SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4py6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZSE_A_PAUA600_0
(PANTOTHENATE KINASE)		 4py6 BROMODOMAIN PROTEIN,
PUTATIVE
(Plasmodium
falciparum) 		4 / 7 TYR A1257
PHE A1263
PHE A1298
ILE A1248
 None
 1.17A 2zseA-4py6A:
undetectable		 2zseA-4py6A:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L2U_A_ELVA397_1
(INTEGRASE)		 4py6 BROMODOMAIN PROTEIN,
PUTATIVE
(Plasmodium
falciparum) 		4 / 5 ASP A1262
TYR A1264
PRO A1260
GLU A1259
 None
 1.50A 3l2uA-4py6A:
undetectable		 3l2uA-4py6A:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R24_A_SAMA302_1
(2'-O-METHYL
TRANSFERASE)		 4py6 BROMODOMAIN PROTEIN,
PUTATIVE
(Plasmodium
falciparum) 		3 / 3 TYR A1257
ASP A1244
ASP A1266
 None
 0.78A 3r24A-4py6A:
undetectable		 3r24A-4py6A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5PBE_A_TYLA2001_1
(BROMODOMAIN ADJACENT
TO ZINC FINGER
DOMAIN PROTEIN 2B)		 4py6 BROMODOMAIN PROTEIN,
PUTATIVE
(Plasmodium
falciparum) 		4 / 6 VAL A1221
TYR A1235
ASN A1278
ILE A1287
 R78  A1401 ( 4.6A)
R78  A1401 ( 4.9A)
R78  A1401 (-3.2A)
R78  A1401 (-4.1A)
 0.73A 5pbeA-4py6A:
15.2		 5pbeA-4py6A:
27.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5Y1Y_A_HNQA201_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 4py6 BROMODOMAIN PROTEIN,
PUTATIVE
(Plasmodium
falciparum) 		4 / 8 VAL A1221
CYH A1274
ASN A1278
ILE A1287
 R78  A1401 ( 4.6A)
R78  A1401 ( 4.1A)
R78  A1401 (-3.2A)
R78  A1401 (-4.1A)
 0.60A 5y1yA-4py6A:
14.5		 5y1yA-4py6A:
30.14