SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4pzk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E71_M_ASCM995_0
(MYROSINASE MA1)		 4pzk TRNA
(CYTIDINE(34)-2'-O)-
METHYLTRANSFERASE
(Bacillus
anthracis) 		4 / 7 GLN A 151
TYR A  99
PHE A 101
PHE A  77
 None
 1.21A 1e71M-4pzkA:
undetectable		 1e71M-4pzkA:
15.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E72_M_ASCM995_0
(MYROSINASE MA1)		 4pzk TRNA
(CYTIDINE(34)-2'-O)-
METHYLTRANSFERASE
(Bacillus
anthracis) 		4 / 7 GLN A 151
TYR A  99
PHE A 101
PHE A  77
 None
 1.22A 1e72M-4pzkA:
undetectable		 1e72M-4pzkA:
15.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OE2_A_CUA502_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 4pzk TRNA
(CYTIDINE(34)-2'-O)-
METHYLTRANSFERASE
(Bacillus
anthracis) 		3 / 3 GLU A  29
HIS A  31
HIS A   4
 None
 0.69A 1oe2A-4pzkA:
undetectable		 1oe2A-4pzkA:
19.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1V2X_A_SAMA400_0
(TRNA (GM18)
METHYLTRANSFERASE)		 4pzk TRNA
(CYTIDINE(34)-2'-O)-
METHYLTRANSFERASE
(Bacillus
anthracis) 		5 / 12 GLY A 104
ILE A 125
MET A 127
SER A 133
LEU A 134
 SAH  A 201 (-3.1A)
SAH  A 201 (-3.9A)
SAH  A 201 (-3.3A)
SAH  A 201 ( 3.8A)
SAH  A 201 (-4.2A)
 0.99A 1v2xA-4pzkA:
16.6		 1v2xA-4pzkA:
31.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1V2X_A_SAMA400_0
(TRNA (GM18)
METHYLTRANSFERASE)		 4pzk TRNA
(CYTIDINE(34)-2'-O)-
METHYLTRANSFERASE
(Bacillus
anthracis) 		7 / 12 PHE A 103
GLY A 104
GLY A 109
ILE A 125
MET A 127
SER A 133
LEU A 134
 SAH  A 201 (-4.9A)
SAH  A 201 (-3.1A)
SAH  A 201 (-3.3A)
SAH  A 201 (-3.9A)
SAH  A 201 (-3.3A)
SAH  A 201 ( 3.8A)
SAH  A 201 (-4.2A)
 0.49A 1v2xA-4pzkA:
16.6		 1v2xA-4pzkA:
31.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X7P_A_SAMA301_0
(RRNA
METHYLTRANSFERASE)		 4pzk TRNA
(CYTIDINE(34)-2'-O)-
METHYLTRANSFERASE
(Bacillus
anthracis) 		6 / 11 GLY A 104
GLY A 109
ILE A 125
MET A 127
SER A 133
LEU A 134
 SAH  A 201 (-3.1A)
SAH  A 201 (-3.3A)
SAH  A 201 (-3.9A)
SAH  A 201 (-3.3A)
SAH  A 201 ( 3.8A)
SAH  A 201 (-4.2A)
 0.82A 1x7pA-4pzkA:
17.4
1x7pB-4pzkA:
17.7		 1x7pA-4pzkA:
21.26
1x7pB-4pzkA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X7P_B_SAMB302_0
(RRNA
METHYLTRANSFERASE)		 4pzk TRNA
(CYTIDINE(34)-2'-O)-
METHYLTRANSFERASE
(Bacillus
anthracis) 		5 / 10 GLY A 104
GLY A 109
ILE A 125
MET A 127
LEU A 134
 SAH  A 201 (-3.1A)
SAH  A 201 (-3.3A)
SAH  A 201 (-3.9A)
SAH  A 201 (-3.3A)
SAH  A 201 (-4.2A)
 0.61A 1x7pA-4pzkA:
17.4
1x7pB-4pzkA:
17.7		 1x7pA-4pzkA:
21.26
1x7pB-4pzkA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_C_SAMC301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4pzk TRNA
(CYTIDINE(34)-2'-O)-
METHYLTRANSFERASE
(Bacillus
anthracis) 		5 / 12 LEU A   7
LEU A 136
GLY A  17
ALA A  20
ALA A  24
 None
SAH  A 201 ( 4.3A)
None
None
None
 1.18A 2bm9C-4pzkA:
undetectable		 2bm9C-4pzkA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_D_SAMD301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4pzk TRNA
(CYTIDINE(34)-2'-O)-
METHYLTRANSFERASE
(Bacillus
anthracis) 		5 / 12 LEU A   7
LEU A 136
GLY A  17
ALA A  20
ALA A  24
 None
SAH  A 201 ( 4.3A)
None
None
None
 1.15A 2bm9D-4pzkA:
2.8		 2bm9D-4pzkA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_E_SAME301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4pzk TRNA
(CYTIDINE(34)-2'-O)-
METHYLTRANSFERASE
(Bacillus
anthracis) 		6 / 12 LEU A   7
LEU A 136
GLY A  17
ASN A  18
ALA A  20
ALA A  24
 None
SAH  A 201 ( 4.3A)
None
None
None
None
 1.31A 2bm9E-4pzkA:
2.5		 2bm9E-4pzkA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BNN_B_FCNB1199_1
(EPOXIDASE)		 4pzk TRNA
(CYTIDINE(34)-2'-O)-
METHYLTRANSFERASE
(Bacillus
anthracis) 		4 / 8 ASN A  71
HIS A   4
GLU A  29
HIS A  31
 None
 1.03A 2bnnA-4pzkA:
undetectable
2bnnB-4pzkA:
undetectable		 2bnnA-4pzkA:
23.36
2bnnB-4pzkA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_E_SAME301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4pzk TRNA
(CYTIDINE(34)-2'-O)-
METHYLTRANSFERASE
(Bacillus
anthracis) 		5 / 12 LEU A   7
LEU A 136
GLY A  17
ALA A  20
ALA A  24
 None
SAH  A 201 ( 4.3A)
None
None
None
 1.18A 2br4E-4pzkA:
undetectable		 2br4E-4pzkA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PKK_A_2FAA501_2
(ADENOSINE KINASE)		 4pzk TRNA
(CYTIDINE(34)-2'-O)-
METHYLTRANSFERASE
(Bacillus
anthracis) 		4 / 4 ALA A 140
VAL A   6
PHE A 101
THR A  28
 None
 1.40A 2pkkA-4pzkA:
undetectable		 2pkkA-4pzkA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GYQ_A_SAMA270_0
(RRNA
(ADENOSINE-2'-O-)-ME
THYLTRANSFERASE)		 4pzk TRNA
(CYTIDINE(34)-2'-O)-
METHYLTRANSFERASE
(Bacillus
anthracis) 		6 / 12 LEU A  79
GLY A 104
ILE A 125
MET A 127
SER A 133
LEU A 134
 SAH  A 201 (-4.0A)
SAH  A 201 (-3.1A)
SAH  A 201 (-3.9A)
SAH  A 201 (-3.3A)
SAH  A 201 ( 3.8A)
SAH  A 201 (-4.2A)
 0.77A 3gyqA-4pzkA:
16.2
3gyqB-4pzkA:
15.9		 3gyqA-4pzkA:
17.59
3gyqB-4pzkA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GYQ_B_SAMB270_0
(RRNA
(ADENOSINE-2'-O-)-ME
THYLTRANSFERASE)		 4pzk TRNA
(CYTIDINE(34)-2'-O)-
METHYLTRANSFERASE
(Bacillus
anthracis) 		6 / 11 LEU A  79
GLY A 104
ILE A 125
MET A 127
SER A 133
LEU A 134
 SAH  A 201 (-4.0A)
SAH  A 201 (-3.1A)
SAH  A 201 (-3.9A)
SAH  A 201 (-3.3A)
SAH  A 201 ( 3.8A)
SAH  A 201 (-4.2A)
 0.54A 3gyqB-4pzkA:
15.9		 3gyqB-4pzkA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3008_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 4pzk TRNA
(CYTIDINE(34)-2'-O)-
METHYLTRANSFERASE
(Bacillus
anthracis) 		4 / 7 HIS A  31
VAL A   5
VAL A  56
ALA A  20
 None
 0.78A 3kp6B-4pzkA:
undetectable		 3kp6B-4pzkA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NK7_A_SAMA770_0
(23S RRNA
METHYLTRANSFERASE)		 4pzk TRNA
(CYTIDINE(34)-2'-O)-
METHYLTRANSFERASE
(Bacillus
anthracis) 		8 / 12 ASN A  15
LEU A  79
GLY A 104
GLY A 109
ILE A 125
MET A 127
SER A 133
ASN A 135
 None
SAH  A 201 (-4.0A)
SAH  A 201 (-3.1A)
SAH  A 201 (-3.3A)
SAH  A 201 (-3.9A)
SAH  A 201 (-3.3A)
SAH  A 201 ( 3.8A)
None
 0.57A 3nk7A-4pzkA:
16.7		 3nk7A-4pzkA:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NK7_A_SAMA770_0
(23S RRNA
METHYLTRANSFERASE)		 4pzk TRNA
(CYTIDINE(34)-2'-O)-
METHYLTRANSFERASE
(Bacillus
anthracis) 		8 / 12 LEU A  79
GLY A 104
GLU A 106
GLY A 109
ILE A 125
MET A 127
SER A 133
ASN A 135
 SAH  A 201 (-4.0A)
SAH  A 201 (-3.1A)
None
SAH  A 201 (-3.3A)
SAH  A 201 (-3.9A)
SAH  A 201 (-3.3A)
SAH  A 201 ( 3.8A)
None
 1.20A 3nk7A-4pzkA:
16.7		 3nk7A-4pzkA:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NK7_B_SAMB770_0
(23S RRNA
METHYLTRANSFERASE)		 4pzk TRNA
(CYTIDINE(34)-2'-O)-
METHYLTRANSFERASE
(Bacillus
anthracis) 		9 / 12 ASN A  15
LEU A  79
PHE A 103
GLY A 104
GLY A 109
ILE A 125
MET A 127
SER A 133
LEU A 134
 None
SAH  A 201 (-4.0A)
SAH  A 201 (-4.9A)
SAH  A 201 (-3.1A)
SAH  A 201 (-3.3A)
SAH  A 201 (-3.9A)
SAH  A 201 (-3.3A)
SAH  A 201 ( 3.8A)
SAH  A 201 (-4.2A)
 0.62A 3nk7B-4pzkA:
16.5		 3nk7B-4pzkA:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NK7_B_SAMB770_0
(23S RRNA
METHYLTRANSFERASE)		 4pzk TRNA
(CYTIDINE(34)-2'-O)-
METHYLTRANSFERASE
(Bacillus
anthracis) 		7 / 12 GLY A 104
GLU A 106
GLY A 109
ILE A 125
MET A 127
SER A 133
LEU A 134
 SAH  A 201 (-3.1A)
None
SAH  A 201 (-3.3A)
SAH  A 201 (-3.9A)
SAH  A 201 (-3.3A)
SAH  A 201 ( 3.8A)
SAH  A 201 (-4.2A)
 1.13A 3nk7B-4pzkA:
16.5		 3nk7B-4pzkA:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NK7_B_SAMB770_0
(23S RRNA
METHYLTRANSFERASE)		 4pzk TRNA
(CYTIDINE(34)-2'-O)-
METHYLTRANSFERASE
(Bacillus
anthracis) 		5 / 12 GLY A 104
ILE A 125
MET A 127
SER A 133
LEU A 134
 SAH  A 201 (-3.1A)
SAH  A 201 (-3.9A)
SAH  A 201 (-3.3A)
SAH  A 201 ( 3.8A)
SAH  A 201 (-4.2A)
 0.75A 3nk7B-4pzkA:
16.5		 3nk7B-4pzkA:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GC9_A_SAMA401_0
(DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL)		 4pzk TRNA
(CYTIDINE(34)-2'-O)-
METHYLTRANSFERASE
(Bacillus
anthracis) 		5 / 12 GLY A 104
VAL A 102
LEU A 110
PRO A 111
VAL A 114
 SAH  A 201 (-3.1A)
None
None
None
None
 1.05A 4gc9A-4pzkA:
undetectable		 4gc9A-4pzkA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X3M_A_ADNA301_1
(RNA 2'-O RIBOSE
METHYLTRANSFERASE)		 4pzk TRNA
(CYTIDINE(34)-2'-O)-
METHYLTRANSFERASE
(Bacillus
anthracis) 		5 / 9 GLY A 104
ILE A 125
MET A 127
SER A 133
THR A 139
 SAH  A 201 (-3.1A)
SAH  A 201 (-3.9A)
SAH  A 201 (-3.3A)
SAH  A 201 ( 3.8A)
SAH  A 201 (-3.6A)
 0.76A 4x3mA-4pzkA:
17.6		 4x3mA-4pzkA:
25.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X3M_B_ADNB301_1
(RNA 2'-O RIBOSE
METHYLTRANSFERASE)		 4pzk TRNA
(CYTIDINE(34)-2'-O)-
METHYLTRANSFERASE
(Bacillus
anthracis) 		6 / 9 GLY A 104
ILE A 125
MET A 127
SER A 133
LEU A 134
THR A 139
 SAH  A 201 (-3.1A)
SAH  A 201 (-3.9A)
SAH  A 201 (-3.3A)
SAH  A 201 ( 3.8A)
SAH  A 201 (-4.2A)
SAH  A 201 (-3.6A)
 0.70A 4x3mB-4pzkA:
17.2		 4x3mB-4pzkA:
25.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DBY_A_ACTA610_0
(SERUM ALBUMIN)		 4pzk TRNA
(CYTIDINE(34)-2'-O)-
METHYLTRANSFERASE
(Bacillus
anthracis) 		3 / 3 TYR A  99
LYS A  94
LYS A  97
 None
 1.32A 5dbyA-4pzkA:
undetectable		 5dbyA-4pzkA:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L0Z_A_SAMA304_0
(PROBABLE RNA
METHYLTRANSFERASE,
TRMH FAMILY)		 4pzk TRNA
(CYTIDINE(34)-2'-O)-
METHYLTRANSFERASE
(Bacillus
anthracis) 		7 / 12 GLY A 104
GLY A 109
ARG A 124
ILE A 125
SER A 133
LEU A 134
LEU A 136
 SAH  A 201 (-3.1A)
SAH  A 201 (-3.3A)
None
SAH  A 201 (-3.9A)
SAH  A 201 ( 3.8A)
SAH  A 201 (-4.2A)
SAH  A 201 ( 4.3A)
 0.59A 5l0zA-4pzkA:
18.9		 5l0zA-4pzkA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L0Z_B_SAMB304_0
(PROBABLE RNA
METHYLTRANSFERASE,
TRMH FAMILY)		 4pzk TRNA
(CYTIDINE(34)-2'-O)-
METHYLTRANSFERASE
(Bacillus
anthracis) 		6 / 10 GLY A 104
GLY A 109
ILE A 125
SER A 133
LEU A 134
LEU A 136
 SAH  A 201 (-3.1A)
SAH  A 201 (-3.3A)
SAH  A 201 (-3.9A)
SAH  A 201 ( 3.8A)
SAH  A 201 (-4.2A)
SAH  A 201 ( 4.3A)
 0.45A 5l0zB-4pzkA:
7.8		 5l0zB-4pzkA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C06_D_FI8D1404_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		 4pzk TRNA
(CYTIDINE(34)-2'-O)-
METHYLTRANSFERASE
(Bacillus
anthracis) 		3 / 3 ARG A  47
LYS A  43
ARG A  34
 None
 1.36A 6c06D-4pzkA:
undetectable		 6c06D-4pzkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GH9_A_MIXA1003_0
(UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 15)		 4pzk TRNA
(CYTIDINE(34)-2'-O)-
METHYLTRANSFERASE
(Bacillus
anthracis) 		4 / 5 ASN A  71
GLY A  27
HIS A   4
ASP A  98
 None
 1.17A 6gh9A-4pzkA:
undetectable		 6gh9A-4pzkA:
17.54