SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4q2c'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

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	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1AV2_C_DVAC6_0 (GRAMICIDIN A)	4q2c	CRISPR-ASSOCIATED HELICASE CAS3 (Thermobaculum terrenum)	3 / 3	ALA A 230 VAL A 235 TRP A 238	None	0.85A	1av2C-4q2cA: undetectable 1av2D-4q2cA: undetectable	1av2C-4q2cA: 1.96 1av2D-4q2cA: 1.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1CMA_B_SAMB105_0 (PROTEIN (MET REPRESSOR))	4q2c	CRISPR-ASSOCIATED HELICASE CAS3 (Thermobaculum terrenum)	5 / 11	LEU A 229 HIS A 98 ALA A 95 PHE A 94 GLY A 97	None NI A1001 (-3.4A) None None None	1.24A	1cmaA-4q2cA: undetectable 1cmaB-4q2cA: undetectable	1cmaA-4q2cA: 7.87 1cmaB-4q2cA: 7.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1DB1_A_VDXA428_2 (VITAMIN D NUCLEAR RECEPTOR)	4q2c	CRISPR-ASSOCIATED HELICASE CAS3 (Thermobaculum terrenum)	4 / 6	LEU A 493 ILE A 324 ARG A 516 VAL A 476	None	1.07A	1db1A-4q2cA: undetectable	1db1A-4q2cA: 15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1DLS_A_MTXA188_2 (DIHYDROFOLATE REDUCTASE)	4q2c	CRISPR-ASSOCIATED HELICASE CAS3 (Thermobaculum terrenum)	4 / 4	TYR A 354 ARG A 465 VAL A 504 THR A 471	None	1.16A	1dlsA-4q2cA: 0.0	1dlsA-4q2cA: 11.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1E9Y_B_HAEB800_1 (UREASE SUBUNIT BETA)	4q2c	CRISPR-ASSOCIATED HELICASE CAS3 (Thermobaculum terrenum)	4 / 5	HIS A 98 HIS A 138 HIS A 171 ASP A 237	NI A1001 (-3.4A) NI A1002 (-3.3A) NI A1002 (-3.3A) NI A1001 ( 2.7A)	0.95A	1e9yB-4q2cA: undetectable	1e9yB-4q2cA: 19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1EI6_A_PPFA410_1 (PHOSPHONOACETATE HYDROLASE)	4q2c	CRISPR-ASSOCIATED HELICASE CAS3 (Thermobaculum terrenum)	4 / 5	ASP A 99 HIS A 138 HIS A 171 HIS A 172	NI A1001 (-2.7A) NI A1002 (-3.3A) NI A1002 (-3.3A) NI A1002 ( 3.3A)	1.19A	1ei6A-4q2cA: undetectable	1ei6A-4q2cA: 18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1EI6_D_PPFD412_1 (PHOSPHONOACETATE HYDROLASE)	4q2c	CRISPR-ASSOCIATED HELICASE CAS3 (Thermobaculum terrenum)	4 / 8	ASP A 99 HIS A 98 HIS A 171 HIS A 52	NI A1001 (-2.7A) NI A1001 (-3.4A) NI A1002 (-3.3A) NI A1001 (-3.2A)	0.77A	1ei6D-4q2cA: undetectable	1ei6D-4q2cA: 18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1H9Z_A_RWFA3001_1 (SERUM ALBUMIN)	4q2c	CRISPR-ASSOCIATED HELICASE CAS3 (Thermobaculum terrenum)	5 / 11	ALA A 586 LEU A 587 LEU A 583 LEU A 610 ALA A 594	None	1.12A	1h9zA-4q2cA: undetectable	1h9zA-4q2cA: 21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1HWI_A_115A2_2 (HMG-COA REDUCTASE)	4q2c	CRISPR-ASSOCIATED HELICASE CAS3 (Thermobaculum terrenum)	4 / 8	CYH A 51 LEU A 206 ALA A 209 LEU A 210	None	0.97A	1hwiB-4q2cA: undetectable	1hwiB-4q2cA: 18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1HWI_D_115D3_1 (HMG-COA REDUCTASE)	4q2c	CRISPR-ASSOCIATED HELICASE CAS3 (Thermobaculum terrenum)	4 / 8	CYH A 51 LEU A 206 ALA A 209 LEU A 210	None	0.96A	1hwiC-4q2cA: undetectable	1hwiC-4q2cA: 18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1KB9_A_PCFA514_0 (CYTOCHROME B CYTOCHROME C1, HEME PROTEIN UBIQUINOL-CYTOCHROME C REDUCTASE COMPLEX CORE PROTEIN I UBIQUINOL-CYTOCHROME C REDUCTASE IRON-SULFUR SUBUNIT)	4q2c	CRISPR-ASSOCIATED HELICASE CAS3 (Thermobaculum terrenum)	4 / 8	ILE A 815 PHE A 227 VAL A 462 SER A 234	None	1.04A	1kb9A-4q2cA: undetectable 1kb9C-4q2cA: undetectable 1kb9D-4q2cA: undetectable 1kb9E-4q2cA: undetectable	1kb9A-4q2cA: 20.00 1kb9C-4q2cA: 17.18 1kb9D-4q2cA: 13.95 1kb9E-4q2cA: 11.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1MJ2_A_SAMA2201_1 (PROTEIN (METHIONINE REPRESSOR))	4q2c	CRISPR-ASSOCIATED HELICASE CAS3 (Thermobaculum terrenum)	4 / 4	HIS A 98 ALA A 95 PHE A 94 GLY A 97	NI A1001 (-3.4A) None None None	0.68A	1mj2B-4q2cA: undetectable	1mj2B-4q2cA: 8.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1MJ2_C_SAMC1200_1 (PROTEIN (METHIONINE REPRESSOR))	4q2c	CRISPR-ASSOCIATED HELICASE CAS3 (Thermobaculum terrenum)	4 / 4	HIS A 98 ALA A 95 PHE A 94 GLY A 97	NI A1001 (-3.4A) None None None	0.74A	1mj2D-4q2cA: undetectable	1mj2D-4q2cA: 8.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1MJ2_C_SAMC2199_0 (PROTEIN (METHIONINE REPRESSOR))	4q2c	CRISPR-ASSOCIATED HELICASE CAS3 (Thermobaculum terrenum)	5 / 12	ALA A 92 PHE A 94 GLY A 96 ARG A 217 LEU A 210	None	1.07A	1mj2C-4q2cA: undetectable 1mj2D-4q2cA: undetectable	1mj2C-4q2cA: 8.82 1mj2D-4q2cA: 8.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1MJ2_C_SAMC2199_0 (PROTEIN (METHIONINE REPRESSOR))	4q2c	CRISPR-ASSOCIATED HELICASE CAS3 (Thermobaculum terrenum)	5 / 12	HIS A 98 ALA A 95 PHE A 94 GLY A 97 LEU A 229	NI A1001 (-3.4A) None None None None	1.27A	1mj2C-4q2cA: undetectable 1mj2D-4q2cA: undetectable	1mj2C-4q2cA: 8.82 1mj2D-4q2cA: 8.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1MJO_A_SAMA199_1 (METHIONINE REPRESSOR)	4q2c	CRISPR-ASSOCIATED HELICASE CAS3 (Thermobaculum terrenum)	4 / 4	HIS A 98 ALA A 95 PHE A 94 GLY A 97	NI A1001 (-3.4A) None None None	0.72A	1mjoB-4q2cA: undetectable	1mjoB-4q2cA: 8.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1MJO_B_SAMB200_0 (METHIONINE REPRESSOR)	4q2c	CRISPR-ASSOCIATED HELICASE CAS3 (Thermobaculum terrenum)	4 / 4	HIS A 98 ALA A 95 PHE A 94 GLY A 97	NI A1001 (-3.4A) None None None	0.77A	1mjoA-4q2cA: undetectable	1mjoA-4q2cA: 8.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1MJO_C_SAMC200_0 (METHIONINE REPRESSOR)	4q2c	CRISPR-ASSOCIATED HELICASE CAS3 (Thermobaculum terrenum)	5 / 12	HIS A 98 ALA A 95 PHE A 94 GLY A 97 LEU A 229	NI A1001 (-3.4A) None None None None	1.22A	1mjoC-4q2cA: undetectable 1mjoD-4q2cA: undetectable	1mjoC-4q2cA: 8.82 1mjoD-4q2cA: 8.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1MJO_D_SAMD200_1 (METHIONINE REPRESSOR)	4q2c	CRISPR-ASSOCIATED HELICASE CAS3 (Thermobaculum terrenum)	4 / 4	HIS A 98 ALA A 95 PHE A 94 GLY A 97	NI A1001 (-3.4A) None None None	0.70A	1mjoD-4q2cA: undetectable	1mjoD-4q2cA: 8.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1MJQ_A_SAMA200_0 (METHIONINE REPRESSOR)	4q2c	CRISPR-ASSOCIATED HELICASE CAS3 (Thermobaculum terrenum)	5 / 11	LEU A 229 HIS A 98 ALA A 95 PHE A 94 GLY A 97	None NI A1001 (-3.4A) None None None	1.18A	1mjqA-4q2cA: undetectable 1mjqB-4q2cA: undetectable	1mjqA-4q2cA: 8.82 1mjqB-4q2cA: 8.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1N2X_A_SAMA401_0 (S-ADENOSYL-METHYLTRA NSFERASE MRAW)	4q2c	CRISPR-ASSOCIATED HELICASE CAS3 (Thermobaculum terrenum)	5 / 12	HIS A 172 THR A 140 GLY A 169 GLY A 173 VAL A 168	NI A1002 ( 3.3A) None None None None	1.29A	1n2xA-4q2cA: 3.1	1n2xA-4q2cA: 14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1NG8_A_DVAA8_0 (GRAMICIDIN A)	4q2c	CRISPR-ASSOCIATED HELICASE CAS3 (Thermobaculum terrenum)	4 / 4	GLY A 390 VAL A 388 TRP A 281 GLY A 280	None	1.15A	1ng8A-4q2cA: undetectable	1ng8A-4q2cA: 1.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1NG8_B_DVAB8_0 (GRAMICIDIN A)	4q2c	CRISPR-ASSOCIATED HELICASE CAS3 (Thermobaculum terrenum)	4 / 4	GLY A 390 VAL A 388 TRP A 281 GLY A 280	None	1.15A	1ng8B-4q2cA: undetectable	1ng8B-4q2cA: 1.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1QW6_A_H4BA901_1 (NITRIC-OXIDE SYNTHASE, BRAIN)	4q2c	CRISPR-ASSOCIATED HELICASE CAS3 (Thermobaculum terrenum)	3 / 3	ARG A 112 VAL A 120 TRP A 35	None	1.25A	1qw6A-4q2cA: undetectable	1qw6A-4q2cA: 18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1S9P_C_DESC500_1 (ESTROGEN-RELATED RECEPTOR GAMMA)	4q2c	CRISPR-ASSOCIATED HELICASE CAS3 (Thermobaculum terrenum)	5 / 12	LEU A 203 CYH A 204 LEU A 206 ALA A 207 LEU A 212	None	1.06A	1s9pC-4q2cA: undetectable	1s9pC-4q2cA: 12.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1SQF_A_SAMA430_1 (SUN PROTEIN)	4q2c	CRISPR-ASSOCIATED HELICASE CAS3 (Thermobaculum terrenum)	3 / 3	PRO A 358 ASP A 450 ASP A 483	None	0.76A	1sqfA-4q2cA: undetectable	1sqfA-4q2cA: 19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1SV5_A_65BA600_0 (REVERSE TRANSCRIPTASE)	4q2c	CRISPR-ASSOCIATED HELICASE CAS3 (Thermobaculum terrenum)	5 / 10	LEU A 91 VAL A 220 VAL A 82 TRP A 72 LEU A 229	None	1.35A	1sv5A-4q2cA: undetectable	1sv5A-4q2cA: 20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1T7J_A_478A200_2 (POL POLYPROTEIN)	4q2c	CRISPR-ASSOCIATED HELICASE CAS3 (Thermobaculum terrenum)	4 / 7	ASP A 196 GLY A 101 ILE A 141 THR A 148	None	0.85A	1t7jB-4q2cA: undetectable	1t7jB-4q2cA: 8.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2AOH_C_FRDC305_1 (POL POLYPROTEIN PEPTIDE INHIBITOR)	4q2c	CRISPR-ASSOCIATED HELICASE CAS3 (Thermobaculum terrenum)	4 / 5	LEU A 660 ASP A 626 GLY A 938 ALA A 662	None	0.93A	2aohA-4q2cA: undetectable	2aohA-4q2cA: 7.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2QBN_A_CAMA442_0 (CYTOCHROME P450-CAM)	4q2c	CRISPR-ASSOCIATED HELICASE CAS3 (Thermobaculum terrenum)	4 / 7	PHE A 93 VAL A 201 VAL A 149 VAL A 153	None	0.97A	2qbnA-4q2cA: undetectable	2qbnA-4q2cA: 18.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2QHF_A_ACTA509_0 (CHORISMATE SYNTHASE)	4q2c	CRISPR-ASSOCIATED HELICASE CAS3 (Thermobaculum terrenum)	3 / 3	ARG A 890 GLN A 604 PRO A 601	None	0.70A	2qhfA-4q2cA: undetectable	2qhfA-4q2cA: 18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2QR2_B_VK3B235_1 (PROTEIN (QUINONE REDUCTASE TYPE 2))	4q2c	CRISPR-ASSOCIATED HELICASE CAS3 (Thermobaculum terrenum)	4 / 6	PHE A 154 TRP A 90 GLY A 96 GLY A 97	None	0.97A	2qr2A-4q2cA: undetectable 2qr2B-4q2cA: undetectable	2qr2A-4q2cA: 11.97 2qr2B-4q2cA: 11.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2QR2_B_VK3B236_1 (PROTEIN (QUINONE REDUCTASE TYPE 2))	4q2c	CRISPR-ASSOCIATED HELICASE CAS3 (Thermobaculum terrenum)	4 / 5	TRP A 90 GLY A 96 GLY A 97 PHE A 154	None	1.02A	2qr2A-4q2cA: undetectable 2qr2B-4q2cA: undetectable	2qr2A-4q2cA: 11.97 2qr2B-4q2cA: 11.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2WA2_B_SAMB1267_1 (NON-STRUCTURAL PROTEIN 5)	4q2c	CRISPR-ASSOCIATED HELICASE CAS3 (Thermobaculum terrenum)	3 / 3	SER A 177 HIS A 461 ASP A 237	None None NI A1001 ( 2.7A)	0.74A	2wa2B-4q2cA: undetectable	2wa2B-4q2cA: 14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2XAD_E_GCSE710_1 (N-ACYL GLM PEUDO-TEICOPLANIN DEACETYLASE TEICOPLANIN)	4q2c	CRISPR-ASSOCIATED HELICASE CAS3 (Thermobaculum terrenum)	4 / 8	HIS A 171 ASP A 237 HIS A 138 ASP A 99	NI A1002 (-3.3A) NI A1001 ( 2.7A) NI A1002 (-3.3A) NI A1001 (-2.7A)	1.06A	2xadA-4q2cA: undetectable	2xadA-4q2cA: 14.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2XAD_F_GCSF710_1 (N-ACYL GLM PEUDO-TEICOPLANIN DEACETYLASE TEICOPLANIN)	4q2c	CRISPR-ASSOCIATED HELICASE CAS3 (Thermobaculum terrenum)	4 / 8	HIS A 171 ASP A 237 HIS A 138 ASP A 99	NI A1002 (-3.3A) NI A1001 ( 2.7A) NI A1002 (-3.3A) NI A1001 (-2.7A)	1.08A	2xadB-4q2cA: undetectable	2xadB-4q2cA: 14.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2XAD_G_GCSG710_1 (N-ACYL GLM PEUDO-TEICOPLANIN DEACETYLASE TEICOPLANIN)	4q2c	CRISPR-ASSOCIATED HELICASE CAS3 (Thermobaculum terrenum)	4 / 8	HIS A 171 ASP A 237 HIS A 138 ASP A 99	NI A1002 (-3.3A) NI A1001 ( 2.7A) NI A1002 (-3.3A) NI A1001 (-2.7A)	1.06A	2xadC-4q2cA: undetectable	2xadC-4q2cA: 14.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2XAD_H_GCSH710_1 (N-ACYL GLM PEUDO-TEICOPLANIN DEACETYLASE TEICOPLANIN)	4q2c	CRISPR-ASSOCIATED HELICASE CAS3 (Thermobaculum terrenum)	4 / 8	HIS A 171 ASP A 237 HIS A 138 ASP A 99	NI A1002 (-3.3A) NI A1001 ( 2.7A) NI A1002 (-3.3A) NI A1001 (-2.7A)	1.08A	2xadD-4q2cA: undetectable	2xadD-4q2cA: 14.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2XDC_F_DVAF8_0 (GRAMICIDIN A)	4q2c	CRISPR-ASSOCIATED HELICASE CAS3 (Thermobaculum terrenum)	3 / 3	TRP A 238 VAL A 427 TRP A 432	None	1.04A	2xdcE-4q2cA: undetectable 2xdcF-4q2cA: undetectable	2xdcE-4q2cA: 1.96 2xdcF-4q2cA: 1.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3AF0_A_PAUA314_0 (PANTOTHENATE KINASE)	4q2c	CRISPR-ASSOCIATED HELICASE CAS3 (Thermobaculum terrenum)	4 / 8	VAL A 414 ASP A 99 GLY A 240 HIS A 171	NI A1003 ( 4.6A) NI A1001 (-2.7A) None NI A1002 (-3.3A)	0.92A	3af0A-4q2cA: undetectable	3af0A-4q2cA: 17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3BJW_B_SVRB512_2 (PHOSPHOLIPASE A2)	4q2c	CRISPR-ASSOCIATED HELICASE CAS3 (Thermobaculum terrenum)	4 / 7	VAL A 845 ILE A 939 GLY A 938 LEU A 627	None	0.90A	3bjwB-4q2cA: 2.4	3bjwB-4q2cA: 7.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3BJW_F_SVRF509_3 (PHOSPHOLIPASE A2)	4q2c	CRISPR-ASSOCIATED HELICASE CAS3 (Thermobaculum terrenum)	4 / 7	VAL A 845 ILE A 939 GLY A 938 LEU A 627	None	0.92A	3bjwF-4q2cA: 2.3	3bjwF-4q2cA: 7.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3BJW_H_SVRH511_3 (PHOSPHOLIPASE A2)	4q2c	CRISPR-ASSOCIATED HELICASE CAS3 (Thermobaculum terrenum)	4 / 7	VAL A 845 ILE A 939 GLY A 938 LEU A 627	None	0.84A	3bjwH-4q2cA: 2.2	3bjwH-4q2cA: 7.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3DH0_A_SAMA220_1 (SAM DEPENDENT METHYLTRANSFERASE)	4q2c	CRISPR-ASSOCIATED HELICASE CAS3 (Thermobaculum terrenum)	4 / 8	ARG A 637 ASP A 450 GLN A 835 GLU A 842	None	1.15A	3dh0A-4q2cA: 3.0	3dh0A-4q2cA: 12.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3EL9_A_DR7A100_1 (PROTEASE)	4q2c	CRISPR-ASSOCIATED HELICASE CAS3 (Thermobaculum terrenum)	4 / 8	ASP A 196 GLY A 101 ILE A 141 THR A 148	None	0.80A	3el9A-4q2cA: undetectable	3el9A-4q2cA: 8.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3FL9_B_TOPB200_1 (DIHYDROFOLATE REDUCTASE (DHFR))	4q2c	CRISPR-ASSOCIATED HELICASE CAS3 (Thermobaculum terrenum)	5 / 12	ALA A 57 LEU A 206 ILE A 100 LEU A 146 THR A 60	None	1.11A	3fl9B-4q2cA: undetectable	3fl9B-4q2cA: 9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3IX9_A_MTXA200_1 (DIHYDROFOLATE REDUCTASE)	4q2c	CRISPR-ASSOCIATED HELICASE CAS3 (Thermobaculum terrenum)	6 / 12	LEU A 747 LEU A 688 GLN A 689 LEU A 755 ARG A 564 THR A 679	None	1.42A	3ix9A-4q2cA: undetectable	3ix9A-4q2cA: 10.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3IX9_B_MTXB200_1 (DIHYDROFOLATE REDUCTASE)	4q2c	CRISPR-ASSOCIATED HELICASE CAS3 (Thermobaculum terrenum)	5 / 12	LEU A 747 LEU A 688 GLN A 689 LEU A 755 THR A 679	None	1.17A	3ix9B-4q2cA: undetectable	3ix9B-4q2cA: 10.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3K8M_A_ACRA720_1 (ALPHA-AMYLASE, SUSG)	4q2c	CRISPR-ASSOCIATED HELICASE CAS3 (Thermobaculum terrenum)	4 / 7	TYR A 378 TRP A 284 LEU A 374 ASN A 386	None	1.34A	3k8mA-4q2cA: undetectable	3k8mA-4q2cA: 20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3K8M_B_ACRB820_1 (ALPHA-AMYLASE, SUSG)	4q2c	CRISPR-ASSOCIATED HELICASE CAS3 (Thermobaculum terrenum)	4 / 7	TYR A 378 TRP A 284 LEU A 374 ASN A 386	None	1.37A	3k8mB-4q2cA: undetectable	3k8mB-4q2cA: 20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3LP0_A_NVPA701_1 (REVERSE TRANSCRIPTASE/RIBONU CLEASE H)	4q2c	CRISPR-ASSOCIATED HELICASE CAS3 (Thermobaculum terrenum)	5 / 9	LEU A 91 VAL A 220 VAL A 82 TRP A 72 LEU A 229	None	1.48A	3lp0A-4q2cA: 1.1	3lp0A-4q2cA: 19.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3LP1_A_NVPA701_1 (REVERSE TRANSCRIPTASE/RIBONU CLEASE H)	4q2c	CRISPR-ASSOCIATED HELICASE CAS3 (Thermobaculum terrenum)	5 / 10	LEU A 91 VAL A 220 VAL A 82 TRP A 72 LEU A 229	None	1.45A	3lp1A-4q2cA: undetectable	3lp1A-4q2cA: 19.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3LSL_A_PZIA801_0 (GLUTAMATE RECEPTOR 2)	4q2c	CRISPR-ASSOCIATED HELICASE CAS3 (Thermobaculum terrenum)	4 / 8	ILE A 759 PRO A 328 SER A 562 PRO A 541	None	0.81A	3lslA-4q2cA: undetectable 3lslD-4q2cA: undetectable	3lslA-4q2cA: 12.76 3lslD-4q2cA: 12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3LSL_D_PZID801_0 (GLUTAMATE RECEPTOR 2)	4q2c	CRISPR-ASSOCIATED HELICASE CAS3 (Thermobaculum terrenum)	4 / 8	PRO A 541 ILE A 759 PRO A 328 SER A 562	None	0.86A	3lslA-4q2cA: undetectable 3lslD-4q2cA: undetectable	3lslA-4q2cA: 12.76 3lslD-4q2cA: 12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3OZW_A_KKKA413_1 (FLAVOHEMOGLOBIN)	4q2c	CRISPR-ASSOCIATED HELICASE CAS3 (Thermobaculum terrenum)	4 / 8	ILE A 659 ALA A 584 LEU A 583 LEU A 606	None	0.62A	3ozwA-4q2cA: 2.3	3ozwA-4q2cA: 18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3QIP_A_NVPA561_1 (REVERSE HIV-1 REVERSE TRANSCRIPTASE P66)	4q2c	CRISPR-ASSOCIATED HELICASE CAS3 (Thermobaculum terrenum)	5 / 10	LEU A 91 VAL A 220 VAL A 82 TRP A 72 LEU A 229	None	1.43A	3qipA-4q2cA: undetectable	3qipA-4q2cA: 19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3QOW_A_SAMA417_1 (HISTONE-LYSINE N-METHYLTRANSFERASE)	4q2c	CRISPR-ASSOCIATED HELICASE CAS3 (Thermobaculum terrenum)	3 / 3	THR A 739 ASP A 685 GLU A 667	None	0.71A	3qowA-4q2cA: undetectable	3qowA-4q2cA: 18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3REM_A_SALA301_1 (SALICYLATE BIOSYNTHESIS PROTEIN PCHB)	4q2c	CRISPR-ASSOCIATED HELICASE CAS3 (Thermobaculum terrenum)	4 / 8	VAL A 600 ARG A 637 VAL A 884 ILE A 939	None	1.01A	3remA-4q2cA: undetectable	3remA-4q2cA: 7.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3REM_B_SALB301_1 (SALICYLATE BIOSYNTHESIS PROTEIN PCHB)	4q2c	CRISPR-ASSOCIATED HELICASE CAS3 (Thermobaculum terrenum)	4 / 8	VAL A 600 ARG A 637 VAL A 884 ILE A 939	None	1.04A	3remB-4q2cA: undetectable	3remB-4q2cA: 7.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3V81_C_NVPC901_1 (HIV-1 REVERSE TRANSCRIPTASE P66 SUBUNIT)	4q2c	CRISPR-ASSOCIATED HELICASE CAS3 (Thermobaculum terrenum)	5 / 8	LEU A 91 VAL A 220 VAL A 82 TRP A 72 LEU A 229	None	1.34A	3v81C-4q2cA: undetectable	3v81C-4q2cA: 19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4C1D_B_X8ZB350_1 (BETA-LACTAMASE CLASS B VIM-2)	4q2c	CRISPR-ASSOCIATED HELICASE CAS3 (Thermobaculum terrenum)	5 / 10	HIS A 172 HIS A 171 ASP A 237 HIS A 138 HIS A 52	NI A1002 ( 3.3A) NI A1002 (-3.3A) NI A1001 ( 2.7A) NI A1002 (-3.3A) NI A1001 (-3.2A)	1.16A	4c1dB-4q2cA: undetectable	4c1dB-4q2cA: 14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4C1F_A_X8ZA300_1 (BETA-LACTAMASE IMP-1)	4q2c	CRISPR-ASSOCIATED HELICASE CAS3 (Thermobaculum terrenum)	5 / 11	HIS A 172 HIS A 171 ASP A 237 HIS A 138 HIS A 52	NI A1002 ( 3.3A) NI A1002 (-3.3A) NI A1001 ( 2.7A) NI A1002 (-3.3A) NI A1001 (-3.2A)	1.25A	4c1fA-4q2cA: undetectable 4c1fB-4q2cA: undetectable	4c1fA-4q2cA: 11.67 4c1fB-4q2cA: 11.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4C1H_A_X8ZA305_1 (BETA-LACTAMASE 2)	4q2c	CRISPR-ASSOCIATED HELICASE CAS3 (Thermobaculum terrenum)	5 / 9	HIS A 172 HIS A 171 ASP A 237 HIS A 138 HIS A 52	NI A1002 ( 3.3A) NI A1002 (-3.3A) NI A1001 ( 2.7A) NI A1002 (-3.3A) NI A1001 (-3.2A)	1.14A	4c1hA-4q2cA: undetectable	4c1hA-4q2cA: 12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4CPZ_H_ZMRH1470_2 (NEURAMINIDASE)	4q2c	CRISPR-ASSOCIATED HELICASE CAS3 (Thermobaculum terrenum)	3 / 3	ARG A 771 ARG A 781 TRP A 784	None	1.47A	4cpzH-4q2cA: undetectable	4cpzH-4q2cA: 18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4J24_A_ESTA600_1 (ESTROGEN RECEPTOR BETA)	4q2c	CRISPR-ASSOCIATED HELICASE CAS3 (Thermobaculum terrenum)	5 / 12	LEU A 466 LEU A 229 ARG A 75 ILE A 807 ILE A 818	None	1.13A	4j24A-4q2cA: undetectable	4j24A-4q2cA: 14.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4J24_B_ESTB600_1 (ESTROGEN RECEPTOR BETA)	4q2c	CRISPR-ASSOCIATED HELICASE CAS3 (Thermobaculum terrenum)	5 / 12	LEU A 466 LEU A 229 ARG A 75 ILE A 807 ILE A 818	None	1.12A	4j24B-4q2cA: undetectable	4j24B-4q2cA: 14.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4M11_C_MXMC606_2 (PROSTAGLANDIN G/H SYNTHASE 2)	4q2c	CRISPR-ASSOCIATED HELICASE CAS3 (Thermobaculum terrenum)	3 / 3	LEU A 694 ARG A 693 MET A 360	None	0.87A	4m11C-4q2cA: 0.9	4m11C-4q2cA: 19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4M83_A_ERYA1400_0 (OLEANDOMYCIN GLYCOSYLTRANSFERASE)	4q2c	CRISPR-ASSOCIATED HELICASE CAS3 (Thermobaculum terrenum)	5 / 11	VAL A 763 TYR A 540 LEU A 519 ALA A 509 SER A 508	None	1.48A	4m83A-4q2cA: undetectable	4m83A-4q2cA: 20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4O0U_A_ADNA501_1 (AURORA KINASE A)	4q2c	CRISPR-ASSOCIATED HELICASE CAS3 (Thermobaculum terrenum)	4 / 6	VAL A 474 ALA A 356 LEU A 453 LEU A 490	None	0.79A	4o0uA-4q2cA: undetectable	4o0uA-4q2cA: 15.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4O2B_B_LOCB503_1 (TUBULIN ALPHA-1B CHAIN TUBULIN BETA-2B CHAIN)	4q2c	CRISPR-ASSOCIATED HELICASE CAS3 (Thermobaculum terrenum)	3 / 3	SER A 854 ALA A 852 VAL A 851	None	0.48A	4o2bA-4q2cA: undetectable	4o2bA-4q2cA: 18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4PUO_A_NVPA901_1 (HIV-1 REVERSE TRANSCRIPTASE, P66 SUBUNIT)	4q2c	CRISPR-ASSOCIATED HELICASE CAS3 (Thermobaculum terrenum)	5 / 9	LEU A 91 VAL A 220 VAL A 82 TRP A 72 LEU A 229	None	1.32A	4puoA-4q2cA: undetectable	4puoA-4q2cA: 19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4PWD_C_NVPC901_1 (HIV-1 REVERSE TRANSCRIPTASE, P66 SUBUNIT)	4q2c	CRISPR-ASSOCIATED HELICASE CAS3 (Thermobaculum terrenum)	4 / 8	LEU A 91 VAL A 82 TRP A 72 LEU A 229	None	1.11A	4pwdC-4q2cA: undetectable	4pwdC-4q2cA: 19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RYA_A_MTLA501_0 (ABC TRANSPORTER SUBSTRATE BINDING PROTEIN (SORBITOL))	4q2c	CRISPR-ASSOCIATED HELICASE CAS3 (Thermobaculum terrenum)	5 / 12	GLY A 158 ALA A 161 PHE A 166 ALA A 143 VAL A 181	None	1.44A	4ryaA-4q2cA: undetectable	4ryaA-4q2cA: 18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4UBP_C_HAEC800_1 (PROTEIN (UREASE (CHAIN C)))	4q2c	CRISPR-ASSOCIATED HELICASE CAS3 (Thermobaculum terrenum)	5 / 6	HIS A 98 HIS A 52 HIS A 138 HIS A 171 ASP A 237	NI A1001 (-3.4A) NI A1001 (-3.2A) NI A1002 (-3.3A) NI A1002 (-3.3A) NI A1001 ( 2.7A)	1.02A	4ubpC-4q2cA: undetectable	4ubpC-4q2cA: 21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4WBO_C_ANWC601_0 (RHODOPSIN KINASE)	4q2c	CRISPR-ASSOCIATED HELICASE CAS3 (Thermobaculum terrenum)	5 / 6	ARG A 707 LEU A 708 ALA A 593 MET A 677 LEU A 694	None	1.40A	4wboC-4q2cA: undetectable	4wboC-4q2cA: 20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4X1I_B_LOCB502_1 (TUBULIN ALPHA CHAIN TUBULIN BETA CHAIN)	4q2c	CRISPR-ASSOCIATED HELICASE CAS3 (Thermobaculum terrenum)	3 / 3	SER A 854 ALA A 852 VAL A 851	None	0.58A	4x1iA-4q2cA: undetectable	4x1iA-4q2cA: 18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4XI3_B_29SB601_2 (ESTROGEN RECEPTOR)	4q2c	CRISPR-ASSOCIATED HELICASE CAS3 (Thermobaculum terrenum)	4 / 5	LEU A 202 GLU A 200 MET A 194 LEU A 129	None	1.35A	4xi3B-4q2cA: undetectable	4xi3B-4q2cA: 14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4XQE_A_AG2A506_1 (HOMOSPERMIDINE SYNTHASE)	4q2c	CRISPR-ASSOCIATED HELICASE CAS3 (Thermobaculum terrenum)	4 / 6	ARG A 704 ARG A 564 ARG A 696 ASP A 673	None	1.27A	4xqeA-4q2cA: undetectable	4xqeA-4q2cA: 21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4XQE_B_AG2B505_1 (HOMOSPERMIDINE SYNTHASE)	4q2c	CRISPR-ASSOCIATED HELICASE CAS3 (Thermobaculum terrenum)	4 / 6	ARG A 704 ARG A 564 ARG A 696 ASP A 673	None	1.25A	4xqeB-4q2cA: undetectable	4xqeB-4q2cA: 21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5EYP_B_LOCB502_1 (TUBULIN ALPHA CHAIN TUBULIN BETA CHAIN)	4q2c	CRISPR-ASSOCIATED HELICASE CAS3 (Thermobaculum terrenum)	3 / 3	SER A 854 ALA A 852 VAL A 851	None	0.57A	5eypA-4q2cA: undetectable	5eypA-4q2cA: 18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5FA8_A_SAMA301_1 (RIBOSOMAL PROTEIN L11 METHYLTRANSFERASE, PUTATIVE)	4q2c	CRISPR-ASSOCIATED HELICASE CAS3 (Thermobaculum terrenum)	3 / 3	THR A 739 ASP A 685 GLU A 667	None	0.75A	5fa8A-4q2cA: undetectable	5fa8A-4q2cA: 9.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5IKT_A_TLFA601_1 (PROSTAGLANDIN G/H SYNTHASE 2)	4q2c	CRISPR-ASSOCIATED HELICASE CAS3 (Thermobaculum terrenum)	3 / 3	LEU A 357 TYR A 354 SER A 392	None	0.89A	5iktA-4q2cA: undetectable	5iktA-4q2cA: 19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5M0O_C_EPAC502_1 (TERMINAL OLEFIN-FORMING FATTY ACID DECARBOXYLASE)	4q2c	CRISPR-ASSOCIATED HELICASE CAS3 (Thermobaculum terrenum)	4 / 8	LEU A 753 ARG A 750 ALA A 746 PRO A 328	None	0.86A	5m0oC-4q2cA: undetectable	5m0oC-4q2cA: 19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5MVM_A_PFLA510_1 (PROTON-GATED ION CHANNEL)	4q2c	CRISPR-ASSOCIATED HELICASE CAS3 (Thermobaculum terrenum)	5 / 9	ILE A 596 ALA A 594 ILE A 595 ALA A 603 LEU A 606	None	1.14A	5mvmA-4q2cA: undetectable 5mvmE-4q2cA: undetectable	5mvmA-4q2cA: 5.81 5mvmE-4q2cA: 5.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5ND3_B_TA1B601_1 (TUBULIN BETA-2B CHAIN)	4q2c	CRISPR-ASSOCIATED HELICASE CAS3 (Thermobaculum terrenum)	5 / 12	VAL A 317 GLU A 316 LEU A 296 LEU A 339 ALA A 314	None	1.20A	5nd3B-4q2cA: undetectable	5nd3B-4q2cA: 18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5NEK_B_AZMB302_1 (PEPTIDOGLYCAN N-ACETYLGLUCOSAMINE DEACETYLASE)	4q2c	CRISPR-ASSOCIATED HELICASE CAS3 (Thermobaculum terrenum)	4 / 8	ASP A 99 HIS A 171 HIS A 138 HIS A 52	NI A1001 (-2.7A) NI A1002 (-3.3A) NI A1002 (-3.3A) NI A1001 (-3.2A)	0.99A	5nekB-4q2cA: undetectable	5nekB-4q2cA: 6.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5NKN_A_LOCA201_2 (NEUTROPHIL GELATINASE-ASSOCIATE D LIPOCALIN)	4q2c	CRISPR-ASSOCIATED HELICASE CAS3 (Thermobaculum terrenum)	3 / 3	VAL A 476 LYS A 472 MET A 350	None	0.91A	5nknA-4q2cA: undetectable	5nknA-4q2cA: 5.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5NZW_A_9F2A1102_1 (DNA CROSS-LINK REPAIR 1A PROTEIN)	4q2c	CRISPR-ASSOCIATED HELICASE CAS3 (Thermobaculum terrenum)	5 / 10	HIS A 98 HIS A 52 HIS A 171 ASP A 237 HIS A 172	NI A1001 (-3.4A) NI A1001 (-3.2A) NI A1002 (-3.3A) NI A1001 ( 2.7A) NI A1002 ( 3.3A)	1.18A	5nzwA-4q2cA: 2.2	5nzwA-4q2cA: 15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5O96_A_SAMA501_0 (RIBOSOMAL RNA SMALL SUBUNIT METHYLTRANSFERASE E)	4q2c	CRISPR-ASSOCIATED HELICASE CAS3 (Thermobaculum terrenum)	5 / 11	LEU A 469 GLU A 495 GLY A 498 ARG A 492 ALA A 455	None	0.99A	5o96A-4q2cA: undetectable 5o96B-4q2cA: undetectable	5o96A-4q2cA: 14.66 5o96B-4q2cA: 14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5OY0_1_PQN1842_1 (PHOTOSYSTEM I P700 CHLOROPHYLL A APOPROTEIN A1 PHOTOSYSTEM I REACTION CENTER SUBUNIT IX)	4q2c	CRISPR-ASSOCIATED HELICASE CAS3 (Thermobaculum terrenum)	5 / 10	ARG A 707 ALA A 586 LEU A 587 GLY A 590 LEU A 937	None	1.24A	5oy01-4q2cA: undetectable 5oy07-4q2cA: undetectable	5oy01-4q2cA: 7.77 5oy07-4q2cA: 3.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5UMW_B_RBFB201_1 (GLYOXALASE/BLEOMYCIN RESISANCE PROTEIN/DIOXYGENASE)	4q2c	CRISPR-ASSOCIATED HELICASE CAS3 (Thermobaculum terrenum)	4 / 7	ARG A 611 TYR A 607 GLU A 936 ARG A 932	None	0.93A	5umwB-4q2cA: undetectable 5umwE-4q2cA: undetectable	5umwB-4q2cA: 8.56 5umwE-4q2cA: 8.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5X6Y_B_SAMB901_0 (MRNA CAPPING ENZYME P5)	4q2c	CRISPR-ASSOCIATED HELICASE CAS3 (Thermobaculum terrenum)	5 / 10	VAL A 414 GLY A 413 ALA A 429 SER A 241 ASN A 242	NI A1003 ( 4.6A) None None NI A1003 ( 4.8A) None	0.82A	5x6yB-4q2cA: undetectable	5x6yB-4q2cA: 22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5YVN_A_ACTA305_0 (GLUTATHIONE S-TRANSFERASE OMEGA-1)	4q2c	CRISPR-ASSOCIATED HELICASE CAS3 (Thermobaculum terrenum)	4 / 6	GLU A 641 LEU A 628 LEU A 645 LEU A 670	None	1.02A	5yvnA-4q2cA: undetectable	5yvnA-4q2cA: 13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5ZRD_A_CUA607_0 (TYROSINASE)	4q2c	CRISPR-ASSOCIATED HELICASE CAS3 (Thermobaculum terrenum)	3 / 3	HIS A 172 HIS A 171 HIS A 138	NI A1002 ( 3.3A) NI A1002 (-3.3A) NI A1002 (-3.3A)	0.47A	5zrdA-4q2cA: undetectable	5zrdA-4q2cA: 20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6AJI_A_AY6A1001_0 (DRUG EXPORTERS OF THE RND SUPERFAMILY-LIKE PROTEIN,ENDOLYSIN)	4q2c	CRISPR-ASSOCIATED HELICASE CAS3 (Thermobaculum terrenum)	5 / 12	LEU A 493 VAL A 502 LEU A 500 VAL A 456 ALA A 455	None	0.82A	6ajiA-4q2cA: undetectable	6ajiA-4q2cA: 23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6B58_A_ACTA609_0 (FUMARATE REDUCTASE FLAVOPROTEIN SUBUNIT)	4q2c	CRISPR-ASSOCIATED HELICASE CAS3 (Thermobaculum terrenum)	3 / 3	HIS A 697 HIS A 700 ARG A 704	None	1.02A	6b58A-4q2cA: undetectable	6b58A-4q2cA: 22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BQG_A_ERMA1201_2 (5-HYDROXYTRYPTAMINE RECEPTOR 2C,SOLUBLE CYTOCHROME B562)	4q2c	CRISPR-ASSOCIATED HELICASE CAS3 (Thermobaculum terrenum)	4 / 5	VAL A 506 LEU A 494 VAL A 456 LEU A 469	None	0.95A	6bqgA-4q2cA: undetectable	6bqgA-4q2cA: 6.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6CDU_F_EY4F500_0 (CHIMERIC ALPHA1GABAA RECEPTOR)	4q2c	CRISPR-ASSOCIATED HELICASE CAS3 (Thermobaculum terrenum)	4 / 7	ALA A 337 THR A 334 ILE A 324 VAL A 505	None	0.95A	6cduF-4q2cA: undetectable 6cduJ-4q2cA: undetectable	6cduF-4q2cA: 15.80 6cduJ-4q2cA: 15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6ESM_A_PZEA307_1 (MATRIX METALLOPROTEINASE-9, MATRIX METALLOPROTEINASE-9)	4q2c	CRISPR-ASSOCIATED HELICASE CAS3 (Thermobaculum terrenum)	3 / 3	TYR A 415 HIS A 138 PHE A 107	None NI A1002 (-3.3A) None	1.04A	6esmA-4q2cA: undetectable	6esmA-4q2cA: 6.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6HQB_A_PQNA2001_0 (PHOTOSYSTEM I P700 CHLOROPHYLL A APOPROTEIN A1 PHOTOSYSTEM I REACTION CENTER SUBUNIT IX)	4q2c	CRISPR-ASSOCIATED HELICASE CAS3 (Thermobaculum terrenum)	5 / 10	ARG A 707 ALA A 586 LEU A 587 GLY A 590 LEU A 937	None	1.31A	6hqbA-4q2cA: undetectable 6hqbJ-4q2cA: undetectable	6hqbA-4q2cA: 6.40 6hqbJ-4q2cA: 3.62

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1AV2_C_DVAC6_0","GRAMICIDIN A","4q2c","CRISPR-ASSOCIATED HELICASE CAS3","Thermobaculum terrenum",3,"ALA A 230;VAL A 235;TRP A 238","None","0.85A","1av2C-4q2cA:undetectable;1av2D-4q2cA:undetectable","1av2C-4q2cA:1.96;1av2D-4q2cA:1.96"],["1CMA_B_SAMB105_0","PROTEIN (MET REPRESSOR)","4q2c","CRISPR-ASSOCIATED HELICASE CAS3","Thermobaculum terrenum",5,"LEU A 229;HIS A  98;ALA A  95;PHE A  94;GLY A  97","None; NI A1001 (-3.4A);None;None;None","1.24A","1cmaA-4q2cA:undetectable;1cmaB-4q2cA:undetectable","1cmaA-4q2cA:7.87;1cmaB-4q2cA:7.87"],["1DB1_A_VDXA428_2","VITAMIN D NUCLEAR RECEPTOR","4q2c","CRISPR-ASSOCIATED HELICASE CAS3","Thermobaculum terrenum",4,"LEU A 493;ILE A 324;ARG A 516;VAL A 476","None","1.07A","1db1A-4q2cA:undetectable","1db1A-4q2cA:15.48"],["1DLS_A_MTXA188_2","DIHYDROFOLATE REDUCTASE","4q2c","CRISPR-ASSOCIATED HELICASE CAS3","Thermobaculum terrenum",4,"TYR A 354;ARG A 465;VAL A 504;THR A 471","None","1.16A","1dlsA-4q2cA:0.0","1dlsA-4q2cA:11.61"],["1E9Y_B_HAEB800_1","UREASE SUBUNIT BETA","4q2c","CRISPR-ASSOCIATED HELICASE CAS3","Thermobaculum terrenum",4,"HIS A  98;HIS A 138;HIS A 171;ASP A 237"," NI A1001 (-3.4A); NI A1002 (-3.3A); NI A1002 (-3.3A); NI A1001 ( 2.7A)","0.95A","1e9yB-4q2cA:undetectable","1e9yB-4q2cA:19.77"],["1EI6_A_PPFA410_1","PHOSPHONOACETATE HYDROLASE","4q2c","CRISPR-ASSOCIATED HELICASE CAS3","Thermobaculum terrenum",4,"ASP A  99;HIS A 138;HIS A 171;HIS A 172"," NI A1001 (-2.7A); NI A1002 (-3.3A); NI A1002 (-3.3A); NI A1002 ( 3.3A)","1.19A","1ei6A-4q2cA:undetectable","1ei6A-4q2cA:18.35"],["1EI6_D_PPFD412_1","PHOSPHONOACETATE HYDROLASE","4q2c","CRISPR-ASSOCIATED HELICASE CAS3","Thermobaculum terrenum",4,"ASP A  99;HIS A  98;HIS A 171;HIS A  52"," NI A1001 (-2.7A); NI A1001 (-3.4A); NI A1002 (-3.3A); NI A1001 (-3.2A)","0.77A","1ei6D-4q2cA:undetectable","1ei6D-4q2cA:18.35"],["1H9Z_A_RWFA3001_1","SERUM ALBUMIN","4q2c","CRISPR-ASSOCIATED HELICASE CAS3","Thermobaculum terrenum",5,"ALA A 586;LEU A 587;LEU A 583;LEU A 610;ALA A 594","None","1.12A","1h9zA-4q2cA:undetectable","1h9zA-4q2cA:21.32"],["1HWI_A_115A2_2","HMG-COA REDUCTASE;HMG-COA REDUCTASE","4q2c","CRISPR-ASSOCIATED HELICASE CAS3","Thermobaculum terrenum",4,"CYH A  51;LEU A 206;ALA A 209;LEU A 210","None","0.97A","1hwiB-4q2cA:undetectable","1hwiB-4q2cA:18.62"],["1HWI_D_115D3_1","HMG-COA REDUCTASE;HMG-COA REDUCTASE","4q2c","CRISPR-ASSOCIATED HELICASE CAS3","Thermobaculum terrenum",4,"CYH A  51;LEU A 206;ALA A 209;LEU A 210","None","0.96A","1hwiC-4q2cA:undetectable","1hwiC-4q2cA:18.62"],["1KB9_A_PCFA514_0","CYTOCHROME B;CYTOCHROME C1, HEME PROTEIN;UBIQUINOL-CYTOCHROME C REDUCTASE COMPLEX CORE PROTEIN I;UBIQUINOL-CYTOCHROME C REDUCTASE IRON-SULFUR SUBUNIT","4q2c","CRISPR-ASSOCIATED HELICASE CAS3","Thermobaculum terrenum",4,"ILE A 815;PHE A 227;VAL A 462;SER A 234","None","1.04A","1kb9A-4q2cA:undetectable;1kb9C-4q2cA:undetectable;1kb9D-4q2cA:undetectable;1kb9E-4q2cA:undetectable","1kb9A-4q2cA:20.00;1kb9C-4q2cA:17.18;1kb9D-4q2cA:13.95;1kb9E-4q2cA:11.33"],["1MJ2_A_SAMA2201_1","PROTEIN (METHIONINE REPRESSOR)","4q2c","CRISPR-ASSOCIATED HELICASE CAS3","Thermobaculum terrenum",4,"HIS A  98;ALA A  95;PHE A  94;GLY A  97"," NI A1001 (-3.4A);None;None;None","0.68A","1mj2B-4q2cA:undetectable","1mj2B-4q2cA:8.82"],["1MJ2_C_SAMC1200_1","PROTEIN (METHIONINE REPRESSOR)","4q2c","CRISPR-ASSOCIATED HELICASE CAS3","Thermobaculum terrenum",4,"HIS A  98;ALA A  95;PHE A  94;GLY A  97"," NI A1001 (-3.4A);None;None;None","0.74A","1mj2D-4q2cA:undetectable","1mj2D-4q2cA:8.82"],["1MJ2_C_SAMC2199_0","PROTEIN (METHIONINE REPRESSOR)","4q2c","CRISPR-ASSOCIATED HELICASE CAS3","Thermobaculum terrenum",5,"ALA A  92;PHE A  94;GLY A  96;ARG A 217;LEU A 210","None","1.07A","1mj2C-4q2cA:undetectable;1mj2D-4q2cA:undetectable","1mj2C-4q2cA:8.82;1mj2D-4q2cA:8.82"],["1MJ2_C_SAMC2199_0","PROTEIN (METHIONINE REPRESSOR)","4q2c","CRISPR-ASSOCIATED HELICASE CAS3","Thermobaculum terrenum",5,"HIS A  98;ALA A  95;PHE A  94;GLY A  97;LEU A 229"," NI A1001 (-3.4A);None;None;None;None","1.27A","1mj2C-4q2cA:undetectable;1mj2D-4q2cA:undetectable","1mj2C-4q2cA:8.82;1mj2D-4q2cA:8.82"],["1MJO_A_SAMA199_1","METHIONINE REPRESSOR","4q2c","CRISPR-ASSOCIATED HELICASE CAS3","Thermobaculum terrenum",4,"HIS A  98;ALA A  95;PHE A  94;GLY A  97"," NI A1001 (-3.4A);None;None;None","0.72A","1mjoB-4q2cA:undetectable","1mjoB-4q2cA:8.82"],["1MJO_B_SAMB200_0","METHIONINE REPRESSOR","4q2c","CRISPR-ASSOCIATED HELICASE CAS3","Thermobaculum terrenum",4,"HIS A  98;ALA A  95;PHE A  94;GLY A  97"," NI A1001 (-3.4A);None;None;None","0.77A","1mjoA-4q2cA:undetectable","1mjoA-4q2cA:8.82"],["1MJO_C_SAMC200_0","METHIONINE REPRESSOR","4q2c","CRISPR-ASSOCIATED HELICASE CAS3","Thermobaculum terrenum",5,"HIS A  98;ALA A  95;PHE A  94;GLY A  97;LEU A 229"," NI A1001 (-3.4A);None;None;None;None","1.22A","1mjoC-4q2cA:undetectable;1mjoD-4q2cA:undetectable","1mjoC-4q2cA:8.82;1mjoD-4q2cA:8.82"],["1MJO_D_SAMD200_1","METHIONINE REPRESSOR","4q2c","CRISPR-ASSOCIATED HELICASE CAS3","Thermobaculum terrenum",4,"HIS A  98;ALA A  95;PHE A  94;GLY A  97"," NI A1001 (-3.4A);None;None;None","0.70A","1mjoD-4q2cA:undetectable","1mjoD-4q2cA:8.82"],["1MJQ_A_SAMA200_0","METHIONINE REPRESSOR","4q2c","CRISPR-ASSOCIATED HELICASE CAS3","Thermobaculum terrenum",5,"LEU A 229;HIS A  98;ALA A  95;PHE A  94;GLY A  97","None; NI A1001 (-3.4A);None;None;None","1.18A","1mjqA-4q2cA:undetectable;1mjqB-4q2cA:undetectable","1mjqA-4q2cA:8.82;1mjqB-4q2cA:8.82"],["1N2X_A_SAMA401_0","S-ADENOSYL-METHYLTRANSFERASE MRAW","4q2c","CRISPR-ASSOCIATED HELICASE CAS3","Thermobaculum terrenum",5,"HIS A 172;THR A 140;GLY A 169;GLY A 173;VAL A 168"," NI A1002 ( 3.3A);None;None;None;None","1.29A","1n2xA-4q2cA:3.1","1n2xA-4q2cA:14.90"],["1NG8_A_DVAA8_0","GRAMICIDIN A","4q2c","CRISPR-ASSOCIATED HELICASE CAS3","Thermobaculum terrenum",4,"GLY A 390;VAL A 388;TRP A 281;GLY A 280","None","1.15A","1ng8A-4q2cA:undetectable","1ng8A-4q2cA:1.63"],["1NG8_B_DVAB8_0","GRAMICIDIN A","4q2c","CRISPR-ASSOCIATED HELICASE CAS3","Thermobaculum terrenum",4,"GLY A 390;VAL A 388;TRP A 281;GLY A 280","None","1.15A","1ng8B-4q2cA:undetectable","1ng8B-4q2cA:1.63"],["1QW6_A_H4BA901_1","NITRIC-OXIDE SYNTHASE, BRAIN","4q2c","CRISPR-ASSOCIATED HELICASE CAS3","Thermobaculum terrenum",3,"ARG A 112;VAL A 120;TRP A  35","None","1.25A","1qw6A-4q2cA:undetectable","1qw6A-4q2cA:18.10"],["1S9P_C_DESC500_1","ESTROGEN-RELATED RECEPTOR GAMMA","4q2c","CRISPR-ASSOCIATED HELICASE CAS3","Thermobaculum terrenum",5,"LEU A 203;CYH A 204;LEU A 206;ALA A 207;LEU A 212","None","1.06A","1s9pC-4q2cA:undetectable","1s9pC-4q2cA:12.67"],["1SQF_A_SAMA430_1","SUN PROTEIN","4q2c","CRISPR-ASSOCIATED HELICASE CAS3","Thermobaculum terrenum",3,"PRO A 358;ASP A 450;ASP A 483","None","0.76A","1sqfA-4q2cA:undetectable","1sqfA-4q2cA:19.64"],["1SV5_A_65BA600_0","REVERSE TRANSCRIPTASE","4q2c","CRISPR-ASSOCIATED HELICASE CAS3","Thermobaculum terrenum",5,"LEU A  91;VAL A 220;VAL A  82;TRP A  72;LEU A 229","None","1.35A","1sv5A-4q2cA:undetectable","1sv5A-4q2cA:20.19"],["1T7J_A_478A200_2","POL POLYPROTEIN;POL POLYPROTEIN","4q2c","CRISPR-ASSOCIATED HELICASE CAS3","Thermobaculum terrenum",4,"ASP A 196;GLY A 101;ILE A 141;THR A 148","None","0.85A","1t7jB-4q2cA:undetectable","1t7jB-4q2cA:8.22"],["2AOH_C_FRDC305_1","POL POLYPROTEIN;PEPTIDE INHIBITOR","4q2c","CRISPR-ASSOCIATED HELICASE CAS3","Thermobaculum terrenum",4,"LEU A 660;ASP A 626;GLY A 938;ALA A 662","None","0.93A","2aohA-4q2cA:undetectable","2aohA-4q2cA:7.21"],["2QBN_A_CAMA442_0","CYTOCHROME P450-CAM","4q2c","CRISPR-ASSOCIATED HELICASE CAS3","Thermobaculum terrenum",4,"PHE A  93;VAL A 201;VAL A 149;VAL A 153","None","0.97A","2qbnA-4q2cA:undetectable","2qbnA-4q2cA:18.19"],["2QHF_A_ACTA509_0","CHORISMATE SYNTHASE","4q2c","CRISPR-ASSOCIATED HELICASE CAS3","Thermobaculum terrenum",3,"ARG A 890;GLN A 604;PRO A 601","None","0.70A","2qhfA-4q2cA:undetectable","2qhfA-4q2cA:18.84"],["2QR2_B_VK3B235_1","PROTEIN (QUINONE REDUCTASE TYPE 2);PROTEIN (QUINONE REDUCTASE TYPE 2)","4q2c","CRISPR-ASSOCIATED HELICASE CAS3","Thermobaculum terrenum",4,"PHE A 154;TRP A  90;GLY A  96;GLY A  97","None","0.97A","2qr2A-4q2cA:undetectable;2qr2B-4q2cA:undetectable","2qr2A-4q2cA:11.97;2qr2B-4q2cA:11.97"],["2QR2_B_VK3B236_1","PROTEIN (QUINONE REDUCTASE TYPE 2);PROTEIN (QUINONE REDUCTASE TYPE 2)","4q2c","CRISPR-ASSOCIATED HELICASE CAS3","Thermobaculum terrenum",4,"TRP A  90;GLY A  96;GLY A  97;PHE A 154","None","1.02A","2qr2A-4q2cA:undetectable;2qr2B-4q2cA:undetectable","2qr2A-4q2cA:11.97;2qr2B-4q2cA:11.97"],["2WA2_B_SAMB1267_1","NON-STRUCTURAL PROTEIN 5","4q2c","CRISPR-ASSOCIATED HELICASE CAS3","Thermobaculum terrenum",3,"SER A 177;HIS A 461;ASP A 237","None;None; NI A1001 ( 2.7A)","0.74A","2wa2B-4q2cA:undetectable","2wa2B-4q2cA:14.47"],["2XAD_E_GCSE710_1","N-ACYL GLM PEUDO-TEICOPLANIN DEACETYLASE;TEICOPLANIN","4q2c","CRISPR-ASSOCIATED HELICASE CAS3","Thermobaculum terrenum",4,"HIS A 171;ASP A 237;HIS A 138;ASP A  99"," NI A1002 (-3.3A); NI A1001 ( 2.7A); NI A1002 (-3.3A); NI A1001 (-2.7A)","1.06A","2xadA-4q2cA:undetectable","2xadA-4q2cA:14.48"],["2XAD_F_GCSF710_1","N-ACYL GLM PEUDO-TEICOPLANIN DEACETYLASE;TEICOPLANIN","4q2c","CRISPR-ASSOCIATED HELICASE CAS3","Thermobaculum terrenum",4,"HIS A 171;ASP A 237;HIS A 138;ASP A  99"," NI A1002 (-3.3A); NI A1001 ( 2.7A); NI A1002 (-3.3A); NI A1001 (-2.7A)","1.08A","2xadB-4q2cA:undetectable","2xadB-4q2cA:14.48"],["2XAD_G_GCSG710_1","N-ACYL GLM PEUDO-TEICOPLANIN DEACETYLASE;TEICOPLANIN","4q2c","CRISPR-ASSOCIATED HELICASE CAS3","Thermobaculum terrenum",4,"HIS A 171;ASP A 237;HIS A 138;ASP A  99"," NI A1002 (-3.3A); NI A1001 ( 2.7A); NI A1002 (-3.3A); NI A1001 (-2.7A)","1.06A","2xadC-4q2cA:undetectable","2xadC-4q2cA:14.48"],["2XAD_H_GCSH710_1","N-ACYL GLM PEUDO-TEICOPLANIN DEACETYLASE;TEICOPLANIN","4q2c","CRISPR-ASSOCIATED HELICASE CAS3","Thermobaculum terrenum",4,"HIS A 171;ASP A 237;HIS A 138;ASP A  99"," NI A1002 (-3.3A); NI A1001 ( 2.7A); NI A1002 (-3.3A); NI A1001 (-2.7A)","1.08A","2xadD-4q2cA:undetectable","2xadD-4q2cA:14.48"],["2XDC_F_DVAF8_0","GRAMICIDIN A","4q2c","CRISPR-ASSOCIATED HELICASE CAS3","Thermobaculum terrenum",3,"TRP A 238;VAL A 427;TRP A 432","None","1.04A","2xdcE-4q2cA:undetectable;2xdcF-4q2cA:undetectable","2xdcE-4q2cA:1.96;2xdcF-4q2cA:1.96"],["3AF0_A_PAUA314_0","PANTOTHENATE KINASE","4q2c","CRISPR-ASSOCIATED HELICASE CAS3","Thermobaculum terrenum",4,"VAL A 414;ASP A  99;GLY A 240;HIS A 171"," NI A1003 ( 4.6A); NI A1001 (-2.7A);None; NI A1002 (-3.3A)","0.92A","3af0A-4q2cA:undetectable","3af0A-4q2cA:17.38"],["3BJW_B_SVRB512_2","PHOSPHOLIPASE A2","4q2c","CRISPR-ASSOCIATED HELICASE CAS3","Thermobaculum terrenum",4,"VAL A 845;ILE A 939;GLY A 938;LEU A 627","None","0.90A","3bjwB-4q2cA:2.4","3bjwB-4q2cA:7.82"],["3BJW_F_SVRF509_3","PHOSPHOLIPASE A2","4q2c","CRISPR-ASSOCIATED HELICASE CAS3","Thermobaculum terrenum",4,"VAL A 845;ILE A 939;GLY A 938;LEU A 627","None","0.92A","3bjwF-4q2cA:2.3","3bjwF-4q2cA:7.82"],["3BJW_H_SVRH511_3","PHOSPHOLIPASE A2","4q2c","CRISPR-ASSOCIATED HELICASE CAS3","Thermobaculum terrenum",4,"VAL A 845;ILE A 939;GLY A 938;LEU A 627","None","0.84A","3bjwH-4q2cA:2.2","3bjwH-4q2cA:7.82"],["3DH0_A_SAMA220_1","SAM DEPENDENT METHYLTRANSFERASE","4q2c","CRISPR-ASSOCIATED HELICASE CAS3","Thermobaculum terrenum",4,"ARG A 637;ASP A 450;GLN A 835;GLU A 842","None","1.15A","3dh0A-4q2cA:3.0","3dh0A-4q2cA:12.08"],["3EL9_A_DR7A100_1","PROTEASE","4q2c","CRISPR-ASSOCIATED HELICASE CAS3","Thermobaculum terrenum",4,"ASP A 196;GLY A 101;ILE A 141;THR A 148","None","0.80A","3el9A-4q2cA:undetectable","3el9A-4q2cA:8.00"],["3FL9_B_TOPB200_1","DIHYDROFOLATE REDUCTASE (DHFR)","4q2c","CRISPR-ASSOCIATED HELICASE CAS3","Thermobaculum terrenum",5,"ALA A  57;LEU A 206;ILE A 100;LEU A 146;THR A  60","None","1.11A","3fl9B-4q2cA:undetectable","3fl9B-4q2cA:9.81"],["3IX9_A_MTXA200_1","DIHYDROFOLATE REDUCTASE","4q2c","CRISPR-ASSOCIATED HELICASE CAS3","Thermobaculum terrenum",6,"LEU A 747;LEU A 688;GLN A 689;LEU A 755;ARG A 564;THR A 679","None","1.42A","3ix9A-4q2cA:undetectable","3ix9A-4q2cA:10.82"],["3IX9_B_MTXB200_1","DIHYDROFOLATE REDUCTASE","4q2c","CRISPR-ASSOCIATED HELICASE CAS3","Thermobaculum terrenum",5,"LEU A 747;LEU A 688;GLN A 689;LEU A 755;THR A 679","None","1.17A","3ix9B-4q2cA:undetectable","3ix9B-4q2cA:10.82"],["3K8M_A_ACRA720_1","ALPHA-AMYLASE, SUSG","4q2c","CRISPR-ASSOCIATED HELICASE CAS3","Thermobaculum terrenum",4,"TYR A 378;TRP A 284;LEU A 374;ASN A 386","None","1.34A","3k8mA-4q2cA:undetectable","3k8mA-4q2cA:20.45"],["3K8M_B_ACRB820_1","ALPHA-AMYLASE, SUSG","4q2c","CRISPR-ASSOCIATED HELICASE CAS3","Thermobaculum terrenum",4,"TYR A 378;TRP A 284;LEU A 374;ASN A 386","None","1.37A","3k8mB-4q2cA:undetectable","3k8mB-4q2cA:20.45"],["3LP0_A_NVPA701_1","REVERSE TRANSCRIPTASE\/RIBONUCLEASE H","4q2c","CRISPR-ASSOCIATED HELICASE CAS3","Thermobaculum terrenum",5,"LEU A  91;VAL A 220;VAL A  82;TRP A  72;LEU A 229","None","1.48A","3lp0A-4q2cA:1.1","3lp0A-4q2cA:19.98"],["3LP1_A_NVPA701_1","REVERSE TRANSCRIPTASE\/RIBONUCLEASE H","4q2c","CRISPR-ASSOCIATED HELICASE CAS3","Thermobaculum terrenum",5,"LEU A  91;VAL A 220;VAL A  82;TRP A  72;LEU A 229","None","1.45A","3lp1A-4q2cA:undetectable","3lp1A-4q2cA:19.98"],["3LSL_A_PZIA801_0","GLUTAMATE RECEPTOR 2","4q2c","CRISPR-ASSOCIATED HELICASE CAS3","Thermobaculum terrenum",4,"ILE A 759;PRO A 328;SER A 562;PRO A 541","None","0.81A","3lslA-4q2cA:undetectable;3lslD-4q2cA:undetectable","3lslA-4q2cA:12.76;3lslD-4q2cA:12.76"],["3LSL_D_PZID801_0","GLUTAMATE RECEPTOR 2","4q2c","CRISPR-ASSOCIATED HELICASE CAS3","Thermobaculum terrenum",4,"PRO A 541;ILE A 759;PRO A 328;SER A 562","None","0.86A","3lslA-4q2cA:undetectable;3lslD-4q2cA:undetectable","3lslA-4q2cA:12.76;3lslD-4q2cA:12.76"],["3OZW_A_KKKA413_1","FLAVOHEMOGLOBIN","4q2c","CRISPR-ASSOCIATED HELICASE CAS3","Thermobaculum terrenum",4,"ILE A 659;ALA A 584;LEU A 583;LEU A 606","None","0.62A","3ozwA-4q2cA:2.3","3ozwA-4q2cA:18.66"],["3QIP_A_NVPA561_1","REVERSE HIV-1 REVERSE TRANSCRIPTASE P66","4q2c","CRISPR-ASSOCIATED HELICASE CAS3","Thermobaculum terrenum",5,"LEU A  91;VAL A 220;VAL A  82;TRP A  72;LEU A 229","None","1.43A","3qipA-4q2cA:undetectable","3qipA-4q2cA:19.67"],["3QOW_A_SAMA417_1","HISTONE-LYSINE N-METHYLTRANSFERASE","4q2c","CRISPR-ASSOCIATED HELICASE CAS3","Thermobaculum terrenum",3,"THR A 739;ASP A 685;GLU A 667","None","0.71A","3qowA-4q2cA:undetectable","3qowA-4q2cA:18.24"],["3REM_A_SALA301_1","SALICYLATE BIOSYNTHESIS PROTEIN PCHB","4q2c","CRISPR-ASSOCIATED HELICASE CAS3","Thermobaculum terrenum",4,"VAL A 600;ARG A 637;VAL A 884;ILE A 939","None","1.01A","3remA-4q2cA:undetectable","3remA-4q2cA:7.34"],["3REM_B_SALB301_1","SALICYLATE BIOSYNTHESIS PROTEIN PCHB","4q2c","CRISPR-ASSOCIATED HELICASE CAS3","Thermobaculum terrenum",4,"VAL A 600;ARG A 637;VAL A 884;ILE A 939","None","1.04A","3remB-4q2cA:undetectable","3remB-4q2cA:7.34"],["3V81_C_NVPC901_1","HIV-1 REVERSE TRANSCRIPTASE P66 SUBUNIT","4q2c","CRISPR-ASSOCIATED HELICASE CAS3","Thermobaculum terrenum",5,"LEU A  91;VAL A 220;VAL A  82;TRP A  72;LEU A 229","None","1.34A","3v81C-4q2cA:undetectable","3v81C-4q2cA:19.83"],["4C1D_B_X8ZB350_1","BETA-LACTAMASE CLASS B VIM-2","4q2c","CRISPR-ASSOCIATED HELICASE CAS3","Thermobaculum terrenum",5,"HIS A 172;HIS A 171;ASP A 237;HIS A 138;HIS A  52"," NI A1002 ( 3.3A); NI A1002 (-3.3A); NI A1001 ( 2.7A); NI A1002 (-3.3A); NI A1001 (-3.2A)","1.16A","4c1dB-4q2cA:undetectable","4c1dB-4q2cA:14.47"],["4C1F_A_X8ZA300_1","BETA-LACTAMASE IMP-1;BETA-LACTAMASE IMP-1","4q2c","CRISPR-ASSOCIATED HELICASE CAS3","Thermobaculum terrenum",5,"HIS A 172;HIS A 171;ASP A 237;HIS A 138;HIS A  52"," NI A1002 ( 3.3A); NI A1002 (-3.3A); NI A1001 ( 2.7A); NI A1002 (-3.3A); NI A1001 (-3.2A)","1.25A","4c1fA-4q2cA:undetectable;4c1fB-4q2cA:undetectable","4c1fA-4q2cA:11.67;4c1fB-4q2cA:11.67"],["4C1H_A_X8ZA305_1","BETA-LACTAMASE 2","4q2c","CRISPR-ASSOCIATED HELICASE CAS3","Thermobaculum terrenum",5,"HIS A 172;HIS A 171;ASP A 237;HIS A 138;HIS A  52"," NI A1002 ( 3.3A); NI A1002 (-3.3A); NI A1001 ( 2.7A); NI A1002 (-3.3A); NI A1001 (-3.2A)","1.14A","4c1hA-4q2cA:undetectable","4c1hA-4q2cA:12.21"],["4CPZ_H_ZMRH1470_2","NEURAMINIDASE","4q2c","CRISPR-ASSOCIATED HELICASE CAS3","Thermobaculum terrenum",3,"ARG A 771;ARG A 781;TRP A 784","None","1.47A","4cpzH-4q2cA:undetectable","4cpzH-4q2cA:18.82"],["4J24_A_ESTA600_1","ESTROGEN RECEPTOR BETA","4q2c","CRISPR-ASSOCIATED HELICASE CAS3","Thermobaculum terrenum",5,"LEU A 466;LEU A 229;ARG A  75;ILE A 807;ILE A 818","None","1.13A","4j24A-4q2cA:undetectable","4j24A-4q2cA:14.42"],["4J24_B_ESTB600_1","ESTROGEN RECEPTOR BETA","4q2c","CRISPR-ASSOCIATED HELICASE CAS3","Thermobaculum terrenum",5,"LEU A 466;LEU A 229;ARG A  75;ILE A 807;ILE A 818","None","1.12A","4j24B-4q2cA:undetectable","4j24B-4q2cA:14.42"],["4M11_C_MXMC606_2","PROSTAGLANDIN G\/H SYNTHASE 2","4q2c","CRISPR-ASSOCIATED HELICASE CAS3","Thermobaculum terrenum",3,"LEU A 694;ARG A 693;MET A 360","None","0.87A","4m11C-4q2cA:0.9","4m11C-4q2cA:19.11"],["4M83_A_ERYA1400_0","OLEANDOMYCIN GLYCOSYLTRANSFERASE","4q2c","CRISPR-ASSOCIATED HELICASE CAS3","Thermobaculum terrenum",5,"VAL A 763;TYR A 540;LEU A 519;ALA A 509;SER A 508","None","1.48A","4m83A-4q2cA:undetectable","4m83A-4q2cA:20.19"],["4O0U_A_ADNA501_1","AURORA KINASE A","4q2c","CRISPR-ASSOCIATED HELICASE CAS3","Thermobaculum terrenum",4,"VAL A 474;ALA A 356;LEU A 453;LEU A 490","None","0.79A","4o0uA-4q2cA:undetectable","4o0uA-4q2cA:15.06"],["4O2B_B_LOCB503_1","TUBULIN ALPHA-1B CHAIN;TUBULIN BETA-2B CHAIN","4q2c","CRISPR-ASSOCIATED HELICASE CAS3","Thermobaculum terrenum",3,"SER A 854;ALA A 852;VAL A 851","None","0.48A","4o2bA-4q2cA:undetectable","4o2bA-4q2cA:18.32"],["4PUO_A_NVPA901_1","HIV-1 REVERSE TRANSCRIPTASE, P66 SUBUNIT","4q2c","CRISPR-ASSOCIATED HELICASE CAS3","Thermobaculum terrenum",5,"LEU A  91;VAL A 220;VAL A  82;TRP A  72;LEU A 229","None","1.32A","4puoA-4q2cA:undetectable","4puoA-4q2cA:19.83"],["4PWD_C_NVPC901_1","HIV-1 REVERSE TRANSCRIPTASE, P66 SUBUNIT","4q2c","CRISPR-ASSOCIATED HELICASE CAS3","Thermobaculum terrenum",4,"LEU A  91;VAL A  82;TRP A  72;LEU A 229","None","1.11A","4pwdC-4q2cA:undetectable","4pwdC-4q2cA:19.83"],["4RYA_A_MTLA501_0","ABC TRANSPORTER SUBSTRATE BINDING PROTEIN (SORBITOL)","4q2c","CRISPR-ASSOCIATED HELICASE CAS3","Thermobaculum terrenum",5,"GLY A 158;ALA A 161;PHE A 166;ALA A 143;VAL A 181","None","1.44A","4ryaA-4q2cA:undetectable","4ryaA-4q2cA:18.44"],["4UBP_C_HAEC800_1","PROTEIN (UREASE (CHAIN C))","4q2c","CRISPR-ASSOCIATED HELICASE CAS3","Thermobaculum terrenum",5,"HIS A  98;HIS A  52;HIS A 138;HIS A 171;ASP A 237"," NI A1001 (-3.4A); NI A1001 (-3.2A); NI A1002 (-3.3A); NI A1002 (-3.3A); NI A1001 ( 2.7A)","1.02A","4ubpC-4q2cA:undetectable","4ubpC-4q2cA:21.02"],["4WBO_C_ANWC601_0","RHODOPSIN KINASE","4q2c","CRISPR-ASSOCIATED HELICASE CAS3","Thermobaculum terrenum",5,"ARG A 707;LEU A 708;ALA A 593;MET A 677;LEU A 694","None","1.40A","4wboC-4q2cA:undetectable","4wboC-4q2cA:20.59"],["4X1I_B_LOCB502_1","TUBULIN ALPHA CHAIN;TUBULIN BETA CHAIN","4q2c","CRISPR-ASSOCIATED HELICASE CAS3","Thermobaculum terrenum",3,"SER A 854;ALA A 852;VAL A 851","None","0.58A","4x1iA-4q2cA:undetectable","4x1iA-4q2cA:18.30"],["4XI3_B_29SB601_2","ESTROGEN RECEPTOR","4q2c","CRISPR-ASSOCIATED HELICASE CAS3","Thermobaculum terrenum",4,"LEU A 202;GLU A 200;MET A 194;LEU A 129","None","1.35A","4xi3B-4q2cA:undetectable","4xi3B-4q2cA:14.39"],["4XQE_A_AG2A506_1","HOMOSPERMIDINE SYNTHASE","4q2c","CRISPR-ASSOCIATED HELICASE CAS3","Thermobaculum terrenum",4,"ARG A 704;ARG A 564;ARG A 696;ASP A 673","None","1.27A","4xqeA-4q2cA:undetectable","4xqeA-4q2cA:21.45"],["4XQE_B_AG2B505_1","HOMOSPERMIDINE SYNTHASE","4q2c","CRISPR-ASSOCIATED HELICASE CAS3","Thermobaculum terrenum",4,"ARG A 704;ARG A 564;ARG A 696;ASP A 673","None","1.25A","4xqeB-4q2cA:undetectable","4xqeB-4q2cA:21.45"],["5EYP_B_LOCB502_1","TUBULIN ALPHA CHAIN;TUBULIN BETA CHAIN","4q2c","CRISPR-ASSOCIATED HELICASE CAS3","Thermobaculum terrenum",3,"SER A 854;ALA A 852;VAL A 851","None","0.57A","5eypA-4q2cA:undetectable","5eypA-4q2cA:18.32"],["5FA8_A_SAMA301_1","RIBOSOMAL PROTEIN L11 METHYLTRANSFERASE, PUTATIVE","4q2c","CRISPR-ASSOCIATED HELICASE CAS3","Thermobaculum terrenum",3,"THR A 739;ASP A 685;GLU A 667","None","0.75A","5fa8A-4q2cA:undetectable","5fa8A-4q2cA:9.84"],["5IKT_A_TLFA601_1","PROSTAGLANDIN G\/H SYNTHASE 2","4q2c","CRISPR-ASSOCIATED HELICASE CAS3","Thermobaculum terrenum",3,"LEU A 357;TYR A 354;SER A 392","None","0.89A","5iktA-4q2cA:undetectable","5iktA-4q2cA:19.48"],["5M0O_C_EPAC502_1","TERMINAL OLEFIN-FORMING FATTY ACID DECARBOXYLASE","4q2c","CRISPR-ASSOCIATED HELICASE CAS3","Thermobaculum terrenum",4,"LEU A 753;ARG A 750;ALA A 746;PRO A 328","None","0.86A","5m0oC-4q2cA:undetectable","5m0oC-4q2cA:19.27"],["5MVM_A_PFLA510_1","PROTON-GATED ION CHANNEL;PROTON-GATED ION CHANNEL","4q2c","CRISPR-ASSOCIATED HELICASE CAS3","Thermobaculum terrenum",5,"ILE A 596;ALA A 594;ILE A 595;ALA A 603;LEU A 606","None","1.14A","5mvmA-4q2cA:undetectable;5mvmE-4q2cA:undetectable","5mvmA-4q2cA:5.81;5mvmE-4q2cA:5.81"],["5ND3_B_TA1B601_1","TUBULIN BETA-2B CHAIN","4q2c","CRISPR-ASSOCIATED HELICASE CAS3","Thermobaculum terrenum",5,"VAL A 317;GLU A 316;LEU A 296;LEU A 339;ALA A 314","None","1.20A","5nd3B-4q2cA:undetectable","5nd3B-4q2cA:18.43"],["5NEK_B_AZMB302_1","PEPTIDOGLYCAN N-ACETYLGLUCOSAMINE DEACETYLASE","4q2c","CRISPR-ASSOCIATED HELICASE CAS3","Thermobaculum terrenum",4,"ASP A  99;HIS A 171;HIS A 138;HIS A  52"," NI A1001 (-2.7A); NI A1002 (-3.3A); NI A1002 (-3.3A); NI A1001 (-3.2A)","0.99A","5nekB-4q2cA:undetectable","5nekB-4q2cA:6.59"],["5NKN_A_LOCA201_2","NEUTROPHIL GELATINASE-ASSOCIATED LIPOCALIN","4q2c","CRISPR-ASSOCIATED HELICASE CAS3","Thermobaculum terrenum",3,"VAL A 476;LYS A 472;MET A 350","None","0.91A","5nknA-4q2cA:undetectable","5nknA-4q2cA:5.95"],["5NZW_A_9F2A1102_1","DNA CROSS-LINK REPAIR 1A PROTEIN","4q2c","CRISPR-ASSOCIATED HELICASE CAS3","Thermobaculum terrenum",5,"HIS A  98;HIS A  52;HIS A 171;ASP A 237;HIS A 172"," NI A1001 (-3.4A); NI A1001 (-3.2A); NI A1002 (-3.3A); NI A1001 ( 2.7A); NI A1002 ( 3.3A)","1.18A","5nzwA-4q2cA:2.2","5nzwA-4q2cA:15.26"],["5O96_A_SAMA501_0","RIBOSOMAL RNA SMALL SUBUNIT METHYLTRANSFERASE E","4q2c","CRISPR-ASSOCIATED HELICASE CAS3","Thermobaculum terrenum",5,"LEU A 469;GLU A 495;GLY A 498;ARG A 492;ALA A 455","None","0.99A","5o96A-4q2cA:undetectable;5o96B-4q2cA:undetectable","5o96A-4q2cA:14.66;5o96B-4q2cA:14.66"],["5OY0_1_PQN1842_1","PHOTOSYSTEM I P700 CHLOROPHYLL A APOPROTEIN A1;PHOTOSYSTEM I REACTION CENTER SUBUNIT IX","4q2c","CRISPR-ASSOCIATED HELICASE CAS3","Thermobaculum terrenum",5,"ARG A 707;ALA A 586;LEU A 587;GLY A 590;LEU A 937","None","1.24A","5oy01-4q2cA:undetectable;5oy07-4q2cA:undetectable","5oy01-4q2cA:7.77;5oy07-4q2cA:3.62"],["5UMW_B_RBFB201_1","GLYOXALASE\/BLEOMYCIN RESISANCE PROTEIN\/DIOXYGENASE;GLYOXALASE\/BLEOMYCIN RESISANCE PROTEIN\/DIOXYGENASE","4q2c","CRISPR-ASSOCIATED HELICASE CAS3","Thermobaculum terrenum",4,"ARG A 611;TYR A 607;GLU A 936;ARG A 932","None","0.93A","5umwB-4q2cA:undetectable;5umwE-4q2cA:undetectable","5umwB-4q2cA:8.56;5umwE-4q2cA:8.56"],["5X6Y_B_SAMB901_0","MRNA CAPPING ENZYME P5","4q2c","CRISPR-ASSOCIATED HELICASE CAS3","Thermobaculum terrenum",5,"VAL A 414;GLY A 413;ALA A 429;SER A 241;ASN A 242"," NI A1003 ( 4.6A);None;None; NI A1003 ( 4.8A);None","0.82A","5x6yB-4q2cA:undetectable","5x6yB-4q2cA:22.86"],["5YVN_A_ACTA305_0","GLUTATHIONE S-TRANSFERASE OMEGA-1","4q2c","CRISPR-ASSOCIATED HELICASE CAS3","Thermobaculum terrenum",4,"GLU A 641;LEU A 628;LEU A 645;LEU A 670","None","1.02A","5yvnA-4q2cA:undetectable","5yvnA-4q2cA:13.87"],["5ZRD_A_CUA607_0","TYROSINASE","4q2c","CRISPR-ASSOCIATED HELICASE CAS3","Thermobaculum terrenum",3,"HIS A 172;HIS A 171;HIS A 138"," NI A1002 ( 3.3A); NI A1002 (-3.3A); NI A1002 (-3.3A)","0.47A","5zrdA-4q2cA:undetectable","5zrdA-4q2cA:20.15"],["6AJI_A_AY6A1001_0","DRUG EXPORTERS OF THE RND SUPERFAMILY-LIKE PROTEIN,ENDOLYSIN","4q2c","CRISPR-ASSOCIATED HELICASE CAS3","Thermobaculum terrenum",5,"LEU A 493;VAL A 502;LEU A 500;VAL A 456;ALA A 455","None","0.82A","6ajiA-4q2cA:undetectable","6ajiA-4q2cA:23.01"],["6B58_A_ACTA609_0","FUMARATE REDUCTASE FLAVOPROTEIN SUBUNIT","4q2c","CRISPR-ASSOCIATED HELICASE CAS3","Thermobaculum terrenum",3,"HIS A 697;HIS A 700;ARG A 704","None","1.02A","6b58A-4q2cA:undetectable","6b58A-4q2cA:22.78"],["6BQG_A_ERMA1201_2","5-HYDROXYTRYPTAMINE RECEPTOR 2C,SOLUBLE CYTOCHROME B562","4q2c","CRISPR-ASSOCIATED HELICASE CAS3","Thermobaculum terrenum",4,"VAL A 506;LEU A 494;VAL A 456;LEU A 469","None","0.95A","6bqgA-4q2cA:undetectable","6bqgA-4q2cA:6.40"],["6CDU_F_EY4F500_0","CHIMERIC ALPHA1GABAA RECEPTOR","4q2c","CRISPR-ASSOCIATED HELICASE CAS3","Thermobaculum terrenum",4,"ALA A 337;THR A 334;ILE A 324;VAL A 505","None","0.95A","6cduF-4q2cA:undetectable;6cduJ-4q2cA:undetectable","6cduF-4q2cA:15.80;6cduJ-4q2cA:15.80"],["6ESM_A_PZEA307_1","MATRIX METALLOPROTEINASE-9,MATRIX METALLOPROTEINASE-9","4q2c","CRISPR-ASSOCIATED HELICASE CAS3","Thermobaculum terrenum",3,"TYR A 415;HIS A 138;PHE A 107","None; NI A1002 (-3.3A);None","1.04A","6esmA-4q2cA:undetectable","6esmA-4q2cA:6.27"],["6HQB_A_PQNA2001_0","PHOTOSYSTEM I P700 CHLOROPHYLL A APOPROTEIN A1;PHOTOSYSTEM I REACTION CENTER SUBUNIT IX","4q2c","CRISPR-ASSOCIATED HELICASE CAS3","Thermobaculum terrenum",5,"ARG A 707;ALA A 586;LEU A 587;GLY A 590;LEU A 937","None","1.31A","6hqbA-4q2cA:undetectable;6hqbJ-4q2cA:undetectable","6hqbA-4q2cA:6.40;6hqbJ-4q2cA:3.62"]]