SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4pyh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DED_A_QPSA2001_1
(CYCLODEXTRIN
GLUCANOTRANSFERASE)		 4pyh PHOSPHOGLUCAN
PHOSPHATASE DSP4,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		4 / 6 TRP A 278
LYS A 307
TRP A 314
ASN A 332
 GLC  A 405 ( 3.7A)
GLC  A 406 (-2.9A)
GLC  A 406 (-4.0A)
GLC  A 405 (-2.9A)
 0.41A 1dedA-4pyhA:
7.3		 1dedA-4pyhA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_D_SAMD3293_0
(GLYCINE
N-METHYLTRANSFERASE)		 4pyh PHOSPHOGLUCAN
PHOSPHATASE DSP4,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 12 GLY A 302
VAL A 338
ALA A 240
SER A 353
LEU A 221
 None
 1.29A 1kiaD-4pyhA:
undetectable		 1kiaD-4pyhA:
24.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q63_A_1UNA1001_2
(PROTEASE RETROPEPSIN)		 4pyh PHOSPHOGLUCAN
PHOSPHATASE DSP4,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		3 / 3 ARG A 364
ASN A 243
THR A 211
 None
 0.84A 2q63A-4pyhA:
undetectable		 2q63A-4pyhA:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_H_ACTH503_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 4pyh PHOSPHOGLUCAN
PHOSPHATASE DSP4,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		4 / 7 ARG A 173
ALA A 244
ILE A 246
GLY A 251
 None
 0.90A 3v4tH-4pyhA:
undetectable		 3v4tH-4pyhA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_A_CHDA506_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4pyh PHOSPHOGLUCAN
PHOSPHATASE DSP4,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		4 / 4 PRO A 206
LEU A 210
ILE A 241
ARG A 242
 None
 1.39A 4f4dA-4pyhA:
undetectable		 4f4dA-4pyhA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PBH_A_BEZA401_0
(TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT, PUTATIVE)		 4pyh PHOSPHOGLUCAN
PHOSPHATASE DSP4,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 12 ILE A 246
THR A 245
ARG A 351
LEU A 352
LEU A 359
 None
 1.33A 4pbhA-4pyhA:
undetectable		 4pbhA-4pyhA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PBH_A_BEZA401_0
(TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT, PUTATIVE)		 4pyh PHOSPHOGLUCAN
PHOSPHATASE DSP4,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 12 ILE A 246
THR A 245
THR A 250
ARG A 351
LEU A 359
 None
 1.23A 4pbhA-4pyhA:
undetectable		 4pbhA-4pyhA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QDJ_A_SAMA301_1
(MAGNESIUM-PROTOPORPH
YRIN
O-METHYLTRANSFERASE)		 4pyh PHOSPHOGLUCAN
PHOSPHATASE DSP4,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		4 / 5 TYR A  90
HIS A  92
ASP A 166
ASP A 171
 None
None
GLC  A 402 ( 2.7A)
GOL  A 409 (-2.6A)
 1.45A 4qdjA-4pyhA:
undetectable		 4qdjA-4pyhA:
24.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTP_A_SAMA301_0
(DNA ADENINE
METHYLASE)		 4pyh PHOSPHOGLUCAN
PHOSPHATASE DSP4,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 12 GLY A 201
ALA A 200
ILE A 101
ASN A  99
GLN A 217
 PO4  A 408 (-3.5A)
GLC  A 402 ( 3.5A)
None
None
None
 1.28A 4rtpA-4pyhA:
undetectable		 4rtpA-4pyhA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJE_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 4pyh PHOSPHOGLUCAN
PHOSPHATASE DSP4,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 12 LEU A 228
ALA A 209
LEU A 111
SER A 198
LEU A 120
 None
None
None
PO4  A 408 (-2.5A)
None
 1.14A 5ljeA-4pyhA:
undetectable		 5ljeA-4pyhA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9Y_A_ACTA412_0
(UNCHARACTERIZED
PROTEIN KDOO)		 4pyh PHOSPHOGLUCAN
PHOSPHATASE DSP4,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		3 / 3 ARG A 349
PHE A 304
ARG A 173
 None
 1.08A 5y9yA-4pyhA:
undetectable		 5y9yA-4pyhA:
22.35