SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4q0m'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_A_CHDA1502_0
(FERROCHELATASE)		 4q0m L-ASPARAGINASE
(Pyrococcus
furiosus) 		4 / 8 LEU A 280
VAL A 268
GLY A 288
MET A 290
 None
 0.93A 1hrkA-4q0mA:
4.4		 1hrkA-4q0mA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_B_CHDB2502_0
(FERROCHELATASE)		 4q0m L-ASPARAGINASE
(Pyrococcus
furiosus) 		4 / 8 LEU A 280
VAL A 268
GLY A 288
MET A 290
 None
 0.95A 1hrkB-4q0mA:
4.7		 1hrkB-4q0mA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXW_B_RITB301_2
(HIV-1 PROTEASE)		 4q0m L-ASPARAGINASE
(Pyrococcus
furiosus) 		5 / 11 ARG A 217
LEU A 251
GLY A 226
VAL A 284
ILE A 205
 None
 1.00A 1hxwB-4q0mA:
undetectable		 1hxwB-4q0mA:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKV_A_EFZA2000_1
(POL POLYPROTEIN)		 4q0m L-ASPARAGINASE
(Pyrococcus
furiosus) 		5 / 9 VAL A 150
VAL A 138
GLY A 149
TRP A 301
LEU A 320
 None
 1.48A 1ikvA-4q0mA:
undetectable		 1ikvA-4q0mA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LHU_A_ESTA301_1
(SEX HORMONE-BINDING
GLOBULIN)		 4q0m L-ASPARAGINASE
(Pyrococcus
furiosus) 		5 / 12 SER A 118
GLY A  10
ASP A  84
LYS A 154
ILE A  12
 None
PO4  A 401 (-3.6A)
PO4  A 401 (-3.0A)
PO4  A 401 ( 4.2A)
None
 1.25A 1lhuA-4q0mA:
undetectable		 1lhuA-4q0mA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1URM_A_BEZA201_0
(PEROXIREDOXIN 5)		 4q0m L-ASPARAGINASE
(Pyrococcus
furiosus) 		5 / 9 PRO A 112
PRO A 121
SER A 118
LEU A  25
THR A 114
 None
 1.50A 1urmA-4q0mA:
undetectable		 1urmA-4q0mA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZY_A_CHDA237_0
(PHOSPHOLIPASE A2,
MAJOR ISOENZYME)		 4q0m L-ASPARAGINASE
(Pyrococcus
furiosus) 		5 / 11 ILE A 227
ILE A 205
MET A 259
GLY A 283
LEU A 244
 None
 0.97A 2azyA-4q0mA:
undetectable		 2azyA-4q0mA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIQ_A_STIA1001_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4q0m L-ASPARAGINASE
(Pyrococcus
furiosus) 		4 / 5 LEU A   5
VAL A 150
LEU A 148
ARG A  98
 None
 1.09A 2oiqA-4q0mA:
undetectable		 2oiqA-4q0mA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VN0_A_TDZA501_1
(CYTOCHROME P450 2C8)		 4q0m L-ASPARAGINASE
(Pyrococcus
furiosus) 		5 / 12 ILE A  93
THR A  89
ASN A  70
VAL A 138
VAL A  79
 None
 1.11A 2vn0A-4q0mA:
undetectable		 2vn0A-4q0mA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1359_1
(PROSTAGLANDIN
REDUCTASE 2)		 4q0m L-ASPARAGINASE
(Pyrococcus
furiosus) 		4 / 6 THR A 306
GLU A 311
LYS A 318
ILE A 285
 None
 1.10A 2w98B-4q0mA:
undetectable		 2w98B-4q0mA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGP_A_PCFA1213_0
(WNT INHIBITORY
FACTOR 1)		 4q0m L-ASPARAGINASE
(Pyrococcus
furiosus) 		5 / 12 LEU A 324
ILE A 302
MET A 290
VAL A 228
VAL A 202
 None
None
None
None
GOL  A 402 (-4.7A)
 1.06A 2ygpA-4q0mA:
undetectable		 2ygpA-4q0mA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BRF_A_SORA2_0
(LIN-12 AND GLP-1
PHENOTYPE PROTEIN 1,
ISOFORM A)		 4q0m L-ASPARAGINASE
(Pyrococcus
furiosus) 		3 / 3 LYS A 313
LYS A 253
VAL A 309
 None
 0.99A 3brfA-4q0mA:
undetectable		 3brfA-4q0mA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_D_TMQD614_1
(DHFR-TS)		 4q0m L-ASPARAGINASE
(Pyrococcus
furiosus) 		5 / 10 ALA A 287
ILE A 237
PRO A 238
ILE A 257
THR A 295
 None
 1.23A 3clbD-4q0mA:
undetectable		 3clbD-4q0mA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CV9_A_VDXA501_1
(CYTOCHROME P450-SU1)		 4q0m L-ASPARAGINASE
(Pyrococcus
furiosus) 		5 / 9 THR A  80
VAL A 140
SER A 165
ILE A  12
GLY A  82
 None
None
None
None
PO4  A 401 (-3.0A)
 1.17A 3cv9A-4q0mA:
undetectable		 3cv9A-4q0mA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELW_A_SAMA4633_0
(METHYLTRANSFERASE)		 4q0m L-ASPARAGINASE
(Pyrococcus
furiosus) 		5 / 12 GLY A 288
GLY A 231
GLY A 235
GLY A 267
ILE A 229
 None
 0.80A 3elwA-4q0mA:
undetectable		 3elwA-4q0mA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HBB_D_TMQD614_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4q0m L-ASPARAGINASE
(Pyrococcus
furiosus) 		5 / 10 ALA A 287
ILE A 237
PRO A 238
ILE A 257
THR A 295
 None
 1.23A 3hbbD-4q0mA:
undetectable		 3hbbD-4q0mA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9L_A_CAMA1419_0
(CYTOCHROME P450)		 4q0m L-ASPARAGINASE
(Pyrococcus
furiosus) 		5 / 12 ILE A 227
LEU A 207
GLY A 231
VAL A 284
ILE A 248
 None
 0.97A 4c9lA-4q0mA:
undetectable		 4c9lA-4q0mA:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9L_B_CAMB1419_0
(CYTOCHROME P450)		 4q0m L-ASPARAGINASE
(Pyrococcus
furiosus) 		5 / 12 ILE A 227
LEU A 207
GLY A 231
VAL A 284
ILE A 248
 None
 0.98A 4c9lB-4q0mA:
undetectable		 4c9lB-4q0mA:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9O_A_CAMA423_0
(CYTOCHROME P450)		 4q0m L-ASPARAGINASE
(Pyrococcus
furiosus) 		5 / 12 ILE A 227
LEU A 207
GLY A 231
VAL A 284
ILE A 248
 None
 0.99A 4c9oA-4q0mA:
undetectable		 4c9oA-4q0mA:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9O_B_CAMB423_0
(CYTOCHROME P450)		 4q0m L-ASPARAGINASE
(Pyrococcus
furiosus) 		5 / 12 ILE A 227
LEU A 207
GLY A 231
VAL A 284
ILE A 248
 None
 1.00A 4c9oB-4q0mA:
undetectable		 4c9oB-4q0mA:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTJ_C_SAMC1263_0
(NON-STRUCTURAL
PROTEIN 5)		 4q0m L-ASPARAGINASE
(Pyrococcus
furiosus) 		5 / 12 GLY A 288
GLY A 231
GLY A 235
GLY A 267
ILE A 229
 None
 0.93A 4ctjC-4q0mA:
undetectable		 4ctjC-4q0mA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JX1_B_CAMB502_0
(CAMPHOR
5-MONOOXYGENASE)		 4q0m L-ASPARAGINASE
(Pyrococcus
furiosus) 		5 / 10 PHE A 216
GLY A 231
VAL A 204
ILE A 227
VAL A 228
 None
 1.14A 4jx1B-4q0mA:
undetectable		 4jx1B-4q0mA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RN6_A_15UA301_1
(THROMBIN HEAVY CHAIN)		 4q0m L-ASPARAGINASE
(Pyrococcus
furiosus) 		5 / 10 LEU A 244
LEU A 270
ALA A 234
ALA A 279
GLY A 231
 None
 1.42A 4rn6A-4q0mA:
undetectable		 4rn6A-4q0mA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EHG_C_SAMC4001_0
(RNA-DIRECTED RNA
POLYMERASE NS5)		 4q0m L-ASPARAGINASE
(Pyrococcus
furiosus) 		5 / 12 GLY A 288
GLY A 231
GLY A 235
GLY A 267
ILE A 229
 None
 0.95A 5ehgC-4q0mA:
undetectable		 5ehgC-4q0mA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HS6_A_J3ZA302_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE 14)		 4q0m L-ASPARAGINASE
(Pyrococcus
furiosus) 		4 / 8 HIS A  81
LEU A  63
TRP A  60
THR A 297
 None
 1.12A 5hs6A-4q0mA:
undetectable		 5hs6A-4q0mA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQR_A_SAMA301_0
(METHYLTRANSFERASE)		 4q0m L-ASPARAGINASE
(Pyrococcus
furiosus) 		5 / 12 GLY A 288
GLY A 231
GLY A 235
GLY A 267
ILE A 229
 None
 0.90A 5kqrA-4q0mA:
undetectable		 5kqrA-4q0mA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQS_A_SAMA307_0
(GENOME POLYPROTEIN)		 4q0m L-ASPARAGINASE
(Pyrococcus
furiosus) 		5 / 12 GLY A 288
GLY A 231
GLY A 235
GLY A 267
ILE A 229
 None
 0.92A 5kqsA-4q0mA:
undetectable		 5kqsA-4q0mA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L6E_A_SAMA601_0
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 4q0m L-ASPARAGINASE
(Pyrococcus
furiosus) 		5 / 12 ILE A 229
PRO A 238
LEU A 244
GLY A 235
GLY A 231
 None
 0.93A 5l6eA-4q0mA:
undetectable		 5l6eA-4q0mA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5B_A_SAMA1001_0
(NS5
METHYLTRANSFERASE)		 4q0m L-ASPARAGINASE
(Pyrococcus
furiosus) 		5 / 12 GLY A 288
GLY A 231
GLY A 235
GLY A 267
ILE A 229
 None
 0.92A 5m5bA-4q0mA:
undetectable		 5m5bA-4q0mA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VIM_A_SAMA301_0
(METHYLTRANSFERASE)		 4q0m L-ASPARAGINASE
(Pyrococcus
furiosus) 		5 / 12 GLY A 288
GLY A 231
GLY A 235
GLY A 267
ILE A 229
 None
 0.94A 5vimA-4q0mA:
undetectable		 5vimA-4q0mA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_B_SAMB601_0
(NS5
METHYLTRANSFERASE)		 4q0m L-ASPARAGINASE
(Pyrococcus
furiosus) 		5 / 12 GLY A 288
GLY A 231
GLY A 235
GLY A 267
ILE A 229
 None
 0.89A 5wz1B-4q0mA:
undetectable		 5wz1B-4q0mA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X23_A_LSNA502_2
(CYTOCHROME P450 2C9)		 4q0m L-ASPARAGINASE
(Pyrococcus
furiosus) 		3 / 3 LEU A 194
VAL A  61
ASP A  62
 4CS  A 405 (-4.9A)
None
None
 0.56A 5x23A-4q0mA:
undetectable		 5x23A-4q0mA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7F_A_SAMA301_0
(PUTATIVE
O-METHYLTRANSFERASE
RV1220C)		 4q0m L-ASPARAGINASE
(Pyrococcus
furiosus) 		5 / 12 GLY A 288
GLY A 235
VAL A 258
ALA A 234
TYR A 273
 None
 1.14A 5x7fA-4q0mA:
undetectable		 5x7fA-4q0mA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y80_A_IREA402_0
(CYCLIN-G-ASSOCIATED
KINASE)		 4q0m L-ASPARAGINASE
(Pyrococcus
furiosus) 		5 / 11 ALA A 162
SER A 109
ILE A  78
THR A  80
ILE A 128
 None
 1.25A 5y80A-4q0mA:
undetectable		 5y80A-4q0mA:
11.25