SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4q04'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_I_BEZI518_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 4q04 URE3-BP SEQUENCE
SPECIFIC DNA BINDING
PROTEIN
(Entamoeba
histolytica) 		4 / 7 ILE A  82
GLY A  80
PHE A 123
ASN A 121
 None
 1.00A 1oniG-4q04A:
undetectable
1oniI-4q04A:
undetectable		 1oniG-4q04A:
19.46
1oniI-4q04A:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A3P_A_ACTA1223_0
(UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 15)		 4q04 URE3-BP SEQUENCE
SPECIFIC DNA BINDING
PROTEIN
(Entamoeba
histolytica) 		4 / 5 ASP A 127
THR A 133
LEU A 134
GLU A 138
 NA  A 301 (-3.2A)
None
None
NA  A 301 ( 4.9A)
 1.33A 4a3pA-4q04A:
undetectable		 4a3pA-4q04A:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LVC_A_ADNA501_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE))		 4q04 URE3-BP SEQUENCE
SPECIFIC DNA BINDING
PROTEIN
(Entamoeba
histolytica) 		4 / 5 GLN A  87
THR A  88
THR A 184
LEU A 219
 None
 1.38A 4lvcA-4q04A:
undetectable		 4lvcA-4q04A:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V32_C_EF2C151_1
(CEREBLON ISOFORM 4)		 4q04 URE3-BP SEQUENCE
SPECIFIC DNA BINDING
PROTEIN
(Entamoeba
histolytica) 		4 / 7 PRO A  40
PHE A  39
TRP A  37
PHE A  96
 None
 1.46A 4v32C-4q04A:
undetectable		 4v32C-4q04A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_A_ACTA803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 4q04 URE3-BP SEQUENCE
SPECIFIC DNA BINDING
PROTEIN
(Entamoeba
histolytica) 		4 / 4 GLU A 138
PRO A 136
ILE A 139
LEU A 134
 NA  A 301 ( 4.9A)
None
None
None
 1.22A 5m45A-4q04A:
undetectable		 5m45A-4q04A:
12.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_D_ACTD803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 4q04 URE3-BP SEQUENCE
SPECIFIC DNA BINDING
PROTEIN
(Entamoeba
histolytica) 		4 / 4 GLU A 138
PRO A 136
ILE A 139
LEU A 134
 NA  A 301 ( 4.9A)
None
None
None
 1.26A 5m45D-4q04A:
undetectable		 5m45D-4q04A:
12.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_G_ACTG803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 4q04 URE3-BP SEQUENCE
SPECIFIC DNA BINDING
PROTEIN
(Entamoeba
histolytica) 		4 / 4 GLU A 138
PRO A 136
ILE A 139
LEU A 134
 NA  A 301 ( 4.9A)
None
None
None
 1.20A 5m45G-4q04A:
undetectable		 5m45G-4q04A:
12.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_J_ACTJ803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 4q04 URE3-BP SEQUENCE
SPECIFIC DNA BINDING
PROTEIN
(Entamoeba
histolytica) 		4 / 4 GLU A 138
PRO A 136
ILE A 139
LEU A 134
 NA  A 301 ( 4.9A)
None
None
None
 1.25A 5m45J-4q04A:
undetectable		 5m45J-4q04A:
12.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5K_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 4q04 URE3-BP SEQUENCE
SPECIFIC DNA BINDING
PROTEIN
(Entamoeba
histolytica) 		4 / 4 GLN A  87
THR A  88
THR A 184
LEU A 219
 None
 1.46A 5m5kA-4q04A:
undetectable		 5m5kA-4q04A:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5K_C_ADNC502_2
(ADENOSYLHOMOCYSTEINA
SE)		 4q04 URE3-BP SEQUENCE
SPECIFIC DNA BINDING
PROTEIN
(Entamoeba
histolytica) 		4 / 4 GLN A  87
THR A  88
THR A 184
LEU A 219
 None
 1.46A 5m5kC-4q04A:
undetectable		 5m5kC-4q04A:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NN8_A_ACRA1016_1
(LYSOSOMAL
ALPHA-GLUCOSIDASE)		 4q04 URE3-BP SEQUENCE
SPECIFIC DNA BINDING
PROTEIN
(Entamoeba
histolytica) 		4 / 5 ASP A  48
GLY A  18
PRO A  46
TRP A  20
 None
 1.20A 5nn8A-4q04A:
undetectable		 5nn8A-4q04A:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_A_ADNA501_2
(-)		 4q04 URE3-BP SEQUENCE
SPECIFIC DNA BINDING
PROTEIN
(Entamoeba
histolytica) 		4 / 5 GLN A  87
THR A  88
THR A 184
LEU A 219
 None
 1.39A 6gbnA-4q04A:
undetectable		 6gbnA-4q04A:
16.44