SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4q2e'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TZ8_B_DESB128_1
(TRANSTHYRETIN)		 4q2e PHOSPHATIDATE
CYTIDYLYLTRANSFERASE
(Thermotoga
maritima) 		5 / 11 LEU A  81
ALA A  59
LEU A 272
LEU A 138
SER A 139
 None
 1.18A 1tz8A-4q2eA:
undetectable
1tz8B-4q2eA:
undetectable		 1tz8A-4q2eA:
17.24
1tz8B-4q2eA:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TZ8_B_DESB128_1
(TRANSTHYRETIN)		 4q2e PHOSPHATIDATE
CYTIDYLYLTRANSFERASE
(Thermotoga
maritima) 		5 / 11 LEU A 272
LEU A 138
SER A 139
LEU A  81
ALA A  59
 None
 1.11A 1tz8A-4q2eA:
undetectable
1tz8B-4q2eA:
undetectable		 1tz8A-4q2eA:
17.24
1tz8B-4q2eA:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDV_E_SAME1287_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 4q2e PHOSPHATIDATE
CYTIDYLYLTRANSFERASE
(Thermotoga
maritima) 		5 / 12 GLY A 195
GLY A 191
ALA A 228
PHE A 169
ASP A 164
 None
None
None
None
MG  A 304 (-3.9A)
 1.16A 2vdvE-4q2eA:
undetectable		 2vdvE-4q2eA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDV_F_SAMF1287_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 4q2e PHOSPHATIDATE
CYTIDYLYLTRANSFERASE
(Thermotoga
maritima) 		5 / 11 GLY A 195
GLY A 191
ALA A 228
PHE A 169
ASP A 164
 None
None
None
None
MG  A 304 (-3.9A)
 1.16A 2vdvF-4q2eA:
undetectable		 2vdvF-4q2eA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G2O_A_SAMA500_0
(PCZA361.24)		 4q2e PHOSPHATIDATE
CYTIDYLYLTRANSFERASE
(Thermotoga
maritima) 		5 / 12 GLY A  60
LEU A  66
LEU A 138
SER A 254
GLY A 263
 None
 1.07A 3g2oA-4q2eA:
undetectable		 3g2oA-4q2eA:
27.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_B_ROCB201_4
(HIV-1 PROTEASE)		 4q2e PHOSPHATIDATE
CYTIDYLYLTRANSFERASE
(Thermotoga
maritima) 		4 / 4 ARG A  74
ASP A 269
GLY A 262
THR A 257
 None
MG  A 304 ( 2.8A)
None
None
 1.34A 3k4vB-4q2eA:
undetectable		 3k4vB-4q2eA:
16.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NBQ_A_URFA400_1
(URIDINE
PHOSPHORYLASE 1)		 4q2e PHOSPHATIDATE
CYTIDYLYLTRANSFERASE
(Thermotoga
maritima) 		5 / 9 THR A 160
GLY A 270
LEU A 271
LEU A 272
ILE A 268
 None
MG  A 304 (-3.9A)
None
None
None
 1.44A 3nbqA-4q2eA:
undetectable		 3nbqA-4q2eA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NBQ_D_URFD400_1
(URIDINE
PHOSPHORYLASE 1)		 4q2e PHOSPHATIDATE
CYTIDYLYLTRANSFERASE
(Thermotoga
maritima) 		5 / 9 THR A 160
GLY A 270
LEU A 271
LEU A 272
ILE A 268
 None
MG  A 304 (-3.9A)
None
None
None
 1.46A 3nbqD-4q2eA:
undetectable		 3nbqD-4q2eA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AFT_D_QMRD301_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4q2e PHOSPHATIDATE
CYTIDYLYLTRANSFERASE
(Thermotoga
maritima) 		4 / 8 TYR A 206
VAL A 156
TYR A 202
VAL A 274
 None
 1.04A 4aftD-4q2eA:
undetectable
4aftE-4q2eA:
undetectable		 4aftD-4q2eA:
22.30
4aftE-4q2eA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_C_RBFC201_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 4q2e PHOSPHATIDATE
CYTIDYLYLTRANSFERASE
(Thermotoga
maritima) 		5 / 9 ILE A  49
LEU A  58
VAL A 134
LEU A 138
ILE A 268
 None
 1.35A 4r38C-4q2eA:
undetectable		 4r38C-4q2eA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_3_BEZ3801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 4q2e PHOSPHATIDATE
CYTIDYLYLTRANSFERASE
(Thermotoga
maritima) 		4 / 4 LEU A 265
ILE A 268
GLY A  60
ILE A  55
 None
 0.88A 5dzk3-4q2eA:
undetectable
5dzkm-4q2eA:
undetectable		 5dzk3-4q2eA:
0.93
5dzkm-4q2eA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNZ_B_TA1B902_1
(TUBULIN BETA-2B
CHAIN)		 4q2e PHOSPHATIDATE
CYTIDYLYLTRANSFERASE
(Thermotoga
maritima) 		5 / 12 ASP A 235
LEU A  56
ALA A 275
SER A 278
PHE A 141
 MG  A 304 ( 3.8A)
None
None
None
None
 1.05A 5hnzB-4q2eA:
undetectable		 5hnzB-4q2eA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5C_B_TA1B502_1
(TUBULIN BETA-2B
CHAIN)		 4q2e PHOSPHATIDATE
CYTIDYLYLTRANSFERASE
(Thermotoga
maritima) 		5 / 12 VAL A 156
LEU A 272
ALA A 275
SER A 278
LEU A 142
 None
 1.05A 5m5cB-4q2eA:
undetectable		 5m5cB-4q2eA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5C_E_TA1E502_1
(TUBULIN BETA-2B
CHAIN)		 4q2e PHOSPHATIDATE
CYTIDYLYLTRANSFERASE
(Thermotoga
maritima) 		5 / 10 VAL A 156
LEU A 272
ALA A 275
SER A 278
LEU A 142
 None
 1.08A 5m5cE-4q2eA:
undetectable		 5m5cE-4q2eA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND4_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 4q2e PHOSPHATIDATE
CYTIDYLYLTRANSFERASE
(Thermotoga
maritima) 		5 / 12 VAL A 156
LEU A 272
ALA A 275
PRO A 143
LEU A 142
 None
 1.22A 5nd4B-4q2eA:
undetectable		 5nd4B-4q2eA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND4_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 4q2e PHOSPHATIDATE
CYTIDYLYLTRANSFERASE
(Thermotoga
maritima) 		5 / 12 VAL A 156
LEU A 272
ALA A 275
SER A 278
LEU A 142
 None
 1.24A 5nd4B-4q2eA:
undetectable		 5nd4B-4q2eA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NUN_A_Z80A201_1
(BETA-LACTOGLOBULIN)		 4q2e PHOSPHATIDATE
CYTIDYLYLTRANSFERASE
(Thermotoga
maritima) 		5 / 9 ALA A  35
VAL A  38
LEU A  51
ILE A  55
ILE A 268
 None
 1.01A 5nunA-4q2eA:
undetectable		 5nunA-4q2eA:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BC9_A_ETSA302_2
(CARBONIC ANHYDRASE 2)		 4q2e PHOSPHATIDATE
CYTIDYLYLTRANSFERASE
(Thermotoga
maritima) 		4 / 5 HIS A 248
GLU A 242
LEU A  81
VAL A 134
 None
K  A 305 (-4.4A)
None
None
 1.18A 6bc9A-4q2eA:
undetectable		 6bc9A-4q2eA:
13.78