None
 1.30A 2cojA-4pxlA:
undetectable
2cojB-4pxlA:
undetectable		 2cojA-4pxlA:
21.70
2cojB-4pxlA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CWK_A_REAA300_1
(CELLULAR RETINOIC
ACID-BINDING PROTEIN
2)		 4pxl CYTOSOLIC ALDEHYDE
DEHYDROGENASE RF2C
(Zea
mays) 		5 / 12 PHE A  92
LEU A 130
ALA A 209
VAL A 221
VAL A 218
 None
 1.20A 3cwkA-4pxlA:
undetectable		 3cwkA-4pxlA:
13.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHX_B_PXLB313_1
(PYRIDOXAL KINASE)		 4pxl CYTOSOLIC ALDEHYDE
DEHYDROGENASE RF2C
(Zea
mays) 		4 / 8 VAL A 239
VAL A 254
HIS A 236
VAL A  65
 None
 1.04A 3fhxB-4pxlA:
undetectable		 3fhxB-4pxlA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LK0_D_Z80D92_1
(PROTEIN S100-B)		 4pxl CYTOSOLIC ALDEHYDE
DEHYDROGENASE RF2C
(Zea
mays) 		3 / 3 HIS A 207
PHE A 176
PHE A 177
 None
 0.78A 3lk0D-4pxlA:
undetectable		 3lk0D-4pxlA:
12.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NXU_A_RITA600_2
(CYTOCHROME P450 3A4)		 4pxl CYTOSOLIC ALDEHYDE
DEHYDROGENASE RF2C
(Zea
mays) 		4 / 7 PHE A 336
ILE A  53
THR A 173
ARG A  45
 None
 1.18A 3nxuA-4pxlA:
undetectable		 3nxuA-4pxlA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UR0_B_SVRB516_1
(RNA-DEPENDENT RNA
POLYMERASE)		 4pxl CYTOSOLIC ALDEHYDE
DEHYDROGENASE RF2C
(Zea
mays) 		5 / 7 PRO A 194
ALA A 195
TRP A 169
ALA A 111
ASP A 110
 None
NAD  A 601 (-3.9A)
NAD  A 601 (-3.8A)
None
NA  A 609 (-3.6A)
 1.28A 3ur0B-4pxlA:
undetectable		 3ur0B-4pxlA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UR0_C_SVRC516_1
(RNA-DEPENDENT RNA
POLYMERASE)		 4pxl CYTOSOLIC ALDEHYDE
DEHYDROGENASE RF2C
(Zea
mays) 		5 / 9 PRO A 194
ALA A 195
TRP A 169
ALA A 111
ASP A 110
 None
NAD  A 601 (-3.9A)
NAD  A 601 (-3.8A)
None
NA  A 609 (-3.6A)
 1.28A 3ur0C-4pxlA:
undetectable		 3ur0C-4pxlA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7T_A_5FWA1001_1
(SUPEROXIDE DISMUTASE
[CU-ZN])		 4pxl CYTOSOLIC ALDEHYDE
DEHYDROGENASE RF2C
(Zea
mays) 		3 / 3 ASP A 349
LYS A 348
ASP A 347
 None
 0.66A 4a7tA-4pxlA:
undetectable		 4a7tA-4pxlA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_H_ZPCH1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4pxl CYTOSOLIC ALDEHYDE
DEHYDROGENASE RF2C
(Zea
mays) 		5 / 7 ILE A 123
TYR A 205
HIS A 207
VAL A 214
PHE A 177
 None
 1.36A 4a97H-4pxlA:
undetectable		 4a97H-4pxlA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_I_ZPCI1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4pxl CYTOSOLIC ALDEHYDE
DEHYDROGENASE RF2C
(Zea
mays) 		4 / 6 ILE A 123
TYR A 205
HIS A 207
VAL A 214
 None
 1.23A 4a97I-4pxlA:
undetectable		 4a97I-4pxlA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZS_A_SAMA1475_1
(METHYLTRANSFERASE
WBDD)		 4pxl CYTOSOLIC ALDEHYDE
DEHYDROGENASE RF2C
(Zea
mays) 		3 / 3 ARG A 356
ASP A 347
GLN A 197
 None
None
NAD  A 601 (-4.2A)
 0.87A 4azsA-4pxlA:
5.3		 4azsA-4pxlA:
23.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1E_A_C2FA3000_1
(DIHYDROPTEROATE
SYNTHASE DHPS)		 4pxl CYTOSOLIC ALDEHYDE
DEHYDROGENASE RF2C
(Zea
mays) 		3 / 3 LYS A  23
ASN A 220
ASP A  32
 None
 0.83A 4o1eA-4pxlA:
undetectable		 4o1eA-4pxlA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R1Z_A_AERA601_1
(CYP17A1 PROTEIN)		 4pxl CYTOSOLIC ALDEHYDE
DEHYDROGENASE RF2C
(Zea
mays) 		5 / 9 ALA A  93
GLY A 125
ALA A 126
THR A 173
VAL A 100
 None
 1.22A 4r1zA-4pxlA:
undetectable		 4r1zA-4pxlA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNV_A_QI9A602_0
(CYTOCHROME P450 2D6)		 4pxl CYTOSOLIC ALDEHYDE
DEHYDROGENASE RF2C
(Zea
mays) 		5 / 9 PHE A 319
LEU A 284
THR A 295
VAL A 276
VAL A 278
 None
 1.36A 4wnvA-4pxlA:
undetectable		 4wnvA-4pxlA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNV_B_QI9B602_0
(CYTOCHROME P450 2D6)		 4pxl CYTOSOLIC ALDEHYDE
DEHYDROGENASE RF2C
(Zea
mays) 		5 / 9 PHE A 319
LEU A 284
THR A 295
VAL A 276
VAL A 278
 None
 1.37A 4wnvB-4pxlA:
undetectable		 4wnvB-4pxlA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNV_C_QI9C602_0
(CYTOCHROME P450 2D6)		 4pxl CYTOSOLIC ALDEHYDE
DEHYDROGENASE RF2C
(Zea
mays) 		5 / 9 PHE A 319
LEU A 284
THR A 295
VAL A 276
VAL A 278
 None
 1.38A 4wnvC-4pxlA:
0.7		 4wnvC-4pxlA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJZ_A_BEZA1001_0
(BENZOATE-COENZYME A
LIGASE)		 4pxl CYTOSOLIC ALDEHYDE
DEHYDROGENASE RF2C
(Zea
mays) 		4 / 8 ALA A  67
GLY A 217
ALA A 216
GLY A  28
 None
 0.70A 4zjzA-4pxlA:
undetectable		 4zjzA-4pxlA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A1R_A_STRA600_1
(CYTOCHROME P450 3A4)		 4pxl CYTOSOLIC ALDEHYDE
DEHYDROGENASE RF2C
(Zea
mays) 		4 / 5 PHE A 458
PHE A 466
PHE A 460
VAL A 304
 PEG  A 610 (-4.0A)
None
PEG  A 610 (-4.2A)
CSO  A 303 ( 3.0A)
 1.08A 5a1rA-4pxlA:
undetectable		 5a1rA-4pxlA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_O_EVPO2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 4pxl CYTOSOLIC ALDEHYDE
DEHYDROGENASE RF2C
(Zea
mays) 		4 / 6 GLU A 352
ASP A 334
ARG A  45
GLY A 112
 None
 0.86A 5cdnC-4pxlA:
undetectable
5cdnD-4pxlA:
undetectable		 5cdnC-4pxlA:
20.64
5cdnD-4pxlA:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDQ_F_MFXF2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 4pxl CYTOSOLIC ALDEHYDE
DEHYDROGENASE RF2C
(Zea
mays) 		4 / 6 SER A 201
ASP A  43
ARG A  45
GLY A 112
 None
 1.03A 5cdqA-4pxlA:
undetectable
5cdqC-4pxlA:
undetectable
5cdqD-4pxlA:
undetectable		 5cdqA-4pxlA:
20.64
5cdqC-4pxlA:
20.64
5cdqD-4pxlA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWA_A_GCSA303_1
(CHITOSANASE)		 4pxl CYTOSOLIC ALDEHYDE
DEHYDROGENASE RF2C
(Zea
mays) 		4 / 5 HIS A 236
VAL A 222
GLY A 230
ALA A 229
 None
None
NAD  A 601 (-3.6A)
None
 1.03A 5hwaA-4pxlA:
undetectable		 5hwaA-4pxlA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NN8_A_ACRA1016_1
(LYSOSOMAL
ALPHA-GLUCOSIDASE)		 4pxl CYTOSOLIC ALDEHYDE
DEHYDROGENASE RF2C
(Zea
mays) 		4 / 5 GLY A  75
PRO A  78
TRP A  77
CYH A 188
 None
 1.36A 5nn8A-4pxlA:
undetectable		 5nn8A-4pxlA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MHT_D_SAMD328_0
(CYTOSINE-SPECIFIC
METHYLTRANSFERASE
HHAI)		 4pxl CYTOSOLIC ALDEHYDE
DEHYDROGENASE RF2C
(Zea
mays) 		5 / 12 GLY A 467
LEU A 428
ASP A 477
ASP A 484
SER A 472
 None
CSO  A 303 (-4.5A)
None
None
EDO  A 604 ( 4.2A)
 1.03A 6mhtA-4pxlA:
3.9		 6mhtA-4pxlA:
21.78