SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4q2h'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIK_A_ADNA799_1
(ADENOSINE KINASE)		 4q2h PROLINE RACEMASE
PROTEIN
(Agrobacterium
tumefaciens) 		5 / 10 THR A 257
GLY A 173
VAL A 147
ALA A  91
ILE A 222
 BCT  A 401 (-2.8A)
None
None
None
None
 0.92A 1likA-4q2hA:
undetectable		 1likA-4q2hA:
24.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OPJ_B_STIB4_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4q2h PROLINE RACEMASE
PROTEIN
(Agrobacterium
tumefaciens) 		4 / 6 LEU A 197
ILE A 284
MET A 229
ARG A  20
 None
None
CSO  A 255 ( 4.0A)
None
 1.09A 1opjB-4q2hA:
undetectable		 1opjB-4q2hA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P2Y_A_NCTA440_1
(CYTOCHROME P450-CAM)		 4q2h PROLINE RACEMASE
PROTEIN
(Agrobacterium
tumefaciens) 		4 / 7 PHE A  81
LEU A 144
GLY A 256
ILE A  83
 None
None
CSO  A 255 (-2.4A)
None
 0.76A 1p2yA-4q2hA:
undetectable		 1p2yA-4q2hA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBC_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)		 4q2h PROLINE RACEMASE
PROTEIN
(Agrobacterium
tumefaciens) 		5 / 10 GLY A  25
VAL A  26
LEU A  54
ARG A   5
ALA A  22
 None
 1.21A 1pbcA-4q2hA:
undetectable		 1pbcA-4q2hA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBF_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)		 4q2h PROLINE RACEMASE
PROTEIN
(Agrobacterium
tumefaciens) 		5 / 9 VAL A  26
LEU A  50
LEU A  54
ARG A   5
ALA A  22
 None
 1.39A 1pbfA-4q2hA:
0.1		 1pbfA-4q2hA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_I_URFI2041_1
(URIDINE
PHOSPHORYLASE)		 4q2h PROLINE RACEMASE
PROTEIN
(Agrobacterium
tumefaciens) 		4 / 8 THR A 309
GLY A 291
GLN A 293
VAL A 277
 None
 0.92A 1rxcI-4q2hA:
undetectable		 1rxcI-4q2hA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_K_URFK2061_1
(URIDINE
PHOSPHORYLASE)		 4q2h PROLINE RACEMASE
PROTEIN
(Agrobacterium
tumefaciens) 		4 / 8 THR A 309
GLY A 291
GLN A 293
VAL A 277
 None
 0.97A 1rxcK-4q2hA:
undetectable		 1rxcK-4q2hA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UKB_A_BEZA1300_0
(2-HYDROXY-6-OXO-7-ME
THYLOCTA-2,4-DIENOAT
E HYDROLASE)		 4q2h PROLINE RACEMASE
PROTEIN
(Agrobacterium
tumefaciens) 		5 / 11 GLY A 174
ALA A 125
ALA A 124
LEU A  38
VAL A 128
 None
 1.01A 1ukbA-4q2hA:
undetectable		 1ukbA-4q2hA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
209D_C_DVAC2_0
(N8-ACTINOMYCIN D)		 4q2h PROLINE RACEMASE
PROTEIN
(Agrobacterium
tumefaciens) 		3 / 3 THR A 117
PRO A 115
THR A 133
 None
 0.78A 209dC-4q2hA:
undetectable		 209dC-4q2hA:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GJ5_A_VD3A164_1
(BETA-LACTOGLOBULIN)		 4q2h PROLINE RACEMASE
PROTEIN
(Agrobacterium
tumefaciens) 		4 / 5 ASP A 169
LEU A 179
MET A 229
ARG A 231
 None
None
CSO  A 255 ( 4.0A)
None
 1.15A 2gj5A-4q2hA:
undetectable		 2gj5A-4q2hA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNJ_A_225A501_1
(CYTOCHROME P450 2C8)		 4q2h PROLINE RACEMASE
PROTEIN
(Agrobacterium
tumefaciens) 		5 / 10 ILE A 219
ALA A 124
VAL A 128
VAL A 147
PRO A 148
 None
 0.93A 2nnjA-4q2hA:
undetectable		 2nnjA-4q2hA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AX7_B_SALB1336_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 4q2h PROLINE RACEMASE
PROTEIN
(Agrobacterium
tumefaciens) 		5 / 9 SER A  97
PHE A  81
VAL A 128
ALA A  79
ALA A  80
 None
 1.49A 3ax7B-4q2hA:
undetectable		 3ax7B-4q2hA:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_H_SVRH504_3
(PHOSPHOLIPASE A2)		 4q2h PROLINE RACEMASE
PROTEIN
(Agrobacterium
tumefaciens) 		5 / 11 VAL A 290
SER A 253
PRO A 254
THR A 241
LYS A 191
 None
CSO  A 255 ( 3.0A)
CSO  A 255 ( 3.3A)
CSO  A 255 ( 4.9A)
None
 1.04A 3bjwH-4q2hA:
undetectable		 3bjwH-4q2hA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CR4_X_PNTX101_0
(PROTEIN S100-B)		 4q2h PROLINE RACEMASE
PROTEIN
(Agrobacterium
tumefaciens) 		3 / 3 CYH A 171
HIS A 152
PHE A 150
 None
 1.13A 3cr4X-4q2hA:
undetectable		 3cr4X-4q2hA:
12.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK3_A_0LIA1_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4q2h PROLINE RACEMASE
PROTEIN
(Agrobacterium
tumefaciens) 		4 / 7 LEU A 197
ILE A 284
MET A 229
ARG A  20
 None
None
CSO  A 255 ( 4.0A)
None
 1.16A 3ik3A-4q2hA:
undetectable		 3ik3A-4q2hA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK3_B_0LIB2_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4q2h PROLINE RACEMASE
PROTEIN
(Agrobacterium
tumefaciens) 		4 / 7 LEU A 197
ILE A 284
MET A 229
ARG A  20
 None
None
CSO  A 255 ( 4.0A)
None
 1.16A 3ik3B-4q2hA:
undetectable		 3ik3B-4q2hA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWW_A_ROCA1001_2
(ENDOTHIAPEPSIN)		 4q2h PROLINE RACEMASE
PROTEIN
(Agrobacterium
tumefaciens) 		4 / 8 GLY A 173
SER A 260
ASP A 251
SER A 253
 None
None
CSO  A 255 (-3.5A)
CSO  A 255 ( 3.0A)
 0.84A 3pwwA-4q2hA:
undetectable		 3pwwA-4q2hA:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WDM_D_ADND301_1
(4-PHOSPHOPANTOATE--B
ETA-ALANINE LIGASE)		 4q2h PROLINE RACEMASE
PROTEIN
(Agrobacterium
tumefaciens) 		5 / 10 ALA A  89
LEU A  70
LEU A  41
LEU A  50
ILE A  29
 None
 1.17A 3wdmD-4q2hA:
undetectable		 3wdmD-4q2hA:
24.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_A_URFA1301_1
(URIDINE
PHOSPHORYLASE)		 4q2h PROLINE RACEMASE
PROTEIN
(Agrobacterium
tumefaciens) 		4 / 8 THR A 309
GLY A 291
GLN A 293
VAL A 277
 None
 0.96A 4e1vA-4q2hA:
undetectable		 4e1vA-4q2hA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_E_URFE1301_1
(URIDINE
PHOSPHORYLASE)		 4q2h PROLINE RACEMASE
PROTEIN
(Agrobacterium
tumefaciens) 		4 / 8 THR A 309
GLY A 291
GLN A 293
VAL A 277
 None
 0.95A 4e1vE-4q2hA:
undetectable		 4e1vE-4q2hA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E47_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 4q2h PROLINE RACEMASE
PROTEIN
(Agrobacterium
tumefaciens) 		5 / 11 ILE A 222
ALA A 125
GLY A 126
GLU A 122
HIS A  90
 None
 1.17A 4e47A-4q2hA:
undetectable		 4e47A-4q2hA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E47_B_SAMB800_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 4q2h PROLINE RACEMASE
PROTEIN
(Agrobacterium
tumefaciens) 		5 / 11 ILE A 222
ALA A 125
GLY A 126
GLU A 122
HIS A  90
 None
 1.19A 4e47B-4q2hA:
undetectable		 4e47B-4q2hA:
22.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LB0_A_ACTA401_0
(UNCHARACTERIZED
PROTEIN)		 4q2h PROLINE RACEMASE
PROTEIN
(Agrobacterium
tumefaciens) 		8 / 9 SER A  93
GLY A  94
SER A  95
TYR A 177
ASP A 251
SER A 253
GLY A 256
THR A 257
 BCT  A 401 (-3.5A)
BCT  A 401 (-3.6A)
BCT  A 401 (-3.4A)
CSO  A 255 ( 4.8A)
CSO  A 255 (-3.5A)
CSO  A 255 ( 3.0A)
CSO  A 255 (-2.4A)
BCT  A 401 (-2.8A)
 0.11A 4lb0A-4q2hA:
59.7		 4lb0A-4q2hA:
77.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LB0_A_ACTA401_0
(UNCHARACTERIZED
PROTEIN)		 4q2h PROLINE RACEMASE
PROTEIN
(Agrobacterium
tumefaciens) 		5 / 9 SER A  93
GLY A  94
SER A  95
TYR A 227
SER A 253
 BCT  A 401 (-3.5A)
BCT  A 401 (-3.6A)
BCT  A 401 (-3.4A)
None
CSO  A 255 ( 3.0A)
 0.97A 4lb0A-4q2hA:
59.7		 4lb0A-4q2hA:
77.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_B_CHDB504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4q2h PROLINE RACEMASE
PROTEIN
(Agrobacterium
tumefaciens) 		3 / 3 LEU A 197
ILE A 283
ARG A 240
 None
 0.68A 4mk4B-4q2hA:
undetectable		 4mk4B-4q2hA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MX0_A_BCZA513_1
(NEURAMINIDASE)		 4q2h PROLINE RACEMASE
PROTEIN
(Agrobacterium
tumefaciens) 		3 / 3 ARG A 269
ASP A 155
ARG A 231
 None
 1.01A 4mx0A-4q2hA:
undetectable		 4mx0A-4q2hA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OQR_A_2UOA502_1
(CYP105AS1)		 4q2h PROLINE RACEMASE
PROTEIN
(Agrobacterium
tumefaciens) 		5 / 9 VAL A 128
ILE A 109
THR A 117
VAL A 142
ALA A 130
 None
 1.20A 4oqrA-4q2hA:
undetectable		 4oqrA-4q2hA:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5I_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4q2h PROLINE RACEMASE
PROTEIN
(Agrobacterium
tumefaciens) 		5 / 12 ILE A  83
LEU A  54
ILE A  29
LEU A  41
ILE A  82
 None
 0.87A 4x5iA-4q2hA:
undetectable		 4x5iA-4q2hA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ALC_L_TIQL1210_2
(ANTI-TICAGRELOR FAB
72, LIGHT CHAIN)		 4q2h PROLINE RACEMASE
PROTEIN
(Agrobacterium
tumefaciens) 		4 / 8 SER A 149
GLY A 173
ILE A 239
GLY A 256
 None
None
GOL  A 402 ( 4.8A)
CSO  A 255 (-2.4A)
 0.66A 5alcL-4q2hA:
undetectable		 5alcL-4q2hA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B2S_A_ACTA107_0
(CRISPR-ASSOCIATED
ENDONUCLEASE CAS9
GUIDE RNA)		 4q2h PROLINE RACEMASE
PROTEIN
(Agrobacterium
tumefaciens) 		3 / 3 VAL A 118
THR A 120
ARG A 129
 None
 0.76A 5b2sB-4q2hA:
0.0		 5b2sB-4q2hA:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B2T_A_ACTA108_0
(CRISPR-ASSOCIATED
ENDONUCLEASE CAS9
GUIDE RNA)		 4q2h PROLINE RACEMASE
PROTEIN
(Agrobacterium
tumefaciens) 		3 / 3 VAL A 118
THR A 120
ARG A 129
 None
 0.78A 5b2tB-4q2hA:
undetectable		 5b2tB-4q2hA:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E2I_A_DMEA605_1
(ACETYLCHOLINESTERASE)		 4q2h PROLINE RACEMASE
PROTEIN
(Agrobacterium
tumefaciens) 		4 / 6 TYR A 227
ASP A 251
TYR A 177
PHE A 288
 None
CSO  A 255 (-3.5A)
CSO  A 255 ( 4.8A)
CSO  A 255 ( 4.7A)
 1.41A 5e2iA-4q2hA:
undetectable		 5e2iA-4q2hA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEO_A_VDYA206_2
(CDL2.3A)		 4q2h PROLINE RACEMASE
PROTEIN
(Agrobacterium
tumefaciens) 		4 / 8 ILE A 304
PRO A 306
MET A 229
ILE A 239
 None
None
CSO  A 255 ( 4.0A)
GOL  A 402 ( 4.8A)
 0.99A 5ieoA-4q2hA:
undetectable		 5ieoA-4q2hA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IK1_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 4q2h PROLINE RACEMASE
PROTEIN
(Agrobacterium
tumefaciens) 		4 / 5 PHE A  81
LEU A 144
GLY A 256
ILE A  83
 None
None
CSO  A 255 (-2.4A)
None
 0.97A 5ik1A-4q2hA:
undetectable		 5ik1A-4q2hA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KB6_A_ADNA401_1
(ADENOSINE KINASE)		 4q2h PROLINE RACEMASE
PROTEIN
(Agrobacterium
tumefaciens) 		5 / 12 THR A 257
GLY A 173
VAL A 147
ALA A  91
ILE A 222
 BCT  A 401 (-2.8A)
None
None
None
None
 0.88A 5kb6A-4q2hA:
undetectable		 5kb6A-4q2hA:
23.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KB6_B_ADNB401_1
(ADENOSINE KINASE)		 4q2h PROLINE RACEMASE
PROTEIN
(Agrobacterium
tumefaciens) 		5 / 12 THR A 257
GLY A 173
VAL A 147
ALA A  91
ILE A 222
 BCT  A 401 (-2.8A)
None
None
None
None
 0.88A 5kb6B-4q2hA:
undetectable		 5kb6B-4q2hA:
23.52