SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4pz2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VPO_H_TESH1010_1
(ANTI-TESTOSTERONE
(HEAVY CHAIN)
ANTI-TESTOSTERONE
(LIGHT CHAIN))		 4pz2 ZMALDH
(Zea
mays) 		5 / 12 SER A 288
ALA A 466
GLY A 467
LEU A 445
PHE A 483
 None
None
None
NAD  A 603 (-4.5A)
EDO  A 604 (-3.8A)
 1.25A 1vpoH-4pz2A:
undetectable
1vpoL-4pz2A:
undetectable		 1vpoH-4pz2A:
17.76
1vpoL-4pz2A:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVD_B_SAMB601_0
(CATECHOL-O-METHYLTRA
NSFERASE)		 4pz2 ZMALDH
(Zea
mays) 		5 / 12 MET A  94
VAL A 176
ALA A  81
ALA A  85
ARG A  93
 None
 1.36A 2avdB-4pz2A:
4.8		 2avdB-4pz2A:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_B_TACB1888_1
(ELONGATION FACTOR
EF-TU)		 4pz2 ZMALDH
(Zea
mays) 		4 / 5 THR A 132
SER A 187
ASP A 136
SER A 215
 None
 1.04A 2hdnA-4pz2A:
undetectable
2hdnB-4pz2A:
undetectable
2hdnD-4pz2A:
undetectable		 2hdnA-4pz2A:
5.72
2hdnB-4pz2A:
23.28
2hdnD-4pz2A:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_D_TACD2888_1
(ELONGATION FACTOR
EF-TU)		 4pz2 ZMALDH
(Zea
mays) 		4 / 5 SER A 215
THR A 132
SER A 187
ASP A 136
 None
 0.99A 2hdnB-4pz2A:
undetectable
2hdnC-4pz2A:
undetectable
2hdnD-4pz2A:
undetectable		 2hdnB-4pz2A:
23.28
2hdnC-4pz2A:
5.72
2hdnD-4pz2A:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_F_TACF3888_1
(ELONGATION FACTOR
EF-TU)		 4pz2 ZMALDH
(Zea
mays) 		4 / 7 THR A 132
SER A 187
ASP A 136
SER A 215
 None
 1.03A 2hdnE-4pz2A:
undetectable
2hdnF-4pz2A:
undetectable
2hdnH-4pz2A:
undetectable		 2hdnE-4pz2A:
5.72
2hdnF-4pz2A:
23.28
2hdnH-4pz2A:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_H_TACH4888_1
(ELONGATION FACTOR
EF-TU)		 4pz2 ZMALDH
(Zea
mays) 		4 / 7 SER A 215
THR A 132
SER A 187
ASP A 136
 None
 1.04A 2hdnF-4pz2A:
undetectable
2hdnG-4pz2A:
undetectable
2hdnH-4pz2A:
undetectable		 2hdnF-4pz2A:
23.28
2hdnG-4pz2A:
5.72
2hdnH-4pz2A:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_J_TACJ5888_1
(ELONGATION FACTOR
EF-TU)		 4pz2 ZMALDH
(Zea
mays) 		4 / 6 THR A 132
SER A 187
ASP A 136
SER A 215
 None
 1.03A 2hdnI-4pz2A:
undetectable
2hdnJ-4pz2A:
undetectable
2hdnL-4pz2A:
undetectable		 2hdnI-4pz2A:
5.72
2hdnJ-4pz2A:
23.28
2hdnL-4pz2A:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_L_TACL6888_1
(ELONGATION FACTOR
EF-TU)		 4pz2 ZMALDH
(Zea
mays) 		4 / 6 SER A 215
THR A 132
SER A 187
ASP A 136
 None
 0.99A 2hdnJ-4pz2A:
undetectable
2hdnK-4pz2A:
undetectable
2hdnL-4pz2A:
undetectable		 2hdnJ-4pz2A:
23.28
2hdnK-4pz2A:
5.72
2hdnL-4pz2A:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_A_DIFA1375_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 4pz2 ZMALDH
(Zea
mays) 		3 / 3 LEU A 219
TYR A 218
GLN A 221
 None
 0.58A 2wekA-4pz2A:
3.6		 2wekA-4pz2A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_B_PAUB248_0
(TYPE III
PANTOTHENATE KINASE)		 4pz2 ZMALDH
(Zea
mays) 		5 / 12 ASN A 276
VAL A 253
VAL A 179
GLY A 178
ILE A 268
 None
 1.12A 3bf1A-4pz2A:
undetectable
3bf1B-4pz2A:
undetectable		 3bf1A-4pz2A:
20.35
3bf1B-4pz2A:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NMU_F_SAMF228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
NOP5/NOP56 RELATED
PROTEIN)		 4pz2 ZMALDH
(Zea
mays) 		5 / 12 TYR A 146
ALA A 107
PHE A 147
SER A 143
ALA A 151
 None
 1.23A 3nmuA-4pz2A:
undetectable
3nmuF-4pz2A:
4.3		 3nmuA-4pz2A:
22.96
3nmuF-4pz2A:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGP_B_017B200_1
(FIV PROTEASE)		 4pz2 ZMALDH
(Zea
mays) 		5 / 10 ALA A 195
GLY A 100
ILE A 102
VAL A 110
LEU A 144
 None
 0.98A 3ogpA-4pz2A:
undetectable		 3ogpA-4pz2A:
12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_A_FUNA201_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		 4pz2 ZMALDH
(Zea
mays) 		5 / 11 SER A 249
VAL A 256
PHE A 258
VAL A 280
ILE A 180
 None
None
NAD  A 603 (-4.6A)
None
NAD  A 603 (-4.4A)
 0.88A 3rf4A-4pz2A:
undetectable
3rf4C-4pz2A:
undetectable		 3rf4A-4pz2A:
13.32
3rf4C-4pz2A:
13.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_B_FUNB202_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		 4pz2 ZMALDH
(Zea
mays) 		5 / 11 ILE A 180
SER A 249
VAL A 256
PHE A 258
VAL A 280
 NAD  A 603 (-4.4A)
None
None
NAD  A 603 (-4.6A)
None
 0.91A 3rf4A-4pz2A:
undetectable
3rf4B-4pz2A:
undetectable		 3rf4A-4pz2A:
13.32
3rf4B-4pz2A:
13.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_C_FUNC203_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		 4pz2 ZMALDH
(Zea
mays) 		5 / 11 ILE A 180
SER A 249
VAL A 256
PHE A 258
VAL A 280
 NAD  A 603 (-4.4A)
None
None
NAD  A 603 (-4.6A)
None
 0.89A 3rf4B-4pz2A:
undetectable
3rf4C-4pz2A:
undetectable		 3rf4B-4pz2A:
13.32
3rf4C-4pz2A:
13.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UR0_C_SVRC516_1
(RNA-DEPENDENT RNA
POLYMERASE)		 4pz2 ZMALDH
(Zea
mays) 		5 / 9 GLY A 227
ALA A 226
ALA A 104
ASP A 108
LEU A 109
 None
 1.19A 3ur0C-4pz2A:
undetectable		 3ur0C-4pz2A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A3U_B_ACTB1358_0
(NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE)		 4pz2 ZMALDH
(Zea
mays) 		5 / 7 PRO A 421
ILE A 399
GLN A 360
GLY A 358
VAL A 346
 None
 1.49A 4a3uB-4pz2A:
2.0		 4a3uB-4pz2A:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_A_FOLA301_1
(FOLATE RECEPTOR
ALPHA)		 4pz2 ZMALDH
(Zea
mays) 		3 / 3 ASP A 136
TRP A 344
SER A 122
 None
 0.95A 4lrhA-4pz2A:
undetectable		 4lrhA-4pz2A:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_A_STRA601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4pz2 ZMALDH
(Zea
mays) 		5 / 12 LEU A 500
ALA A 195
ILE A 154
GLY A 149
ALA A 148
 None
 1.04A 4nkxA-4pz2A:
undetectable		 4nkxA-4pz2A:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_D_STRD601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4pz2 ZMALDH
(Zea
mays) 		5 / 12 LEU A 500
ALA A 195
ILE A 154
GLY A 149
ALA A 148
 None
 0.99A 4nkxD-4pz2A:
undetectable		 4nkxD-4pz2A:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1E_A_C2FA3000_1
(DIHYDROPTEROATE
SYNTHASE DHPS)		 4pz2 ZMALDH
(Zea
mays) 		3 / 3 LYS A  37
ASN A 234
ASP A  46
 None
 0.86A 4o1eA-4pz2A:
undetectable		 4o1eA-4pz2A:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVY_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 4pz2 ZMALDH
(Zea
mays) 		6 / 10 ALA A  82
ALA A  84
ALA A  81
VAL A 205
GLY A 175
ASP A 252
 None
 1.42A 4qvyK-4pz2A:
undetectable
4qvyL-4pz2A:
undetectable		 4qvyK-4pz2A:
17.93
4qvyL-4pz2A:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVY_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 4pz2 ZMALDH
(Zea
mays) 		6 / 10 ALA A  82
ALA A  84
ALA A  81
VAL A 205
GLY A 175
ASP A 252
 None
 1.43A 4qvyY-4pz2A:
undetectable
4qvyZ-4pz2A:
undetectable		 4qvyY-4pz2A:
17.93
4qvyZ-4pz2A:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4N_C_ACTC201_0
(NITROGEN REGULATORY
PROTEIN P-II)		 4pz2 ZMALDH
(Zea
mays) 		4 / 5 VAL A 318
VAL A 468
GLY A 467
PHE A 483
 None
None
None
EDO  A 604 (-3.8A)
 0.98A 5d4nA-4pz2A:
undetectable
5d4nC-4pz2A:
undetectable		 5d4nA-4pz2A:
15.00
5d4nC-4pz2A:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWA_A_GCSA303_1
(CHITOSANASE)		 4pz2 ZMALDH
(Zea
mays) 		4 / 5 HIS A 250
VAL A 236
GLY A 244
ALA A 243
 None
None
NAD  A 603 (-3.6A)
None
 0.86A 5hwaA-4pz2A:
undetectable		 5hwaA-4pz2A:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND2_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 4pz2 ZMALDH
(Zea
mays) 		5 / 12 ASP A 494
GLU A 495
ALA A 195
SER A 143
LEU A 500
 None
 1.37A 5nd2B-4pz2A:
undetectable		 5nd2B-4pz2A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NN8_A_ACRA1016_1
(LYSOSOMAL
ALPHA-GLUCOSIDASE)		 4pz2 ZMALDH
(Zea
mays) 		4 / 5 GLY A  89
PRO A  92
TRP A  91
CYH A 202
 None
 1.35A 5nn8A-4pz2A:
undetectable		 5nn8A-4pz2A:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FHW_A_ACRA801_2
(GLUCOAMYLASE P)		 4pz2 ZMALDH
(Zea
mays) 		3 / 3 TRP A  91
GLU A  90
GLU A  98
 None
 0.91A 6fhwA-4pz2A:
undetectable		 6fhwA-4pz2A:
9.65