SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4pzv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

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	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1E7C_A_HLTA4007_1 (SERUM ALBUMIN)	4pzv	2-AMINO-4-HYDROXY-6- HYDROXYMETHYLDIHYDRO PTERIDINE PYROPHOSPHOKINASE/DI HYDROPTEROATE SYNTHASE (Francisella tularensis)	4 / 8	HIS A 268 ASP A 232 LEU A 231 LEU A 235	None	0.97A	1e7cA-4pzvA: undetectable	1e7cA-4pzvA: 21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1F86_B_T44B528_1 (TRANSTHYRETIN THR119MET VARIANT)	4pzv	2-AMINO-4-HYDROXY-6- HYDROXYMETHYLDIHYDRO PTERIDINE PYROPHOSPHOKINASE/DI HYDROPTEROATE SYNTHASE (Francisella tularensis)	4 / 4	LYS A 36 LEU A 167 ALA A 37 LEU A 39	None	1.50A	1f86B-4pzvA: undetectable	1f86B-4pzvA: 14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1GTI_F_CCSF47_0 (GLUTATHIONE S-TRANSFERASE)	4pzv	2-AMINO-4-HYDROXY-6- HYDROXYMETHYLDIHYDRO PTERIDINE PYROPHOSPHOKINASE/DI HYDROPTEROATE SYNTHASE (Francisella tularensis)	4 / 5	THR A 166 LEU A 163 GLY A 204 TYR A 247	None	1.25A	1gtiF-4pzvA: undetectable	1gtiF-4pzvA: 19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1HRK_B_CHDB2503_0 (FERROCHELATASE)	4pzv	2-AMINO-4-HYDROXY-6- HYDROXYMETHYLDIHYDRO PTERIDINE PYROPHOSPHOKINASE/DI HYDROPTEROATE SYNTHASE (Francisella tularensis)	4 / 4	LEU A 386 PRO A 383 LEU A 397 ARG A 399	None	1.44A	1hrkB-4pzvA: 2.8	1hrkB-4pzvA: 24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1KI7_A_ID2A1_0 (THYMIDINE KINASE)	4pzv	2-AMINO-4-HYDROXY-6- HYDROXYMETHYLDIHYDRO PTERIDINE PYROPHOSPHOKINASE/DI HYDROPTEROATE SYNTHASE (Francisella tularensis)	5 / 12	GLU A 206 ILE A 416 ILE A 413 ARG A 172 GLU A 409	None	1.34A	1ki7A-4pzvA: undetectable	1ki7A-4pzvA: 19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1MZ9_A_VDYA1002_1 (CARTILAGE OLIGOMERIC MATRIX PROTEIN)	4pzv	2-AMINO-4-HYDROXY-6- HYDROXYMETHYLDIHYDRO PTERIDINE PYROPHOSPHOKINASE/DI HYDROPTEROATE SYNTHASE (Francisella tularensis)	4 / 4	ILE A 201 LEU A 197 VAL A 176 ALA A 212	None	0.94A	1mz9A-4pzvA: undetectable	1mz9A-4pzvA: 9.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1MZ9_A_VDYA1002_3 (CARTILAGE OLIGOMERIC MATRIX PROTEIN)	4pzv	2-AMINO-4-HYDROXY-6- HYDROXYMETHYLDIHYDRO PTERIDINE PYROPHOSPHOKINASE/DI HYDROPTEROATE SYNTHASE (Francisella tularensis)	4 / 5	ILE A 201 LEU A 197 VAL A 176 ALA A 212	None	0.97A	1mz9C-4pzvA: undetectable	1mz9C-4pzvA: 9.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1NCW_H_BEZH601_0 (IMMUNOGLOBULIN IGG2A)	4pzv	2-AMINO-4-HYDROXY-6- HYDROXYMETHYLDIHYDRO PTERIDINE PYROPHOSPHOKINASE/DI HYDROPTEROATE SYNTHASE (Francisella tularensis)	5 / 9	ASN A 320 TYR A 324 LEU A 312 GLY A 351 GLY A 347	EDO A 502 (-4.0A) None None None None	1.38A	1ncwH-4pzvA: undetectable 1ncwL-4pzvA: undetectable	1ncwH-4pzvA: 16.75 1ncwL-4pzvA: 17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1NV8_A_SAMA300_0 (HEMK PROTEIN)	4pzv	2-AMINO-4-HYDROXY-6- HYDROXYMETHYLDIHYDRO PTERIDINE PYROPHOSPHOKINASE/DI HYDROPTEROATE SYNTHASE (Francisella tularensis)	5 / 12	PHE A 348 ILE A 305 GLY A 351 GLY A 349 ALA A 357	None	1.10A	1nv8A-4pzvA: undetectable	1nv8A-4pzvA: 22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1Q8J_A_C2FA801_0 (5-METHYLTETRAHYDROFO LATE S-HOMOCYSTEINE METHYLTRANSFERASE)	4pzv	2-AMINO-4-HYDROXY-6- HYDROXYMETHYLDIHYDRO PTERIDINE PYROPHOSPHOKINASE/DI HYDROPTEROATE SYNTHASE (Francisella tularensis)	5 / 12	ASP A 254 ASN A 276 ASP A 345 GLY A 378 SER A 380	None	0.79A	1q8jA-4pzvA: 9.2	1q8jA-4pzvA: 22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2HRC_B_CHDB1604_0 (FERROCHELATASE)	4pzv	2-AMINO-4-HYDROXY-6- HYDROXYMETHYLDIHYDRO PTERIDINE PYROPHOSPHOKINASE/DI HYDROPTEROATE SYNTHASE (Francisella tularensis)	4 / 4	LEU A 386 PRO A 383 LEU A 397 ARG A 399	None	1.41A	2hrcB-4pzvA: 2.9	2hrcB-4pzvA: 24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2KI5_A_AC2A1_1 (PROTEIN (THYMIDINE KINASE))	4pzv	2-AMINO-4-HYDROXY-6- HYDROXYMETHYLDIHYDRO PTERIDINE PYROPHOSPHOKINASE/DI HYDROPTEROATE SYNTHASE (Francisella tularensis)	5 / 12	GLU A 206 ILE A 416 ILE A 413 ARG A 172 GLU A 409	None	1.48A	2ki5A-4pzvA: undetectable	2ki5A-4pzvA: 18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2QD2_A_CHDA426_0 (FERROCHELATASE)	4pzv	2-AMINO-4-HYDROXY-6- HYDROXYMETHYLDIHYDRO PTERIDINE PYROPHOSPHOKINASE/DI HYDROPTEROATE SYNTHASE (Francisella tularensis)	4 / 4	LEU A 388 PRO A 383 LEU A 386 ARG A 399	None	1.42A	2qd2A-4pzvA: undetectable	2qd2A-4pzvA: 24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2QHF_A_ACTA507_0 (CHORISMATE SYNTHASE)	4pzv	2-AMINO-4-HYDROXY-6- HYDROXYMETHYLDIHYDRO PTERIDINE PYROPHOSPHOKINASE/DI HYDROPTEROATE SYNTHASE (Francisella tularensis)	3 / 3	LEU A 157 ASN A 125 ARG A 153	None	0.89A	2qhfA-4pzvA: undetectable	2qhfA-4pzvA: 21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2YCJ_A_C2FA3000_0 (5-METHYLTETRAHYDROFO LATE CORRINOID/IRON SULFUR PROTEIN METHYLTRANSFERASE)	4pzv	2-AMINO-4-HYDROXY-6- HYDROXYMETHYLDIHYDRO PTERIDINE PYROPHOSPHOKINASE/DI HYDROPTEROATE SYNTHASE (Francisella tularensis)	5 / 12	ASP A 209 ASN A 276 ASP A 345 GLY A 378 SER A 380	None	1.13A	2ycjA-4pzvA: 4.7	2ycjA-4pzvA: 20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2YCJ_A_C2FA3000_0 (5-METHYLTETRAHYDROFO LATE CORRINOID/IRON SULFUR PROTEIN METHYLTRANSFERASE)	4pzv	2-AMINO-4-HYDROXY-6- HYDROXYMETHYLDIHYDRO PTERIDINE PYROPHOSPHOKINASE/DI HYDROPTEROATE SYNTHASE (Francisella tularensis)	5 / 12	ASP A 254 ASN A 276 ASP A 345 GLY A 378 SER A 380	None	0.84A	2ycjA-4pzvA: 4.7	2ycjA-4pzvA: 20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3ERD_A_DESA600_1 (ESTROGEN RECEPTOR ALPHA)	4pzv	2-AMINO-4-HYDROXY-6- HYDROXYMETHYLDIHYDRO PTERIDINE PYROPHOSPHOKINASE/DI HYDROPTEROATE SYNTHASE (Francisella tularensis)	5 / 12	LEU A 133 ALA A 131 LEU A 157 LEU A 154 LEU A 150	None None None None EDO A 508 (-3.2A)	1.24A	3erdA-4pzvA: undetectable	3erdA-4pzvA: 22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3GWX_B_EPAB3_1 (PROTEIN (PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR (PPAR-DELTA)))	4pzv	2-AMINO-4-HYDROXY-6- HYDROXYMETHYLDIHYDRO PTERIDINE PYROPHOSPHOKINASE/DI HYDROPTEROATE SYNTHASE (Francisella tularensis)	5 / 12	CYH A 280 GLU A 326 HIS A 301 ILE A 342 LEU A 303	None EDO A 507 (-3.8A) None None None	1.46A	3gwxB-4pzvA: undetectable	3gwxB-4pzvA: 23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3HCO_A_CHDA3_0 (FERROCHELATASE, MITOCHONDRIAL)	4pzv	2-AMINO-4-HYDROXY-6- HYDROXYMETHYLDIHYDRO PTERIDINE PYROPHOSPHOKINASE/DI HYDROPTEROATE SYNTHASE (Francisella tularensis)	4 / 4	LEU A 388 PRO A 383 LEU A 386 ARG A 402	None	1.23A	3hcoA-4pzvA: 2.8	3hcoA-4pzvA: 24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3K13_B_THHB643_0 (5-METHYLTETRAHYDROFO LATE-HOMOCYSTEINE METHYLTRANSFERASE)	4pzv	2-AMINO-4-HYDROXY-6- HYDROXYMETHYLDIHYDRO PTERIDINE PYROPHOSPHOKINASE/DI HYDROPTEROATE SYNTHASE (Francisella tularensis)	5 / 12	ASP A 209 ASN A 276 VAL A 298 GLY A 378 SER A 380	None	1.08A	3k13B-4pzvA: 19.1	3k13B-4pzvA: 21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3K13_B_THHB643_0 (5-METHYLTETRAHYDROFO LATE-HOMOCYSTEINE METHYLTRANSFERASE)	4pzv	2-AMINO-4-HYDROXY-6- HYDROXYMETHYLDIHYDRO PTERIDINE PYROPHOSPHOKINASE/DI HYDROPTEROATE SYNTHASE (Francisella tularensis)	5 / 12	ASP A 254 ASN A 276 VAL A 298 GLY A 378 SER A 380	None	0.60A	3k13B-4pzvA: 19.1	3k13B-4pzvA: 21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3O01_B_DXCB1_0 (CELL INVASION PROTEIN SIPD)	4pzv	2-AMINO-4-HYDROXY-6- HYDROXYMETHYLDIHYDRO PTERIDINE PYROPHOSPHOKINASE/DI HYDROPTEROATE SYNTHASE (Francisella tularensis)	5 / 9	ARG A 126 ILE A 124 ASN A 60 ALA A 129 LEU A 150	J1D A 501 ( 4.1A) None J1D A 501 (-3.1A) None EDO A 508 (-3.2A)	1.47A	3o01A-4pzvA: undetectable 3o01B-4pzvA: undetectable	3o01A-4pzvA: 20.95 3o01B-4pzvA: 20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3TJ7_A_ACTA609_0 (GBAA_1210 PROTEIN)	4pzv	2-AMINO-4-HYDROXY-6- HYDROXYMETHYLDIHYDRO PTERIDINE PYROPHOSPHOKINASE/DI HYDROPTEROATE SYNTHASE (Francisella tularensis)	3 / 3	LYS A 382 VAL A 385 HIS A 379	EDO A 503 ( 4.3A) None None	1.21A	3tj7A-4pzvA: undetectable	3tj7A-4pzvA: 20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4AX8_A_SAMA1474_0 (WBDD)	4pzv	2-AMINO-4-HYDROXY-6- HYDROXYMETHYLDIHYDRO PTERIDINE PYROPHOSPHOKINASE/DI HYDROPTEROATE SYNTHASE (Francisella tularensis)	5 / 12	ALA A 168 ASN A 169 ILE A 18 SER A 38 ILE A 7	None	0.94A	4ax8A-4pzvA: undetectable	4ax8A-4pzvA: 21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4AZV_A_SAMA1474_0 (WBDD)	4pzv	2-AMINO-4-HYDROXY-6- HYDROXYMETHYLDIHYDRO PTERIDINE PYROPHOSPHOKINASE/DI HYDROPTEROATE SYNTHASE (Francisella tularensis)	5 / 12	ALA A 168 ASN A 169 ILE A 18 SER A 38 ILE A 7	None	0.96A	4azvA-4pzvA: 2.3	4azvA-4pzvA: 21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4DJE_B_C2FB302_0 (5-METHYLTETRAHYDROFO LATE CORRINOID/IRON SULFUR PROTEIN METHYLTRANSFERASE)	4pzv	2-AMINO-4-HYDROXY-6- HYDROXYMETHYLDIHYDRO PTERIDINE PYROPHOSPHOKINASE/DI HYDROPTEROATE SYNTHASE (Francisella tularensis)	6 / 12	ASP A 209 ASP A 254 ASN A 276 ASP A 345 GLY A 378 SER A 380	None	0.81A	4djeB-4pzvA: 18.6	4djeB-4pzvA: 21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4DJF_B_C2FB300_0 (5-METHYLTETRAHYDROFO LATE CORRINOID/IRON SULFUR PROTEIN METHYLTRANSFERASE)	4pzv	2-AMINO-4-HYDROXY-6- HYDROXYMETHYLDIHYDRO PTERIDINE PYROPHOSPHOKINASE/DI HYDROPTEROATE SYNTHASE (Francisella tularensis)	5 / 12	ASP A 209 ASP A 254 ASN A 276 GLY A 378 SER A 380	None	0.65A	4djfB-4pzvA: 17.4	4djfB-4pzvA: 21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4EOH_A_TEPA402_1 (PYRIDOXAL KINASE)	4pzv	2-AMINO-4-HYDROXY-6- HYDROXYMETHYLDIHYDRO PTERIDINE PYROPHOSPHOKINASE/DI HYDROPTEROATE SYNTHASE (Francisella tularensis)	4 / 5	GLY A 347 THR A 215 VAL A 278 ASP A 345	None EDO A 503 (-3.7A) None None	0.68A	4eohA-4pzvA: undetectable	4eohA-4pzvA: 21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4G19_A_ACTA304_0 (GLUTATHIONE TRANSFERASE GTE1)	4pzv	2-AMINO-4-HYDROXY-6- HYDROXYMETHYLDIHYDRO PTERIDINE PYROPHOSPHOKINASE/DI HYDROPTEROATE SYNTHASE (Francisella tularensis)	4 / 5	ALA A 375 ILE A 367 LEU A 371 LYS A 368	None	1.10A	4g19A-4pzvA: undetectable	4g19A-4pzvA: 23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4KLR_A_CHDA505_0 (FERROCHELATASE, MITOCHONDRIAL)	4pzv	2-AMINO-4-HYDROXY-6- HYDROXYMETHYLDIHYDRO PTERIDINE PYROPHOSPHOKINASE/DI HYDROPTEROATE SYNTHASE (Francisella tularensis)	4 / 5	LEU A 388 PRO A 383 LEU A 386 ARG A 402	None	1.00A	4klrA-4pzvA: 2.8	4klrA-4pzvA: 21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4KM0_B_CP6B201_1 (DIHYDROFOLATE REDUCTASE)	4pzv	2-AMINO-4-HYDROXY-6- HYDROXYMETHYLDIHYDRO PTERIDINE PYROPHOSPHOKINASE/DI HYDROPTEROATE SYNTHASE (Francisella tularensis)	5 / 12	ILE A 210 ILE A 271 PHE A 234 LEU A 245 ILE A 208	None	1.02A	4km0B-4pzvA: undetectable	4km0B-4pzvA: 17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4M5M_A_DX4A401_0 (2-AMINO-4-HYDROXY-6- HYDROXYMETHYLDIHYDRO PTERIDINE PYROPHOSPHOKINASE)	4pzv	2-AMINO-4-HYDROXY-6- HYDROXYMETHYLDIHYDRO PTERIDINE PYROPHOSPHOKINASE/DI HYDROPTEROATE SYNTHASE (Francisella tularensis)	4 / 8	GLY A 8 ASN A 60 ARG A 97 PHE A 128	J1D A 501 ( 4.3A) J1D A 501 (-3.1A) J1D A 501 (-2.8A) J1D A 501 (-3.1A)	0.47A	4m5mA-4pzvA: 23.9	4m5mA-4pzvA: 16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4XDT_A_ACTA406_0 (FAD:PROTEIN FMN TRANSFERASE)	4pzv	2-AMINO-4-HYDROXY-6- HYDROXYMETHYLDIHYDRO PTERIDINE PYROPHOSPHOKINASE/DI HYDROPTEROATE SYNTHASE (Francisella tularensis)	4 / 5	LYS A 155 ARG A 153 LEU A 150 ASP A 149	None None EDO A 508 (-3.2A) EDO A 508 (-4.2A)	1.45A	4xdtA-4pzvA: undetectable	4xdtA-4pzvA: 22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4ZN7_A_DESA601_1 (ESTROGEN RECEPTOR)	4pzv	2-AMINO-4-HYDROXY-6- HYDROXYMETHYLDIHYDRO PTERIDINE PYROPHOSPHOKINASE/DI HYDROPTEROATE SYNTHASE (Francisella tularensis)	5 / 12	LEU A 133 ALA A 131 LEU A 157 LEU A 154 LEU A 150	None None None None EDO A 508 (-3.2A)	1.21A	4zn7A-4pzvA: undetectable	4zn7A-4pzvA: 21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5CVT_B_ACTB200_0 (N5-CARBOXYAMINOIMIDA ZOLE RIBONUCLEOTIDE MUTASE)	4pzv	2-AMINO-4-HYDROXY-6- HYDROXYMETHYLDIHYDRO PTERIDINE PYROPHOSPHOKINASE/DI HYDROPTEROATE SYNTHASE (Francisella tularensis)	3 / 3	ASN A 393 ALA A 395 ARG A 399	None	0.77A	5cvtB-4pzvA: undetectable	5cvtB-4pzvA: 18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5VOP_A_C2FA3001_1 (5-METHYLTETRAHYDROFO LATE HOMOCYSTEINE S-METHYLTRANSFERASE)	4pzv	2-AMINO-4-HYDROXY-6- HYDROXYMETHYLDIHYDRO PTERIDINE PYROPHOSPHOKINASE/DI HYDROPTEROATE SYNTHASE (Francisella tularensis)	3 / 3	ASP A 254 ASN A 276 ASP A 345	None	0.54A	5vopA-4pzvA: 16.8	5vopA-4pzvA: 19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5VOP_B_C2FB3001_1 (5-METHYLTETRAHYDROFO LATE HOMOCYSTEINE S-METHYLTRANSFERASE)	4pzv	2-AMINO-4-HYDROXY-6- HYDROXYMETHYLDIHYDRO PTERIDINE PYROPHOSPHOKINASE/DI HYDROPTEROATE SYNTHASE (Francisella tularensis)	3 / 3	ASP A 254 ASN A 276 ASP A 345	None	0.54A	5vopB-4pzvA: 8.2	5vopB-4pzvA: 19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5Y2T_B_8LXB501_0 (PEROXISOME PROLIFERATOR-ACTIVAT ED RECEPTOR GAMMA)	4pzv	2-AMINO-4-HYDROXY-6- HYDROXYMETHYLDIHYDRO PTERIDINE PYROPHOSPHOKINASE/DI HYDROPTEROATE SYNTHASE (Francisella tularensis)	5 / 12	LEU A 231 ILE A 210 ILE A 15 TYR A 247 ILE A 272	None	1.17A	5y2tB-4pzvA: undetectable	5y2tB-4pzvA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6NMP_C_CHDC307_0 (CYTOCHROME C OXIDASE SUBUNIT 3 CYTOCHROME C OXIDASE SUBUNIT 7A1, MITOCHONDRIAL)	4pzv	2-AMINO-4-HYDROXY-6- HYDROXYMETHYLDIHYDRO PTERIDINE PYROPHOSPHOKINASE/DI HYDROPTEROATE SYNTHASE (Francisella tularensis)	4 / 6	LYS A 328 GLN A 327 LEU A 371 PHE A 344	None	1.08A	6nmpC-4pzvA: undetectable 6nmpJ-4pzvA: undetectable	6nmpC-4pzvA: 18.22 6nmpJ-4pzvA: 7.82

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1E7C_A_HLTA4007_1","SERUM ALBUMIN","4pzv","2-AMINO-4-HYDROXY-6-HYDROXYMETHYLDIHYDROPTERIDINE PYROPHOSPHOKINASE\/DIHYDROPTEROATE SYNTHASE","Francisella tularensis",4,"HIS A 268;ASP A 232;LEU A 231;LEU A 235","None","0.97A","1e7cA-4pzvA:undetectable","1e7cA-4pzvA:21.90"],["1F86_B_T44B528_1","TRANSTHYRETIN THR119MET VARIANT","4pzv","2-AMINO-4-HYDROXY-6-HYDROXYMETHYLDIHYDROPTERIDINE PYROPHOSPHOKINASE\/DIHYDROPTEROATE SYNTHASE","Francisella tularensis",4,"LYS A  36;LEU A 167;ALA A  37;LEU A  39","None","1.50A","1f86B-4pzvA:undetectable","1f86B-4pzvA:14.49"],["1GTI_F_CCSF47_0","GLUTATHIONE S-TRANSFERASE","4pzv","2-AMINO-4-HYDROXY-6-HYDROXYMETHYLDIHYDROPTERIDINE PYROPHOSPHOKINASE\/DIHYDROPTEROATE SYNTHASE","Francisella tularensis",4,"THR A 166;LEU A 163;GLY A 204;TYR A 247","None","1.25A","1gtiF-4pzvA:undetectable","1gtiF-4pzvA:19.00"],["1HRK_B_CHDB2503_0","FERROCHELATASE","4pzv","2-AMINO-4-HYDROXY-6-HYDROXYMETHYLDIHYDROPTERIDINE PYROPHOSPHOKINASE\/DIHYDROPTEROATE SYNTHASE","Francisella tularensis",4,"LEU A 386;PRO A 383;LEU A 397;ARG A 399","None","1.44A","1hrkB-4pzvA:2.8","1hrkB-4pzvA:24.11"],["1KI7_A_ID2A1_0","THYMIDINE KINASE","4pzv","2-AMINO-4-HYDROXY-6-HYDROXYMETHYLDIHYDROPTERIDINE PYROPHOSPHOKINASE\/DIHYDROPTEROATE SYNTHASE","Francisella tularensis",5,"GLU A 206;ILE A 416;ILE A 413;ARG A 172;GLU A 409","None","1.34A","1ki7A-4pzvA:undetectable","1ki7A-4pzvA:19.09"],["1MZ9_A_VDYA1002_1","CARTILAGE OLIGOMERIC MATRIX PROTEIN","4pzv","2-AMINO-4-HYDROXY-6-HYDROXYMETHYLDIHYDROPTERIDINE PYROPHOSPHOKINASE\/DIHYDROPTEROATE SYNTHASE","Francisella tularensis",4,"ILE A 201;LEU A 197;VAL A 176;ALA A 212","None","0.94A","1mz9A-4pzvA:undetectable","1mz9A-4pzvA:9.63"],["1MZ9_A_VDYA1002_3","CARTILAGE OLIGOMERIC MATRIX PROTEIN;CARTILAGE OLIGOMERIC MATRIX PROTEIN","4pzv","2-AMINO-4-HYDROXY-6-HYDROXYMETHYLDIHYDROPTERIDINE PYROPHOSPHOKINASE\/DIHYDROPTEROATE SYNTHASE","Francisella tularensis",4,"ILE A 201;LEU A 197;VAL A 176;ALA A 212","None","0.97A","1mz9C-4pzvA:undetectable","1mz9C-4pzvA:9.63"],["1NCW_H_BEZH601_0","IMMUNOGLOBULIN IGG2A","4pzv","2-AMINO-4-HYDROXY-6-HYDROXYMETHYLDIHYDROPTERIDINE PYROPHOSPHOKINASE\/DIHYDROPTEROATE SYNTHASE","Francisella tularensis",5,"ASN A 320;TYR A 324;LEU A 312;GLY A 351;GLY A 347","EDO A 502 (-4.0A);None;None;None;None","1.38A","1ncwH-4pzvA:undetectable;1ncwL-4pzvA:undetectable","1ncwH-4pzvA:16.75;1ncwL-4pzvA:17.81"],["1NV8_A_SAMA300_0","HEMK PROTEIN","4pzv","2-AMINO-4-HYDROXY-6-HYDROXYMETHYLDIHYDROPTERIDINE PYROPHOSPHOKINASE\/DIHYDROPTEROATE SYNTHASE","Francisella tularensis",5,"PHE A 348;ILE A 305;GLY A 351;GLY A 349;ALA A 357","None","1.10A","1nv8A-4pzvA:undetectable","1nv8A-4pzvA:22.60"],["1Q8J_A_C2FA801_0","5-METHYLTETRAHYDROFOLATE S-HOMOCYSTEINE METHYLTRANSFERASE","4pzv","2-AMINO-4-HYDROXY-6-HYDROXYMETHYLDIHYDROPTERIDINE PYROPHOSPHOKINASE\/DIHYDROPTEROATE SYNTHASE","Francisella tularensis",5,"ASP A 254;ASN A 276;ASP A 345;GLY A 378;SER A 380","None","0.79A","1q8jA-4pzvA:9.2","1q8jA-4pzvA:22.18"],["2HRC_B_CHDB1604_0","FERROCHELATASE","4pzv","2-AMINO-4-HYDROXY-6-HYDROXYMETHYLDIHYDROPTERIDINE PYROPHOSPHOKINASE\/DIHYDROPTEROATE SYNTHASE","Francisella tularensis",4,"LEU A 386;PRO A 383;LEU A 397;ARG A 399","None","1.41A","2hrcB-4pzvA:2.9","2hrcB-4pzvA:24.11"],["2KI5_A_AC2A1_1","PROTEIN (THYMIDINE KINASE)","4pzv","2-AMINO-4-HYDROXY-6-HYDROXYMETHYLDIHYDROPTERIDINE PYROPHOSPHOKINASE\/DIHYDROPTEROATE SYNTHASE","Francisella tularensis",5,"GLU A 206;ILE A 416;ILE A 413;ARG A 172;GLU A 409","None","1.48A","2ki5A-4pzvA:undetectable","2ki5A-4pzvA:18.12"],["2QD2_A_CHDA426_0","FERROCHELATASE","4pzv","2-AMINO-4-HYDROXY-6-HYDROXYMETHYLDIHYDROPTERIDINE PYROPHOSPHOKINASE\/DIHYDROPTEROATE SYNTHASE","Francisella tularensis",4,"LEU A 388;PRO A 383;LEU A 386;ARG A 399","None","1.42A","2qd2A-4pzvA:undetectable","2qd2A-4pzvA:24.11"],["2QHF_A_ACTA507_0","CHORISMATE SYNTHASE","4pzv","2-AMINO-4-HYDROXY-6-HYDROXYMETHYLDIHYDROPTERIDINE PYROPHOSPHOKINASE\/DIHYDROPTEROATE SYNTHASE","Francisella tularensis",3,"LEU A 157;ASN A 125;ARG A 153","None","0.89A","2qhfA-4pzvA:undetectable","2qhfA-4pzvA:21.67"],["2YCJ_A_C2FA3000_0","5-METHYLTETRAHYDROFOLATE CORRINOID\/IRON SULFUR PROTEIN METHYLTRANSFERASE","4pzv","2-AMINO-4-HYDROXY-6-HYDROXYMETHYLDIHYDROPTERIDINE PYROPHOSPHOKINASE\/DIHYDROPTEROATE SYNTHASE","Francisella tularensis",5,"ASP A 209;ASN A 276;ASP A 345;GLY A 378;SER A 380","None","1.13A","2ycjA-4pzvA:4.7","2ycjA-4pzvA:20.50"],["2YCJ_A_C2FA3000_0","5-METHYLTETRAHYDROFOLATE CORRINOID\/IRON SULFUR PROTEIN METHYLTRANSFERASE","4pzv","2-AMINO-4-HYDROXY-6-HYDROXYMETHYLDIHYDROPTERIDINE PYROPHOSPHOKINASE\/DIHYDROPTEROATE SYNTHASE","Francisella tularensis",5,"ASP A 254;ASN A 276;ASP A 345;GLY A 378;SER A 380","None","0.84A","2ycjA-4pzvA:4.7","2ycjA-4pzvA:20.50"],["3ERD_A_DESA600_1","ESTROGEN RECEPTOR ALPHA","4pzv","2-AMINO-4-HYDROXY-6-HYDROXYMETHYLDIHYDROPTERIDINE PYROPHOSPHOKINASE\/DIHYDROPTEROATE SYNTHASE","Francisella tularensis",5,"LEU A 133;ALA A 131;LEU A 157;LEU A 154;LEU A 150","None;None;None;None;EDO A 508 (-3.2A)","1.24A","3erdA-4pzvA:undetectable","3erdA-4pzvA:22.17"],["3GWX_B_EPAB3_1","PROTEIN (PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR (PPAR-DELTA))","4pzv","2-AMINO-4-HYDROXY-6-HYDROXYMETHYLDIHYDROPTERIDINE PYROPHOSPHOKINASE\/DIHYDROPTEROATE SYNTHASE","Francisella tularensis",5,"CYH A 280;GLU A 326;HIS A 301;ILE A 342;LEU A 303","None;EDO A 507 (-3.8A);None;None;None","1.46A","3gwxB-4pzvA:undetectable","3gwxB-4pzvA:23.28"],["3HCO_A_CHDA3_0","FERROCHELATASE, MITOCHONDRIAL","4pzv","2-AMINO-4-HYDROXY-6-HYDROXYMETHYLDIHYDROPTERIDINE PYROPHOSPHOKINASE\/DIHYDROPTEROATE SYNTHASE","Francisella tularensis",4,"LEU A 388;PRO A 383;LEU A 386;ARG A 402","None","1.23A","3hcoA-4pzvA:2.8","3hcoA-4pzvA:24.11"],["3K13_B_THHB643_0","5-METHYLTETRAHYDROFOLATE-HOMOCYSTEINE METHYLTRANSFERASE","4pzv","2-AMINO-4-HYDROXY-6-HYDROXYMETHYLDIHYDROPTERIDINE PYROPHOSPHOKINASE\/DIHYDROPTEROATE SYNTHASE","Francisella tularensis",5,"ASP A 209;ASN A 276;VAL A 298;GLY A 378;SER A 380","None","1.08A","3k13B-4pzvA:19.1","3k13B-4pzvA:21.96"],["3K13_B_THHB643_0","5-METHYLTETRAHYDROFOLATE-HOMOCYSTEINE METHYLTRANSFERASE","4pzv","2-AMINO-4-HYDROXY-6-HYDROXYMETHYLDIHYDROPTERIDINE PYROPHOSPHOKINASE\/DIHYDROPTEROATE SYNTHASE","Francisella tularensis",5,"ASP A 254;ASN A 276;VAL A 298;GLY A 378;SER A 380","None","0.60A","3k13B-4pzvA:19.1","3k13B-4pzvA:21.96"],["3O01_B_DXCB1_0","CELL INVASION PROTEIN SIPD","4pzv","2-AMINO-4-HYDROXY-6-HYDROXYMETHYLDIHYDROPTERIDINE PYROPHOSPHOKINASE\/DIHYDROPTEROATE SYNTHASE","Francisella tularensis",5,"ARG A 126;ILE A 124;ASN A  60;ALA A 129;LEU A 150","J1D A 501 ( 4.1A);None;J1D A 501 (-3.1A);None;EDO A 508 (-3.2A)","1.47A","3o01A-4pzvA:undetectable;3o01B-4pzvA:undetectable","3o01A-4pzvA:20.95;3o01B-4pzvA:20.95"],["3TJ7_A_ACTA609_0","GBAA_1210 PROTEIN","4pzv","2-AMINO-4-HYDROXY-6-HYDROXYMETHYLDIHYDROPTERIDINE PYROPHOSPHOKINASE\/DIHYDROPTEROATE SYNTHASE","Francisella tularensis",3,"LYS A 382;VAL A 385;HIS A 379","EDO A 503 ( 4.3A);None;None","1.21A","3tj7A-4pzvA:undetectable","3tj7A-4pzvA:20.80"],["4AX8_A_SAMA1474_0","WBDD","4pzv","2-AMINO-4-HYDROXY-6-HYDROXYMETHYLDIHYDROPTERIDINE PYROPHOSPHOKINASE\/DIHYDROPTEROATE SYNTHASE","Francisella tularensis",5,"ALA A 168;ASN A 169;ILE A  18;SER A  38;ILE A   7","None","0.94A","4ax8A-4pzvA:undetectable","4ax8A-4pzvA:21.02"],["4AZV_A_SAMA1474_0","WBDD","4pzv","2-AMINO-4-HYDROXY-6-HYDROXYMETHYLDIHYDROPTERIDINE PYROPHOSPHOKINASE\/DIHYDROPTEROATE SYNTHASE","Francisella tularensis",5,"ALA A 168;ASN A 169;ILE A  18;SER A  38;ILE A   7","None","0.96A","4azvA-4pzvA:2.3","4azvA-4pzvA:21.02"],["4DJE_B_C2FB302_0","5-METHYLTETRAHYDROFOLATE CORRINOID\/IRON SULFUR PROTEIN METHYLTRANSFERASE","4pzv","2-AMINO-4-HYDROXY-6-HYDROXYMETHYLDIHYDROPTERIDINE PYROPHOSPHOKINASE\/DIHYDROPTEROATE SYNTHASE","Francisella tularensis",6,"ASP A 209;ASP A 254;ASN A 276;ASP A 345;GLY A 378;SER A 380","None","0.81A","4djeB-4pzvA:18.6","4djeB-4pzvA:21.28"],["4DJF_B_C2FB300_0","5-METHYLTETRAHYDROFOLATE CORRINOID\/IRON SULFUR PROTEIN METHYLTRANSFERASE","4pzv","2-AMINO-4-HYDROXY-6-HYDROXYMETHYLDIHYDROPTERIDINE PYROPHOSPHOKINASE\/DIHYDROPTEROATE SYNTHASE","Francisella tularensis",5,"ASP A 209;ASP A 254;ASN A 276;GLY A 378;SER A 380","None","0.65A","4djfB-4pzvA:17.4","4djfB-4pzvA:21.28"],["4EOH_A_TEPA402_1","PYRIDOXAL KINASE","4pzv","2-AMINO-4-HYDROXY-6-HYDROXYMETHYLDIHYDROPTERIDINE PYROPHOSPHOKINASE\/DIHYDROPTEROATE SYNTHASE","Francisella tularensis",4,"GLY A 347;THR A 215;VAL A 278;ASP A 345","None;EDO A 503 (-3.7A);None;None","0.68A","4eohA-4pzvA:undetectable","4eohA-4pzvA:21.87"],["4G19_A_ACTA304_0","GLUTATHIONE TRANSFERASE GTE1","4pzv","2-AMINO-4-HYDROXY-6-HYDROXYMETHYLDIHYDROPTERIDINE PYROPHOSPHOKINASE\/DIHYDROPTEROATE SYNTHASE","Francisella tularensis",4,"ALA A 375;ILE A 367;LEU A 371;LYS A 368","None","1.10A","4g19A-4pzvA:undetectable","4g19A-4pzvA:23.64"],["4KLR_A_CHDA505_0","FERROCHELATASE, MITOCHONDRIAL","4pzv","2-AMINO-4-HYDROXY-6-HYDROXYMETHYLDIHYDROPTERIDINE PYROPHOSPHOKINASE\/DIHYDROPTEROATE SYNTHASE","Francisella tularensis",4,"LEU A 388;PRO A 383;LEU A 386;ARG A 402","None","1.00A","4klrA-4pzvA:2.8","4klrA-4pzvA:21.70"],["4KM0_B_CP6B201_1","DIHYDROFOLATE REDUCTASE","4pzv","2-AMINO-4-HYDROXY-6-HYDROXYMETHYLDIHYDROPTERIDINE PYROPHOSPHOKINASE\/DIHYDROPTEROATE SYNTHASE","Francisella tularensis",5,"ILE A 210;ILE A 271;PHE A 234;LEU A 245;ILE A 208","None","1.02A","4km0B-4pzvA:undetectable","4km0B-4pzvA:17.34"],["4M5M_A_DX4A401_0","2-AMINO-4-HYDROXY-6-HYDROXYMETHYLDIHYDROPTERIDINE PYROPHOSPHOKINASE","4pzv","2-AMINO-4-HYDROXY-6-HYDROXYMETHYLDIHYDROPTERIDINE PYROPHOSPHOKINASE\/DIHYDROPTEROATE SYNTHASE","Francisella tularensis",4,"GLY A   8;ASN A  60;ARG A  97;PHE A 128","J1D A 501 ( 4.3A);J1D A 501 (-3.1A);J1D A 501 (-2.8A);J1D A 501 (-3.1A)","0.47A","4m5mA-4pzvA:23.9","4m5mA-4pzvA:16.99"],["4XDT_A_ACTA406_0","FAD:PROTEIN FMN TRANSFERASE","4pzv","2-AMINO-4-HYDROXY-6-HYDROXYMETHYLDIHYDROPTERIDINE PYROPHOSPHOKINASE\/DIHYDROPTEROATE SYNTHASE","Francisella tularensis",4,"LYS A 155;ARG A 153;LEU A 150;ASP A 149","None;None;EDO A 508 (-3.2A);EDO A 508 (-4.2A)","1.45A","4xdtA-4pzvA:undetectable","4xdtA-4pzvA:22.14"],["4ZN7_A_DESA601_1","ESTROGEN RECEPTOR","4pzv","2-AMINO-4-HYDROXY-6-HYDROXYMETHYLDIHYDROPTERIDINE PYROPHOSPHOKINASE\/DIHYDROPTEROATE SYNTHASE","Francisella tularensis",5,"LEU A 133;ALA A 131;LEU A 157;LEU A 154;LEU A 150","None;None;None;None;EDO A 508 (-3.2A)","1.21A","4zn7A-4pzvA:undetectable","4zn7A-4pzvA:21.99"],["5CVT_B_ACTB200_0","N5-CARBOXYAMINOIMIDAZOLE RIBONUCLEOTIDE MUTASE","4pzv","2-AMINO-4-HYDROXY-6-HYDROXYMETHYLDIHYDROPTERIDINE PYROPHOSPHOKINASE\/DIHYDROPTEROATE SYNTHASE","Francisella tularensis",3,"ASN A 393;ALA A 395;ARG A 399","None","0.77A","5cvtB-4pzvA:undetectable","5cvtB-4pzvA:18.83"],["5VOP_A_C2FA3001_1","5-METHYLTETRAHYDROFOLATE HOMOCYSTEINE S-METHYLTRANSFERASE","4pzv","2-AMINO-4-HYDROXY-6-HYDROXYMETHYLDIHYDROPTERIDINE PYROPHOSPHOKINASE\/DIHYDROPTEROATE SYNTHASE","Francisella tularensis",3,"ASP A 254;ASN A 276;ASP A 345","None","0.54A","5vopA-4pzvA:16.8","5vopA-4pzvA:19.72"],["5VOP_B_C2FB3001_1","5-METHYLTETRAHYDROFOLATE HOMOCYSTEINE S-METHYLTRANSFERASE","4pzv","2-AMINO-4-HYDROXY-6-HYDROXYMETHYLDIHYDROPTERIDINE PYROPHOSPHOKINASE\/DIHYDROPTEROATE SYNTHASE","Francisella tularensis",3,"ASP A 254;ASN A 276;ASP A 345","None","0.54A","5vopB-4pzvA:8.2","5vopB-4pzvA:19.72"],["5Y2T_B_8LXB501_0","PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA","4pzv","2-AMINO-4-HYDROXY-6-HYDROXYMETHYLDIHYDROPTERIDINE PYROPHOSPHOKINASE\/DIHYDROPTEROATE SYNTHASE","Francisella tularensis",5,"LEU A 231;ILE A 210;ILE A  15;TYR A 247;ILE A 272","None","1.17A","5y2tB-4pzvA:undetectable","5y2tB-4pzvA:undetectable"],["6NMP_C_CHDC307_0","CYTOCHROME C OXIDASE SUBUNIT 3;CYTOCHROME C OXIDASE SUBUNIT 7A1, MITOCHONDRIAL","4pzv","2-AMINO-4-HYDROXY-6-HYDROXYMETHYLDIHYDROPTERIDINE PYROPHOSPHOKINASE\/DIHYDROPTEROATE SYNTHASE","Francisella tularensis",4,"LYS A 328;GLN A 327;LEU A 371;PHE A 344","None","1.08A","6nmpC-4pzvA:undetectable;6nmpJ-4pzvA:undetectable","6nmpC-4pzvA:18.22;6nmpJ-4pzvA:7.82"]]