SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4py8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y03_A_5FWA601_1
(BETA-1 ADRENERGIC
RECEPTOR)		 4py8 ANTIBODY 3.1 HEAVY
CHAIN
(Homo
sapiens) 		5 / 12 VAL I 168
VAL I 187
SER I 185
ASN I 202
ASN I 160
 None
 1.35A 2y03A-4py8I:
undetectable		 2y03A-4py8I:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y03_B_5FWB601_1
(BETA-1 ADRENERGIC
RECEPTOR)		 4py8 ANTIBODY 3.1 HEAVY
CHAIN
(Homo
sapiens) 		5 / 12 VAL I 168
VAL I 187
SER I 185
ASN I 202
ASN I 160
 None
 1.42A 2y03B-4py8I:
undetectable		 2y03B-4py8I:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NYA_A_JTZA1203_1
(BETA-2 ADRENERGIC
RECEPTOR, LYSOZYME)		 4py8 ANTIBODY 3.1 HEAVY
CHAIN
(Homo
sapiens) 		5 / 12 VAL I 168
VAL I 187
SER I 185
ASN I 202
ASN I 160
 None
 1.40A 3nyaA-4py8I:
undetectable		 3nyaA-4py8I:
16.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXT_A_MTXA2000_1
(ANTI-METHOTREXATE
CDR1-3 GRAFT VHH)		 4py8 ANTIBODY 3.1 HEAVY
CHAIN
(Homo
sapiens) 		5 / 12 VAL I   2
ALA I  24
ARG I  72
ASN I  77
VAL I  79
 None
 0.72A 3qxtA-4py8I:
21.0		 3qxtA-4py8I:
65.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LDO_A_ALEA1402_1
(LYSOZYME, BETA-2
ADRENERGIC RECEPTOR)		 4py8 ANTIBODY 3.1 HEAVY
CHAIN
(Homo
sapiens) 		5 / 10 VAL I 168
VAL I 187
SER I 185
ASN I 202
ASN I 160
 None
 1.46A 4ldoA-4py8I:
undetectable		 4ldoA-4py8I:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_A_ACRA1421_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 4py8 ANTIBODY 3.1 HEAVY
CHAIN
(Homo
sapiens) 		4 / 5 TYR I  32
TYR I  53
GLY I 102
GLY I 101
 None
 1.11A 5x7pA-4py8I:
undetectable		 5x7pA-4py8I:
10.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7M_B_68HB405_0
(BETA-1 ADRENERGIC
RECEPTOR)		 4py8 ANTIBODY 3.1 HEAVY
CHAIN
(Homo
sapiens) 		5 / 12 VAL I 168
VAL I 187
SER I 185
ASN I 202
ASN I 160
 None
 1.38A 6h7mB-4py8I:
undetectable		 6h7mB-4py8I:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7M_B_68HB405_0
(BETA-1 ADRENERGIC
RECEPTOR)		 4py8 ANTIBODY 3.1 HEAVY
CHAIN
(Homo
sapiens) 		5 / 12 VAL I 168
VAL I 187
SER I 185
ASN I 202
TYR I 199
 None
 1.46A 6h7mB-4py8I:
undetectable		 6h7mB-4py8I:
18.57