SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4pzl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RH3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 4pzl ADENYLATE KINASE
(Francisella
tularensis) 		5 / 12 ILE A  26
LEU A   5
SER A 208
ILE A 211
LEU A 215
 None
 1.34A 1rh3A-4pzlA:
undetectable		 1rh3A-4pzlA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFS_A_J01A500_1
(ORF12)		 4pzl ADENYLATE KINASE
(Francisella
tularensis) 		4 / 8 LEU A   5
GLY A  14
ALA A  17
LYS A  18
 None
None
None
GOL  A 303 (-3.6A)
 0.68A 2xfsA-4pzlA:
undetectable		 2xfsA-4pzlA:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XH9_A_J01A1436_1
(ORF12)		 4pzl ADENYLATE KINASE
(Francisella
tularensis) 		4 / 8 LEU A   5
GLY A  14
ALA A  17
LYS A  18
 None
None
None
GOL  A 303 (-3.6A)
 0.77A 2xh9A-4pzlA:
undetectable		 2xh9A-4pzlA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB153_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4pzl ADENYLATE KINASE
(Francisella
tularensis) 		4 / 6 ILE A  65
THR A 190
PHE A 185
PHE A 181
 None
 1.20A 3elzB-4pzlA:
undetectable		 3elzB-4pzlA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H5G_C_LEIC16_0
(COIL SER L16D-PEN)		 4pzl ADENYLATE KINASE
(Francisella
tularensis) 		4 / 6 LEU A  99
GLN A  94
LEU A  96
GLU A  95
 None
 1.11A 3h5gB-4pzlA:
undetectable
3h5gC-4pzlA:
undetectable		 3h5gB-4pzlA:
10.22
3h5gC-4pzlA:
10.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SJ4_X_DXCX75_0
(CYTOCHROME C7)		 4pzl ADENYLATE KINASE
(Francisella
tularensis) 		5 / 9 ILE A  20
LEU A  82
LYS A 197
ILE A 196
GLY A   7
 None
None
FMT  A 302 ( 4.6A)
None
None
 0.97A 3sj4X-4pzlA:
undetectable		 3sj4X-4pzlA:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BMV_C_VLBC507_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA-1B
CHAIN)		 4pzl ADENYLATE KINASE
(Francisella
tularensis) 		4 / 6 ASP A 104
TYR A 182
PRO A  87
LEU A   6
 None
 0.97A 5bmvB-4pzlA:
3.6		 5bmvB-4pzlA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HI6_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 4pzl ADENYLATE KINASE
(Francisella
tularensis) 		5 / 12 ILE A  26
LEU A   5
SER A 208
ILE A 211
LEU A 215
 None
 1.15A 5hi6A-4pzlA:
undetectable		 5hi6A-4pzlA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WYQ_A_SAMA401_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 4pzl ADENYLATE KINASE
(Francisella
tularensis) 		5 / 12 GLY A 200
ILE A 179
VAL A 107
LEU A   6
GLY A   7
 None
 0.91A 5wyqA-4pzlA:
undetectable		 5wyqA-4pzlA:
24.83