SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4q0k'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3A_A_TEPA1435_1
(CHITINASE)		 4q0k PHYTOHORMONE BINDING
PROTEIN MTPHBP
(Medicago
truncatula) 		3 / 3 TRP A  19
GLU A  77
TYR A  75
 None
GOL  A 203 (-3.7A)
GOL  A 203 (-4.6A)
 1.23A 2a3aA-4q0kA:
undetectable		 2a3aA-4q0kA:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRQ_A_ERYA195_0
(REPRESSOR PROTEIN
MPHR(A))		 4q0k PHYTOHORMONE BINDING
PROTEIN MTPHBP
(Medicago
truncatula) 		5 / 12 THR A  52
VAL A  41
TYR A  99
VAL A  38
THR A 141
 GOL  A 204 ( 4.7A)
None
None
None
GA3  A 201 (-2.8A)
 1.31A 3frqA-4q0kA:
undetectable		 3frqA-4q0kA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBE_A_2FAA401_1
(ADENOSINE KINASE)		 4q0k PHYTOHORMONE BINDING
PROTEIN MTPHBP
(Medicago
truncatula) 		5 / 12 GLY A  89
GLY A  90
ASN A  93
PHE A  58
ALA A  63
 None
GOL  A 202 (-3.6A)
None
GOL  A 202 (-3.8A)
GOL  A 202 (-3.6A)
 1.06A 4ubeA-4q0kA:
undetectable		 4ubeA-4q0kA:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_D_SORD1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 4q0k PHYTOHORMONE BINDING
PROTEIN MTPHBP
(Medicago
truncatula) 		4 / 6 LYS A  53
GLY A  49
GLY A  48
ASP A  47
 None
GOL  A 203 (-3.5A)
GOL  A 204 (-3.6A)
GOL  A 203 (-3.0A)
 0.87A 5a06D-4q0kA:
undetectable		 5a06D-4q0kA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXI_A_LSNA503_1
(CYTOCHROME P450 2C9)		 4q0k PHYTOHORMONE BINDING
PROTEIN MTPHBP
(Medicago
truncatula) 		5 / 12 ILE A  82
GLN A  68
LEU A  34
PRO A  31
PHE A  56
 None
GOL  A 202 ( 3.1A)
None
None
GA3  A 201 (-3.6A)
 1.18A 5xxiA-4q0kA:
undetectable		 5xxiA-4q0kA:
14.80