SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4q22'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DMI_A_BHSA1610_1
(NITRIC OXIDE
SYNTHASE)		 4q22 GLYCOSIDE HYDROLASE
FAMILY 18
(Serratia
proteamaculans) 		4 / 8 VAL A 377
ALA A 392
PHE A 394
GLU A 372
 None
 1.09A 1dmiA-4q22A:
undetectable
1dmiB-4q22A:
undetectable		 1dmiA-4q22A:
21.41
1dmiB-4q22A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DYI_B_FOLB161_0
(DIHYDROFOLATE
REDUCTASE)		 4q22 GLYCOSIDE HYDROLASE
FAMILY 18
(Serratia
proteamaculans) 		5 / 12 LEU A 318
PHE A 313
ILE A 331
LEU A 335
THR A 284
 None
 1.12A 1dyiB-4q22A:
undetectable		 1dyiB-4q22A:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E9L_A_GCSA800_1
(YM1 SECRETORY
PROTEIN)		 4q22 GLYCOSIDE HYDROLASE
FAMILY 18
(Serratia
proteamaculans) 		6 / 9 TYR A  28
PHE A  58
GLY A 113
ASP A 151
ASP A 223
TRP A 395
 ACT  A 502 (-3.4A)
None
ACT  A 502 ( 4.6A)
ACT  A 502 (-3.0A)
GOL  A 504 (-2.7A)
GOL  A 504 (-3.7A)
 1.10A 1e9lA-4q22A:
39.3		 1e9lA-4q22A:
29.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E9L_A_GCSA800_1
(YM1 SECRETORY
PROTEIN)		 4q22 GLYCOSIDE HYDROLASE
FAMILY 18
(Serratia
proteamaculans) 		7 / 9 TYR A  28
PHE A  58
GLY A 113
ASP A 151
MET A 220
TYR A 222
ASP A 223
 ACT  A 502 (-3.4A)
None
ACT  A 502 ( 4.6A)
ACT  A 502 (-3.0A)
ACT  A 502 ( 3.1A)
GOL  A 504 ( 4.6A)
GOL  A 504 (-2.7A)
 0.91A 1e9lA-4q22A:
39.3		 1e9lA-4q22A:
29.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JOM_A_FFOA161_0
(DIHYDROFOLATE
REDUCTASE)		 4q22 GLYCOSIDE HYDROLASE
FAMILY 18
(Serratia
proteamaculans) 		5 / 11 LEU A 318
PHE A 313
ILE A 331
LEU A 335
THR A 284
 None
 1.15A 1jomA-4q22A:
undetectable		 1jomA-4q22A:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N5X_A_TEIA3006_1
(XANTHINE
DEHYDROGENASE)		 4q22 GLYCOSIDE HYDROLASE
FAMILY 18
(Serratia
proteamaculans) 		5 / 12 LEU A 190
LEU A 150
PHE A 119
ALA A 123
ALA A 122
 None
 1.07A 1n5xA-4q22A:
undetectable		 1n5xA-4q22A:
15.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N5X_B_TEIB4006_1
(XANTHINE
DEHYDROGENASE)		 4q22 GLYCOSIDE HYDROLASE
FAMILY 18
(Serratia
proteamaculans) 		5 / 12 LEU A 190
LEU A 150
PHE A 119
ALA A 123
ALA A 122
 None
 1.07A 1n5xB-4q22A:
undetectable		 1n5xB-4q22A:
15.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_D_DESD600_1
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 4q22 GLYCOSIDE HYDROLASE
FAMILY 18
(Serratia
proteamaculans) 		5 / 12 LEU A 219
LEU A 271
TYR A 383
LEU A 260
ILE A 217
 None
 1.13A 1s9pD-4q22A:
undetectable		 1s9pD-4q22A:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_B_9CRB600_1
(RETINOIC ACID
RECEPTOR, BETA)		 4q22 GLYCOSIDE HYDROLASE
FAMILY 18
(Serratia
proteamaculans) 		5 / 12 LEU A 271
LEU A 219
SER A 200
LEU A 235
LEU A 389
 None
 1.04A 1xdkB-4q22A:
undetectable		 1xdkB-4q22A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_A_STRA1001_2
(MINERALOCORTICOID
RECEPTOR)		 4q22 GLYCOSIDE HYDROLASE
FAMILY 18
(Serratia
proteamaculans) 		4 / 4 LEU A 389
LEU A  24
SER A  25
LEU A 413
 None
 1.19A 1ya3A-4q22A:
undetectable		 1ya3A-4q22A:
19.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2A3A_A_TEPA1433_1
(CHITINASE)		 4q22 GLYCOSIDE HYDROLASE
FAMILY 18
(Serratia
proteamaculans) 		8 / 11 TYR A  28
PHE A  58
GLY A 113
ASP A 151
MET A 220
TYR A 222
TYR A 276
TRP A 395
 ACT  A 502 (-3.4A)
None
ACT  A 502 ( 4.6A)
ACT  A 502 (-3.0A)
ACT  A 502 ( 3.1A)
GOL  A 504 ( 4.6A)
GOL  A 504 ( 4.7A)
GOL  A 504 (-3.7A)
 0.84A 2a3aA-4q22A:
37.7		 2a3aA-4q22A:
30.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2A3A_A_TEPA1433_1
(CHITINASE)		 4q22 GLYCOSIDE HYDROLASE
FAMILY 18
(Serratia
proteamaculans) 		9 / 11 TYR A  28
PHE A  58
GLY A 113
GLU A 153
MET A 220
TYR A 222
ASP A 223
TYR A 276
TRP A 395
 ACT  A 502 (-3.4A)
None
ACT  A 502 ( 4.6A)
ACT  A 502 (-3.8A)
ACT  A 502 ( 3.1A)
GOL  A 504 ( 4.6A)
GOL  A 504 (-2.7A)
GOL  A 504 ( 4.7A)
GOL  A 504 (-3.7A)
 0.55A 2a3aA-4q22A:
37.7		 2a3aA-4q22A:
30.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2A3A_A_TEPA1433_1
(CHITINASE)		 4q22 GLYCOSIDE HYDROLASE
FAMILY 18
(Serratia
proteamaculans) 		7 / 11 TYR A  28
PHE A  58
GLY A 113
TRP A 114
GLU A 153
MET A 220
TRP A 395
 ACT  A 502 (-3.4A)
None
ACT  A 502 ( 4.6A)
None
ACT  A 502 (-3.8A)
ACT  A 502 ( 3.1A)
GOL  A 504 (-3.7A)
 0.78A 2a3aA-4q22A:
37.7		 2a3aA-4q22A:
30.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2A3A_A_TEPA1435_1
(CHITINASE)		 4q22 GLYCOSIDE HYDROLASE
FAMILY 18
(Serratia
proteamaculans) 		3 / 3 TRP A 114
GLU A 153
TYR A 154
 None
ACT  A 502 (-3.8A)
None
 0.51A 2a3aA-4q22A:
37.7		 2a3aA-4q22A:
30.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2A3A_B_TEPB2433_1
(CHITINASE)		 4q22 GLYCOSIDE HYDROLASE
FAMILY 18
(Serratia
proteamaculans) 		8 / 9 PHE A  58
GLY A 113
GLU A 153
MET A 220
TYR A 222
ASP A 223
TYR A 276
TRP A 395
 None
ACT  A 502 ( 4.6A)
ACT  A 502 (-3.8A)
ACT  A 502 ( 3.1A)
GOL  A 504 ( 4.6A)
GOL  A 504 (-2.7A)
GOL  A 504 ( 4.7A)
GOL  A 504 (-3.7A)
 0.48A 2a3aB-4q22A:
37.7		 2a3aB-4q22A:
30.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2A3A_B_TEPB2433_1
(CHITINASE)		 4q22 GLYCOSIDE HYDROLASE
FAMILY 18
(Serratia
proteamaculans) 		5 / 9 PHE A  58
GLY A 113
GLU A 153
TYR A 325
TRP A 395
 None
ACT  A 502 ( 4.6A)
ACT  A 502 (-3.8A)
None
GOL  A 504 (-3.7A)
 1.50A 2a3aB-4q22A:
37.7		 2a3aB-4q22A:
30.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2A3B_A_CFFA1433_1
(CHITINASE)		 4q22 GLYCOSIDE HYDROLASE
FAMILY 18
(Serratia
proteamaculans) 		4 / 5 TRP A 114
TYR A 154
MET A 220
ASP A 223
 None
None
ACT  A 502 ( 3.1A)
GOL  A 504 (-2.7A)
 0.69A 2a3bA-4q22A:
37.6		 2a3bA-4q22A:
30.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2A3B_A_CFFA1435_1
(CHITINASE)		 4q22 GLYCOSIDE HYDROLASE
FAMILY 18
(Serratia
proteamaculans) 		7 / 11 PHE A  58
GLY A 113
TRP A 114
GLU A 153
MET A 220
TYR A 222
TRP A 395
 None
ACT  A 502 ( 4.6A)
None
ACT  A 502 (-3.8A)
ACT  A 502 ( 3.1A)
GOL  A 504 ( 4.6A)
GOL  A 504 (-3.7A)
 0.80A 2a3bA-4q22A:
37.6		 2a3bA-4q22A:
30.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2A3B_A_CFFA1435_1
(CHITINASE)		 4q22 GLYCOSIDE HYDROLASE
FAMILY 18
(Serratia
proteamaculans) 		8 / 11 PHE A  58
GLY A 113
TRP A 114
MET A 220
TYR A 222
ASP A 223
TYR A 276
TRP A 395
 None
ACT  A 502 ( 4.6A)
None
ACT  A 502 ( 3.1A)
GOL  A 504 ( 4.6A)
GOL  A 504 (-2.7A)
GOL  A 504 ( 4.7A)
GOL  A 504 (-3.7A)
 0.59A 2a3bA-4q22A:
37.6		 2a3bA-4q22A:
30.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2A3B_A_CFFA1435_1
(CHITINASE)		 4q22 GLYCOSIDE HYDROLASE
FAMILY 18
(Serratia
proteamaculans) 		7 / 11 TYR A  28
PHE A  58
GLY A 113
GLU A 153
MET A 220
TYR A 222
TRP A 395
 ACT  A 502 (-3.4A)
None
ACT  A 502 ( 4.6A)
ACT  A 502 (-3.8A)
ACT  A 502 ( 3.1A)
GOL  A 504 ( 4.6A)
GOL  A 504 (-3.7A)
 0.82A 2a3bA-4q22A:
37.6		 2a3bA-4q22A:
30.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2A3B_A_CFFA1435_1
(CHITINASE)		 4q22 GLYCOSIDE HYDROLASE
FAMILY 18
(Serratia
proteamaculans) 		8 / 11 TYR A  28
PHE A  58
GLY A 113
MET A 220
TYR A 222
ASP A 223
TYR A 276
TRP A 395
 ACT  A 502 (-3.4A)
None
ACT  A 502 ( 4.6A)
ACT  A 502 ( 3.1A)
GOL  A 504 ( 4.6A)
GOL  A 504 (-2.7A)
GOL  A 504 ( 4.7A)
GOL  A 504 (-3.7A)
 0.57A 2a3bA-4q22A:
37.6		 2a3bA-4q22A:
30.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2A3B_B_CFFB2435_1
(CHITINASE)		 4q22 GLYCOSIDE HYDROLASE
FAMILY 18
(Serratia
proteamaculans) 		7 / 10 PHE A  58
GLY A 113
ASP A 151
GLU A 153
MET A 220
TYR A 222
TRP A 395
 None
ACT  A 502 ( 4.6A)
ACT  A 502 (-3.0A)
ACT  A 502 (-3.8A)
ACT  A 502 ( 3.1A)
GOL  A 504 ( 4.6A)
GOL  A 504 (-3.7A)
 0.98A 2a3bB-4q22A:
37.6		 2a3bB-4q22A:
30.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2A3B_B_CFFB2435_1
(CHITINASE)		 4q22 GLYCOSIDE HYDROLASE
FAMILY 18
(Serratia
proteamaculans) 		7 / 10 PHE A  58
GLY A 113
MET A 220
TYR A 222
ASP A 223
TYR A 276
TRP A 395
 None
ACT  A 502 ( 4.6A)
ACT  A 502 ( 3.1A)
GOL  A 504 ( 4.6A)
GOL  A 504 (-2.7A)
GOL  A 504 ( 4.7A)
GOL  A 504 (-3.7A)
 0.39A 2a3bB-4q22A:
37.6		 2a3bB-4q22A:
30.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2A3C_A_PNXA1434_1
(CHITINASE)		 4q22 GLYCOSIDE HYDROLASE
FAMILY 18
(Serratia
proteamaculans) 		8 / 12 TYR A  28
PHE A  58
GLY A 113
ASP A 151
GLU A 153
MET A 220
TYR A 222
TRP A 395
 ACT  A 502 (-3.4A)
None
ACT  A 502 ( 4.6A)
ACT  A 502 (-3.0A)
ACT  A 502 (-3.8A)
ACT  A 502 ( 3.1A)
GOL  A 504 ( 4.6A)
GOL  A 504 (-3.7A)
 1.02A 2a3cA-4q22A:
37.6		 2a3cA-4q22A:
30.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2A3C_A_PNXA1434_1
(CHITINASE)		 4q22 GLYCOSIDE HYDROLASE
FAMILY 18
(Serratia
proteamaculans) 		8 / 12 TYR A  28
PHE A  58
GLY A 113
MET A 220
TYR A 222
ASP A 223
TYR A 276
TRP A 395
 ACT  A 502 (-3.4A)
None
ACT  A 502 ( 4.6A)
ACT  A 502 ( 3.1A)
GOL  A 504 ( 4.6A)
GOL  A 504 (-2.7A)
GOL  A 504 ( 4.7A)
GOL  A 504 (-3.7A)
 0.56A 2a3cA-4q22A:
37.6		 2a3cA-4q22A:
30.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2A3C_B_PNXB2433_1
(CHITINASE)		 4q22 GLYCOSIDE HYDROLASE
FAMILY 18
(Serratia
proteamaculans) 		6 / 12 PHE A  58
ASP A 151
GLU A 153
MET A 220
TYR A 222
TRP A 395
 None
ACT  A 502 (-3.0A)
ACT  A 502 (-3.8A)
ACT  A 502 ( 3.1A)
GOL  A 504 ( 4.6A)
GOL  A 504 (-3.7A)
 1.04A 2a3cB-4q22A:
37.7		 2a3cB-4q22A:
30.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2A3C_B_PNXB2433_1
(CHITINASE)		 4q22 GLYCOSIDE HYDROLASE
FAMILY 18
(Serratia
proteamaculans) 		6 / 12 PHE A  58
GLY A 113
GLU A 153
MET A 220
TYR A 222
TRP A 395
 None
ACT  A 502 ( 4.6A)
ACT  A 502 (-3.8A)
ACT  A 502 ( 3.1A)
GOL  A 504 ( 4.6A)
GOL  A 504 (-3.7A)
 0.73A 2a3cB-4q22A:
37.7		 2a3cB-4q22A:
30.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2A3C_B_PNXB2433_1
(CHITINASE)		 4q22 GLYCOSIDE HYDROLASE
FAMILY 18
(Serratia
proteamaculans) 		7 / 12 PHE A  58
GLY A 113
MET A 220
TYR A 222
ASP A 223
TYR A 276
TRP A 395
 None
ACT  A 502 ( 4.6A)
ACT  A 502 ( 3.1A)
GOL  A 504 ( 4.6A)
GOL  A 504 (-2.7A)
GOL  A 504 ( 4.7A)
GOL  A 504 (-3.7A)
 0.37A 2a3cB-4q22A:
37.7		 2a3cB-4q22A:
30.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E7F_B_C2FB4000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 4q22 GLYCOSIDE HYDROLASE
FAMILY 18
(Serratia
proteamaculans) 		5 / 12 GLU A 372
LEU A 389
SER A 376
GLN A 352
ILE A 273
 None
 1.32A 2e7fB-4q22A:
5.2		 2e7fB-4q22A:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GL0_B_ADNB902_1
(CONSERVED
HYPOTHETICAL PROTEIN)		 4q22 GLYCOSIDE HYDROLASE
FAMILY 18
(Serratia
proteamaculans) 		5 / 11 PHE A 132
HIS A  80
ILE A 133
THR A 125
ALA A 124
 None
 1.48A 2gl0B-4q22A:
undetectable
2gl0C-4q22A:
undetectable		 2gl0B-4q22A:
18.34
2gl0C-4q22A:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HMY_B_SAMB328_0
(PROTEIN
(CYTOSINE-SPECIFIC
METHYLTRANSFERASE
HHAI))		 4q22 GLYCOSIDE HYDROLASE
FAMILY 18
(Serratia
proteamaculans) 		5 / 12 GLY A 113
GLY A 115
ILE A  82
LEU A  84
VAL A  35
 ACT  A 502 ( 4.6A)
GOL  A 503 (-4.6A)
None
OMT  A  89 ( 4.4A)
None
 1.09A 2hmyB-4q22A:
undetectable		 2hmyB-4q22A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OGY_B_C2FB4000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 4q22 GLYCOSIDE HYDROLASE
FAMILY 18
(Serratia
proteamaculans) 		5 / 12 GLU A 372
LEU A 389
SER A 376
GLN A 352
ILE A 273
 None
 1.36A 2ogyB-4q22A:
7.7		 2ogyB-4q22A:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNJ_B_CHDB501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4q22 GLYCOSIDE HYDROLASE
FAMILY 18
(Serratia
proteamaculans) 		5 / 12 LEU A 180
LEU A 177
ILE A  82
PRO A 155
VAL A 205
 None
 1.19A 2pnjB-4q22A:
undetectable		 2pnjB-4q22A:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UY4_A_AZMA1311_1
(ENDOCHITINASE)		 4q22 GLYCOSIDE HYDROLASE
FAMILY 18
(Serratia
proteamaculans) 		7 / 9 TYR A  28
PHE A  58
GLY A 113
ASP A 151
GLU A 153
TYR A 222
TRP A 395
 ACT  A 502 (-3.4A)
None
ACT  A 502 ( 4.6A)
ACT  A 502 (-3.0A)
ACT  A 502 (-3.8A)
GOL  A 504 ( 4.6A)
GOL  A 504 (-3.7A)
 0.35A 2uy4A-4q22A:
18.0		 2uy4A-4q22A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XTK_A_AZMA1339_1
(CLASS III CHITINASE
CHIA1)		 4q22 GLYCOSIDE HYDROLASE
FAMILY 18
(Serratia
proteamaculans) 		7 / 11 TYR A  28
PHE A  58
GLY A 113
ASP A 151
GLU A 153
TYR A 222
TRP A 395
 ACT  A 502 (-3.4A)
None
ACT  A 502 ( 4.6A)
ACT  A 502 (-3.0A)
ACT  A 502 (-3.8A)
GOL  A 504 ( 4.6A)
GOL  A 504 (-3.7A)
 0.68A 2xtkA-4q22A:
19.6		 2xtkA-4q22A:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XTK_B_AZMB1339_1
(CLASS III CHITINASE
CHIA1)		 4q22 GLYCOSIDE HYDROLASE
FAMILY 18
(Serratia
proteamaculans) 		7 / 10 TYR A  28
PHE A  58
GLY A 113
ASP A 151
GLU A 153
TYR A 222
TRP A 395
 ACT  A 502 (-3.4A)
None
ACT  A 502 ( 4.6A)
ACT  A 502 (-3.0A)
ACT  A 502 (-3.8A)
GOL  A 504 ( 4.6A)
GOL  A 504 (-3.7A)
 0.53A 2xtkB-4q22A:
19.5		 2xtkB-4q22A:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_B_CHDB6_0
(FERROCHELATASE)		 4q22 GLYCOSIDE HYDROLASE
FAMILY 18
(Serratia
proteamaculans) 		5 / 12 LEU A 180
LEU A 177
ILE A  82
PRO A 155
VAL A 205
 None
 1.24A 3aqiB-4q22A:
undetectable		 3aqiB-4q22A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G6M_A_CFFA1_1
(CHITINASE)		 4q22 GLYCOSIDE HYDROLASE
FAMILY 18
(Serratia
proteamaculans) 		6 / 11 TYR A  28
PHE A  58
GLY A 113
ASP A 151
TYR A 222
TRP A 395
 ACT  A 502 (-3.4A)
None
ACT  A 502 ( 4.6A)
ACT  A 502 (-3.0A)
GOL  A 504 ( 4.6A)
GOL  A 504 (-3.7A)
 0.94A 3g6mA-4q22A:
38.1		 3g6mA-4q22A:
29.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G6M_A_CFFA1_1
(CHITINASE)		 4q22 GLYCOSIDE HYDROLASE
FAMILY 18
(Serratia
proteamaculans) 		10 / 11 TYR A  28
PHE A  58
GLY A 113
TRP A 114
GLU A 153
MET A 220
TYR A 222
ASP A 223
TYR A 276
TRP A 395
 ACT  A 502 (-3.4A)
None
ACT  A 502 ( 4.6A)
None
ACT  A 502 (-3.8A)
ACT  A 502 ( 3.1A)
GOL  A 504 ( 4.6A)
GOL  A 504 (-2.7A)
GOL  A 504 ( 4.7A)
GOL  A 504 (-3.7A)
 0.62A 3g6mA-4q22A:
38.1		 3g6mA-4q22A:
29.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G6M_A_CFFA427_1
(CHITINASE)		 4q22 GLYCOSIDE HYDROLASE
FAMILY 18
(Serratia
proteamaculans) 		4 / 5 TRP A 114
TYR A 154
MET A 220
ASP A 223
 None
None
ACT  A 502 ( 3.1A)
GOL  A 504 (-2.7A)
 0.46A 3g6mA-4q22A:
38.1		 3g6mA-4q22A:
29.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_D_30BD500_2
(GENOME POLYPROTEIN)		 4q22 GLYCOSIDE HYDROLASE
FAMILY 18
(Serratia
proteamaculans) 		4 / 4 PHE A 394
TYR A 328
VAL A 256
LEU A 219
 None
 1.37A 3keeD-4q22A:
undetectable		 3keeD-4q22A:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_B_TFPB201_1
(PROTEIN S100-A4)		 4q22 GLYCOSIDE HYDROLASE
FAMILY 18
(Serratia
proteamaculans) 		4 / 8 GLY A 195
ILE A 210
PHE A 132
PHE A 119
 None
 0.71A 3ko0B-4q22A:
undetectable
3ko0J-4q22A:
undetectable		 3ko0B-4q22A:
13.23
3ko0J-4q22A:
13.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_K_TFPK201_1
(PROTEIN S100-A4)		 4q22 GLYCOSIDE HYDROLASE
FAMILY 18
(Serratia
proteamaculans) 		4 / 8 GLY A 195
ILE A 210
PHE A 132
PHE A 119
 None
 0.72A 3ko0K-4q22A:
undetectable
3ko0S-4q22A:
undetectable		 3ko0K-4q22A:
13.23
3ko0S-4q22A:
13.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_A_AICA375_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 4q22 GLYCOSIDE HYDROLASE
FAMILY 18
(Serratia
proteamaculans) 		5 / 11 GLY A 112
ASN A 218
ASN A  55
SER A 110
LEU A 150
 None
 1.39A 3ndvA-4q22A:
undetectable
3ndvB-4q22A:
undetectable		 3ndvA-4q22A:
23.78
3ndvB-4q22A:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_A_AICA375_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 4q22 GLYCOSIDE HYDROLASE
FAMILY 18
(Serratia
proteamaculans) 		5 / 11 GLY A 113
ASN A 218
ASN A  55
SER A 110
LEU A 150
 ACT  A 502 ( 4.6A)
None
None
None
None
 1.36A 3ndvA-4q22A:
undetectable
3ndvB-4q22A:
undetectable		 3ndvA-4q22A:
23.78
3ndvB-4q22A:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_B_AICB376_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 4q22 GLYCOSIDE HYDROLASE
FAMILY 18
(Serratia
proteamaculans) 		5 / 11 GLY A 112
ASN A 218
ASN A  55
SER A 110
LEU A 150
 None
 1.34A 3ndvA-4q22A:
undetectable
3ndvB-4q22A:
undetectable		 3ndvA-4q22A:
23.78
3ndvB-4q22A:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_B_AICB376_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 4q22 GLYCOSIDE HYDROLASE
FAMILY 18
(Serratia
proteamaculans) 		5 / 11 GLY A 113
ASN A 218
ASN A  55
SER A 110
LEU A 150
 ACT  A 502 ( 4.6A)
None
None
None
None
 1.38A 3ndvA-4q22A:
undetectable
3ndvB-4q22A:
undetectable		 3ndvA-4q22A:
23.78
3ndvB-4q22A:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_C_AICC375_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 4q22 GLYCOSIDE HYDROLASE
FAMILY 18
(Serratia
proteamaculans) 		5 / 11 GLY A 112
ASN A 218
ASN A  55
SER A 110
LEU A 150
 None
 1.35A 3ndvC-4q22A:
undetectable
3ndvD-4q22A:
undetectable		 3ndvC-4q22A:
23.78
3ndvD-4q22A:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_C_AICC375_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 4q22 GLYCOSIDE HYDROLASE
FAMILY 18
(Serratia
proteamaculans) 		5 / 11 GLY A 113
ASN A 218
ASN A  55
SER A 110
LEU A 150
 ACT  A 502 ( 4.6A)
None
None
None
None
 1.37A 3ndvC-4q22A:
undetectable
3ndvD-4q22A:
undetectable		 3ndvC-4q22A:
23.78
3ndvD-4q22A:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_D_AICD374_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 4q22 GLYCOSIDE HYDROLASE
FAMILY 18
(Serratia
proteamaculans) 		5 / 11 GLY A 112
ASN A 218
ASN A  55
SER A 110
LEU A 150
 None
 1.40A 3ndvC-4q22A:
undetectable
3ndvD-4q22A:
undetectable		 3ndvC-4q22A:
23.78
3ndvD-4q22A:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_D_AICD374_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 4q22 GLYCOSIDE HYDROLASE
FAMILY 18
(Serratia
proteamaculans) 		5 / 11 GLY A 113
ASN A 218
ASN A  55
SER A 110
LEU A 150
 ACT  A 502 ( 4.6A)
None
None
None
None
 1.37A 3ndvC-4q22A:
undetectable
3ndvD-4q22A:
undetectable		 3ndvC-4q22A:
23.78
3ndvD-4q22A:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UBO_B_ADNB353_2
(ADENOSINE KINASE)		 4q22 GLYCOSIDE HYDROLASE
FAMILY 18
(Serratia
proteamaculans) 		4 / 5 SER A  57
ILE A 148
TYR A  28
GLY A  59
 None
None
ACT  A 502 (-3.4A)
None
 0.96A 3uboB-4q22A:
2.2		 3uboB-4q22A:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WQV_A_GCSA501_1
(CHITINASE)		 4q22 GLYCOSIDE HYDROLASE
FAMILY 18
(Serratia
proteamaculans) 		7 / 11 PHE A  58
GLY A 113
ASP A 151
GLU A 153
TYR A 325
ARG A 278
TRP A 395
 None
ACT  A 502 ( 4.6A)
ACT  A 502 (-3.0A)
ACT  A 502 (-3.8A)
None
GOL  A 504 (-4.1A)
GOL  A 504 (-3.7A)
 1.48A 3wqvA-4q22A:
41.2		 3wqvA-4q22A:
29.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WQV_A_GCSA501_1
(CHITINASE)		 4q22 GLYCOSIDE HYDROLASE
FAMILY 18
(Serratia
proteamaculans) 		11 / 11 PHE A  58
GLY A 113
TRP A 114
ASP A 151
GLU A 153
MET A 220
TYR A 222
ASP A 223
TYR A 276
ARG A 278
TRP A 395
 None
ACT  A 502 ( 4.6A)
None
ACT  A 502 (-3.0A)
ACT  A 502 (-3.8A)
ACT  A 502 ( 3.1A)
GOL  A 504 ( 4.6A)
GOL  A 504 (-2.7A)
GOL  A 504 ( 4.7A)
GOL  A 504 (-4.1A)
GOL  A 504 (-3.7A)
 0.40A 3wqvA-4q22A:
41.2		 3wqvA-4q22A:
29.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WQW_A_GCSA501_1
(CHITINASE)		 4q22 GLYCOSIDE HYDROLASE
FAMILY 18
(Serratia
proteamaculans) 		7 / 11 PHE A  58
GLY A 113
ASP A 151
GLU A 153
TYR A 325
ARG A 278
TRP A 395
 None
ACT  A 502 ( 4.6A)
ACT  A 502 (-3.0A)
ACT  A 502 (-3.8A)
None
GOL  A 504 (-4.1A)
GOL  A 504 (-3.7A)
 1.48A 3wqwA-4q22A:
41.2		 3wqwA-4q22A:
29.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WQW_A_GCSA501_1
(CHITINASE)		 4q22 GLYCOSIDE HYDROLASE
FAMILY 18
(Serratia
proteamaculans) 		11 / 11 PHE A  58
GLY A 113
TRP A 114
ASP A 151
GLU A 153
MET A 220
TYR A 222
ASP A 223
TYR A 276
ARG A 278
TRP A 395
 None
ACT  A 502 ( 4.6A)
None
ACT  A 502 (-3.0A)
ACT  A 502 (-3.8A)
ACT  A 502 ( 3.1A)
GOL  A 504 ( 4.6A)
GOL  A 504 (-2.7A)
GOL  A 504 ( 4.7A)
GOL  A 504 (-4.1A)
GOL  A 504 (-3.7A)
 0.41A 3wqwA-4q22A:
41.2		 3wqwA-4q22A:
29.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I1N_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4q22 GLYCOSIDE HYDROLASE
FAMILY 18
(Serratia
proteamaculans) 		5 / 11 ILE A 273
ALA A 252
LEU A 389
LEU A 413
THR A 221
 None
 1.30A 4i1nA-4q22A:
undetectable		 4i1nA-4q22A:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WQ4_B_ACTB403_0
(TRNA N6-ADENOSINE
THREONYLCARBAMOYLTRA
NSFERASE)		 4q22 GLYCOSIDE HYDROLASE
FAMILY 18
(Serratia
proteamaculans) 		3 / 3 ARG A 341
ASP A 338
ARG A 342
 None
 0.62A 4wq4B-4q22A:
undetectable		 4wq4B-4q22A:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0R_A_PX9A201_0
(BETA-LACTOGLOBULIN)		 4q22 GLYCOSIDE HYDROLASE
FAMILY 18
(Serratia
proteamaculans) 		5 / 12 LEU A 269
LEU A 219
ILE A 217
LEU A 214
ILE A 192
 None
 0.73A 4y0rA-4q22A:
undetectable		 4y0rA-4q22A:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YBN_A_ACTA303_0
(FLAVIN-NUCLEOTIDE-BI
NDING PROTEIN)		 4q22 GLYCOSIDE HYDROLASE
FAMILY 18
(Serratia
proteamaculans) 		3 / 3 VAL A 207
TYR A 259
ALA A 262
 None
 0.45A 4ybnA-4q22A:
undetectable		 4ybnA-4q22A:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_R_BEZR801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 4q22 GLYCOSIDE HYDROLASE
FAMILY 18
(Serratia
proteamaculans) 		4 / 7 PHE A 173
SER A 120
ALA A 123
PRO A 155
 None
 0.95A 5dzkD-4q22A:
undetectable
5dzkR-4q22A:
undetectable		 5dzkD-4q22A:
20.51
5dzkR-4q22A:
2.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_R_BEZR801_1
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 4q22 GLYCOSIDE HYDROLASE
FAMILY 18
(Serratia
proteamaculans) 		4 / 8 PHE A 173
SER A 120
ALA A 123
PRO A 155
 None
 0.96A 5dzkd-4q22A:
undetectable
5dzkr-4q22A:
undetectable		 5dzkd-4q22A:
20.51
5dzkr-4q22A:
2.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_T_BEZT801_1
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 4q22 GLYCOSIDE HYDROLASE
FAMILY 18
(Serratia
proteamaculans) 		4 / 8 PHE A 173
SER A 120
ALA A 123
PRO A 155
 None
 0.95A 5dzkF-4q22A:
undetectable
5dzkT-4q22A:
undetectable		 5dzkF-4q22A:
20.51
5dzkT-4q22A:
2.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GQB_A_GCSA602_1
(CHITINASE)		 4q22 GLYCOSIDE HYDROLASE
FAMILY 18
(Serratia
proteamaculans) 		3 / 3 TRP A 114
GLU A 153
ASP A 223
 None
ACT  A 502 (-3.8A)
GOL  A 504 (-2.7A)
 0.56A 5gqbA-4q22A:
36.8		 5gqbA-4q22A:
25.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GQB_A_GCSA603_1
(CHITINASE)		 4q22 GLYCOSIDE HYDROLASE
FAMILY 18
(Serratia
proteamaculans) 		8 / 8 PHE A  58
GLY A 113
TRP A 114
GLU A 153
TYR A 222
ASP A 223
ARG A 278
TRP A 395
 None
ACT  A 502 ( 4.6A)
None
ACT  A 502 (-3.8A)
GOL  A 504 ( 4.6A)
GOL  A 504 (-2.7A)
GOL  A 504 (-4.1A)
GOL  A 504 (-3.7A)
 0.51A 5gqbA-4q22A:
36.9		 5gqbA-4q22A:
25.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K9D_A_CE9A402_0
(DIHYDROOROTATE
DEHYDROGENASE
(QUINONE),
MITOCHONDRIAL)		 4q22 GLYCOSIDE HYDROLASE
FAMILY 18
(Serratia
proteamaculans) 		5 / 12 ALA A 406
HIS A 407
LEU A 409
ALA A 410
THR A  49
 None
 0.70A 5k9dA-4q22A:
5.0		 5k9dA-4q22A:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B54_A_OAQA302_0
(SULFOTRANSFERASE)		 4q22 GLYCOSIDE HYDROLASE
FAMILY 18
(Serratia
proteamaculans) 		5 / 12 ILE A 217
LEU A 260
LEU A 214
THR A 174
LEU A 177
 None
 1.24A 6b54A-4q22A:
undetectable		 6b54A-4q22A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_A_LLLA301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 4q22 GLYCOSIDE HYDROLASE
FAMILY 18
(Serratia
proteamaculans) 		4 / 6 ASP A 223
TYR A 154
GLU A 153
ASP A 151
 GOL  A 504 (-2.7A)
None
ACT  A 502 (-3.8A)
ACT  A 502 (-3.0A)
 1.33A 6mn5A-4q22A:
undetectable		 6mn5A-4q22A:
10.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_C_LLLC301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 4q22 GLYCOSIDE HYDROLASE
FAMILY 18
(Serratia
proteamaculans) 		4 / 6 ASP A 223
TYR A 154
GLU A 153
ASP A 151
 GOL  A 504 (-2.7A)
None
ACT  A 502 (-3.8A)
ACT  A 502 (-3.0A)
 1.32A 6mn5C-4q22A:
undetectable		 6mn5C-4q22A:
10.82