SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4py4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DMA_A_NCAA700_0
(EXOTOXIN A)		 4py4 POLY [ADP-RIBOSE]
POLYMERASE 14
(Homo
sapiens) 		4 / 7 HIS A1682
GLY A1683
TYR A1714
TYR A1727
 XL2  A1901 (-4.0A)
XL2  A1901 (-3.6A)
XL2  A1901 (-3.7A)
XL2  A1901 (-3.6A)
 0.16A 1dmaA-4py4A:
5.6		 1dmaA-4py4A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DMA_B_NCAB700_0
(EXOTOXIN A)		 4py4 POLY [ADP-RIBOSE]
POLYMERASE 14
(Homo
sapiens) 		5 / 6 HIS A1682
GLY A1683
TYR A1714
ALA A1716
TYR A1727
 XL2  A1901 (-4.0A)
XL2  A1901 (-3.6A)
XL2  A1901 (-3.7A)
XL2  A1901 (-3.4A)
XL2  A1901 (-3.6A)
 0.35A 1dmaB-4py4A:
5.2		 1dmaB-4py4A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_A_NFZA1219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 4py4 POLY [ADP-RIBOSE]
POLYMERASE 14
(Homo
sapiens) 		4 / 8 TYR A1739
PHE A1681
THR A1713
PHE A1697
 None
 1.07A 1ykiA-4py4A:
undetectable
1ykiB-4py4A:
undetectable		 1ykiA-4py4A:
21.93
1ykiB-4py4A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_B_NFZB2219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 4py4 POLY [ADP-RIBOSE]
POLYMERASE 14
(Homo
sapiens) 		4 / 8 THR A1713
PHE A1697
TYR A1739
PHE A1681
 None
 1.06A 1ykiA-4py4A:
undetectable
1ykiB-4py4A:
undetectable		 1ykiA-4py4A:
21.93
1ykiB-4py4A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_D_NFZD4219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 4py4 POLY [ADP-RIBOSE]
POLYMERASE 14
(Homo
sapiens) 		4 / 8 THR A1713
PHE A1697
TYR A1739
PHE A1681
 None
 1.06A 1ykiC-4py4A:
undetectable
1ykiD-4py4A:
undetectable		 1ykiC-4py4A:
21.93
1ykiD-4py4A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_E_CLME221_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4py4 POLY [ADP-RIBOSE]
POLYMERASE 14
(Homo
sapiens) 		3 / 3 PHE A1643
CYH A1640
HIS A1642
 None
 1.31A 3u9fF-4py4A:
undetectable		 3u9fF-4py4A:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9H_A_NCAA1163_0
(TANKYRASE-2)		 4py4 POLY [ADP-RIBOSE]
POLYMERASE 14
(Homo
sapiens) 		6 / 8 HIS A1682
GLY A1683
TYR A1714
ALA A1716
SER A1722
TYR A1727
 XL2  A1901 (-4.0A)
XL2  A1901 (-3.6A)
XL2  A1901 (-3.7A)
XL2  A1901 (-3.4A)
XL2  A1901 (-2.6A)
XL2  A1901 (-3.6A)
 0.35A 3u9hA-4py4A:
18.7		 3u9hA-4py4A:
26.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9H_B_NCAB1164_0
(TANKYRASE-2)		 4py4 POLY [ADP-RIBOSE]
POLYMERASE 14
(Homo
sapiens) 		6 / 8 HIS A1682
GLY A1683
TYR A1714
ALA A1716
SER A1722
TYR A1727
 XL2  A1901 (-4.0A)
XL2  A1901 (-3.6A)
XL2  A1901 (-3.7A)
XL2  A1901 (-3.4A)
XL2  A1901 (-2.6A)
XL2  A1901 (-3.6A)
 0.37A 3u9hB-4py4A:
18.5		 3u9hB-4py4A:
26.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB513_1
(HEMOLYTIC LECTIN
CEL-III)		 4py4 POLY [ADP-RIBOSE]
POLYMERASE 14
(Homo
sapiens) 		4 / 6 CYH A1640
THR A1639
ASN A1720
ILE A1797
 None
 1.28A 3w9tB-4py4A:
undetectable		 3w9tB-4py4A:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AE1_A_NCAA1536_0
(DIPHTHERIA TOXIN)		 4py4 POLY [ADP-RIBOSE]
POLYMERASE 14
(Homo
sapiens) 		4 / 6 HIS A1682
GLY A1683
TYR A1714
TYR A1727
 XL2  A1901 (-4.0A)
XL2  A1901 (-3.6A)
XL2  A1901 (-3.7A)
XL2  A1901 (-3.6A)
 0.29A 4ae1A-4py4A:
6.8		 4ae1A-4py4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AE1_B_NCAB1536_0
(DIPHTHERIA TOXIN)		 4py4 POLY [ADP-RIBOSE]
POLYMERASE 14
(Homo
sapiens) 		4 / 5 HIS A1682
GLY A1683
TYR A1714
TYR A1727
 XL2  A1901 (-4.0A)
XL2  A1901 (-3.6A)
XL2  A1901 (-3.7A)
XL2  A1901 (-3.6A)
 0.26A 4ae1B-4py4A:
6.2		 4ae1B-4py4A:
13.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BJC_A_RPBA2162_1
(TANKYRASE-2)		 4py4 POLY [ADP-RIBOSE]
POLYMERASE 14
(Homo
sapiens) 		6 / 8 HIS A1682
GLY A1683
TYR A1714
ALA A1716
SER A1722
TYR A1727
 XL2  A1901 (-4.0A)
XL2  A1901 (-3.6A)
XL2  A1901 (-3.7A)
XL2  A1901 (-3.4A)
XL2  A1901 (-2.6A)
XL2  A1901 (-3.6A)
 0.29A 4bjcA-4py4A:
18.9		 4bjcA-4py4A:
26.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_A_SAMA401_1
(METHYLTRANSFERASE
NSUN4)		 4py4 POLY [ADP-RIBOSE]
POLYMERASE 14
(Homo
sapiens) 		3 / 3 ASP A1731
ARG A1735
ASP A1725
 None
 0.81A 4fp9A-4py4A:
undetectable		 4fp9A-4py4A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_C_SAMC401_1
(METHYLTRANSFERASE
NSUN4)		 4py4 POLY [ADP-RIBOSE]
POLYMERASE 14
(Homo
sapiens) 		3 / 3 ASP A1731
ARG A1735
ASP A1725
 None
 0.86A 4fp9C-4py4A:
undetectable		 4fp9C-4py4A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYF_A_NCAA1201_0
(TANKYRASE-2)		 4py4 POLY [ADP-RIBOSE]
POLYMERASE 14
(Homo
sapiens) 		6 / 7 HIS A1682
GLY A1683
TYR A1714
ALA A1716
SER A1722
TYR A1727
 XL2  A1901 (-4.0A)
XL2  A1901 (-3.6A)
XL2  A1901 (-3.7A)
XL2  A1901 (-3.4A)
XL2  A1901 (-2.6A)
XL2  A1901 (-3.6A)
 0.55A 4hyfA-4py4A:
17.7		 4hyfA-4py4A:
26.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYF_B_NCAB1201_0
(TANKYRASE-2)		 4py4 POLY [ADP-RIBOSE]
POLYMERASE 14
(Homo
sapiens) 		6 / 8 HIS A1682
GLY A1683
TYR A1714
ALA A1716
SER A1722
TYR A1727
 XL2  A1901 (-4.0A)
XL2  A1901 (-3.6A)
XL2  A1901 (-3.7A)
XL2  A1901 (-3.4A)
XL2  A1901 (-2.6A)
XL2  A1901 (-3.6A)
 0.56A 4hyfB-4py4A:
17.7		 4hyfB-4py4A:
26.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYF_C_NCAC1201_0
(TANKYRASE-2)		 4py4 POLY [ADP-RIBOSE]
POLYMERASE 14
(Homo
sapiens) 		6 / 8 HIS A1682
GLY A1683
TYR A1714
ALA A1716
SER A1722
TYR A1727
 XL2  A1901 (-4.0A)
XL2  A1901 (-3.6A)
XL2  A1901 (-3.7A)
XL2  A1901 (-3.4A)
XL2  A1901 (-2.6A)
XL2  A1901 (-3.6A)
 0.53A 4hyfC-4py4A:
17.6		 4hyfC-4py4A:
26.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RV6_A_RPBA1103_1
(POLY [ADP-RIBOSE]
POLYMERASE 1)		 4py4 POLY [ADP-RIBOSE]
POLYMERASE 14
(Homo
sapiens) 		6 / 11 HIS A1682
GLY A1683
TYR A1714
ALA A1716
SER A1722
TYR A1727
 XL2  A1901 (-4.0A)
XL2  A1901 (-3.6A)
XL2  A1901 (-3.7A)
XL2  A1901 (-3.4A)
XL2  A1901 (-2.6A)
XL2  A1901 (-3.6A)
 0.38A 4rv6A-4py4A:
17.0		 4rv6A-4py4A:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RV6_B_RPBB1103_1
(POLY [ADP-RIBOSE]
POLYMERASE 1)		 4py4 POLY [ADP-RIBOSE]
POLYMERASE 14
(Homo
sapiens) 		6 / 11 HIS A1682
GLY A1683
TYR A1714
ALA A1716
SER A1722
TYR A1727
 XL2  A1901 (-4.0A)
XL2  A1901 (-3.6A)
XL2  A1901 (-3.7A)
XL2  A1901 (-3.4A)
XL2  A1901 (-2.6A)
XL2  A1901 (-3.6A)
 0.38A 4rv6B-4py4A:
16.6		 4rv6B-4py4A:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_A_RFPA502_1
(RIFAMPIN
MONOOXYGENASE)		 4py4 POLY [ADP-RIBOSE]
POLYMERASE 14
(Homo
sapiens) 		5 / 12 LEU A1680
MET A1667
VAL A1743
THR A1713
GLY A1712
 None
 1.16A 6brdA-4py4A:
undetectable		 6brdA-4py4A:
18.28