SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4pxq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FO4_A_SALA3005_1
(XANTHINE
DEHYDROGENASE)		 4pxq D-GLUCURONYL C5
EPIMERASE B
(Danio
rerio) 		5 / 9 LEU A 351
THR A 219
VAL A 250
LEU A 226
ALA A 217
 None
 1.40A 1fo4A-4pxqA:
1.2		 1fo4A-4pxqA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HBP_A_RTLA184_0
(RETINOL BINDING
PROTEIN)		 4pxq D-GLUCURONYL C5
EPIMERASE B
(Danio
rerio) 		5 / 11 LEU A 505
ALA A 184
ALA A 418
MET A 419
LEU A 490
 None
 1.27A 1hbpA-4pxqA:
undetectable		 1hbpA-4pxqA:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXB_A_ROCA100_3
(HIV-1 PROTEASE)		 4pxq D-GLUCURONYL C5
EPIMERASE B
(Danio
rerio) 		5 / 12 LEU A 322
ASP A 325
GLY A 308
VAL A 276
ILE A 289
 None
 1.07A 1hxbB-4pxqA:
undetectable		 1hxbB-4pxqA:
10.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICU_A_NIOA221_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 4pxq D-GLUCURONYL C5
EPIMERASE B
(Danio
rerio) 		4 / 6 THR A 293
PHE A 241
GLU A 245
GLY A 355
 None
 1.16A 1icuA-4pxqA:
undetectable
1icuB-4pxqA:
undetectable		 1icuA-4pxqA:
15.90
1icuB-4pxqA:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICU_B_NIOB219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 4pxq D-GLUCURONYL C5
EPIMERASE B
(Danio
rerio) 		4 / 6 PHE A 241
GLU A 245
GLY A 355
THR A 293
 None
 1.16A 1icuA-4pxqA:
undetectable
1icuB-4pxqA:
undetectable		 1icuA-4pxqA:
15.90
1icuB-4pxqA:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IIU_A_RTLA176_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 4pxq D-GLUCURONYL C5
EPIMERASE B
(Danio
rerio) 		5 / 11 LEU A 505
ALA A 184
ALA A 418
MET A 419
LEU A 490
 None
 1.33A 1iiuA-4pxqA:
undetectable		 1iiuA-4pxqA:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JGL_L_ESTL911_1
(IG GAMMA-1-CHAIN
IG KAPPA-CHAIN)		 4pxq D-GLUCURONYL C5
EPIMERASE B
(Danio
rerio) 		5 / 10 GLY A 479
ALA A 542
TYR A 528
HIS A 547
TRP A 573
 None
None
SGN  A 804 (-4.3A)
None
None
 1.20A 1jglH-4pxqA:
undetectable
1jglL-4pxqA:
undetectable		 1jglH-4pxqA:
17.54
1jglL-4pxqA:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PJ7_A_FFOA2887_1
(N,N-DIMETHYLGLYCINE
OXIDASE)		 4pxq D-GLUCURONYL C5
EPIMERASE B
(Danio
rerio) 		3 / 3 ASP A 321
THR A 367
GLU A 197
 None
 0.84A 1pj7A-4pxqA:
undetectable		 1pj7A-4pxqA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SDT_B_MK1B902_1
(PROTEASE RETROPEPSIN)		 4pxq D-GLUCURONYL C5
EPIMERASE B
(Danio
rerio) 		6 / 10 LEU A 322
ASP A 325
GLY A 308
ILE A 309
VAL A 276
ILE A 289
 None
 1.25A 1sdtA-4pxqA:
undetectable		 1sdtA-4pxqA:
10.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_F_9CRF1600_1
(RETINOIC ACID
RECEPTOR, BETA)		 4pxq D-GLUCURONYL C5
EPIMERASE B
(Danio
rerio) 		5 / 12 LEU A 513
LEU A 484
ILE A 481
ILE A 485
LEU A 554
 None
 1.01A 1xdkF-4pxqA:
undetectable		 1xdkF-4pxqA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOI_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 4pxq D-GLUCURONYL C5
EPIMERASE B
(Danio
rerio) 		4 / 5 ASP A 325
GLY A 308
VAL A 276
ILE A 289
 None
 0.91A 2aoiA-4pxqA:
undetectable		 2aoiA-4pxqA:
10.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVO_B_MK1B902_1
(POL POLYPROTEIN)		 4pxq D-GLUCURONYL C5
EPIMERASE B
(Danio
rerio) 		6 / 9 LEU A 322
ASP A 325
GLY A 308
ILE A 309
VAL A 276
ILE A 289
 None
 1.28A 2avoA-4pxqA:
undetectable		 2avoA-4pxqA:
10.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C12_B_SPMB1433_1
(NITROALKANE OXIDASE)		 4pxq D-GLUCURONYL C5
EPIMERASE B
(Danio
rerio) 		5 / 11 GLN A 384
ALA A 441
SER A 420
LEU A 422
VAL A 423
 None
 1.33A 2c12B-4pxqA:
undetectable		 2c12B-4pxqA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C12_D_SPMD1434_1
(NITROALKANE OXIDASE)		 4pxq D-GLUCURONYL C5
EPIMERASE B
(Danio
rerio) 		5 / 10 GLN A 384
ALA A 441
SER A 420
LEU A 422
VAL A 423
 None
 1.35A 2c12D-4pxqA:
1.7		 2c12D-4pxqA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G72_A_SAMA2001_1
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 4pxq D-GLUCURONYL C5
EPIMERASE B
(Danio
rerio) 		4 / 6 TYR A 468
TYR A 528
GLY A 479
TYR A 546
 None
SGN  A 804 (-4.3A)
None
UAP  A 801 ( 3.6A)
 1.20A 2g72A-4pxqA:
undetectable		 2g72A-4pxqA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4P_A_TPVA300_2
(PROTEASE)		 4pxq D-GLUCURONYL C5
EPIMERASE B
(Danio
rerio) 		6 / 9 LEU A 322
ASP A 325
GLY A 308
ILE A 309
VAL A 276
ILE A 289
 None
 1.14A 2o4pB-4pxqA:
undetectable		 2o4pB-4pxqA:
10.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_A_SNLA1001_2
(MINERALOCORTICOID
RECEPTOR)		 4pxq D-GLUCURONYL C5
EPIMERASE B
(Danio
rerio) 		4 / 5 LEU A 439
ALA A 437
TRP A 390
LEU A 422
 None
 1.23A 2oaxA-4pxqA:
undetectable		 2oaxA-4pxqA:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6O_A_SAMA500_0
(HYPOTHETICAL PROTEIN)		 4pxq D-GLUCURONYL C5
EPIMERASE B
(Danio
rerio) 		4 / 7 ASP A 378
VAL A 381
ALA A 437
THR A 429
 None
 1.06A 2q6oA-4pxqA:
undetectable		 2q6oA-4pxqA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5Q_B_1UNB900_1
(PROTEASE)		 4pxq D-GLUCURONYL C5
EPIMERASE B
(Danio
rerio) 		5 / 9 LEU A 322
ASP A 325
GLY A 308
VAL A 276
ILE A 289
 None
 1.11A 2r5qA-4pxqA:
undetectable		 2r5qA-4pxqA:
9.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5Q_D_1UND900_1
(PROTEASE)		 4pxq D-GLUCURONYL C5
EPIMERASE B
(Danio
rerio) 		5 / 9 LEU A 322
ASP A 325
GLY A 308
VAL A 276
ILE A 289
 None
 1.11A 2r5qC-4pxqA:
undetectable		 2r5qC-4pxqA:
9.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWM_A_SAMA301_0
(CATECHOL
O-METHYLTRANSFERASE)		 4pxq D-GLUCURONYL C5
EPIMERASE B
(Danio
rerio) 		5 / 12 ASN A 552
GLY A 558
TYR A 131
ILE A 565
SER A 563
 None
 1.38A 3bwmA-4pxqA:
undetectable		 3bwmA-4pxqA:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CCF_A_BEZA261_0
(CYCLOPROPANE-FATTY-A
CYL-PHOSPHOLIPID
SYNTHASE)		 4pxq D-GLUCURONYL C5
EPIMERASE B
(Danio
rerio) 		4 / 8 HIS A 125
GLY A 579
PHE A 106
ARG A 581
 None
 1.36A 3ccfA-4pxqA:
undetectable		 3ccfA-4pxqA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D1Y_A_ROCA201_2
(HIV-1 PROTEASE)		 4pxq D-GLUCURONYL C5
EPIMERASE B
(Danio
rerio) 		6 / 9 LEU A 322
ASP A 325
GLY A 308
ILE A 309
VAL A 276
ILE A 289
 None
 1.15A 3d1yB-4pxqA:
undetectable		 3d1yB-4pxqA:
11.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FZG_A_SAMA300_0
(16S RRNA METHYLASE)		 4pxq D-GLUCURONYL C5
EPIMERASE B
(Danio
rerio) 		5 / 12 HIS A 354
SER A 273
GLY A 249
LEU A 351
VAL A 288
 None
 1.21A 3fzgA-4pxqA:
undetectable		 3fzgA-4pxqA:
15.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCN_A_CHDA3_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4pxq D-GLUCURONYL C5
EPIMERASE B
(Danio
rerio) 		4 / 7 LEU A 380
ARG A 424
SER A 411
GLY A 486
 None
 1.10A 3hcnA-4pxqA:
undetectable		 3hcnA-4pxqA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQA_A_DX4A270_0
(PTERIDINE REDUCTASE
1)		 4pxq D-GLUCURONYL C5
EPIMERASE B
(Danio
rerio) 		4 / 6 ARG A 424
PHE A 488
TYR A 506
PRO A 139
 None
 1.44A 3jqaA-4pxqA:
undetectable		 3jqaA-4pxqA:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQA_B_DX4B270_0
(PTERIDINE REDUCTASE
1)		 4pxq D-GLUCURONYL C5
EPIMERASE B
(Danio
rerio) 		4 / 6 ARG A 424
PHE A 488
TYR A 506
PRO A 139
 None
 1.46A 3jqaB-4pxqA:
undetectable		 3jqaB-4pxqA:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQA_C_DX4C270_0
(PTERIDINE REDUCTASE
1)		 4pxq D-GLUCURONYL C5
EPIMERASE B
(Danio
rerio) 		4 / 6 ARG A 424
PHE A 488
TYR A 506
PRO A 139
 None
 1.40A 3jqaC-4pxqA:
undetectable		 3jqaC-4pxqA:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQA_D_DX4D270_0
(PTERIDINE REDUCTASE
1)		 4pxq D-GLUCURONYL C5
EPIMERASE B
(Danio
rerio) 		4 / 6 ARG A 424
PHE A 488
TYR A 506
PRO A 139
 None
 1.44A 3jqaD-4pxqA:
undetectable		 3jqaD-4pxqA:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OY4_B_017B200_1
(HIV-1 PROTEASE)		 4pxq D-GLUCURONYL C5
EPIMERASE B
(Danio
rerio) 		6 / 11 LEU A 322
ASP A 325
GLY A 308
ILE A 309
VAL A 276
ILE A 289
 None
 1.26A 3oy4A-4pxqA:
undetectable		 3oy4A-4pxqA:
10.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_D_SAMD6735_0
(16S RRNA METHYLASE)		 4pxq D-GLUCURONYL C5
EPIMERASE B
(Danio
rerio) 		5 / 12 GLY A 165
GLY A 162
VAL A 318
ALA A 371
ALA A 372
 None
 1.06A 3p2kD-4pxqA:
undetectable		 3p2kD-4pxqA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCB_A_017A201_1
(PROTEASE)		 4pxq D-GLUCURONYL C5
EPIMERASE B
(Danio
rerio) 		5 / 12 LEU A 322
ASP A 325
GLY A 308
ILE A 309
VAL A 276
 None
 1.07A 3ucbA-4pxqA:
undetectable		 3ucbA-4pxqA:
10.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UNC_A_SALA1338_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 4pxq D-GLUCURONYL C5
EPIMERASE B
(Danio
rerio) 		5 / 9 LEU A 351
THR A 219
VAL A 250
LEU A 226
ALA A 217
 None
 1.39A 3uncA-4pxqA:
2.2		 3uncA-4pxqA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UNC_B_SALB1338_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 4pxq D-GLUCURONYL C5
EPIMERASE B
(Danio
rerio) 		5 / 9 LEU A 351
THR A 219
VAL A 250
LEU A 226
ALA A 217
 None
 1.39A 3uncB-4pxqA:
2.2		 3uncB-4pxqA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B53_B_ACTB1445_0
(IG GAMMA-4 CHAIN C
REGION)		 4pxq D-GLUCURONYL C5
EPIMERASE B
(Danio
rerio) 		3 / 3 GLU A 467
GLY A 479
SER A 411
 None
 0.67A 4b53B-4pxqA:
undetectable		 4b53B-4pxqA:
11.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CEV_A_GAIA407_0
(PROTEIN (ARGINASE))		 4pxq D-GLUCURONYL C5
EPIMERASE B
(Danio
rerio) 		4 / 6 ARG A 531
HIS A 532
LEU A 541
ASP A 529
 SGN  A 804 (-3.1A)
None
None
None
 1.38A 4cevA-4pxqA:
undetectable
4cevB-4pxqA:
undetectable		 4cevA-4pxqA:
18.89
4cevB-4pxqA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CEV_C_GAIC409_0
(PROTEIN (ARGINASE))		 4pxq D-GLUCURONYL C5
EPIMERASE B
(Danio
rerio) 		4 / 6 ASP A 529
ARG A 531
HIS A 532
LEU A 541
 None
SGN  A 804 (-3.1A)
None
None
 1.38A 4cevA-4pxqA:
undetectable
4cevC-4pxqA:
undetectable		 4cevA-4pxqA:
18.89
4cevC-4pxqA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CEV_D_GAID410_0
(PROTEIN (ARGINASE))		 4pxq D-GLUCURONYL C5
EPIMERASE B
(Danio
rerio) 		4 / 6 ARG A 531
HIS A 532
LEU A 541
ASP A 529
 SGN  A 804 (-3.1A)
None
None
None
 1.36A 4cevD-4pxqA:
undetectable
4cevE-4pxqA:
undetectable		 4cevD-4pxqA:
18.89
4cevE-4pxqA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CEV_F_GAIF411_0
(PROTEIN (ARGINASE))		 4pxq D-GLUCURONYL C5
EPIMERASE B
(Danio
rerio) 		4 / 6 ARG A 531
HIS A 532
LEU A 541
ASP A 529
 SGN  A 804 (-3.1A)
None
None
None
 1.36A 4cevE-4pxqA:
undetectable
4cevF-4pxqA:
undetectable		 4cevE-4pxqA:
18.89
4cevF-4pxqA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQE_B_017B101_1
(ASPARTYL PROTEASE)		 4pxq D-GLUCURONYL C5
EPIMERASE B
(Danio
rerio) 		6 / 11 LEU A 322
ASP A 325
GLY A 308
ILE A 309
VAL A 276
ILE A 289
 None
 1.31A 4dqeA-4pxqA:
undetectable		 4dqeA-4pxqA:
11.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGJ_A_1PQA304_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4pxq D-GLUCURONYL C5
EPIMERASE B
(Danio
rerio) 		4 / 8 GLN A 553
ILE A 485
PHE A 146
GLU A 467
 None
 1.02A 4fgjA-4pxqA:
undetectable
4fgjB-4pxqA:
undetectable		 4fgjA-4pxqA:
18.54
4fgjB-4pxqA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOU_A_C04A207_1
(UNCHARACTERIZED
PROTEIN)		 4pxq D-GLUCURONYL C5
EPIMERASE B
(Danio
rerio) 		3 / 3 GLY A 284
GLU A 279
THR A 280
 None
 0.45A 4kouA-4pxqA:
undetectable		 4kouA-4pxqA:
13.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4C_B_CAMB502_0
(CAMPHOR
5-MONOOXYGENASE)		 4pxq D-GLUCURONYL C5
EPIMERASE B
(Danio
rerio) 		4 / 8 LEU A 278
VAL A 348
ASP A 321
ILE A 261
 None
 0.86A 4l4cB-4pxqA:
undetectable		 4l4cB-4pxqA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_A_CHDA503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4pxq D-GLUCURONYL C5
EPIMERASE B
(Danio
rerio) 		5 / 10 LEU A 513
LEU A 517
ILE A 481
THR A 522
HIS A 547
 None
 1.17A 4mk4A-4pxqA:
undetectable		 4mk4A-4pxqA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGF_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 4pxq D-GLUCURONYL C5
EPIMERASE B
(Danio
rerio) 		4 / 6 THR A 343
GLU A 282
THR A 281
LEU A 326
 None
 0.99A 4pgfA-4pxqA:
undetectable		 4pgfA-4pxqA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QKN_A_JMSA602_1
(ALPHA-KETOGLUTARATE-
DEPENDENT
DIOXYGENASE FTO)		 4pxq D-GLUCURONYL C5
EPIMERASE B
(Danio
rerio) 		4 / 8 LEU A 226
THR A 219
VAL A 352
HIS A 354
 None
 1.16A 4qknA-4pxqA:
4.3		 4qknA-4pxqA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_D_SAMD301_1
(PUTATIVE
METHYLTRANSFERASE
BUD23)		 4pxq D-GLUCURONYL C5
EPIMERASE B
(Danio
rerio) 		4 / 5 GLN A 185
LEU A 188
SER A 189
ASP A 325
 UAP  A 801 (-3.6A)
None
None
None
 1.29A 4qtuD-4pxqA:
undetectable		 4qtuD-4pxqA:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UAC_A_ACRA501_2
(CARBOHYDRATE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN, CUT1 FAMILY
(TC 3.A.1.1.-))		 4pxq D-GLUCURONYL C5
EPIMERASE B
(Danio
rerio) 		4 / 7 SER A 124
TRP A 544
ASP A 545
THR A 548
 None
None
UAP  A 801 (-3.6A)
None
 1.27A 4uacA-4pxqA:
undetectable		 4uacA-4pxqA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_A_6ZPA902_1
(GLUTAMATE RECEPTOR 2)		 4pxq D-GLUCURONYL C5
EPIMERASE B
(Danio
rerio) 		4 / 8 SER A 247
PRO A 221
SER A 275
SER A 225
 None
 1.14A 5l1fA-4pxqA:
undetectable
5l1fB-4pxqA:
undetectable		 5l1fA-4pxqA:
21.53
5l1fB-4pxqA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5D_A_SAMA306_1
(METHYLTRANSFERASE)		 4pxq D-GLUCURONYL C5
EPIMERASE B
(Danio
rerio) 		4 / 7 LEU A 484
SER A 420
ILE A 181
ASN A 478
 None
None
SGN  A 802 (-4.4A)
UAP  A 801 ( 4.6A)
 1.04A 5n5dA-4pxqA:
undetectable		 5n5dA-4pxqA:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_B_ACRB1421_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 4pxq D-GLUCURONYL C5
EPIMERASE B
(Danio
rerio) 		4 / 6 TYR A 118
GLU A 122
TYR A 115
GLY A 117
 None
 0.97A 5x7pB-4pxqA:
undetectable		 5x7pB-4pxqA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_C_GLYC713_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 4pxq D-GLUCURONYL C5
EPIMERASE B
(Danio
rerio) 		3 / 3 GLN A 555
TYR A 131
ASN A 552
 None
 0.88A 6dwdC-4pxqA:
undetectable		 6dwdC-4pxqA:
20.68