SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4q1v'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Z_A_COCA301_1
(CHIMERA OF IG KAPPA
CHAIN: HUMAN
CONSTANT REGION AND
MOUSE VARIABLE
REGION)		 4q1v PUTATIVE DIPEPTIDYL
AMINOPEPTIDASE IV
(Bacteroides
ovatus) 		4 / 8 TYR A 161
LEU A 200
GLU A 143
TRP A 193
 None
 1.10A 1i7zA-4q1vA:
undetectable		 1i7zA-4q1vA:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KW0_A_H4BA429_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 4q1v PUTATIVE DIPEPTIDYL
AMINOPEPTIDASE IV
(Bacteroides
ovatus) 		5 / 12 VAL A 399
LEU A 380
LEU A 561
HIS A 522
GLU A 315
 None
 1.38A 1kw0A-4q1vA:
undetectable		 1kw0A-4q1vA:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MMK_A_H4BA1427_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 4q1v PUTATIVE DIPEPTIDYL
AMINOPEPTIDASE IV
(Bacteroides
ovatus) 		5 / 12 VAL A 399
LEU A 380
LEU A 561
HIS A 522
GLU A 315
 None
 1.37A 1mmkA-4q1vA:
undetectable		 1mmkA-4q1vA:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MMT_A_H4BA1426_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 4q1v PUTATIVE DIPEPTIDYL
AMINOPEPTIDASE IV
(Bacteroides
ovatus) 		5 / 11 VAL A 399
LEU A 380
LEU A 561
HIS A 522
GLU A 315
 None
 1.32A 1mmtA-4q1vA:
undetectable		 1mmtA-4q1vA:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X70_A_715A801_1
(DIPEPTIDYL PEPTIDASE
IV)		 4q1v PUTATIVE DIPEPTIDYL
AMINOPEPTIDASE IV
(Bacteroides
ovatus) 		5 / 12 TYR A 518
VAL A 629
TYR A 635
TYR A 639
HIS A 710
 PEG  A 801 ( 4.0A)
None
None
None
None
 0.34A 1x70A-4q1vA:
35.7		 1x70A-4q1vA:
28.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X70_B_715B801_1
(DIPEPTIDYL PEPTIDASE
IV)		 4q1v PUTATIVE DIPEPTIDYL
AMINOPEPTIDASE IV
(Bacteroides
ovatus) 		5 / 12 SER A 603
VAL A 629
TYR A 635
TYR A 639
HIS A 710
 None
 0.36A 1x70B-4q1vA:
35.8		 1x70B-4q1vA:
28.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOW_A_THAA400_1
(HISTAMINE
N-METHYLTRANSFERASE)		 4q1v PUTATIVE DIPEPTIDYL
AMINOPEPTIDASE IV
(Bacteroides
ovatus) 		4 / 7 PHE A 604
GLU A 575
TYR A 313
TRP A 632
 None
 0.98A 2aowA-4q1vA:
undetectable		 2aowA-4q1vA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOX_A_THAA400_1
(HISTAMINE
N-METHYLTRANSFERASE)		 4q1v PUTATIVE DIPEPTIDYL
AMINOPEPTIDASE IV
(Bacteroides
ovatus) 		4 / 8 PHE A 604
GLU A 575
TYR A 313
TRP A 632
 None
 0.86A 2aoxA-4q1vA:
undetectable		 2aoxA-4q1vA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOX_B_THAB401_1
(HISTAMINE
N-METHYLTRANSFERASE)		 4q1v PUTATIVE DIPEPTIDYL
AMINOPEPTIDASE IV
(Bacteroides
ovatus) 		4 / 7 PHE A 604
GLU A 575
TYR A 313
TRP A 632
 None
 0.86A 2aoxB-4q1vA:
undetectable		 2aoxB-4q1vA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DTT_C_H4BC1002_1
(HYPOTHETICAL PROTEIN
PH0634)		 4q1v PUTATIVE DIPEPTIDYL
AMINOPEPTIDASE IV
(Bacteroides
ovatus) 		4 / 6 ASP A 262
THR A 646
GLU A 641
GLU A 648
 None
 1.36A 2dttB-4q1vA:
undetectable
2dttC-4q1vA:
undetectable		 2dttB-4q1vA:
10.79
2dttC-4q1vA:
10.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNJ_B_CHDB502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4q1v PUTATIVE DIPEPTIDYL
AMINOPEPTIDASE IV
(Bacteroides
ovatus) 		4 / 7 MET A 541
ILE A 724
PRO A 512
GLY A 598
 None
 1.02A 2pnjB-4q1vA:
3.1		 2pnjB-4q1vA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RGU_A_356A901_1
(DIPEPTIDYL PEPTIDASE
4)		 4q1v PUTATIVE DIPEPTIDYL
AMINOPEPTIDASE IV
(Bacteroides
ovatus) 		5 / 12 GLU A 636
TRP A 602
SER A 603
TYR A 639
HIS A 710
 None
 1.23A 2rguA-4q1vA:
35.8		 2rguA-4q1vA:
28.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RGU_A_356A901_1
(DIPEPTIDYL PEPTIDASE
4)		 4q1v PUTATIVE DIPEPTIDYL
AMINOPEPTIDASE IV
(Bacteroides
ovatus) 		5 / 12 GLU A 636
TYR A 518
TRP A 602
TYR A 639
HIS A 710
 None
PEG  A 801 ( 4.0A)
None
None
None
 1.46A 2rguA-4q1vA:
35.8		 2rguA-4q1vA:
28.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RGU_A_356A901_1
(DIPEPTIDYL PEPTIDASE
4)		 4q1v PUTATIVE DIPEPTIDYL
AMINOPEPTIDASE IV
(Bacteroides
ovatus) 		6 / 12 TRP A 602
SER A 603
VAL A 629
TYR A 635
TYR A 639
HIS A 710
 None
 0.73A 2rguA-4q1vA:
35.8		 2rguA-4q1vA:
28.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RGU_A_356A901_1
(DIPEPTIDYL PEPTIDASE
4)		 4q1v PUTATIVE DIPEPTIDYL
AMINOPEPTIDASE IV
(Bacteroides
ovatus) 		6 / 12 TYR A 518
TRP A 602
VAL A 629
TYR A 635
TYR A 639
HIS A 710
 PEG  A 801 ( 4.0A)
None
None
None
None
None
 0.88A 2rguA-4q1vA:
35.8		 2rguA-4q1vA:
28.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RGU_B_356B902_1
(DIPEPTIDYL PEPTIDASE
4)		 4q1v PUTATIVE DIPEPTIDYL
AMINOPEPTIDASE IV
(Bacteroides
ovatus) 		5 / 11 GLU A 636
TRP A 602
SER A 603
TYR A 639
HIS A 710
 None
 1.23A 2rguB-4q1vA:
35.6		 2rguB-4q1vA:
28.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RGU_B_356B902_1
(DIPEPTIDYL PEPTIDASE
4)		 4q1v PUTATIVE DIPEPTIDYL
AMINOPEPTIDASE IV
(Bacteroides
ovatus) 		5 / 11 GLU A 636
TYR A 518
TRP A 602
TYR A 639
HIS A 710
 None
PEG  A 801 ( 4.0A)
None
None
None
 1.40A 2rguB-4q1vA:
35.6		 2rguB-4q1vA:
28.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RGU_B_356B902_1
(DIPEPTIDYL PEPTIDASE
4)		 4q1v PUTATIVE DIPEPTIDYL
AMINOPEPTIDASE IV
(Bacteroides
ovatus) 		6 / 11 TRP A 602
SER A 603
VAL A 629
TYR A 635
TYR A 639
HIS A 710
 None
 0.73A 2rguB-4q1vA:
35.6		 2rguB-4q1vA:
28.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RGU_B_356B902_1
(DIPEPTIDYL PEPTIDASE
4)		 4q1v PUTATIVE DIPEPTIDYL
AMINOPEPTIDASE IV
(Bacteroides
ovatus) 		6 / 11 TYR A 518
TRP A 602
VAL A 629
TYR A 635
TYR A 639
HIS A 710
 PEG  A 801 ( 4.0A)
None
None
None
None
None
 0.85A 2rguB-4q1vA:
35.6		 2rguB-4q1vA:
28.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W1B_A_DXCA2034_0
(ACRIFLAVIN
RESISTANCE PROTEIN B)		 4q1v PUTATIVE DIPEPTIDYL
AMINOPEPTIDASE IV
(Bacteroides
ovatus) 		3 / 3 PHE A 420
SER A 426
LEU A 402
 None
 0.71A 2w1bA-4q1vA:
undetectable		 2w1bA-4q1vA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_B_DIFB1376_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 4q1v PUTATIVE DIPEPTIDYL
AMINOPEPTIDASE IV
(Bacteroides
ovatus) 		4 / 7 TYR A 365
VAL A 371
GLY A 369
ALA A 368
 None
 0.88A 2wekB-4q1vA:
2.6		 2wekB-4q1vA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_A_HSMA1161_1
(ALLERGEN ARG R 1)		 4q1v PUTATIVE DIPEPTIDYL
AMINOPEPTIDASE IV
(Bacteroides
ovatus) 		4 / 5 VAL A 228
TYR A 230
VAL A 682
ASP A 678
 None
 1.26A 2x45A-4q1vA:
undetectable		 2x45A-4q1vA:
11.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1161_1
(ALLERGEN ARG R 1)		 4q1v PUTATIVE DIPEPTIDYL
AMINOPEPTIDASE IV
(Bacteroides
ovatus) 		4 / 5 VAL A 228
TYR A 230
VAL A 682
ASP A 678
 None
 1.31A 2x45C-4q1vA:
undetectable		 2x45C-4q1vA:
11.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_C_SAMC530_1
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 4q1v PUTATIVE DIPEPTIDYL
AMINOPEPTIDASE IV
(Bacteroides
ovatus) 		3 / 3 TYR A 643
GLU A 564
ASN A 340
 None
 0.98A 2y7hC-4q1vA:
undetectable		 2y7hC-4q1vA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZUL_A_SAMA376_0
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 4q1v PUTATIVE DIPEPTIDYL
AMINOPEPTIDASE IV
(Bacteroides
ovatus) 		5 / 12 PHE A 604
GLY A 601
GLY A 606
ALA A 611
LEU A 612
 None
 1.00A 2zulA-4q1vA:
undetectable		 2zulA-4q1vA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AI8_A_HNQA255_1
(CATHEPSIN B)		 4q1v PUTATIVE DIPEPTIDYL
AMINOPEPTIDASE IV
(Bacteroides
ovatus) 		4 / 7 GLY A 605
HIS A 710
CYH A 681
TRP A 602
 None
 1.22A 3ai8A-4q1vA:
undetectable		 3ai8A-4q1vA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AI8_A_HNQA255_1
(CATHEPSIN B)		 4q1v PUTATIVE DIPEPTIDYL
AMINOPEPTIDASE IV
(Bacteroides
ovatus) 		4 / 7 GLY A 606
HIS A 710
CYH A 681
TRP A 602
 None
 1.19A 3ai8A-4q1vA:
undetectable		 3ai8A-4q1vA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AI8_B_HNQB255_1
(CATHEPSIN B)		 4q1v PUTATIVE DIPEPTIDYL
AMINOPEPTIDASE IV
(Bacteroides
ovatus) 		4 / 6 GLY A 605
HIS A 710
CYH A 681
TRP A 602
 None
 1.20A 3ai8B-4q1vA:
undetectable		 3ai8B-4q1vA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJM_A_BJMA1_1
(DIPEPTIDYL PEPTIDASE
4)		 4q1v PUTATIVE DIPEPTIDYL
AMINOPEPTIDASE IV
(Bacteroides
ovatus) 		6 / 12 TYR A 518
SER A 603
VAL A 629
TYR A 635
TYR A 639
HIS A 710
 PEG  A 801 ( 4.0A)
None
None
None
None
None
 0.49A 3bjmA-4q1vA:
34.0		 3bjmA-4q1vA:
28.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJM_B_BJMB2_1
(DIPEPTIDYL PEPTIDASE
4)		 4q1v PUTATIVE DIPEPTIDYL
AMINOPEPTIDASE IV
(Bacteroides
ovatus) 		6 / 12 TYR A 518
SER A 603
VAL A 629
TYR A 635
TYR A 639
HIS A 710
 PEG  A 801 ( 4.0A)
None
None
None
None
None
 0.50A 3bjmB-4q1vA:
33.9		 3bjmB-4q1vA:
28.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF502_2
(PHOSPHOLIPASE A2)		 4q1v PUTATIVE DIPEPTIDYL
AMINOPEPTIDASE IV
(Bacteroides
ovatus) 		4 / 5 ILE A 481
SER A 480
PRO A 479
PRO A 502
 None
 1.41A 3bjwC-4q1vA:
undetectable		 3bjwC-4q1vA:
11.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DMH_A_SAMA384_0
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 4q1v PUTATIVE DIPEPTIDYL
AMINOPEPTIDASE IV
(Bacteroides
ovatus) 		5 / 12 PHE A 604
GLY A 601
GLY A 606
ALA A 611
LEU A 612
 None
 0.96A 3dmhA-4q1vA:
undetectable		 3dmhA-4q1vA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM3_B_478B200_1
(PROTEASE)		 4q1v PUTATIVE DIPEPTIDYL
AMINOPEPTIDASE IV
(Bacteroides
ovatus) 		5 / 10 LEU A 279
GLY A 243
ALA A 201
GLY A 177
ILE A 268
 None
 0.94A 3em3A-4q1vA:
undetectable		 3em3A-4q1vA:
9.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0B_A_T22A800_1
(DIPEPTIDYL PEPTIDASE
4)		 4q1v PUTATIVE DIPEPTIDYL
AMINOPEPTIDASE IV
(Bacteroides
ovatus) 		5 / 12 SER A 603
VAL A 629
TYR A 635
TYR A 639
HIS A 710
 None
 0.63A 3g0bA-4q1vA:
33.5		 3g0bA-4q1vA:
27.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0B_A_T22A800_1
(DIPEPTIDYL PEPTIDASE
4)		 4q1v PUTATIVE DIPEPTIDYL
AMINOPEPTIDASE IV
(Bacteroides
ovatus) 		5 / 12 TYR A 518
VAL A 629
TYR A 635
TYR A 639
HIS A 710
 PEG  A 801 ( 4.0A)
None
None
None
None
 0.73A 3g0bA-4q1vA:
33.5		 3g0bA-4q1vA:
27.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0B_B_T22B800_1
(DIPEPTIDYL PEPTIDASE
4)		 4q1v PUTATIVE DIPEPTIDYL
AMINOPEPTIDASE IV
(Bacteroides
ovatus) 		5 / 12 SER A 603
VAL A 629
TYR A 635
TYR A 639
HIS A 710
 None
 0.63A 3g0bB-4q1vA:
36.5		 3g0bB-4q1vA:
27.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0B_B_T22B800_1
(DIPEPTIDYL PEPTIDASE
4)		 4q1v PUTATIVE DIPEPTIDYL
AMINOPEPTIDASE IV
(Bacteroides
ovatus) 		5 / 12 TYR A 518
VAL A 629
TYR A 635
TYR A 639
HIS A 710
 PEG  A 801 ( 4.0A)
None
None
None
None
 0.74A 3g0bB-4q1vA:
36.5		 3g0bB-4q1vA:
27.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0B_C_T22C800_1
(DIPEPTIDYL PEPTIDASE
4)		 4q1v PUTATIVE DIPEPTIDYL
AMINOPEPTIDASE IV
(Bacteroides
ovatus) 		5 / 12 SER A 603
VAL A 629
TYR A 635
TYR A 639
HIS A 710
 None
 0.67A 3g0bC-4q1vA:
37.8		 3g0bC-4q1vA:
27.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0B_C_T22C800_1
(DIPEPTIDYL PEPTIDASE
4)		 4q1v PUTATIVE DIPEPTIDYL
AMINOPEPTIDASE IV
(Bacteroides
ovatus) 		5 / 12 TYR A 518
VAL A 629
TYR A 635
TYR A 639
HIS A 710
 PEG  A 801 ( 4.0A)
None
None
None
None
 0.77A 3g0bC-4q1vA:
37.8		 3g0bC-4q1vA:
27.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0B_D_T22D800_1
(DIPEPTIDYL PEPTIDASE
4)		 4q1v PUTATIVE DIPEPTIDYL
AMINOPEPTIDASE IV
(Bacteroides
ovatus) 		5 / 12 SER A 603
VAL A 629
TYR A 635
TYR A 639
HIS A 710
 None
 0.63A 3g0bD-4q1vA:
35.8		 3g0bD-4q1vA:
27.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0B_D_T22D800_1
(DIPEPTIDYL PEPTIDASE
4)		 4q1v PUTATIVE DIPEPTIDYL
AMINOPEPTIDASE IV
(Bacteroides
ovatus) 		5 / 12 TYR A 518
VAL A 629
TYR A 635
TYR A 639
HIS A 710
 PEG  A 801 ( 4.0A)
None
None
None
None
 0.74A 3g0bD-4q1vA:
35.8		 3g0bD-4q1vA:
27.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU9_B_SPMB700_1
(POLYAMINE OXIDASE)		 4q1v PUTATIVE DIPEPTIDYL
AMINOPEPTIDASE IV
(Bacteroides
ovatus) 		4 / 7 TYR A 497
GLU A 482
TYR A 591
PHE A 505
 None
 1.21A 3ku9B-4q1vA:
undetectable		 3ku9B-4q1vA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXV_C_478C200_1
(HIV-1 PROTEASE)		 4q1v PUTATIVE DIPEPTIDYL
AMINOPEPTIDASE IV
(Bacteroides
ovatus) 		5 / 9 LEU A 279
GLY A 243
ALA A 201
GLY A 177
ILE A 268
 None
 0.97A 3oxvC-4q1vA:
undetectable		 3oxvC-4q1vA:
8.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PFG_A_SAMA264_1
(N-METHYLTRANSFERASE)		 4q1v PUTATIVE DIPEPTIDYL
AMINOPEPTIDASE IV
(Bacteroides
ovatus) 		3 / 3 TYR A 635
TYR A 230
GLU A 184
 None
 0.95A 3pfgA-4q1vA:
undetectable		 3pfgA-4q1vA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_C_ACTC4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 4q1v PUTATIVE DIPEPTIDYL
AMINOPEPTIDASE IV
(Bacteroides
ovatus) 		4 / 4 GLY A 626
GLY A 606
THR A 609
LEU A 670
 None
 0.90A 3si7C-4q1vA:
undetectable
3si7D-4q1vA:
undetectable		 3si7C-4q1vA:
15.99
3si7D-4q1vA:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SMT_A_ACTA500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD3)		 4q1v PUTATIVE DIPEPTIDYL
AMINOPEPTIDASE IV
(Bacteroides
ovatus) 		3 / 3 PHE A 407
SER A 417
GLN A 418
 None
 0.97A 3smtA-4q1vA:
undetectable		 3smtA-4q1vA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W2T_A_LF7A801_1
(DIPEPTIDYL PEPTIDASE
4)		 4q1v PUTATIVE DIPEPTIDYL
AMINOPEPTIDASE IV
(Bacteroides
ovatus) 		6 / 12 TYR A 518
SER A 603
VAL A 629
TYR A 635
TYR A 639
HIS A 710
 PEG  A 801 ( 4.0A)
None
None
None
None
None
 0.36A 3w2tA-4q1vA:
35.3		 3w2tA-4q1vA:
27.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W2T_B_LF7B801_1
(DIPEPTIDYL PEPTIDASE
4)		 4q1v PUTATIVE DIPEPTIDYL
AMINOPEPTIDASE IV
(Bacteroides
ovatus) 		6 / 12 TYR A 518
SER A 603
VAL A 629
TYR A 635
TYR A 639
HIS A 710
 PEG  A 801 ( 4.0A)
None
None
None
None
None
 0.39A 3w2tB-4q1vA:
35.4		 3w2tB-4q1vA:
27.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DXU_A_ACAA711_1
(LACTOTRANSFERRIN)		 4q1v PUTATIVE DIPEPTIDYL
AMINOPEPTIDASE IV
(Bacteroides
ovatus) 		4 / 6 GLY A  38
VAL A 718
PRO A  36
GLY A 536
 None
 0.67A 4dxuA-4q1vA:
undetectable		 4dxuA-4q1vA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E47_C_SAMC800_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 4q1v PUTATIVE DIPEPTIDYL
AMINOPEPTIDASE IV
(Bacteroides
ovatus) 		5 / 11 ILE A 280
ALA A 289
GLU A 315
GLY A 363
ASN A 361
 None
 1.30A 4e47C-4q1vA:
undetectable		 4e47C-4q1vA:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_A_715A801_1
(DIPEPTIDYL PEPTIDASE
4)		 4q1v PUTATIVE DIPEPTIDYL
AMINOPEPTIDASE IV
(Bacteroides
ovatus) 		5 / 12 TYR A 518
SER A 603
VAL A 629
TYR A 635
HIS A 710
 PEG  A 801 ( 4.0A)
None
None
None
None
 0.35A 4ffwA-4q1vA:
35.5		 4ffwA-4q1vA:
27.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_B_715B801_1
(DIPEPTIDYL PEPTIDASE
4)		 4q1v PUTATIVE DIPEPTIDYL
AMINOPEPTIDASE IV
(Bacteroides
ovatus) 		6 / 12 TYR A 518
SER A 603
VAL A 629
TYR A 635
TYR A 639
HIS A 710
 PEG  A 801 ( 4.0A)
None
None
None
None
None
 0.32A 4ffwB-4q1vA:
32.4		 4ffwB-4q1vA:
27.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FIM_A_CELA711_1
(LACTOTRANSFERRIN)		 4q1v PUTATIVE DIPEPTIDYL
AMINOPEPTIDASE IV
(Bacteroides
ovatus) 		5 / 9 GLU A  39
GLY A  38
VAL A 718
PRO A  36
GLY A 536
 None
 1.25A 4fimA-4q1vA:
undetectable		 4fimA-4q1vA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOR_A_FLPA711_1
(LACTOTRANSFERRIN)		 4q1v PUTATIVE DIPEPTIDYL
AMINOPEPTIDASE IV
(Bacteroides
ovatus) 		4 / 7 GLY A  38
VAL A 718
PRO A  36
GLY A 536
 None
 0.67A 4forA-4q1vA:
undetectable		 4forA-4q1vA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FVQ_A_ACTA904_0
(TYROSINE-PROTEIN
KINASE JAK2)		 4q1v PUTATIVE DIPEPTIDYL
AMINOPEPTIDASE IV
(Bacteroides
ovatus) 		3 / 3 PHE A 134
VAL A 152
GLU A 143
 None
 0.57A 4fvqA-4q1vA:
undetectable		 4fvqA-4q1vA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JDS_B_SAMB401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 4q1v PUTATIVE DIPEPTIDYL
AMINOPEPTIDASE IV
(Bacteroides
ovatus) 		5 / 11 ILE A 280
ALA A 289
GLU A 315
GLY A 363
ASN A 361
 None
 1.31A 4jdsB-4q1vA:
undetectable		 4jdsB-4q1vA:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JDS_C_SAMC401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 4q1v PUTATIVE DIPEPTIDYL
AMINOPEPTIDASE IV
(Bacteroides
ovatus) 		5 / 11 ILE A 280
ALA A 289
GLU A 315
GLY A 363
ASN A 361
 None
 1.30A 4jdsC-4q1vA:
2.7		 4jdsC-4q1vA:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JDS_D_SAMD401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 4q1v PUTATIVE DIPEPTIDYL
AMINOPEPTIDASE IV
(Bacteroides
ovatus) 		5 / 11 ILE A 280
ALA A 289
GLU A 315
GLY A 363
ASN A 361
 None
 1.32A 4jdsD-4q1vA:
1.7		 4jdsD-4q1vA:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM8_A_RFXA603_1
(TRANSPORTER)		 4q1v PUTATIVE DIPEPTIDYL
AMINOPEPTIDASE IV
(Bacteroides
ovatus) 		5 / 12 VAL A 517
TYR A 518
GLY A 572
SER A 603
GLY A 606
 None
PEG  A 801 ( 4.0A)
None
None
None
 1.06A 4mm8A-4q1vA:
undetectable		 4mm8A-4q1vA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMD_A_29EA603_1
(TRANSPORTER)		 4q1v PUTATIVE DIPEPTIDYL
AMINOPEPTIDASE IV
(Bacteroides
ovatus) 		5 / 10 VAL A 517
TYR A 518
GLY A 572
SER A 603
GLY A 606
 None
PEG  A 801 ( 4.0A)
None
None
None
 1.01A 4mmdA-4q1vA:
undetectable		 4mmdA-4q1vA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NED_A_PFNA709_1
(LACTOTRANSFERRIN)		 4q1v PUTATIVE DIPEPTIDYL
AMINOPEPTIDASE IV
(Bacteroides
ovatus) 		4 / 6 ASP A 490
ASP A 578
SER A 556
ALA A 566
 None
 1.20A 4nedA-4q1vA:
undetectable		 4nedA-4q1vA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4POO_B_SAMB301_0
(PUTATIVE RNA
METHYLASE)		 4q1v PUTATIVE DIPEPTIDYL
AMINOPEPTIDASE IV
(Bacteroides
ovatus) 		5 / 12 HIS A 710
ASP A 679
ILE A 637
SER A 237
HIS A 238
 None
 1.37A 4pooB-4q1vA:
2.3		 4pooB-4q1vA:
14.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q15_A_HFGA803_1
(PROLINE--TRNA LIGASE)		 4q1v PUTATIVE DIPEPTIDYL
AMINOPEPTIDASE IV
(Bacteroides
ovatus) 		3 / 3 GLU A 400
THR A 485
HIS A 496
 None
 0.87A 4q15A-4q1vA:
undetectable		 4q15A-4q1vA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YDQ_B_HFGB802_1
(PROLINE--TRNA LIGASE)		 4q1v PUTATIVE DIPEPTIDYL
AMINOPEPTIDASE IV
(Bacteroides
ovatus) 		3 / 3 GLU A 400
THR A 485
HIS A 496
 None
 0.83A 4ydqB-4q1vA:
2.2		 4ydqB-4q1vA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HPU_A_IPHA101_0
(INSULIN, CHAIN A
INSULIN, CHAIN B)		 4q1v PUTATIVE DIPEPTIDYL
AMINOPEPTIDASE IV
(Bacteroides
ovatus) 		4 / 4 CYH A  57
LEU A 466
LEU A 454
ALA A 464
 None
 0.96A 5hpuA-4q1vA:
undetectable
5hpuB-4q1vA:
undetectable		 5hpuA-4q1vA:
2.83
5hpuB-4q1vA:
4.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LOG_A_LDPA1004_1
(PUTATIVE
O-METHYLTRANSFERASE)		 4q1v PUTATIVE DIPEPTIDYL
AMINOPEPTIDASE IV
(Bacteroides
ovatus) 		4 / 6 MET A 478
ASP A 474
ASN A 471
TRP A 530
 None
 1.45A 5logA-4q1vA:
undetectable		 5logA-4q1vA:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_B_ACRB1421_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 4q1v PUTATIVE DIPEPTIDYL
AMINOPEPTIDASE IV
(Bacteroides
ovatus) 		4 / 6 MET A 541
TYR A 727
GLU A 722
GLY A 623
 None
 0.87A 5x7pB-4q1vA:
undetectable		 5x7pB-4q1vA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZWR_B_9KLB402_0
(EST-Y29)		 4q1v PUTATIVE DIPEPTIDYL
AMINOPEPTIDASE IV
(Bacteroides
ovatus) 		5 / 12 TYR A 123
PHE A 114
ILE A  84
LEU A  96
ALA A  93
 None
 1.41A 5zwrB-4q1vA:
undetectable		 5zwrB-4q1vA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B1E_B_LF7B801_1
(DIPEPTIDYL PEPTIDASE
4)		 4q1v PUTATIVE DIPEPTIDYL
AMINOPEPTIDASE IV
(Bacteroides
ovatus) 		6 / 12 TYR A 518
SER A 603
VAL A 629
TYR A 635
TYR A 639
HIS A 710
 PEG  A 801 ( 4.0A)
None
None
None
None
None
 0.39A 6b1eB-4q1vA:
34.0		 6b1eB-4q1vA:
28.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6PAH_A_DAHA600_1
(PHENYLALANINE
4-MONOOXYGENASE)		 4q1v PUTATIVE DIPEPTIDYL
AMINOPEPTIDASE IV
(Bacteroides
ovatus) 		4 / 6 LEU A 571
PRO A 521
HIS A 522
GLU A 315
 None
 0.93A 6pahA-4q1vA:
undetectable		 6pahA-4q1vA:
16.20