SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4q16'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EIZ_A_SAMA301_0
(FTSJ)		 4q16 NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Deinococcus
radiodurans) 		5 / 12 ALA A 102
GLY A  53
GLY A  64
LEU A 155
LEU A  84
 None
 0.94A 1eizA-4q16A:
undetectable		 1eizA-4q16A:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EJ0_A_SAMA301_0
(FTSJ)		 4q16 NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Deinococcus
radiodurans) 		5 / 12 ALA A 102
GLY A  53
GLY A  64
LEU A 155
LEU A  84
 None
 0.96A 1ej0A-4q16A:
undetectable		 1ej0A-4q16A:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_A_DVAA6_0
(GRAMICIDIN D)		 4q16 NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Deinococcus
radiodurans) 		3 / 3 ALA A 269
VAL A 272
TRP A 279
 None
 0.94A 1w5uA-4q16A:
undetectable
1w5uB-4q16A:
undetectable		 1w5uA-4q16A:
5.02
1w5uB-4q16A:
5.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AA6_A_STRA401_1
(MINERALOCORTICOID
RECEPTOR)		 4q16 NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Deinococcus
radiodurans) 		5 / 12 LEU A 201
LEU A 202
ALA A 199
GLN A  58
LEU A 190
 None
 1.44A 2aa6A-4q16A:
undetectable		 2aa6A-4q16A:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DG4_A_RAPA501_1
(FK506-BINDING
PROTEIN 1A)		 4q16 NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Deinococcus
radiodurans) 		5 / 11 ASP A  40
GLU A  72
VAL A  71
PHE A  50
HIS A  79
 None
None
None
None
SO4  A 302 (-3.8A)
 1.24A 2dg4A-4q16A:
undetectable		 2dg4A-4q16A:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A302_1
(THIOPURINE
S-METHYLTRANSFERASE)		 4q16 NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Deinococcus
radiodurans) 		4 / 6 THR A 174
PHE A 261
LEU A 244
LEU A  19
 None
 0.80A 3bgdA-4q16A:
undetectable		 3bgdA-4q16A:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B302_1
(THIOPURINE
S-METHYLTRANSFERASE)		 4q16 NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Deinococcus
radiodurans) 		4 / 7 THR A 174
PHE A 261
LEU A 244
LEU A  19
 None
 0.73A 3bgdB-4q16A:
undetectable		 3bgdB-4q16A:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_C_SAMC300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 4q16 NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Deinococcus
radiodurans) 		5 / 12 LEU A  52
TRP A 212
GLY A  64
LEU A  66
ALA A 199
 None
 1.30A 3ou7C-4q16A:
2.7		 3ou7C-4q16A:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEU_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4q16 NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Deinococcus
radiodurans) 		4 / 7 ASP A  59
ASP A 167
ASP A 241
GLU A 171
 SO4  A 301 (-4.2A)
None
None
None
 1.18A 4feuB-4q16A:
undetectable		 4feuB-4q16A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEU_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4q16 NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Deinococcus
radiodurans) 		4 / 8 ASP A  59
ASP A 167
ASP A 241
GLU A 171
 SO4  A 301 (-4.2A)
None
None
None
 1.14A 4feuF-4q16A:
undetectable		 4feuF-4q16A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEV_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4q16 NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Deinococcus
radiodurans) 		4 / 7 ASP A  59
ASP A 167
ASP A 241
GLU A 171
 SO4  A 301 (-4.2A)
None
None
None
 1.19A 4fevD-4q16A:
undetectable		 4fevD-4q16A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEV_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4q16 NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Deinococcus
radiodurans) 		4 / 7 ASP A  59
ASP A 167
ASP A 241
GLU A 171
 SO4  A 301 (-4.2A)
None
None
None
 1.18A 4fevF-4q16A:
undetectable		 4fevF-4q16A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEW_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4q16 NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Deinococcus
radiodurans) 		4 / 8 ASP A  59
ASP A 167
ASP A 241
GLU A 171
 SO4  A 301 (-4.2A)
None
None
None
 1.20A 4fewD-4q16A:
undetectable		 4fewD-4q16A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEW_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4q16 NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Deinococcus
radiodurans) 		4 / 8 ASP A  59
ASP A 167
ASP A 241
GLU A 171
 SO4  A 301 (-4.2A)
None
None
None
 1.20A 4fewF-4q16A:
undetectable		 4fewF-4q16A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEX_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4q16 NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Deinococcus
radiodurans) 		4 / 7 ASP A  59
ASP A 167
ASP A 241
GLU A 171
 SO4  A 301 (-4.2A)
None
None
None
 1.23A 4fexB-4q16A:
undetectable		 4fexB-4q16A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4q16 NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Deinococcus
radiodurans) 		4 / 8 ASP A  59
ASP A 167
ASP A 241
GLU A 171
 SO4  A 301 (-4.2A)
None
None
None
 1.21A 4gkhB-4q16A:
undetectable		 4gkhB-4q16A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_G_KANG301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4q16 NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Deinococcus
radiodurans) 		4 / 7 ASP A  59
ASP A 167
ASP A 241
GLU A 171
 SO4  A 301 (-4.2A)
None
None
None
 1.21A 4gkhG-4q16A:
undetectable		 4gkhG-4q16A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_J_KANJ301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4q16 NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Deinococcus
radiodurans) 		4 / 6 ASP A  59
ASP A 167
ASP A 241
GLU A 171
 SO4  A 301 (-4.2A)
None
None
None
 1.20A 4gkhJ-4q16A:
undetectable		 4gkhJ-4q16A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKI_A_KANA301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4q16 NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Deinococcus
radiodurans) 		4 / 8 ASP A  59
ASP A 167
ASP A 241
GLU A 171
 SO4  A 301 (-4.2A)
None
None
None
 1.22A 4gkiA-4q16A:
undetectable		 4gkiA-4q16A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKI_C_KANC301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4q16 NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Deinococcus
radiodurans) 		4 / 8 ASP A  59
ASP A 167
ASP A 241
GLU A 171
 SO4  A 301 (-4.2A)
None
None
None
 1.20A 4gkiC-4q16A:
undetectable		 4gkiC-4q16A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KIC_B_SAMB401_1
(METHYLTRANSFERASE
MPPJ)		 4q16 NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Deinococcus
radiodurans) 		3 / 3 ARG A  34
ASP A  59
ASP A 182
 None
SO4  A 301 (-4.2A)
None
 0.92A 4kicB-4q16A:
undetectable		 4kicB-4q16A:
24.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1A_A_AB1A101_2
(MDR769 HIV-1
PROTEASE)		 4q16 NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Deinococcus
radiodurans) 		4 / 6 ARG A 136
ASN A 142
ASP A 182
GLY A 175
 None
 0.99A 4l1aB-4q16A:
undetectable		 4l1aB-4q16A:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_A_AERA601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4q16 NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Deinococcus
radiodurans) 		5 / 12 LEU A 173
ILE A  15
ILE A  16
ALA A 242
VAL A  21
 None
 0.83A 4nkvA-4q16A:
undetectable		 4nkvA-4q16A:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_B_AERB601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4q16 NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Deinococcus
radiodurans) 		5 / 12 LEU A 173
ILE A  15
ILE A  16
ALA A 242
VAL A  21
 None
 0.84A 4nkvB-4q16A:
undetectable		 4nkvB-4q16A:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_C_AERC601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4q16 NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Deinococcus
radiodurans) 		5 / 12 LEU A 173
ILE A  15
ILE A  16
ALA A 242
VAL A  21
 None
 0.82A 4nkvC-4q16A:
undetectable		 4nkvC-4q16A:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_D_AERD601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4q16 NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Deinococcus
radiodurans) 		5 / 12 LEU A 173
ILE A  15
ILE A  16
ALA A 242
VAL A  21
 None
 0.83A 4nkvD-4q16A:
undetectable		 4nkvD-4q16A:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_A_STRA601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4q16 NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Deinococcus
radiodurans) 		5 / 12 LEU A 173
ILE A  15
ILE A  16
ALA A 242
VAL A  21
 None
 0.83A 4nkxA-4q16A:
undetectable		 4nkxA-4q16A:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAD_A_CLMA206_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)		 4q16 NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Deinococcus
radiodurans) 		4 / 4 ALA A 122
ALA A 125
ALA A 126
ALA A 129
 None
 0.10A 4oadA-4q16A:
undetectable		 4oadA-4q16A:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAE_A_CLMA208_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)		 4q16 NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Deinococcus
radiodurans) 		4 / 4 ALA A 122
ALA A 125
ALA A 126
ALA A 129
 None
 0.11A 4oaeA-4q16A:
undetectable		 4oaeA-4q16A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H5F_A_SAMA301_1
(PROTEIN ARGININE
N-METHYLTRANSFERASE
SFM1)		 4q16 NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Deinococcus
radiodurans) 		4 / 5 GLY A  57
PRO A 208
THR A  61
GLN A 101
 SO4  A 301 (-3.3A)
None
None
None
 1.05A 5h5fA-4q16A:
undetectable		 5h5fA-4q16A:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0O_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 4q16 NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Deinococcus
radiodurans) 		3 / 3 ALA A 207
GLN A  58
THR A  61
 None
 0.67A 5n0oA-4q16A:
undetectable		 5n0oA-4q16A:
22.44