SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4q05'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA206_1
(CARDIAC TROPONIN C)		 4q05 ESTERASE E25
(uncultured
bacterium) 		4 / 8 GLN A 325
PRO A 322
GLU A 323
GLU A 330
 None
 1.18A 1dtlA-4q05A:
undetectable		 1dtlA-4q05A:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FAP_A_RAPA108_2
(FK506-BINDING
PROTEIN
FRAP)		 4q05 ESTERASE E25
(uncultured
bacterium) 		4 / 8 LEU A 304
GLY A 184
TYR A 307
PHE A 305
 NA  A 401 (-4.2A)
None
None
None
 1.06A 1fapB-4q05A:
undetectable		 1fapB-4q05A:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXB_A_ROCA100_4
(HIV-1 PROTEASE)		 4q05 ESTERASE E25
(uncultured
bacterium) 		4 / 4 GLY A 313
ASP A 282
GLY A 309
THR A  41
 None
 1.05A 1hxbB-4q05A:
undetectable		 1hxbB-4q05A:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JIN_A_KTNA801_1
(CYTOCHROME P450
107A1)		 4q05 ESTERASE E25
(uncultured
bacterium) 		5 / 11 SER A 146
ALA A 181
THR A 116
ALA A 327
LEU A 335
 None
 1.04A 1jinA-4q05A:
undetectable		 1jinA-4q05A:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_K_FUAK712_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4q05 ESTERASE E25
(uncultured
bacterium) 		3 / 3 VAL A  72
ALA A 128
HIS A 117
 None
 0.76A 1q23L-4q05A:
undetectable		 1q23L-4q05A:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RLB_E_REAE176_1
(RETINOL BINDING
PROTEIN)		 4q05 ESTERASE E25
(uncultured
bacterium) 		5 / 10 ALA A 327
ALA A 329
LEU A 336
GLN A 337
ASP A 303
 None
 1.11A 1rlbE-4q05A:
undetectable		 1rlbE-4q05A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1O_B_CAMB2422_0
(CYTOCHROME P450-CAM)		 4q05 ESTERASE E25
(uncultured
bacterium) 		5 / 9 PHE A 113
THR A 192
LEU A 212
GLY A 213
ILE A 136
 None
 1.26A 2a1oB-4q05A:
undetectable		 2a1oB-4q05A:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ADM_A_SAMA500_0
(ADENINE-N6-DNA-METHY
LTRANSFERASE TAQI)		 4q05 ESTERASE E25
(uncultured
bacterium) 		5 / 11 ALA A  30
GLU A 323
ILE A 310
ALA A 321
PRO A  27
 None
 1.14A 2admA-4q05A:
undetectable		 2admA-4q05A:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ADM_B_SAMB500_0
(ADENINE-N6-DNA-METHY
LTRANSFERASE TAQI)		 4q05 ESTERASE E25
(uncultured
bacterium) 		5 / 11 ALA A  30
GLU A 323
ILE A 310
ALA A 321
PRO A  27
 None
 1.15A 2admB-4q05A:
undetectable		 2admB-4q05A:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VD0_B_D27B1200_0
(GLUTATHIONE-REQUIRIN
G PROSTAGLANDIN D
SYNTHASE)		 4q05 ESTERASE E25
(uncultured
bacterium) 		5 / 10 GLY A 184
ALA A 287
TYR A 149
THR A 192
LEU A 212
 None
 1.33A 2vd0B-4q05A:
undetectable		 2vd0B-4q05A:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDV_E_SAME1287_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 4q05 ESTERASE E25
(uncultured
bacterium) 		5 / 12 GLY A 188
GLY A 184
ILE A 147
ALA A 160
THR A 214
 None
 1.12A 2vdvE-4q05A:
undetectable		 2vdvE-4q05A:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDV_F_SAMF1287_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 4q05 ESTERASE E25
(uncultured
bacterium) 		5 / 11 GLY A 188
GLY A 184
ILE A 147
ALA A 160
THR A 214
 None
 1.12A 2vdvF-4q05A:
undetectable		 2vdvF-4q05A:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DH0_A_SAMA220_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 4q05 ESTERASE E25
(uncultured
bacterium) 		5 / 12 LEU A 212
VAL A 114
GLY A 184
PHE A 275
ALA A 181
 None
 1.15A 3dh0A-4q05A:
3.2		 3dh0A-4q05A:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_D_ROCD201_2
(HIV-1 PROTEASE)		 4q05 ESTERASE E25
(uncultured
bacterium) 		4 / 4 GLY A 313
ASP A 282
GLY A 309
THR A  41
 None
 1.06A 3k4vC-4q05A:
undetectable		 3k4vC-4q05A:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_A_SAMA300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 4q05 ESTERASE E25
(uncultured
bacterium) 		5 / 12 GLY A 183
GLY A 213
SER A 185
LEU A 276
ALA A 209
 None
 1.13A 3ou6A-4q05A:
2.9		 3ou6A-4q05A:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_B_SAMB300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 4q05 ESTERASE E25
(uncultured
bacterium) 		5 / 12 GLY A 183
GLY A 213
SER A 185
LEU A 276
ALA A 209
 None
 1.15A 3ou6B-4q05A:
3.0		 3ou6B-4q05A:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_B_SAMB300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 4q05 ESTERASE E25
(uncultured
bacterium) 		5 / 12 GLY A 183
GLY A 213
SER A 185
LEU A 276
ALA A 209
 None
 1.16A 3ou7B-4q05A:
2.9		 3ou7B-4q05A:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SNF_A_ACTA110_0
(PROTEIN P-30)		 4q05 ESTERASE E25
(uncultured
bacterium) 		4 / 5 ILE A 277
THR A 214
SER A 185
PHE A 211
 None
 0.98A 3snfA-4q05A:
undetectable		 3snfA-4q05A:
13.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_B_VIVB301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 4q05 ESTERASE E25
(uncultured
bacterium) 		5 / 12 ILE A 136
LEU A 195
VAL A  94
ILE A 180
LEU A 171
 None
 0.98A 3w67B-4q05A:
undetectable		 3w67B-4q05A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_B_VIVB301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 4q05 ESTERASE E25
(uncultured
bacterium) 		5 / 12 ILE A 136
LEU A 195
VAL A  94
ILE A 180
LEU A 171
 None
 0.88A 3w68B-4q05A:
undetectable		 3w68B-4q05A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRK_D_CAMD502_0
(CAMPHOR
5-MONOOXYGENASE)		 4q05 ESTERASE E25
(uncultured
bacterium) 		4 / 5 LEU A 210
GLY A 183
THR A 116
VAL A 164
 None
 0.98A 3wrkD-4q05A:
undetectable		 3wrkD-4q05A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A79_B_P1BB601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 4q05 ESTERASE E25
(uncultured
bacterium) 		5 / 12 PRO A 272
LEU A 210
LEU A 195
ILE A 200
PHE A 165
 None
 1.40A 4a79B-4q05A:
undetectable		 4a79B-4q05A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_D_CLQD303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4q05 ESTERASE E25
(uncultured
bacterium) 		4 / 6 GLY A 184
GLY A 183
GLU A 132
ILE A 136
 None
 0.81A 4fglD-4q05A:
2.8		 4fglD-4q05A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L8F_B_MTXB301_1
(GAMMA-GLUTAMYL
HYDROLASE)		 4q05 ESTERASE E25
(uncultured
bacterium) 		5 / 11 GLY A 119
GLY A 187
GLY A 188
GLU A 132
HIS A 312
 None
 1.06A 4l8fB-4q05A:
4.3		 4l8fB-4q05A:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L8F_D_MTXD301_1
(GAMMA-GLUTAMYL
HYDROLASE)		 4q05 ESTERASE E25
(uncultured
bacterium) 		5 / 11 GLY A 119
GLY A 187
GLY A 188
GLU A 132
HIS A 312
 None
 1.07A 4l8fD-4q05A:
3.6		 4l8fD-4q05A:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGF_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 4q05 ESTERASE E25
(uncultured
bacterium) 		4 / 6 GLU A 323
THR A 324
THR A 214
HIS A 312
 None
 0.96A 4pgfA-4q05A:
5.7		 4pgfA-4q05A:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WH5_A_3QBA204_1
(LINCOSAMIDE
RESISTANCE PROTEIN)		 4q05 ESTERASE E25
(uncultured
bacterium) 		5 / 12 GLY A 279
ASP A 282
PHE A 211
ILE A 277
ALA A 327
 None
 1.23A 4wh5A-4q05A:
undetectable		 4wh5A-4q05A:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BW4_A_SAMA301_0
(16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE)		 4q05 ESTERASE E25
(uncultured
bacterium) 		5 / 12 GLY A 216
GLY A 187
THR A 192
LEU A 212
LEU A 284
 None
 1.13A 5bw4A-4q05A:
undetectable		 5bw4A-4q05A:
27.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_A_SAMA902_0
(MRNA CAPPING ENZYME
P5)		 4q05 ESTERASE E25
(uncultured
bacterium) 		5 / 12 GLY A 188
PRO A 215
HIS A 312
THR A 116
VAL A 114
 None
 1.33A 5x6yA-4q05A:
undetectable		 5x6yA-4q05A:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YOD_B_BEZB201_0
(NS3 PROTEASE)		 4q05 ESTERASE E25
(uncultured
bacterium) 		4 / 5 HIS A 312
ALA A 120
SER A 186
GLY A 118
 None
 1.00A 5yodB-4q05A:
undetectable		 5yodB-4q05A:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YOD_D_BEZD201_0
(NS3 PROTEASE)		 4q05 ESTERASE E25
(uncultured
bacterium) 		4 / 5 HIS A 312
ALA A 120
SER A 186
GLY A 118
 None
 1.04A 5yodD-4q05A:
undetectable		 5yodD-4q05A:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_B_GMJB301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 4q05 ESTERASE E25
(uncultured
bacterium) 		5 / 12 LEU A 335
SER A 146
ILE A 136
THR A 130
LEU A 210
 None
 1.39A 6djzB-4q05A:
undetectable		 6djzB-4q05A:
23.06