SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4q0w'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIN_A_TFPA155_1
(CALMODULIN)		 4q0w DNA REPAIR PROTEIN
RAD2
(Saccharomyces
cerevisiae) 		4 / 7 GLN A 859
GLU A 856
MET A 939
ALA A 937
 None
 1.35A 1linA-4q0wA:
undetectable		 1linA-4q0wA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_A_ROFA502_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 4q0w DNA REPAIR PROTEIN
RAD2
(Saccharomyces
cerevisiae) 		5 / 12 ASP A 815
LEU A 818
THR A 822
ILE A 824
SER A 842
 CA  A1001 (-3.5A)
None
None
None
None
 1.42A 1xoqA-4q0wA:
undetectable		 1xoqA-4q0wA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_B_ROFB501_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 4q0w DNA REPAIR PROTEIN
RAD2
(Saccharomyces
cerevisiae) 		5 / 12 ASP A 815
LEU A 818
THR A 822
ILE A 824
SER A 842
 CA  A1001 (-3.5A)
None
None
None
None
 1.43A 1xoqB-4q0wA:
undetectable		 1xoqB-4q0wA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OPX_A_DXCA1001_0
(ALDEHYDE
DEHYDROGENASE A)		 4q0w DNA REPAIR PROTEIN
RAD2
(Saccharomyces
cerevisiae) 		4 / 7 LEU A  65
PHE A  58
PHE A 829
ILE A 810
 None
 0.96A 2opxA-4q0wA:
3.0		 2opxA-4q0wA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_E_SVRE510_2
(PHOSPHOLIPASE A2)		 4q0w DNA REPAIR PROTEIN
RAD2
(Saccharomyces
cerevisiae) 		4 / 6 VAL A  75
GLY A 783
ARG A 781
LEU A 960
 None
 1.07A 3bjwE-4q0wA:
undetectable		 3bjwE-4q0wA:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HZN_D_ACTD229_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 4q0w DNA REPAIR PROTEIN
RAD2
(Saccharomyces
cerevisiae) 		4 / 4 ASP A 900
GLY A 897
LYS A 903
GLU A 907
 None
 1.27A 3hznD-4q0wA:
undetectable		 3hznD-4q0wA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LP9_D_SPMD230_1
(LS-24)		 4q0w DNA REPAIR PROTEIN
RAD2
(Saccharomyces
cerevisiae) 		3 / 3 GLU A 883
GLU A 907
ASN A 908
 None
 0.83A 3lp9B-4q0wA:
undetectable
3lp9D-4q0wA:
undetectable		 3lp9B-4q0wA:
22.99
3lp9D-4q0wA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OND_A_ADNA506_1
(ADENOSYLHOMOCYSTEINA
SE)		 4q0w DNA REPAIR PROTEIN
RAD2
(Saccharomyces
cerevisiae) 		5 / 12 THR A 811
ASP A  77
GLU A 792
LYS A  84
ASP A 864
 None
None
CA  A1001 (-4.5A)
CA  A1001 ( 4.3A)
CA  A1001 (-4.2A)
 1.48A 3ondA-4q0wA:
2.6		 3ondA-4q0wA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PFJ_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 4q0w DNA REPAIR PROTEIN
RAD2
(Saccharomyces
cerevisiae) 		5 / 12 THR A 811
ASP A  77
GLU A 792
LYS A  84
ASP A 864
 None
None
CA  A1001 (-4.5A)
CA  A1001 ( 4.3A)
CA  A1001 (-4.2A)
 1.44A 4pfjA-4q0wA:
2.6		 4pfjA-4q0wA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R7I_A_STIA1001_2
(MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR)		 4q0w DNA REPAIR PROTEIN
RAD2
(Saccharomyces
cerevisiae) 		4 / 5 VAL A 816
VAL A  75
TYR A 825
ARG A 940
 None
 1.10A 4r7iA-4q0wA:
undetectable		 4r7iA-4q0wA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXA_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 4q0w DNA REPAIR PROTEIN
RAD2
(Saccharomyces
cerevisiae) 		5 / 12 THR A 811
ASP A  77
GLU A 792
LYS A  84
ASP A 864
 None
None
CA  A1001 (-4.5A)
CA  A1001 ( 4.3A)
CA  A1001 (-4.2A)
 1.46A 5axaA-4q0wA:
2.7		 5axaA-4q0wA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_A_RBVA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 4q0w DNA REPAIR PROTEIN
RAD2
(Saccharomyces
cerevisiae) 		5 / 12 THR A 811
ASP A  77
GLU A 792
LYS A  84
ASP A 864
 None
None
CA  A1001 (-4.5A)
CA  A1001 ( 4.3A)
CA  A1001 (-4.2A)
 1.47A 5axdA-4q0wA:
2.7		 5axdA-4q0wA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_C_RBVC502_1
(ADENOSYLHOMOCYSTEINA
SE)		 4q0w DNA REPAIR PROTEIN
RAD2
(Saccharomyces
cerevisiae) 		5 / 12 THR A 811
ASP A  77
GLU A 792
LYS A  84
ASP A 864
 None
None
CA  A1001 (-4.5A)
CA  A1001 ( 4.3A)
CA  A1001 (-4.2A)
 1.47A 5axdC-4q0wA:
2.7		 5axdC-4q0wA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G48_A_1FLA1375_1
(DNA POLYMERASE III
SUBUNIT BETA)		 4q0w DNA REPAIR PROTEIN
RAD2
(Saccharomyces
cerevisiae) 		4 / 8 LEU A 779
PRO A  72
ILE A  62
LEU A 778
 None
 0.87A 5g48A-4q0wA:
undetectable		 5g48A-4q0wA:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M36_A_BEZA303_0
(14-3-3 PROTEIN
ZETA/DELTA)		 4q0w DNA REPAIR PROTEIN
RAD2
(Saccharomyces
cerevisiae) 		3 / 3 MET A 964
GLN A 967
ARG A 781
 None
 1.12A 5m36A-4q0wA:
undetectable		 5m36A-4q0wA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SXQ_B_NIZB808_1
(CATALASE-PEROXIDASE)		 4q0w DNA REPAIR PROTEIN
RAD2
(Saccharomyces
cerevisiae) 		4 / 8 GLU A 794
GLU A 792
VAL A  80
GLY A   2
 CA  A1001 (-2.9A)
CA  A1001 (-4.5A)
None
None
 1.03A 5sxqB-4q0wA:
undetectable		 5sxqB-4q0wA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYJ_A_NIZA809_1
(CATALASE-PEROXIDASE)		 4q0w DNA REPAIR PROTEIN
RAD2
(Saccharomyces
cerevisiae) 		4 / 8 GLU A 794
GLU A 792
VAL A  80
GLY A   2
 CA  A1001 (-2.9A)
CA  A1001 (-4.5A)
None
None
 1.04A 5syjA-4q0wA:
undetectable		 5syjA-4q0wA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V96_A_ADNA502_1
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE)		 4q0w DNA REPAIR PROTEIN
RAD2
(Saccharomyces
cerevisiae) 		5 / 12 THR A 811
ASP A  77
GLU A 792
LYS A  84
ASP A 864
 None
None
CA  A1001 (-4.5A)
CA  A1001 ( 4.3A)
CA  A1001 (-4.2A)
 1.48A 5v96A-4q0wA:
2.7		 5v96A-4q0wA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V96_B_ADNB502_1
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE)		 4q0w DNA REPAIR PROTEIN
RAD2
(Saccharomyces
cerevisiae) 		5 / 12 THR A 811
ASP A  77
GLU A 792
LYS A  84
ASP A 864
 None
None
CA  A1001 (-4.5A)
CA  A1001 ( 4.3A)
CA  A1001 (-4.2A)
 1.45A 5v96B-4q0wA:
2.4		 5v96B-4q0wA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V96_C_ADNC502_1
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE)		 4q0w DNA REPAIR PROTEIN
RAD2
(Saccharomyces
cerevisiae) 		5 / 12 THR A 811
ASP A  77
GLU A 792
LYS A  84
ASP A 864
 None
None
CA  A1001 (-4.5A)
CA  A1001 ( 4.3A)
CA  A1001 (-4.2A)
 1.46A 5v96C-4q0wA:
2.8		 5v96C-4q0wA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V96_D_ADND502_1
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE)		 4q0w DNA REPAIR PROTEIN
RAD2
(Saccharomyces
cerevisiae) 		5 / 12 THR A 811
ASP A  77
GLU A 792
LYS A  84
ASP A 864
 None
None
CA  A1001 (-4.5A)
CA  A1001 ( 4.3A)
CA  A1001 (-4.2A)
 1.46A 5v96D-4q0wA:
2.7		 5v96D-4q0wA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_A_GMJA301_1
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 4q0w DNA REPAIR PROTEIN
RAD2
(Saccharomyces
cerevisiae) 		4 / 6 SER A 863
TYR A 865
ASP A 813
GLU A 794
 None
None
CA  A1001 (-3.4A)
CA  A1001 (-2.9A)
 1.45A 6djzA-4q0wA:
undetectable		 6djzA-4q0wA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3M_A_ADNA502_1
(-)		 4q0w DNA REPAIR PROTEIN
RAD2
(Saccharomyces
cerevisiae) 		5 / 12 THR A 811
ASP A  77
GLU A 792
LYS A  84
ASP A 864
 None
None
CA  A1001 (-4.5A)
CA  A1001 ( 4.3A)
CA  A1001 (-4.2A)
 1.50A 6f3mA-4q0wA:
3.2		 6f3mA-4q0wA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3M_B_ADNB502_1
(-)		 4q0w DNA REPAIR PROTEIN
RAD2
(Saccharomyces
cerevisiae) 		5 / 12 THR A 811
ASP A  77
GLU A 792
LYS A  84
ASP A 864
 None
None
CA  A1001 (-4.5A)
CA  A1001 ( 4.3A)
CA  A1001 (-4.2A)
 1.50A 6f3mB-4q0wA:
3.2		 6f3mB-4q0wA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FN9_A_BEZA302_0
(14-3-3 PROTEIN
ZETA/DELTA)		 4q0w DNA REPAIR PROTEIN
RAD2
(Saccharomyces
cerevisiae) 		3 / 3 MET A 964
GLN A 967
ARG A 781
 None
 1.14A 6fn9A-4q0wA:
undetectable		 6fn9A-4q0wA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FNA_B_BEZB302_0
(14-3-3 PROTEIN
ZETA/DELTA)		 4q0w DNA REPAIR PROTEIN
RAD2
(Saccharomyces
cerevisiae) 		3 / 3 MET A 964
GLN A 967
ARG A 781
 None
 1.16A 6fnaB-4q0wA:
undetectable		 6fnaB-4q0wA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FNB_A_BEZA301_0
(14-3-3 PROTEIN
ZETA/DELTA)		 4q0w DNA REPAIR PROTEIN
RAD2
(Saccharomyces
cerevisiae) 		3 / 3 MET A 964
GLN A 967
ARG A 781
 None
 1.14A 6fnbA-4q0wA:
undetectable		 6fnbA-4q0wA:
20.75