SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4q20'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NH8_A_HISA289_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 4q20 SENSOR PROTEIN DIVL
(Caulobacter
vibrioides) 		4 / 5 ASP A 599
LEU A 610
ALA A 729
LEU A 726
 None
 1.16A 1nh8A-4q20A:
undetectable		 1nh8A-4q20A:
27.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_D_SAMD301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4q20 SENSOR PROTEIN DIVL
(Caulobacter
vibrioides) 		3 / 3 ASP A 662
ASP A 631
ASN A 623
 None
 0.77A 2bm9D-4q20A:
undetectable		 2bm9D-4q20A:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D4S_A_TIMA401_1
(BETA-2 ADRENERGIC
RECEPTOR/T4-LYSOZYME
CHIMERA)		 4q20 SENSOR PROTEIN DIVL
(Caulobacter
vibrioides) 		5 / 12 THR A 672
ASP A 695
VAL A 678
VAL A 693
ASN A 667
 None
 1.42A 3d4sA-4q20A:
undetectable		 3d4sA-4q20A:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJW_A_ACTA603_0
(CHOLINE OXIDASE)		 4q20 SENSOR PROTEIN DIVL
(Caulobacter
vibrioides) 		3 / 3 ARG A 575
HIS A 579
SER A 573
 None
 1.00A 4mjwA-4q20A:
undetectable
4mjwB-4q20A:
undetectable		 4mjwA-4q20A:
18.49
4mjwB-4q20A:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJW_B_ACTB603_0
(CHOLINE OXIDASE)		 4q20 SENSOR PROTEIN DIVL
(Caulobacter
vibrioides) 		3 / 3 SER A 573
ARG A 575
HIS A 579
 None
 1.01A 4mjwA-4q20A:
undetectable
4mjwB-4q20A:
undetectable		 4mjwA-4q20A:
18.49
4mjwB-4q20A:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PO0_A_NPSA603_1
(SERUM ALBUMIN)		 4q20 SENSOR PROTEIN DIVL
(Caulobacter
vibrioides) 		5 / 10 ASN A 623
VAL A 665
LEU A 680
LEU A 639
VAL A 641
 None
 1.13A 4po0A-4q20A:
undetectable		 4po0A-4q20A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y8W_B_STRB603_1
(CYTOCHROME P450
21-HYDROXYLASE)		 4q20 SENSOR PROTEIN DIVL
(Caulobacter
vibrioides) 		5 / 12 ASP A 619
VAL A 689
LEU A 754
ILE A 650
GLY A 652
 None
 1.01A 4y8wB-4q20A:
undetectable		 4y8wB-4q20A:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IMS_A_ACTA708_0
(ACETOLACTATE
SYNTHASE CATALYTIC
SUBUNIT,
MITOCHONDRIAL)		 4q20 SENSOR PROTEIN DIVL
(Caulobacter
vibrioides) 		3 / 3 GLY A 718
GLY A 719
GLN A 589
 None
 0.49A 5imsA-4q20A:
undetectable		 5imsA-4q20A:
20.00