SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4pys'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CRB_A_RTLA200_0
(CELLULAR RETINOL
BINDING PROTEIN)		 4pys BETA-N-ACETYLHEXOSAM
INIDASE
(Bacteroides
fragilis) 		5 / 12 PHE A 352
LEU A 364
ALA A 340
ILE A 270
ARG A 338
 None
 1.08A 1crbA-4pysA:
undetectable		 1crbA-4pysA:
12.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DG5_A_TOPA201_1
(DIHYDROFOLATE
REDUCTASE)		 4pys BETA-N-ACETYLHEXOSAM
INIDASE
(Bacteroides
fragilis) 		5 / 11 ALA A 225
ILE A 222
PHE A 176
LEU A 180
ILE A 161
 None
 1.18A 1dg5A-4pysA:
undetectable		 1dg5A-4pysA:
14.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Z_A_COCA301_1
(CHIMERA OF IG KAPPA
CHAIN: HUMAN
CONSTANT REGION AND
MOUSE VARIABLE
REGION)		 4pys BETA-N-ACETYLHEXOSAM
INIDASE
(Bacteroides
fragilis) 		4 / 8 LEU A 180
SER A 151
GLU A 455
TRP A 178
 None
 1.11A 1i7zA-4pysA:
undetectable		 1i7zA-4pysA:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_D_SAMD3293_0
(GLYCINE
N-METHYLTRANSFERASE)		 4pys BETA-N-ACETYLHEXOSAM
INIDASE
(Bacteroides
fragilis) 		5 / 12 GLY A 354
ASP A 303
ALA A 386
LEU A 441
TYR A 402
 FMT  A 607 (-3.0A)
GOL  A 603 (-3.0A)
None
None
GOL  A 603 ( 4.5A)
 1.40A 1kiaD-4pysA:
undetectable		 1kiaD-4pysA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9Y_A_FUNA500_1
(CARBONIC ANHYDRASE
II)		 4pys BETA-N-ACETYLHEXOSAM
INIDASE
(Bacteroides
fragilis) 		5 / 12 VAL A 289
VAL A 218
LEU A 180
THR A 181
TRP A 186
 None
 1.09A 1z9yA-4pysA:
undetectable		 1z9yA-4pysA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGP_A_PCFA1213_0
(WNT INHIBITORY
FACTOR 1)		 4pys BETA-N-ACETYLHEXOSAM
INIDASE
(Bacteroides
fragilis) 		5 / 12 LEU A 196
ILE A 236
LEU A 300
MET A 238
PHE A 335
 None
 0.91A 2ygpA-4pysA:
undetectable		 2ygpA-4pysA:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J7Z_A_ERYA9000_0
(23S RRNA
50S RIBOSOMAL
PROTEIN L22
ERMCL NASCENT CHAIN)		 4pys BETA-N-ACETYLHEXOSAM
INIDASE
(Bacteroides
fragilis) 		3 / 3 LYS A  20
ILE A 115
PHE A 111
 None
 0.81A 3j7zS-4pysA:
undetectable
3j7za-4pysA:
undetectable		 3j7zS-4pysA:
14.48
3j7za-4pysA:
3.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQ7_B_DX2B271_1
(PTERIDINE REDUCTASE
1)		 4pys BETA-N-ACETYLHEXOSAM
INIDASE
(Bacteroides
fragilis) 		4 / 8 PHE A 405
ASP A 450
TYR A 413
TRP A 373
 FMT  A 606 (-4.6A)
GOL  A 604 (-3.0A)
None
GOL  A 603 (-3.6A)
 0.93A 3jq7B-4pysA:
undetectable		 3jq7B-4pysA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LMY_A_CP6A562_1
(BETA-HEXOSAMINIDASE
SUBUNIT BETA)		 4pys BETA-N-ACETYLHEXOSAM
INIDASE
(Bacteroides
fragilis) 		8 / 12 ARG A 153
HIS A 179
ASP A 237
HIS A 241
ASP A 303
TRP A 373
TYR A 402
TRP A 448
 GOL  A 604 (-3.5A)
None
None
GOL  A 603 (-4.2A)
GOL  A 603 (-3.0A)
GOL  A 603 (-3.6A)
GOL  A 603 ( 4.5A)
GOL  A 604 ( 3.6A)
 0.99A 3lmyA-4pysA:
39.2		 3lmyA-4pysA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LMY_B_CP6B563_1
(BETA-HEXOSAMINIDASE
SUBUNIT BETA)		 4pys BETA-N-ACETYLHEXOSAM
INIDASE
(Bacteroides
fragilis) 		9 / 12 ARG A 153
HIS A 179
ASP A 237
HIS A 241
ASP A 303
TRP A 353
TRP A 373
TYR A 402
TRP A 448
 GOL  A 604 (-3.5A)
None
None
GOL  A 603 (-4.2A)
GOL  A 603 (-3.0A)
GOL  A 603 (-3.7A)
GOL  A 603 (-3.6A)
GOL  A 603 ( 4.5A)
GOL  A 604 ( 3.6A)
 0.98A 3lmyB-4pysA:
39.2		 3lmyB-4pysA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MYU_B_VIBB500_1
(HIGH AFFINITY
TRANSPORT SYSTEM
PROTEIN P37)		 4pys BETA-N-ACETYLHEXOSAM
INIDASE
(Bacteroides
fragilis) 		5 / 10 ASN A 174
TYR A 224
ASP A 166
ILE A 112
GLY A 229
 None
 1.43A 3myuB-4pysA:
undetectable		 3myuB-4pysA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QFX_B_CP6B702_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4pys BETA-N-ACETYLHEXOSAM
INIDASE
(Bacteroides
fragilis) 		5 / 12 ALA A 225
ILE A 222
PHE A 176
LEU A 180
ILE A 161
 None
 1.07A 3qfxB-4pysA:
undetectable		 3qfxB-4pysA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ6_A_SAMA300_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 4pys BETA-N-ACETYLHEXOSAM
INIDASE
(Bacteroides
fragilis) 		5 / 12 ILE A  23
ILE A 136
ILE A  79
ARG A 119
LEU A  39
 FMT  A 609 (-4.5A)
None
None
None
None
 0.98A 3uj6A-4pysA:
undetectable		 3uj6A-4pysA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_A_T1CA404_1
(TETX2 PROTEIN)		 4pys BETA-N-ACETYLHEXOSAM
INIDASE
(Bacteroides
fragilis) 		5 / 12 ASN A 269
GLY A 240
ALA A 201
GLY A 200
GLN A 209
 None
 1.20A 3v3oA-4pysA:
undetectable		 3v3oA-4pysA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEU_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4pys BETA-N-ACETYLHEXOSAM
INIDASE
(Bacteroides
fragilis) 		4 / 7 ASP A 303
ASP A 450
GLU A 243
GLU A 235
 GOL  A 603 (-3.0A)
GOL  A 604 (-3.0A)
None
None
 1.16A 4feuB-4pysA:
undetectable		 4feuB-4pysA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4pys BETA-N-ACETYLHEXOSAM
INIDASE
(Bacteroides
fragilis) 		4 / 8 ASP A 303
ASP A 450
GLU A 243
GLU A 235
 GOL  A 603 (-3.0A)
GOL  A 604 (-3.0A)
None
None
 1.17A 4gkhF-4pysA:
undetectable		 4gkhF-4pysA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4H1N_A_CGEA505_1
(CYTOCHROME P450 2B4)		 4pys BETA-N-ACETYLHEXOSAM
INIDASE
(Bacteroides
fragilis) 		5 / 11 ILE A 188
PHE A 271
ILE A 236
ALA A 245
ALA A 244
 None
 1.07A 4h1nA-4pysA:
undetectable		 4h1nA-4pysA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_C_377C401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4pys BETA-N-ACETYLHEXOSAM
INIDASE
(Bacteroides
fragilis) 		4 / 6 TYR A 431
GLU A 480
TYR A 425
LEU A 426
 GOL  A 602 (-4.5A)
GOL  A 602 (-4.9A)
None
None
 1.15A 4twdB-4pysA:
undetectable
4twdC-4pysA:
undetectable		 4twdB-4pysA:
19.85
4twdC-4pysA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_E_377E401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4pys BETA-N-ACETYLHEXOSAM
INIDASE
(Bacteroides
fragilis) 		4 / 6 TYR A 431
GLU A 480
TYR A 425
LEU A 426
 GOL  A 602 (-4.5A)
GOL  A 602 (-4.9A)
None
None
 1.12A 4twdD-4pysA:
undetectable
4twdE-4pysA:
undetectable		 4twdD-4pysA:
19.85
4twdE-4pysA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_G_377G401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4pys BETA-N-ACETYLHEXOSAM
INIDASE
(Bacteroides
fragilis) 		4 / 6 TYR A 431
GLU A 480
TYR A 425
LEU A 426
 GOL  A 602 (-4.5A)
GOL  A 602 (-4.9A)
None
None
 1.23A 4twdF-4pysA:
undetectable
4twdG-4pysA:
undetectable		 4twdF-4pysA:
19.85
4twdG-4pysA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_J_377J401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4pys BETA-N-ACETYLHEXOSAM
INIDASE
(Bacteroides
fragilis) 		4 / 6 TYR A 431
GLU A 480
TYR A 425
LEU A 426
 GOL  A 602 (-4.5A)
GOL  A 602 (-4.9A)
None
None
 1.19A 4twdI-4pysA:
undetectable
4twdJ-4pysA:
undetectable		 4twdI-4pysA:
19.85
4twdJ-4pysA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YBB_B_SAMB601_1
(TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT)		 4pys BETA-N-ACETYLHEXOSAM
INIDASE
(Bacteroides
fragilis) 		4 / 7 ALA A 242
GLY A 183
GLY A 185
GLU A 243
 None
 0.76A 5ybbB-4pysA:
undetectable		 5ybbB-4pysA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_A_ECLA1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 4pys BETA-N-ACETYLHEXOSAM
INIDASE
(Bacteroides
fragilis) 		4 / 7 ILE A 320
LEU A 325
ILE A 270
ALA A 337
 None
 0.56A 6b5vA-4pysA:
undetectable
6b5vC-4pysA:
undetectable		 6b5vA-4pysA:
9.46
6b5vC-4pysA:
9.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_C_ECLC1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 4pys BETA-N-ACETYLHEXOSAM
INIDASE
(Bacteroides
fragilis) 		4 / 7 ILE A 320
LEU A 325
ILE A 270
ALA A 337
 None
 0.57A 6b5vC-4pysA:
undetectable
6b5vD-4pysA:
undetectable		 6b5vC-4pysA:
9.46
6b5vD-4pysA:
9.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_D_ECLD1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 4pys BETA-N-ACETYLHEXOSAM
INIDASE
(Bacteroides
fragilis) 		4 / 7 ALA A 337
ILE A 320
LEU A 325
ILE A 270
 None
 0.56A 6b5vB-4pysA:
undetectable
6b5vD-4pysA:
undetectable		 6b5vB-4pysA:
9.46
6b5vD-4pysA:
9.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA819_0
(GEPHYRIN)		 4pys BETA-N-ACETYLHEXOSAM
INIDASE
(Bacteroides
fragilis) 		3 / 3 ARG A 187
GLY A 185
GLU A 182
 None
 0.63A 6fgdA-4pysA:
3.0		 6fgdA-4pysA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN8_A_GLYA607_0
(UNCHARACTERIZED
PROTEIN)		 4pys BETA-N-ACETYLHEXOSAM
INIDASE
(Bacteroides
fragilis) 		4 / 4 GLU A 235
ASP A 150
ARG A 153
TRP A 448
 None
None
GOL  A 604 (-3.5A)
GOL  A 604 ( 3.6A)
 1.16A 6mn8A-4pysA:
undetectable		 6mn8A-4pysA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N91_A_DCFA401_1
(ADENOSINE DEAMINASE)		 4pys BETA-N-ACETYLHEXOSAM
INIDASE
(Bacteroides
fragilis) 		4 / 4 HIS A 299
LEU A 364
TYR A 391
GLY A 354
 None
None
None
FMT  A 607 (-3.0A)
 1.04A 6n91A-4pysA:
4.6		 6n91A-4pysA:
10.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N91_B_DCFB401_1
(ADENOSINE DEAMINASE)		 4pys BETA-N-ACETYLHEXOSAM
INIDASE
(Bacteroides
fragilis) 		4 / 4 HIS A 299
LEU A 364
TYR A 391
GLY A 354
 None
None
None
FMT  A 607 (-3.0A)
 1.05A 6n91B-4pysA:
4.7		 6n91B-4pysA:
10.31