SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4pza'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2BM9_F_SAMF301_0 (CEPHALOSPORIN HYDROXYLASE CMCI)	4pza	GLUCOSYL-3-PHOSPHOGL YCERATE PHOSPHATASE (Mycobacterium tuberculosis)	5 / 12	GLY A 160 GLY A 12 ASN A 186 ALA A 187 ALA A 216	PO4 A 601 (-3.5A) None None None None	0.99A	2bm9F-4pzaA: undetectable	2bm9F-4pzaA: 23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2OKC_A_SAMA500_0 (TYPE I RESTRICTION ENZYME STYSJI M PROTEIN)	4pza	GLUCOSYL-3-PHOSPHOGL YCERATE PHOSPHATASE (Mycobacterium tuberculosis)	5 / 12	ALA A 158 GLY A 160 GLY A 185 THR A 85 SER A 56	None PO4 A 601 (-3.5A) None None None	1.05A	2okcA-4pzaA: undetectable	2okcA-4pzaA: 19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3UY4_A_PAUA302_0 (PANTOTHENATE SYNTHETASE)	4pza	GLUCOSYL-3-PHOSPHOGL YCERATE PHOSPHATASE (Mycobacterium tuberculosis)	4 / 8	ARG A 60 HIS A 159 VAL A 126 ASP A 57	PO4 A 601 (-3.8A) PO4 A 601 (-3.9A) None None	1.12A	3uy4A-4pzaA: undetectable	3uy4A-4pzaA: 19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6HQB_A_PQNA2001_0 (PHOTOSYSTEM I P700 CHLOROPHYLL A APOPROTEIN A1 PHOTOSYSTEM I REACTION CENTER SUBUNIT IX)	4pza	GLUCOSYL-3-PHOSPHOGL YCERATE PHOSPHATASE (Mycobacterium tuberculosis)	5 / 10	TRP A 189 ALA A 41 LEU A 45 GLY A 46 LEU A 171	None	1.34A	6hqbA-4pzaA: undetectable 6hqbJ-4pzaA: undetectable	6hqbA-4pzaA: 14.29 6hqbJ-4pzaA: 12.07

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["2BM9_F_SAMF301_0","CEPHALOSPORIN HYDROXYLASE CMCI","4pza","GLUCOSYL-3-PHOSPHOGLYCERATE PHOSPHATASE","Mycobacterium tuberculosis",5,"GLY A 160;GLY A  12;ASN A 186;ALA A 187;ALA A 216","PO4 A 601 (-3.5A);None;None;None;None","0.99A","2bm9F-4pzaA:undetectable","2bm9F-4pzaA:23.53"],["2OKC_A_SAMA500_0","TYPE I RESTRICTION ENZYME STYSJI M PROTEIN","4pza","GLUCOSYL-3-PHOSPHOGLYCERATE PHOSPHATASE","Mycobacterium tuberculosis",5,"ALA A 158;GLY A 160;GLY A 185;THR A  85;SER A  56","None;PO4 A 601 (-3.5A);None;None;None","1.05A","2okcA-4pzaA:undetectable","2okcA-4pzaA:19.24"],["3UY4_A_PAUA302_0","PANTOTHENATE SYNTHETASE","4pza","GLUCOSYL-3-PHOSPHOGLYCERATE PHOSPHATASE","Mycobacterium tuberculosis",4,"ARG A  60;HIS A 159;VAL A 126;ASP A  57","PO4 A 601 (-3.8A);PO4 A 601 (-3.9A);None;None","1.12A","3uy4A-4pzaA:undetectable","3uy4A-4pzaA:19.78"],["6HQB_A_PQNA2001_0","PHOTOSYSTEM I P700 CHLOROPHYLL A APOPROTEIN A1;PHOTOSYSTEM I REACTION CENTER SUBUNIT IX","4pza","GLUCOSYL-3-PHOSPHOGLYCERATE PHOSPHATASE","Mycobacterium tuberculosis",5,"TRP A 189;ALA A  41;LEU A  45;GLY A  46;LEU A 171","None","1.34A","6hqbA-4pzaA:undetectable;6hqbJ-4pzaA:undetectable","6hqbA-4pzaA:14.29;6hqbJ-4pzaA:12.07"]]