SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4pz7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7A_A_PFLA4002_1
(SERUM ALBUMIN)		 4pz7 MRNA-CAPPING ENZYME
SUBUNIT ALPHA
(Schizosaccharomy
ces
pombe) 		3 / 3 PHE A 144
LEU A 147
SER A  44
 GPL  A  67 ( 3.3A)
None
GPL  A  67 ( 4.9A)
 0.90A 1e7aA-4pz7A:
undetectable		 1e7aA-4pz7A:
23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_A_CHDA130_1
(FATTY ACID-BINDING
PROTEIN)		 4pz7 MRNA-CAPPING ENZYME
SUBUNIT ALPHA
(Schizosaccharomy
ces
pombe) 		3 / 3 TYR A 106
ARG A 140
GLN A 138
 None
 1.01A 1tw4A-4pz7A:
undetectable		 1tw4A-4pz7A:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_B_STRB2001_1
(MINERALOCORTICOID
RECEPTOR)		 4pz7 MRNA-CAPPING ENZYME
SUBUNIT ALPHA
(Schizosaccharomy
ces
pombe) 		5 / 12 GLN A  55
LEU A  54
LEU A 239
CYH A 225
THR A 226
 None
 1.42A 1ya3B-4pz7A:
undetectable		 1ya3B-4pz7A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E5D_A_NCAA1501_0
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 4pz7 MRNA-CAPPING ENZYME
SUBUNIT ALPHA
(Schizosaccharomy
ces
pombe) 		4 / 7 ARG A  72
ASP A 145
ASP A 124
TYR A 230
 GPL  A  67 (-4.6A)
None
None
None
 1.06A 2e5dA-4pz7A:
undetectable
2e5dB-4pz7A:
undetectable		 2e5dA-4pz7A:
23.68
2e5dB-4pz7A:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E5D_B_NCAB1502_0
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 4pz7 MRNA-CAPPING ENZYME
SUBUNIT ALPHA
(Schizosaccharomy
ces
pombe) 		4 / 7 ASP A 124
TYR A 230
ARG A  72
ASP A 145
 None
None
GPL  A  67 (-4.6A)
None
 1.07A 2e5dA-4pz7A:
undetectable
2e5dB-4pz7A:
undetectable		 2e5dA-4pz7A:
23.68
2e5dB-4pz7A:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9D_A_ACTA1117_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 4pz7 MRNA-CAPPING ENZYME
SUBUNIT ALPHA
(Schizosaccharomy
ces
pombe) 		3 / 3 ASP A  93
ARG A  72
ARG A  94
 None
GPL  A  67 (-4.6A)
None
 1.06A 2j9dA-4pz7A:
undetectable
2j9dC-4pz7A:
undetectable		 2j9dA-4pz7A:
14.07
2j9dC-4pz7A:
14.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OMB_D_IPHD2002_0
(BENCE JONES KWR
PROTEIN -
IMMUNOGLOBULIN LIGHT
CHAIN)		 4pz7 MRNA-CAPPING ENZYME
SUBUNIT ALPHA
(Schizosaccharomy
ces
pombe) 		4 / 7 HIS A  80
PRO A  81
TYR A  76
TYR A  90
 SO4  A 507 (-3.5A)
None
None
None
 1.19A 2ombC-4pz7A:
undetectable
2ombD-4pz7A:
undetectable		 2ombC-4pz7A:
21.28
2ombD-4pz7A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JAY_A_SAMA1102_0
(STRUCTURAL PROTEIN
VP3)		 4pz7 MRNA-CAPPING ENZYME
SUBUNIT ALPHA
(Schizosaccharomy
ces
pombe) 		5 / 12 ILE A 203
GLY A 202
GLY A 200
PHE A 207
ILE A 363
 None
 1.09A 3jayA-4pz7A:
undetectable		 3jayA-4pz7A:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A83_A_DXCA1160_0
(MAJOR POLLEN
ALLERGEN BET V 1-A)		 4pz7 MRNA-CAPPING ENZYME
SUBUNIT ALPHA
(Schizosaccharomy
ces
pombe) 		5 / 12 PHE A 188
PRO A 189
PHE A 190
LEU A 123
ILE A 170
 None
 1.26A 4a83A-4pz7A:
undetectable		 4a83A-4pz7A:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4E_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 4pz7 MRNA-CAPPING ENZYME
SUBUNIT ALPHA
(Schizosaccharomy
ces
pombe) 		4 / 8 THR A 192
THR A 121
LEU A 174
VAL A  89
 None
 1.13A 4l4eA-4pz7A:
undetectable		 4l4eA-4pz7A:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4F_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 4pz7 MRNA-CAPPING ENZYME
SUBUNIT ALPHA
(Schizosaccharomy
ces
pombe) 		4 / 8 THR A 192
THR A 121
LEU A 174
VAL A  89
 None
 1.13A 4l4fA-4pz7A:
undetectable		 4l4fA-4pz7A:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8F_A_BRLA501_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4pz7 MRNA-CAPPING ENZYME
SUBUNIT ALPHA
(Schizosaccharomy
ces
pombe) 		4 / 5 GLY A 125
LEU A 159
LEU A 238
LEU A  34
 None
None
GPL  A  67 ( 4.7A)
None
 0.86A 4o8fA-4pz7A:
undetectable		 4o8fA-4pz7A:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UY8_7_TRP71002_0
(TRYPTOPHANASE)		 4pz7 MRNA-CAPPING ENZYME
SUBUNIT ALPHA
(Schizosaccharomy
ces
pombe) 		4 / 4 ILE A 249
ASN A 335
ILE A 311
VAL A 312
 None
SO4  A 502 (-3.9A)
None
None
 1.28A 4uy87-4pz7A:
undetectable		 4uy87-4pz7A:
5.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BPH_A_ACTA403_0
(D-ALANINE--D-ALANINE
LIGASE)		 4pz7 MRNA-CAPPING ENZYME
SUBUNIT ALPHA
(Schizosaccharomy
ces
pombe) 		4 / 6 TYR A 230
ARG A  72
GLY A 125
LEU A  74
 None
GPL  A  67 (-4.6A)
None
None
 1.21A 5bphA-4pz7A:
undetectable		 5bphA-4pz7A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_B_CVIB301_1
(REGULATORY PROTEIN
TETR)		 4pz7 MRNA-CAPPING ENZYME
SUBUNIT ALPHA
(Schizosaccharomy
ces
pombe) 		4 / 8 GLY A  43
ARG A 162
ASP A 145
ASP A 235
 None
 1.00A 5vlmB-4pz7A:
undetectable		 5vlmB-4pz7A:
17.62