SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4pzc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CET_A_CLQA1001_0
(PROTEIN (L-LACTATE
DEHYDROGENASE))		 4pzc 3-HYDROXYACYL-COA
DEHYDROGENASE
(Cupriavidus
necator) 		5 / 9 GLY A  10
ASP A  33
ILE A  34
ALA A  90
ILE A 100
 None
 1.18A 1cetA-4pzcA:
9.5		 1cetA-4pzcA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CET_A_CLQA1001_0
(PROTEIN (L-LACTATE
DEHYDROGENASE))		 4pzc 3-HYDROXYACYL-COA
DEHYDROGENASE
(Cupriavidus
necator) 		5 / 9 VAL A   9
GLY A  10
ASP A  33
ILE A  34
ALA A  90
 None
 0.38A 1cetA-4pzcA:
9.5		 1cetA-4pzcA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CET_A_CLQA1001_0
(PROTEIN (L-LACTATE
DEHYDROGENASE))		 4pzc 3-HYDROXYACYL-COA
DEHYDROGENASE
(Cupriavidus
necator) 		5 / 9 VAL A   9
GLY A  10
ASP A  33
ILE A  34
TYR A  77
 None
 0.97A 1cetA-4pzcA:
9.5		 1cetA-4pzcA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_M_TRPM81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4pzc 3-HYDROXYACYL-COA
DEHYDROGENASE
(Cupriavidus
necator) 		5 / 11 GLY A 156
THR A 163
HIS A 164
THR A 159
ALA A 115
 None
 1.15A 1gtnM-4pzcA:
undetectable
1gtnN-4pzcA:
undetectable		 1gtnM-4pzcA:
14.04
1gtnN-4pzcA:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_O_TRPO81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4pzc 3-HYDROXYACYL-COA
DEHYDROGENASE
(Cupriavidus
necator) 		5 / 10 GLY A 156
THR A 163
HIS A 164
THR A 159
ALA A 115
 None
 1.14A 1gtnO-4pzcA:
undetectable
1gtnP-4pzcA:
undetectable		 1gtnO-4pzcA:
14.04
1gtnP-4pzcA:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_U_TRPU81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4pzc 3-HYDROXYACYL-COA
DEHYDROGENASE
(Cupriavidus
necator) 		5 / 10 GLY A 156
THR A 163
HIS A 164
THR A 159
ALA A 115
 None
 1.13A 1gtnU-4pzcA:
undetectable
1gtnV-4pzcA:
undetectable		 1gtnU-4pzcA:
14.04
1gtnV-4pzcA:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_T_TRPT81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4pzc 3-HYDROXYACYL-COA
DEHYDROGENASE
(Cupriavidus
necator) 		5 / 10 GLY A 156
THR A 163
HIS A 164
THR A 159
ALA A 115
 None
 1.13A 1utdT-4pzcA:
undetectable
1utdU-4pzcA:
undetectable		 1utdT-4pzcA:
14.04
1utdU-4pzcA:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X8V_A_ESLA472_1
(CYTOCHROME P450 51)		 4pzc 3-HYDROXYACYL-COA
DEHYDROGENASE
(Cupriavidus
necator) 		4 / 6 MET A 244
VAL A 246
LEU A 247
PHE A 251
 None
 1.17A 1x8vA-4pzcA:
undetectable		 1x8vA-4pzcA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VE3_B_REAB1445_1
(PUTATIVE CYTOCHROME
P450 120)		 4pzc 3-HYDROXYACYL-COA
DEHYDROGENASE
(Cupriavidus
necator) 		5 / 12 THR A 163
ALA A 115
THR A  83
VAL A 108
GLY A 109
 None
 1.24A 2ve3B-4pzcA:
undetectable		 2ve3B-4pzcA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_A_SALA1302_1
(LYSR-TYPE REGULATORY
PROTEIN)		 4pzc 3-HYDROXYACYL-COA
DEHYDROGENASE
(Cupriavidus
necator) 		5 / 11 THR A 159
GLY A 156
GLY A 138
PHE A 187
ILE A 154
 None
 1.39A 2y7kA-4pzcA:
undetectable		 2y7kA-4pzcA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_C_SALC1302_1
(LYSR-TYPE REGULATORY
PROTEIN)		 4pzc 3-HYDROXYACYL-COA
DEHYDROGENASE
(Cupriavidus
necator) 		5 / 12 THR A 159
GLY A 156
GLY A 138
PHE A 187
ILE A 154
 None
 1.34A 2y7kC-4pzcA:
undetectable		 2y7kC-4pzcA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7P_A_SALA1000_1
(LYSR-TYPE REGULATORY
PROTEIN)		 4pzc 3-HYDROXYACYL-COA
DEHYDROGENASE
(Cupriavidus
necator) 		5 / 10 THR A 159
GLY A 156
GLY A 138
PHE A 187
ILE A 154
 None
 1.38A 2y7pA-4pzcA:
undetectable		 2y7pA-4pzcA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7W_A_SALA1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 4pzc 3-HYDROXYACYL-COA
DEHYDROGENASE
(Cupriavidus
necator) 		5 / 9 THR A 159
GLY A 156
GLY A 138
PHE A 187
ILE A 154
 None
 1.35A 2y7wA-4pzcA:
2.0		 2y7wA-4pzcA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MTE_B_SAMB220_0
(16S RRNA METHYLASE)		 4pzc 3-HYDROXYACYL-COA
DEHYDROGENASE
(Cupriavidus
necator) 		5 / 12 GLY A 278
GLY A 276
ALA A 232
THR A 239
LEU A 237
 None
 1.04A 3mteB-4pzcA:
5.1		 3mteB-4pzcA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NRR_A_D16A530_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4pzc 3-HYDROXYACYL-COA
DEHYDROGENASE
(Cupriavidus
necator) 		5 / 12 ALA A 230
ILE A 197
LEU A 237
GLY A 236
MET A 262
 None
 1.12A 3nrrA-4pzcA:
undetectable		 3nrrA-4pzcA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NRR_B_D16B530_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4pzc 3-HYDROXYACYL-COA
DEHYDROGENASE
(Cupriavidus
necator) 		5 / 12 ALA A 230
ILE A 197
LEU A 237
GLY A 236
MET A 262
 None
 1.10A 3nrrB-4pzcA:
undetectable		 3nrrB-4pzcA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_A_SAMA6735_0
(16S RRNA METHYLASE)		 4pzc 3-HYDROXYACYL-COA
DEHYDROGENASE
(Cupriavidus
necator) 		5 / 12 GLY A 278
GLY A 276
ALA A 232
THR A 239
LEU A 237
 None
 1.04A 3p2kA-4pzcA:
5.2		 3p2kA-4pzcA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_C_ZPCC1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4pzc 3-HYDROXYACYL-COA
DEHYDROGENASE
(Cupriavidus
necator) 		5 / 12 PHE A 142
VAL A 189
ASN A 190
GLU A  92
VAL A 181
 None
 1.26A 4a97B-4pzcA:
undetectable
4a97C-4pzcA:
undetectable		 4a97B-4pzcA:
22.66
4a97C-4pzcA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4pzc 3-HYDROXYACYL-COA
DEHYDROGENASE
(Cupriavidus
necator) 		5 / 10 ALA A 115
GLY A 156
THR A 163
HIS A 164
THR A 159
 None
 1.19A 5eeuF-4pzcA:
undetectable
5eeuG-4pzcA:
undetectable		 5eeuF-4pzcA:
14.04
5eeuG-4pzcA:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4pzc 3-HYDROXYACYL-COA
DEHYDROGENASE
(Cupriavidus
necator) 		5 / 10 GLY A 156
THR A 163
HIS A 164
THR A 159
ALA A 115
 None
 1.14A 5eeuO-4pzcA:
undetectable
5eeuP-4pzcA:
undetectable		 5eeuO-4pzcA:
14.04
5eeuP-4pzcA:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_R_TRPR101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4pzc 3-HYDROXYACYL-COA
DEHYDROGENASE
(Cupriavidus
necator) 		5 / 10 GLY A 156
THR A 163
HIS A 164
THR A 159
ALA A 115
 None
 1.14A 5eeuQ-4pzcA:
undetectable
5eeuR-4pzcA:
undetectable		 5eeuQ-4pzcA:
14.04
5eeuR-4pzcA:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4pzc 3-HYDROXYACYL-COA
DEHYDROGENASE
(Cupriavidus
necator) 		5 / 10 ALA A 115
GLY A 156
THR A 163
HIS A 164
THR A 159
 None
 1.20A 5eevF-4pzcA:
undetectable
5eevG-4pzcA:
undetectable		 5eevF-4pzcA:
14.04
5eevG-4pzcA:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4pzc 3-HYDROXYACYL-COA
DEHYDROGENASE
(Cupriavidus
necator) 		5 / 10 GLY A 156
THR A 163
HIS A 164
THR A 159
ALA A 115
 None
 1.14A 5eevO-4pzcA:
undetectable
5eevP-4pzcA:
undetectable		 5eevO-4pzcA:
14.04
5eevP-4pzcA:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_R_TRPR101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4pzc 3-HYDROXYACYL-COA
DEHYDROGENASE
(Cupriavidus
necator) 		5 / 10 GLY A 156
THR A 163
HIS A 164
THR A 159
ALA A 115
 None
 1.15A 5eevQ-4pzcA:
undetectable
5eevR-4pzcA:
undetectable		 5eevQ-4pzcA:
14.04
5eevR-4pzcA:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4pzc 3-HYDROXYACYL-COA
DEHYDROGENASE
(Cupriavidus
necator) 		5 / 10 GLY A 156
THR A 163
HIS A 164
THR A 159
ALA A 115
 None
 1.14A 5eewO-4pzcA:
undetectable
5eewP-4pzcA:
undetectable		 5eewO-4pzcA:
14.04
5eewP-4pzcA:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_R_TRPR101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4pzc 3-HYDROXYACYL-COA
DEHYDROGENASE
(Cupriavidus
necator) 		5 / 10 GLY A 156
THR A 163
HIS A 164
THR A 159
ALA A 115
 None
 1.15A 5eewQ-4pzcA:
undetectable
5eewR-4pzcA:
undetectable		 5eewQ-4pzcA:
14.04
5eewR-4pzcA:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4pzc 3-HYDROXYACYL-COA
DEHYDROGENASE
(Cupriavidus
necator) 		5 / 10 GLY A 156
THR A 163
HIS A 164
THR A 159
ALA A 115
 None
 1.14A 5eexO-4pzcA:
undetectable
5eexP-4pzcA:
undetectable		 5eexO-4pzcA:
14.04
5eexP-4pzcA:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4pzc 3-HYDROXYACYL-COA
DEHYDROGENASE
(Cupriavidus
necator) 		5 / 10 GLY A 156
THR A 163
HIS A 164
THR A 159
ALA A 115
 None
 1.14A 5eeyO-4pzcA:
undetectable
5eeyP-4pzcA:
undetectable		 5eeyO-4pzcA:
14.04
5eeyP-4pzcA:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4pzc 3-HYDROXYACYL-COA
DEHYDROGENASE
(Cupriavidus
necator) 		5 / 10 GLY A 156
THR A 163
HIS A 164
THR A 159
ALA A 115
 None
 1.14A 5eezO-4pzcA:
undetectable
5eezP-4pzcA:
undetectable		 5eezO-4pzcA:
14.04
5eezP-4pzcA:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4pzc 3-HYDROXYACYL-COA
DEHYDROGENASE
(Cupriavidus
necator) 		5 / 10 GLY A 156
THR A 163
HIS A 164
THR A 159
ALA A 115
 None
 1.14A 5ef0O-4pzcA:
undetectable
5ef0P-4pzcA:
undetectable		 5ef0O-4pzcA:
14.04
5ef0P-4pzcA:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4pzc 3-HYDROXYACYL-COA
DEHYDROGENASE
(Cupriavidus
necator) 		5 / 10 GLY A 156
THR A 163
HIS A 164
THR A 159
ALA A 115
 None
 1.14A 5ef1O-4pzcA:
undetectable
5ef1P-4pzcA:
undetectable		 5ef1O-4pzcA:
14.04
5ef1P-4pzcA:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4pzc 3-HYDROXYACYL-COA
DEHYDROGENASE
(Cupriavidus
necator) 		5 / 10 GLY A 156
THR A 163
HIS A 164
THR A 159
ALA A 115
 None
 1.15A 5ef2O-4pzcA:
undetectable
5ef2P-4pzcA:
undetectable		 5ef2O-4pzcA:
14.04
5ef2P-4pzcA:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4pzc 3-HYDROXYACYL-COA
DEHYDROGENASE
(Cupriavidus
necator) 		5 / 10 GLY A 156
THR A 163
HIS A 164
THR A 159
ALA A 115
 None
 1.15A 5ef3O-4pzcA:
undetectable
5ef3P-4pzcA:
undetectable		 5ef3O-4pzcA:
14.04
5ef3P-4pzcA:
14.04