SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4py9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A27_A_ESTA350_1
(17-BETA-HYDROXYSTERO
ID-DEHYDROGENASE)		 4py9 PUTATIVE
EXOPOLYPHOSPHATASE-R
ELATED PROTEIN
(Bacteroides
fragilis) 		5 / 12 GLY A  71
MET A  69
LEU A  41
VAL A  58
PHE A  62
 None
 1.37A 1a27A-4py9A:
4.2		 1a27A-4py9A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_A_RBFA501_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 4py9 PUTATIVE
EXOPOLYPHOSPHATASE-R
ELATED PROTEIN
(Bacteroides
fragilis) 		5 / 12 GLY A  42
SER A  39
ILE A 123
ILE A 153
LEU A 152
 None
 1.27A 1kyvA-4py9A:
undetectable
1kyvE-4py9A:
undetectable		 1kyvA-4py9A:
19.13
1kyvE-4py9A:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_C_RBFC503_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 4py9 PUTATIVE
EXOPOLYPHOSPHATASE-R
ELATED PROTEIN
(Bacteroides
fragilis) 		5 / 12 ILE A 153
LEU A 152
GLY A  42
SER A  39
ILE A 123
 None
 1.27A 1kyvB-4py9A:
undetectable
1kyvC-4py9A:
undetectable		 1kyvB-4py9A:
19.13
1kyvC-4py9A:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_D_RBFD504_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 4py9 PUTATIVE
EXOPOLYPHOSPHATASE-R
ELATED PROTEIN
(Bacteroides
fragilis) 		5 / 12 ILE A 153
LEU A 152
GLY A  42
SER A  39
ILE A 123
 None
 1.25A 1kyvC-4py9A:
undetectable
1kyvD-4py9A:
2.7		 1kyvC-4py9A:
19.13
1kyvD-4py9A:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_E_RBFE505_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 4py9 PUTATIVE
EXOPOLYPHOSPHATASE-R
ELATED PROTEIN
(Bacteroides
fragilis) 		5 / 12 ILE A 153
LEU A 152
GLY A  42
SER A  39
ILE A 123
 None
 1.26A 1kyvD-4py9A:
2.8
1kyvE-4py9A:
undetectable		 1kyvD-4py9A:
19.13
1kyvE-4py9A:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_C_SAMC2293_0
(GLYCINE
N-METHYLTRANSFERASE)		 4py9 PUTATIVE
EXOPOLYPHOSPHATASE-R
ELATED PROTEIN
(Bacteroides
fragilis) 		5 / 12 GLY A 173
THR A 176
SER A  39
SER A 143
HIS A 125
 None
NA  A 406 (-3.9A)
None
None
PO4  A 402 (-4.3A)
 1.26A 1nbiC-4py9A:
undetectable		 1nbiC-4py9A:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_D_SAMD3293_0
(GLYCINE
N-METHYLTRANSFERASE)		 4py9 PUTATIVE
EXOPOLYPHOSPHATASE-R
ELATED PROTEIN
(Bacteroides
fragilis) 		5 / 12 GLY A 173
THR A 176
SER A  39
SER A 143
HIS A 125
 None
NA  A 406 (-3.9A)
None
None
PO4  A 402 (-4.3A)
 1.26A 1nbiD-4py9A:
undetectable		 1nbiD-4py9A:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P91_A_SAMA1401_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE A)		 4py9 PUTATIVE
EXOPOLYPHOSPHATASE-R
ELATED PROTEIN
(Bacteroides
fragilis) 		5 / 11 LEU A  66
GLY A 173
GLY A  38
ILE A 207
TYR A 208
 None
 0.99A 1p91A-4py9A:
undetectable		 1p91A-4py9A:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_B_BAXB1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 4py9 PUTATIVE
EXOPOLYPHOSPHATASE-R
ELATED PROTEIN
(Bacteroides
fragilis) 		3 / 3 ILE A  26
ASP A  99
PHE A 100
 None
 0.46A 1uwjB-4py9A:
undetectable		 1uwjB-4py9A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OPX_A_DXCA1003_0
(ALDEHYDE
DEHYDROGENASE A)		 4py9 PUTATIVE
EXOPOLYPHOSPHATASE-R
ELATED PROTEIN
(Bacteroides
fragilis) 		4 / 5 ILE A   6
LEU A 152
ASP A  12
ALA A   7
 NA  A 407 (-4.2A)
None
None
None
 1.00A 2opxA-4py9A:
2.9		 2opxA-4py9A:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM4_V_DR7V100_2
(PROTEASE)		 4py9 PUTATIVE
EXOPOLYPHOSPHATASE-R
ELATED PROTEIN
(Bacteroides
fragilis) 		5 / 10 ASP A  99
ILE A  37
GLY A  38
VAL A  54
ILE A  26
 None
 0.95A 3em4V-4py9A:
undetectable		 3em4V-4py9A:
13.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SG9_B_KANB305_1
(APH(2'')-ID)		 4py9 PUTATIVE
EXOPOLYPHOSPHATASE-R
ELATED PROTEIN
(Bacteroides
fragilis) 		4 / 8 ASP A 124
SER A 138
ASP A  99
GLU A 141
 NA  A 408 (-3.9A)
NA  A 408 (-2.3A)
None
None
 1.05A 3sg9B-4py9A:
undetectable		 3sg9B-4py9A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SJ4_X_DXCX75_0
(CYTOCHROME C7)		 4py9 PUTATIVE
EXOPOLYPHOSPHATASE-R
ELATED PROTEIN
(Bacteroides
fragilis) 		5 / 9 ILE A  26
LEU A  98
ILE A 153
MET A 174
GLY A 173
 None
 1.27A 3sj4X-4py9A:
undetectable		 3sj4X-4py9A:
12.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FO4_B_MOAB502_1
(INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE)		 4py9 PUTATIVE
EXOPOLYPHOSPHATASE-R
ELATED PROTEIN
(Bacteroides
fragilis) 		4 / 8 SER A  72
GLY A  34
THR A 172
GLY A  42
 None
NA  A 406 ( 4.4A)
None
None
 0.71A 4fo4B-4py9A:
undetectable		 4fo4B-4py9A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JUO_F_LFXF101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B
E-SITE DNA)		 4py9 PUTATIVE
EXOPOLYPHOSPHATASE-R
ELATED PROTEIN
(Bacteroides
fragilis) 		3 / 4 SER A 267
GLY A 224
GLU A 247
 None
 0.44A 4juoA-4py9A:
1.3
4juoC-4py9A:
2.7		 4juoA-4py9A:
22.11
4juoC-4py9A:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KMF_A_6U9A1301_1
(ION TRANSPORT
PROTEIN)		 4py9 PUTATIVE
EXOPOLYPHOSPHATASE-R
ELATED PROTEIN
(Bacteroides
fragilis) 		4 / 6 THR A 182
GLY A 180
TYR A 208
ILE A 207
 None
 0.87A 5kmfA-4py9A:
undetectable
5kmfC-4py9A:
undetectable		 5kmfA-4py9A:
22.25
5kmfC-4py9A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUR_E_PFLE406_1
(PROTON-GATED ION
CHANNEL)		 4py9 PUTATIVE
EXOPOLYPHOSPHATASE-R
ELATED PROTEIN
(Bacteroides
fragilis) 		5 / 10 ILE A 170
MET A 174
ILE A 194
ILE A 193
ILE A 190
 None
 0.98A 5murE-4py9A:
undetectable		 5murE-4py9A:
12.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4py9 PUTATIVE
EXOPOLYPHOSPHATASE-R
ELATED PROTEIN
(Bacteroides
fragilis) 		3 / 3 TYR A 208
ARG A 209
THR A 214
 None
 1.03A 5z84J-4py9A:
undetectable		 5z84J-4py9A:
11.96