SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4pz0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_A_DVAA6_0
(GRAMICIDIN A)		 4pz0 SUGAR ABC
TRANSPORTER,
SUGAR-BINDING
PROTEIN
(Bacillus
anthracis) 		3 / 3 ALA A  37
VAL A  96
TRP A 121
 None
 0.98A 1c4dA-4pz0A:
undetectable
1c4dB-4pz0A:
undetectable		 1c4dA-4pz0A:
3.82
1c4dB-4pz0A:
3.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_B_DVAB6_0
(GRAMICIDIN A)		 4pz0 SUGAR ABC
TRANSPORTER,
SUGAR-BINDING
PROTEIN
(Bacillus
anthracis) 		3 / 3 TRP A 121
ALA A  37
VAL A  96
 None
 0.88A 1c4dA-4pz0A:
undetectable
1c4dB-4pz0A:
undetectable		 1c4dA-4pz0A:
3.82
1c4dB-4pz0A:
3.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK2_A_T44A3003_1
(SERUM ALBUMIN)		 4pz0 SUGAR ABC
TRANSPORTER,
SUGAR-BINDING
PROTEIN
(Bacillus
anthracis) 		4 / 6 PHE A  86
LYS A  35
ALA A  37
MET A  95
 None
 1.26A 1hk2A-4pz0A:
undetectable		 1hk2A-4pz0A:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VM1_A_TAZA504_1
(BETA-LACTAMASE SHV-1)		 4pz0 SUGAR ABC
TRANSPORTER,
SUGAR-BINDING
PROTEIN
(Bacillus
anthracis) 		3 / 3 ASP A 218
TYR A 216
GLU A 191
 None
 0.72A 1vm1A-4pz0A:
undetectable		 1vm1A-4pz0A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8L_A_SAMA400_0
(HYPOTHETICAL PROTEIN
LMO1582)		 4pz0 SUGAR ABC
TRANSPORTER,
SUGAR-BINDING
PROTEIN
(Bacillus
anthracis) 		5 / 12 ALA A  37
ASN A 286
VAL A  96
LEU A 119
ASP A  92
 None
 1.01A 2f8lA-4pz0A:
undetectable		 2f8lA-4pz0A:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2N_C_X2NC1479_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 4pz0 SUGAR ABC
TRANSPORTER,
SUGAR-BINDING
PROTEIN
(Bacillus
anthracis) 		5 / 12 PHE A  47
PHE A  38
ALA A  55
ALA A 279
LEU A 331
 PAV  A 401 (-3.8A)
None
None
None
None
 1.07A 2x2nC-4pz0A:
undetectable		 2x2nC-4pz0A:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L4D_D_TPFD490_1
(STEROL 14-ALPHA
DEMETHYLASE)		 4pz0 SUGAR ABC
TRANSPORTER,
SUGAR-BINDING
PROTEIN
(Bacillus
anthracis) 		4 / 8 PHE A  38
ALA A  55
ALA A 279
LEU A 331
 None
 1.02A 3l4dD-4pz0A:
undetectable		 3l4dD-4pz0A:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BJC_A_RPBA2162_1
(TANKYRASE-2)		 4pz0 SUGAR ABC
TRANSPORTER,
SUGAR-BINDING
PROTEIN
(Bacillus
anthracis) 		4 / 8 TYR A 197
LYS A 204
SER A 205
GLU A 199
 None
 0.79A 4bjcA-4pz0A:
undetectable		 4bjcA-4pz0A:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOR_A_FLPA711_1
(LACTOTRANSFERRIN)		 4pz0 SUGAR ABC
TRANSPORTER,
SUGAR-BINDING
PROTEIN
(Bacillus
anthracis) 		4 / 7 GLY A 327
VAL A 311
PRO A 313
ASN A 314
 None
 0.38A 4forA-4pz0A:
undetectable		 4forA-4pz0A:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NU7_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 4)		 4pz0 SUGAR ABC
TRANSPORTER,
SUGAR-BINDING
PROTEIN
(Bacillus
anthracis) 		4 / 8 ALA A 323
VAL A 330
TYR A 319
GLN A 317
 None
EDO  A 407 ( 4.8A)
None
None
 1.00A 5nu7A-4pz0A:
undetectable		 5nu7A-4pz0A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_D_ERMD1201_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 4pz0 SUGAR ABC
TRANSPORTER,
SUGAR-BINDING
PROTEIN
(Bacillus
anthracis) 		5 / 12 SER A  97
VAL A 330
VAL A 335
GLN A 141
LEU A 142
 PAV  A 401 ( 4.5A)
EDO  A 407 ( 4.8A)
None
EDO  A 407 ( 3.6A)
None
 1.24A 5tudD-4pz0A:
undetectable		 5tudD-4pz0A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_A_EY4A502_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 4pz0 SUGAR ABC
TRANSPORTER,
SUGAR-BINDING
PROTEIN
(Bacillus
anthracis) 		4 / 7 ALA A 285
THR A 282
TYR A 283
VAL A 289
 None
 0.86A 6cduA-4pz0A:
undetectable
6cduE-4pz0A:
undetectable		 6cduA-4pz0A:
22.86
6cduE-4pz0A:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_H_EY4H500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 4pz0 SUGAR ABC
TRANSPORTER,
SUGAR-BINDING
PROTEIN
(Bacillus
anthracis) 		4 / 7 VAL A 289
ALA A 285
THR A 282
TYR A 283
 None
 0.85A 6cduH-4pz0A:
undetectable
6cduI-4pz0A:
undetectable		 6cduH-4pz0A:
22.86
6cduI-4pz0A:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6J20_A_GBQA1201_0
(SUBSTANCE-P
RECEPTOR,ENDOLYSIN)		 4pz0 SUGAR ABC
TRANSPORTER,
SUGAR-BINDING
PROTEIN
(Bacillus
anthracis) 		5 / 12 ASN A 144
VAL A 336
ILE A 182
THR A 249
PHE A 251
 None
EDO  A 403 ( 4.8A)
None
None
None
 1.48A 6j20A-4pz0A:
undetectable		 6j20A-4pz0A:
21.04