SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4pyt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PN0_A_IPHA6012_0
(PHENOL
2-MONOOXYGENASE)		 4pyt UDP-N-ACETYLENOLPYRU
VOYLGLUCOSAMINE
REDUCTASE
(unidentified) 		5 / 10 GLY A 259
VAL A 254
MET A 292
ILE A 280
GLY A 236
 None
 1.49A 1pn0A-4pytA:
undetectable		 1pn0A-4pytA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PN0_B_IPHB6022_0
(PHENOL
2-MONOOXYGENASE)		 4pyt UDP-N-ACETYLENOLPYRU
VOYLGLUCOSAMINE
REDUCTASE
(unidentified) 		5 / 10 GLY A 259
VAL A 254
MET A 292
ILE A 280
GLY A 236
 None
 1.48A 1pn0B-4pytA:
undetectable		 1pn0B-4pytA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PN0_C_IPHC6032_0
(PHENOL
2-MONOOXYGENASE)		 4pyt UDP-N-ACETYLENOLPYRU
VOYLGLUCOSAMINE
REDUCTASE
(unidentified) 		5 / 10 GLY A 259
VAL A 254
MET A 292
ILE A 280
GLY A 236
 None
 1.49A 1pn0C-4pytA:
undetectable		 1pn0C-4pytA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PN0_D_IPHD6042_0
(PHENOL
2-MONOOXYGENASE)		 4pyt UDP-N-ACETYLENOLPYRU
VOYLGLUCOSAMINE
REDUCTASE
(unidentified) 		5 / 10 GLY A 259
VAL A 254
MET A 292
ILE A 280
GLY A 236
 None
 1.50A 1pn0D-4pytA:
undetectable		 1pn0D-4pytA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OA1_B_ADNB2005_1
(TRYPTOPHAN
HALOGENASE)		 4pyt UDP-N-ACETYLENOLPYRU
VOYLGLUCOSAMINE
REDUCTASE
(unidentified) 		4 / 7 GLY A  31
GLY A  32
VAL A 273
LEU A  70
 None
 0.82A 2oa1B-4pytA:
undetectable		 2oa1B-4pytA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VN0_A_TDZA501_1
(CYTOCHROME P450 2C8)		 4pyt UDP-N-ACETYLENOLPYRU
VOYLGLUCOSAMINE
REDUCTASE
(unidentified) 		5 / 12 ILE A  63
LEU A  22
VAL A 299
GLU A 301
ILE A  30
 FAD  A 401 ( 4.1A)
None
None
None
None
 1.23A 2vn0A-4pytA:
undetectable		 2vn0A-4pytA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G88_A_SAMA303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 4pyt UDP-N-ACETYLENOLPYRU
VOYLGLUCOSAMINE
REDUCTASE
(unidentified) 		5 / 11 GLY A 250
ASP A 272
ALA A 268
THR A 269
ALA A 265
 None
 1.00A 3g88A-4pytA:
undetectable		 3g88A-4pytA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G88_B_SAMB303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 4pyt UDP-N-ACETYLENOLPYRU
VOYLGLUCOSAMINE
REDUCTASE
(unidentified) 		5 / 11 GLY A 250
ASP A 272
ALA A 268
THR A 269
ALA A 265
 None
 1.00A 3g88B-4pytA:
undetectable		 3g88B-4pytA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H0A_A_9RAA500_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4pyt UDP-N-ACETYLENOLPYRU
VOYLGLUCOSAMINE
REDUCTASE
(unidentified) 		3 / 3 ILE A 262
PHE A 227
HIS A 247
 None
 0.66A 3h0aA-4pytA:
undetectable		 3h0aA-4pytA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGK_A_0TXA302_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4pyt UDP-N-ACETYLENOLPYRU
VOYLGLUCOSAMINE
REDUCTASE
(unidentified) 		4 / 7 GLY A  32
GLY A  31
ASN A  24
GLU A  74
 None
 1.05A 4fgkB-4pytA:
undetectable		 4fgkB-4pytA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_A_CLQA303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4pyt UDP-N-ACETYLENOLPYRU
VOYLGLUCOSAMINE
REDUCTASE
(unidentified) 		5 / 12 GLY A 131
GLY A 132
VAL A 190
PHE A 171
ILE A 145
 FAD  A 401 (-3.5A)
FAD  A 401 (-3.6A)
None
None
None
 1.11A 4fglA-4pytA:
undetectable
4fglB-4pytA:
undetectable		 4fglA-4pytA:
20.06
4fglB-4pytA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M6T_A_SAMA201_0
(RNA POLYMERASE
II-ASSOCIATED FACTOR
1 HOMOLOG, LINKER,
RNA
POLYMERASE-ASSOCIATE
D PROTEIN LEO1)		 4pyt UDP-N-ACETYLENOLPYRU
VOYLGLUCOSAMINE
REDUCTASE
(unidentified) 		4 / 4 ILE A  63
VAL A  38
VAL A  80
ARG A  61
 FAD  A 401 ( 4.1A)
None
None
FAD  A 401 (-4.0A)
 1.36A 4m6tA-4pytA:
undetectable		 4m6tA-4pytA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJV_D_RITD500_2
(PROTEASE)		 4pyt UDP-N-ACETYLENOLPYRU
VOYLGLUCOSAMINE
REDUCTASE
(unidentified) 		5 / 12 GLY A 267
ALA A 268
ILE A 262
THR A  26
ILE A  30
 None
 1.12A 4njvD-4pytA:
undetectable		 4njvD-4pytA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BYJ_A_OQRA302_0
(SULFOTRANSFERASE)		 4pyt UDP-N-ACETYLENOLPYRU
VOYLGLUCOSAMINE
REDUCTASE
(unidentified) 		5 / 12 ILE A  39
LEU A   8
VAL A  79
GLY A  64
THR A  49
 CL  A 405 ( 4.8A)
None
None
FAD  A 401 (-3.5A)
None
 1.11A 5byjA-4pytA:
undetectable		 5byjA-4pytA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I71_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 4pyt UDP-N-ACETYLENOLPYRU
VOYLGLUCOSAMINE
REDUCTASE
(unidentified) 		5 / 12 ALA A  62
GLY A  64
LEU A  83
GLY A 300
VAL A  71
 FAD  A 401 (-4.1A)
FAD  A 401 (-3.5A)
FAD  A 401 (-3.9A)
None
None
 1.37A 5i71A-4pytA:
undetectable		 5i71A-4pytA:
20.22