SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4q25'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UOB_A_PNNA1311_1
(DEACETOXYCEPHALOSPOR
IN C SYNTHETASE)		 4q25 PHOSPHATE-SPECIFIC
TRANSPORT SYSTEM
ACCESSORY PROTEIN
PHOU HOMOLOG
(Pseudomonas
aeruginosa) 		3 / 3 ARG A 203
ARG A 199
ILE A 133
 None
 0.69A 1uobA-4q25A:
undetectable		 1uobA-4q25A:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B0Q_A_NMYA305_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E)		 4q25 PHOSPHATE-SPECIFIC
TRANSPORT SYSTEM
ACCESSORY PROTEIN
PHOU HOMOLOG
(Pseudomonas
aeruginosa) 		5 / 12 GLU A 213
ASP A  99
ASP A 163
ARG A 203
ASP A 167
 None
 1.23A 2b0qA-4q25A:
0.2		 2b0qA-4q25A:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1477_0
(MJ0495-LIKE PROTEIN)		 4q25 PHOSPHATE-SPECIFIC
TRANSPORT SYSTEM
ACCESSORY PROTEIN
PHOU HOMOLOG
(Pseudomonas
aeruginosa) 		4 / 6 GLY A 104
ARG A 199
ILE A 204
LEU A 100
 None
 1.21A 4ac9C-4q25A:
undetectable		 4ac9C-4q25A:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_2
(SEPIAPTERIN
REDUCTASE)		 4q25 PHOSPHATE-SPECIFIC
TRANSPORT SYSTEM
ACCESSORY PROTEIN
PHOU HOMOLOG
(Pseudomonas
aeruginosa) 		3 / 3 LEU A 100
MET A  29
ASP A 152
 None
 0.55A 4j7xB-4q25A:
undetectable		 4j7xB-4q25A:
22.52