SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4q2n'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_A_MTXA605_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 4q2n INAD-LIKE PROTEIN
(Homo
sapiens) 		5 / 12 VAL A 437
ALA A 441
LEU A 376
LEU A 447
ILE A 380
 None
 1.00A 2oipA-4q2nA:
undetectable		 2oipA-4q2nA:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA508_0
(CHORISMATE SYNTHASE)		 4q2n INAD-LIKE PROTEIN
(Homo
sapiens) 		4 / 5 LEU A 438
ASP A 422
ALA A 441
ILE A 426
 None
 1.12A 2qhfA-4q2nA:
undetectable		 2qhfA-4q2nA:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9G_A_TOPA1159_1
(DIHYDROFOLATE
REDUCTASE)		 4q2n INAD-LIKE PROTEIN
(Homo
sapiens) 		5 / 10 ALA A 441
LEU A 376
LEU A 447
VAL A 421
ILE A 380
 None
 0.97A 2w9gA-4q2nA:
undetectable		 2w9gA-4q2nA:
24.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9H_A_TOPA1160_1
(DIHYDROFOLATE
REDUCTASE)		 4q2n INAD-LIKE PROTEIN
(Homo
sapiens) 		5 / 10 ALA A 441
LEU A 376
LEU A 447
VAL A 421
ILE A 380
 None
 1.05A 2w9hA-4q2nA:
undetectable		 2w9hA-4q2nA:
24.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_B_TOPB200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 4q2n INAD-LIKE PROTEIN
(Homo
sapiens) 		5 / 12 ALA A 441
LEU A 376
LEU A 447
VAL A 421
ILE A 380
 None
 1.03A 3fl9B-4q2nA:
undetectable		 3fl9B-4q2nA:
24.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_E_TOPE200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 4q2n INAD-LIKE PROTEIN
(Homo
sapiens) 		5 / 10 ALA A 441
LEU A 376
LEU A 447
VAL A 421
ILE A 380
 None
 0.97A 3fl9E-4q2nA:
undetectable		 3fl9E-4q2nA:
24.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_G_TOPG200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 4q2n INAD-LIKE PROTEIN
(Homo
sapiens) 		5 / 12 ALA A 441
LEU A 376
LEU A 447
VAL A 421
ILE A 380
 None
 1.14A 3fl9G-4q2nA:
undetectable		 3fl9G-4q2nA:
24.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRB_X_TOPX300_1
(DIHYDROFOLATE
REDUCTASE)		 4q2n INAD-LIKE PROTEIN
(Homo
sapiens) 		5 / 11 ALA A 441
LEU A 376
LEU A 447
VAL A 421
ILE A 380
 None
 0.93A 3frbX-4q2nA:
undetectable		 3frbX-4q2nA:
24.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRE_X_TOPX300_1
(DIHYDROFOLATE
REDUCTASE)		 4q2n INAD-LIKE PROTEIN
(Homo
sapiens) 		5 / 9 ALA A 441
LEU A 376
LEU A 447
VAL A 421
ILE A 380
 None
 0.91A 3freX-4q2nA:
undetectable		 3freX-4q2nA:
24.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NUO_B_478B478_1
(PROTEASE)		 4q2n INAD-LIKE PROTEIN
(Homo
sapiens) 		5 / 9 ASP A 416
ILE A 412
GLY A 377
VAL A 421
ILE A 418
 None
 1.13A 3nuoA-4q2nA:
undetectable		 3nuoA-4q2nA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_B_MTXB603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 4q2n INAD-LIKE PROTEIN
(Homo
sapiens) 		5 / 12 VAL A 437
ALA A 441
LEU A 376
LEU A 447
ILE A 380
 None
 1.00A 4ky8B-4q2nA:
undetectable		 4ky8B-4q2nA:
11.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_E_MTXE603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 4q2n INAD-LIKE PROTEIN
(Homo
sapiens) 		5 / 12 VAL A 437
ALA A 441
LEU A 376
LEU A 447
ILE A 380
 None
 1.02A 4ky8E-4q2nA:
undetectable		 4ky8E-4q2nA:
11.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_B_MXMB606_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4q2n INAD-LIKE PROTEIN
(Homo
sapiens) 		6 / 12 VAL A 366
ILE A 418
VAL A 397
LEU A 449
ALA A 406
LEU A 376
 None
 1.36A 4m11B-4q2nA:
undetectable		 4m11B-4q2nA:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_A_MTXA604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4q2n INAD-LIKE PROTEIN
(Homo
sapiens) 		5 / 12 VAL A 437
ALA A 441
LEU A 376
LEU A 447
ILE A 380
 None
 1.01A 4q0dA-4q2nA:
undetectable		 4q0dA-4q2nA:
11.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_B_MTXB604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4q2n INAD-LIKE PROTEIN
(Homo
sapiens) 		5 / 12 VAL A 437
ALA A 441
LEU A 376
LEU A 447
ILE A 380
 None
 1.01A 4q0dB-4q2nA:
undetectable		 4q0dB-4q2nA:
11.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_E_MTXE604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4q2n INAD-LIKE PROTEIN
(Homo
sapiens) 		5 / 12 VAL A 437
ALA A 441
LEU A 376
LEU A 447
ILE A 380
 None
 1.01A 4q0dE-4q2nA:
undetectable		 4q0dE-4q2nA:
11.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUG_A_VIVA301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 4q2n INAD-LIKE PROTEIN
(Homo
sapiens) 		5 / 12 VAL A 434
VAL A 445
LEU A 368
VAL A 366
ILE A 412
 None
 1.03A 5mugA-4q2nA:
undetectable		 5mugA-4q2nA:
23.46