SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4q2b'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_G_SAMG199_0
(METHIONINE REPRESSOR)		 4q2b ENDO-1,4-BETA-D-GLUC
ANASE
(Pseudomonas
putida) 		5 / 10 ARG A 246
GLU A  55
ALA A 117
ALA A 114
GLY A 166
 TRS  A 402 ( 4.2A)
TRS  A 402 (-3.3A)
TRS  A 402 ( 4.8A)
TRS  A 402 (-3.4A)
None
 1.31A 1mjqG-4q2bA:
undetectable
1mjqH-4q2bA:
undetectable		 1mjqG-4q2bA:
15.04
1mjqH-4q2bA:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQF_A_SAMA430_1
(SUN PROTEIN)		 4q2b ENDO-1,4-BETA-D-GLUC
ANASE
(Pseudomonas
putida) 		3 / 3 PRO A 219
ASP A 241
ASP A 286
 None
 0.77A 1sqfA-4q2bA:
undetectable		 1sqfA-4q2bA:
25.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OUZ_A_C3DA999_0
(ESTROGEN RECEPTOR)		 4q2b ENDO-1,4-BETA-D-GLUC
ANASE
(Pseudomonas
putida) 		5 / 12 LEU A 163
LEU A 222
LEU A 208
GLY A 160
LEU A 156
 None
 1.04A 2ouzA-4q2bA:
undetectable		 2ouzA-4q2bA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0G_D_LEUD1883_0
(AMINOACYL-TRNA
SYNTHETASE)		 4q2b ENDO-1,4-BETA-D-GLUC
ANASE
(Pseudomonas
putida) 		4 / 5 TYR A 182
ASP A 116
TYR A  59
TYR A 335
 None
TRS  A 402 (-2.8A)
None
None
 1.48A 2v0gD-4q2bA:
2.8		 2v0gD-4q2bA:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6R_A_CTCA1385_0
(TETX2 PROTEIN)		 4q2b ENDO-1,4-BETA-D-GLUC
ANASE
(Pseudomonas
putida) 		5 / 10 ASP A 220
PHE A 217
ASN A 238
GLY A 290
PRO A 282
 None
 1.47A 2y6rA-4q2bA:
undetectable		 2y6rA-4q2bA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_A_PZIA802_0
(GLUTAMATE RECEPTOR 2)		 4q2b ENDO-1,4-BETA-D-GLUC
ANASE
(Pseudomonas
putida) 		3 / 3 ASP A 116
ASN A 179
SER A  54
 TRS  A 402 (-2.8A)
None
TRS  A 402 ( 4.9A)
 0.96A 3lslA-4q2bA:
undetectable
3lslD-4q2bA:
undetectable		 3lslA-4q2bA:
22.07
3lslD-4q2bA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_D_PZID802_0
(GLUTAMATE RECEPTOR 2)		 4q2b ENDO-1,4-BETA-D-GLUC
ANASE
(Pseudomonas
putida) 		3 / 3 SER A  54
ASP A 116
ASN A 179
 TRS  A 402 ( 4.9A)
TRS  A 402 (-2.8A)
None
 0.94A 3lslA-4q2bA:
undetectable
3lslD-4q2bA:
undetectable		 3lslA-4q2bA:
22.07
3lslD-4q2bA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_1
(SEPIAPTERIN
REDUCTASE)		 4q2b ENDO-1,4-BETA-D-GLUC
ANASE
(Pseudomonas
putida) 		5 / 12 PHE A  31
TRP A  28
ALA A  64
GLY A  40
LEU A  76
 None
 1.25A 4j7xB-4q2bA:
undetectable		 4j7xB-4q2bA:
26.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8C_A_ADNA401_2
(SUGAR KINASE)		 4q2b ENDO-1,4-BETA-D-GLUC
ANASE
(Pseudomonas
putida) 		3 / 3 SER A 115
TYR A 182
PRO A  94
 None
 0.88A 4k8cA-4q2bA:
undetectable		 4k8cA-4q2bA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAH_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 4q2b ENDO-1,4-BETA-D-GLUC
ANASE
(Pseudomonas
putida) 		3 / 3 SER A 115
TYR A 182
PRO A  94
 None
 0.91A 4kahA-4q2bA:
undetectable		 4kahA-4q2bA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAH_B_ADNB502_2
(PROBABLE SUGAR
KINASE PROTEIN)		 4q2b ENDO-1,4-BETA-D-GLUC
ANASE
(Pseudomonas
putida) 		3 / 3 SER A 115
TYR A 182
PRO A  94
 None
 0.90A 4kahB-4q2bA:
undetectable		 4kahB-4q2bA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAN_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 4q2b ENDO-1,4-BETA-D-GLUC
ANASE
(Pseudomonas
putida) 		3 / 3 SER A 115
TYR A 182
PRO A  94
 None
 0.89A 4kanA-4q2bA:
undetectable		 4kanA-4q2bA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAN_B_ADNB401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 4q2b ENDO-1,4-BETA-D-GLUC
ANASE
(Pseudomonas
putida) 		3 / 3 SER A 115
TYR A 182
PRO A  94
 None
 0.87A 4kanB-4q2bA:
undetectable		 4kanB-4q2bA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KBE_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 4q2b ENDO-1,4-BETA-D-GLUC
ANASE
(Pseudomonas
putida) 		3 / 3 SER A 115
TYR A 182
PRO A  94
 None
 0.88A 4kbeA-4q2bA:
undetectable		 4kbeA-4q2bA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KBE_B_ADNB401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 4q2b ENDO-1,4-BETA-D-GLUC
ANASE
(Pseudomonas
putida) 		3 / 3 SER A 115
TYR A 182
PRO A  94
 None
 0.90A 4kbeB-4q2bA:
undetectable		 4kbeB-4q2bA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYK_B_IMNB300_1
(LACTOYLGLUTATHIONE
LYASE)		 4q2b ENDO-1,4-BETA-D-GLUC
ANASE
(Pseudomonas
putida) 		5 / 12 ALA A  27
PHE A  63
PHE A 354
GLY A 299
LEU A 249
 None
 1.19A 4kykA-4q2bA:
undetectable
4kykB-4q2bA:
undetectable		 4kykA-4q2bA:
19.55
4kykB-4q2bA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 4q2b ENDO-1,4-BETA-D-GLUC
ANASE
(Pseudomonas
putida) 		3 / 3 SER A 115
TYR A 182
PRO A  94
 None
 0.88A 4lbgA-4q2bA:
undetectable		 4lbgA-4q2bA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_B_ADNB401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 4q2b ENDO-1,4-BETA-D-GLUC
ANASE
(Pseudomonas
putida) 		3 / 3 SER A 115
TYR A 182
PRO A  94
 None
 0.90A 4lbgB-4q2bA:
undetectable		 4lbgB-4q2bA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_B_FOLB301_1
(FOLATE RECEPTOR
ALPHA)		 4q2b ENDO-1,4-BETA-D-GLUC
ANASE
(Pseudomonas
putida) 		3 / 3 ASP A 167
TRP A 198
SER A 115
 None
 0.78A 4lrhB-4q2bA:
undetectable		 4lrhB-4q2bA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_F_FOLF301_1
(FOLATE RECEPTOR
ALPHA)		 4q2b ENDO-1,4-BETA-D-GLUC
ANASE
(Pseudomonas
putida) 		3 / 3 ASP A 167
TRP A 198
SER A 115
 None
 0.83A 4lrhF-4q2bA:
undetectable		 4lrhF-4q2bA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N49_A_SAMA601_1
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 4q2b ENDO-1,4-BETA-D-GLUC
ANASE
(Pseudomonas
putida) 		4 / 4 ASN A 113
GLY A 166
ASP A 189
ASP A 116
 None
None
None
TRS  A 402 (-2.8A)
 1.23A 4n49A-4q2bA:
undetectable		 4n49A-4q2bA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NSB_A_AINA402_1
(CHITINASE-3-LIKE
PROTEIN 1)		 4q2b ENDO-1,4-BETA-D-GLUC
ANASE
(Pseudomonas
putida) 		4 / 7 THR A 152
TRP A 198
TRP A 146
LEU A  93
 None
 1.04A 4nsbA-4q2bA:
undetectable		 4nsbA-4q2bA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_E_HCYE900_1
(GLUCOCORTICOID
RECEPTOR)		 4q2b ENDO-1,4-BETA-D-GLUC
ANASE
(Pseudomonas
putida) 		5 / 12 LEU A 201
GLY A 199
ARG A 207
ILE A 148
PHE A 191
 None
 1.49A 4p6xE-4q2bA:
undetectable		 4p6xE-4q2bA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XJ7_A_ADNA303_1
(5'/3'-NUCLEOTIDASE
SURE)		 4q2b ENDO-1,4-BETA-D-GLUC
ANASE
(Pseudomonas
putida) 		5 / 10 GLY A 141
ALA A  85
ILE A 121
LEU A 144
LEU A 125
 None
 1.12A 4xj7A-4q2bA:
undetectable
4xj7B-4q2bA:
undetectable		 4xj7A-4q2bA:
23.98
4xj7B-4q2bA:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XJ7_D_ADND303_1
(5'/3'-NUCLEOTIDASE
SURE)		 4q2b ENDO-1,4-BETA-D-GLUC
ANASE
(Pseudomonas
putida) 		5 / 10 LEU A 144
LEU A 125
GLY A 141
ALA A  85
ILE A 121
 None
 1.13A 4xj7C-4q2bA:
undetectable
4xj7D-4q2bA:
undetectable		 4xj7C-4q2bA:
23.98
4xj7D-4q2bA:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BS8_G_MFXG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 4q2b ENDO-1,4-BETA-D-GLUC
ANASE
(Pseudomonas
putida) 		5 / 7 ALA A 203
ASP A 193
ARG A 190
GLY A 358
GLU A 127
 None
None
FMT  A 405 (-3.1A)
None
None
 1.41A 5bs8A-4q2bA:
undetectable
5bs8C-4q2bA:
undetectable
5bs8D-4q2bA:
undetectable		 5bs8A-4q2bA:
21.84
5bs8C-4q2bA:
21.84
5bs8D-4q2bA:
24.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGC_A_ACTA811_0
(GEPHYRIN)		 4q2b ENDO-1,4-BETA-D-GLUC
ANASE
(Pseudomonas
putida) 		3 / 3 LEU A 156
LEU A 164
ARG A 154
 None
 0.59A 6fgcA-4q2bA:
undetectable		 6fgcA-4q2bA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA810_0
(GEPHYRIN)		 4q2b ENDO-1,4-BETA-D-GLUC
ANASE
(Pseudomonas
putida) 		3 / 3 LEU A 156
LEU A 164
ARG A 154
 None
 0.63A 6fgdA-4q2bA:
undetectable		 6fgdA-4q2bA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GTQ_A_ACTA204_0
(N-ACETYLTRANSFERASE)		 4q2b ENDO-1,4-BETA-D-GLUC
ANASE
(Pseudomonas
putida) 		4 / 5 LEU A 156
THR A 176
THR A 225
GLY A 175
 None
 1.24A 6gtqA-4q2bA:
undetectable		 6gtqA-4q2bA:
19.72