SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4q34'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMA_B_SAMB105_0
(PROTEIN (MET
REPRESSOR))		 4q34 UNCHARACTERIZED
PROTEIN
(Parabacteroides
distasonis) 		5 / 11 GLU A  81
LEU A 103
HIS A 193
PHE A  76
GLY A  74
 GOL  A 404 (-3.6A)
None
None
None
None
 1.23A 1cmaA-4q34A:
undetectable
1cmaB-4q34A:
undetectable		 1cmaA-4q34A:
18.46
1cmaB-4q34A:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMC_A_SAMA105_0
(MET REPRESSOR)		 4q34 UNCHARACTERIZED
PROTEIN
(Parabacteroides
distasonis) 		5 / 10 PHE A  76
GLY A  74
GLU A  81
LEU A 103
HIS A 193
 None
None
GOL  A 404 (-3.6A)
None
None
 1.24A 1cmcA-4q34A:
undetectable
1cmcB-4q34A:
undetectable		 1cmcA-4q34A:
18.46
1cmcB-4q34A:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSG_B_MK1B902_1
(HIV-1 PROTEASE)		 4q34 UNCHARACTERIZED
PROTEIN
(Parabacteroides
distasonis) 		5 / 10 LEU A 294
VAL A 258
ILE A 210
GLY A 200
VAL A 301
 None
None
GOL  A 406 (-3.9A)
None
None
 1.00A 1hsgA-4q34A:
undetectable		 1hsgA-4q34A:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OHR_A_1UNA201_2
(ASPARTYLPROTEASE)		 4q34 UNCHARACTERIZED
PROTEIN
(Parabacteroides
distasonis) 		5 / 9 LEU A 294
VAL A 258
ILE A 210
GLY A 200
VAL A 301
 None
None
GOL  A 406 (-3.9A)
None
None
 0.92A 1ohrB-4q34A:
undetectable		 1ohrB-4q34A:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U70_A_MTXA187_2
(DIHYDROFOLATE
REDUCTASE)		 4q34 UNCHARACTERIZED
PROTEIN
(Parabacteroides
distasonis) 		4 / 4 SER A 215
ILE A 262
VAL A 222
THR A 237
 None
 1.13A 1u70A-4q34A:
undetectable		 1u70A-4q34A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_D_SAMD301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4q34 UNCHARACTERIZED
PROTEIN
(Parabacteroides
distasonis) 		3 / 3 ASP A 176
ASP A 183
ASN A 202
 None
 0.72A 2bm9D-4q34A:
undetectable		 2bm9D-4q34A:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QWX_B_ML1B233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4q34 UNCHARACTERIZED
PROTEIN
(Parabacteroides
distasonis) 		4 / 7 GLY A  74
MET A 162
GLY A 219
PHE A 317
 None
 0.98A 2qwxA-4q34A:
undetectable
2qwxB-4q34A:
undetectable		 2qwxA-4q34A:
22.35
2qwxB-4q34A:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D4S_A_TIMA401_2
(BETA-2 ADRENERGIC
RECEPTOR/T4-LYSOZYME
CHIMERA)		 4q34 UNCHARACTERIZED
PROTEIN
(Parabacteroides
distasonis) 		3 / 3 THR A 192
SER A 215
PHE A 317
 None
 0.80A 3d4sA-4q34A:
undetectable		 3d4sA-4q34A:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FU8_A_ACTA302_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 4q34 UNCHARACTERIZED
PROTEIN
(Parabacteroides
distasonis) 		4 / 5 HIS A 316
GLN A  75
GLY A  72
SER A 194
 None
None
None
CL  A 401 ( 4.0A)
 1.32A 4fu8A-4q34A:
undetectable		 4fu8A-4q34A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FUB_A_ACTA311_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 4q34 UNCHARACTERIZED
PROTEIN
(Parabacteroides
distasonis) 		3 / 3 TYR A 264
ARG A 135
HIS A 316
 None
 1.21A 4fubA-4q34A:
undetectable		 4fubA-4q34A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_B_SAMB601_0
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 4q34 UNCHARACTERIZED
PROTEIN
(Parabacteroides
distasonis) 		5 / 12 ALA A  33
GLY A  49
GLY A  36
THR A 116
GLY A 113
 None
 0.94A 4n48B-4q34A:
undetectable		 4n48B-4q34A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1802_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 4q34 UNCHARACTERIZED
PROTEIN
(Parabacteroides
distasonis) 		4 / 7 SER A 239
THR A 237
PHE A 235
ILE A 245
 None
 1.16A 5vkqA-4q34A:
undetectable
5vkqB-4q34A:
undetectable		 5vkqA-4q34A:
11.10
5vkqB-4q34A:
11.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1803_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 4q34 UNCHARACTERIZED
PROTEIN
(Parabacteroides
distasonis) 		4 / 8 THR A 237
PHE A 171
PHE A 235
ILE A 245
 None
 0.91A 5vkqB-4q34A:
undetectable
5vkqC-4q34A:
undetectable		 5vkqB-4q34A:
11.10
5vkqC-4q34A:
11.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1803_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 4q34 UNCHARACTERIZED
PROTEIN
(Parabacteroides
distasonis) 		4 / 7 SER A 239
THR A 237
PHE A 235
ILE A 245
 None
 1.14A 5vkqC-4q34A:
undetectable
5vkqD-4q34A:
undetectable		 5vkqC-4q34A:
11.10
5vkqD-4q34A:
11.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W4Z_B_RBFB502_2
(RIBOFLAVIN LYASE)		 4q34 UNCHARACTERIZED
PROTEIN
(Parabacteroides
distasonis) 		4 / 4 ASN A 314
GLN A 147
ASP A 321
THR A  79
 None
 1.36A 5w4zB-4q34A:
undetectable		 5w4zB-4q34A:
12.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W4Z_B_RBFB502_2
(RIBOFLAVIN LYASE)		 4q34 UNCHARACTERIZED
PROTEIN
(Parabacteroides
distasonis) 		4 / 4 ASN A 323
GLN A 147
ASP A 321
THR A  79
 None
 1.47A 5w4zB-4q34A:
undetectable		 5w4zB-4q34A:
12.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DIL_B_TPVB201_0
(HIV-1 PROTEASE)		 4q34 UNCHARACTERIZED
PROTEIN
(Parabacteroides
distasonis) 		5 / 12 LEU A 294
VAL A 258
ILE A 210
GLY A 200
VAL A 301
 None
None
GOL  A 406 (-3.9A)
None
None
 1.01A 6dilA-4q34A:
undetectable		 6dilA-4q34A:
11.15