SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4py5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_1
(DNA GYRASE SUBUNIT B)		 4py5 RIBONUCLEASE
(Thermovibrio
ammonificans) 		5 / 12 ARG A 103
ILE A 127
ILE A 216
ALA A 220
THR A 128
 None
 1.25A 1kijB-4py5A:
undetectable		 1kijB-4py5A:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXF_A_DZPA2001_1
(SERUM ALBUMIN)		 4py5 RIBONUCLEASE
(Thermovibrio
ammonificans) 		6 / 12 LEU A 138
TYR A 143
LEU A  89
VAL A  91
GLU A 158
LEU A 157
 None
None
None
None
SO4  A 306 ( 4.8A)
None
 1.34A 2bxfA-4py5A:
undetectable		 2bxfA-4py5A:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K8M_A_ACRA720_1
(ALPHA-AMYLASE, SUSG)		 4py5 RIBONUCLEASE
(Thermovibrio
ammonificans) 		4 / 7 GLU A 187
LEU A 157
LYS A  82
ASN A 154
 None
None
C  B   6 ( 2.8A)
SO4  A 306 (-3.8A)
 1.20A 3k8mA-4py5A:
undetectable		 3k8mA-4py5A:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_A_GJZA506_1
(CHOLESTEROL
24-HYDROXYLASE)		 4py5 RIBONUCLEASE
(Thermovibrio
ammonificans) 		4 / 6 LEU A 107
ILE A 216
ALA A 213
THR A 128
 None
 1.10A 3mdrA-4py5A:
undetectable		 3mdrA-4py5A:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KSZ_A_CYSA620_0
(LACTOPEROXIDASE)		 4py5 RIBONUCLEASE
(Thermovibrio
ammonificans) 		3 / 3 ARG A 162
GLU A 158
PHE A 182
 None
SO4  A 306 ( 4.8A)
None
 0.88A 4kszA-4py5A:
undetectable		 4kszA-4py5A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MX0_A_BCZA513_1
(NEURAMINIDASE)		 4py5 RIBONUCLEASE
(Thermovibrio
ammonificans) 		3 / 3 ARG A 202
ASP A 208
ARG A 198
 SO4  A 302 (-2.8A)
None
SO4  A 302 (-2.8A)
 1.01A 4mx0A-4py5A:
undetectable		 4mx0A-4py5A:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MA7_A_TPFA602_0
(CYTOCHROME P450 3A4)		 4py5 RIBONUCLEASE
(Thermovibrio
ammonificans) 		4 / 7 ARG A  34
ALA A  20
ILE A  39
ALA A  38
 None
None
U  B  17 ( 4.6A)
None
 0.82A 6ma7A-4py5A:
undetectable		 6ma7A-4py5A:
13.16