SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4q38'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK3_A_T44A3001_1
(SERUM ALBUMIN)
4q38 PUTATIVE
UNCHARACTERIZED
PROTEIN TCP24

(Actinoplanes
teichomyceticus)
5 / 11 TRP A 163
PRO A  93
LEU A 173
HIS A 196
ALA A 184
TEC  A 404 (-4.6A)
None
None
TEC  A 404 (-4.1A)
None
1.46A 1hk3A-4q38A:
undetectable
1hk3A-4q38A:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW5_A_SAMA401_1
(MODIFICATION
METHYLASE RSRI)
4q38 PUTATIVE
UNCHARACTERIZED
PROTEIN TCP24

(Actinoplanes
teichomyceticus)
3 / 3 ASP A 275
HIS A 306
ASP A 240
None
0.63A 1nw5A-4q38A:
undetectable
1nw5A-4q38A:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_1
(DNA TOPOISOMERASE II)
4q38 PUTATIVE
UNCHARACTERIZED
PROTEIN TCP24

(Actinoplanes
teichomyceticus)
4 / 7 ASN A 286
TYR A 285
LEU A 293
GLN A 288
None
1.00A 1qzrA-4q38A:
0.0
1qzrA-4q38A:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_2
(DNA TOPOISOMERASE II)
4q38 PUTATIVE
UNCHARACTERIZED
PROTEIN TCP24

(Actinoplanes
teichomyceticus)
4 / 7 ASN A 286
TYR A 285
LEU A 293
GLN A 288
None
0.90A 1qzrB-4q38A:
undetectable
1qzrB-4q38A:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_A_CHDA130_0
(FATTY ACID-BINDING
PROTEIN)
4q38 PUTATIVE
UNCHARACTERIZED
PROTEIN TCP24

(Actinoplanes
teichomyceticus)
5 / 12 LEU A  23
LEU A  20
ALA A  81
ILE A  82
THR A 166
None
0.96A 1tw4A-4q38A:
undetectable
1tw4A-4q38A:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZP4_C_C2FC997_0
(5,10-METHYLENETETRAH
YDROFOLATE REDUCTASE)
4q38 PUTATIVE
UNCHARACTERIZED
PROTEIN TCP24

(Actinoplanes
teichomyceticus)
5 / 10 ASP A 275
GLN A 242
SER A 251
TYR A 246
LEU A 299
None
None
COA  A 403 (-2.5A)
None
COA  A 403 (-3.9A)
1.43A 1zp4C-4q38A:
0.0
1zp4C-4q38A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZU_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)
4q38 PUTATIVE
UNCHARACTERIZED
PROTEIN TCP24

(Actinoplanes
teichomyceticus)
4 / 8 SER A 212
ARG A 215
GLN A 180
PHE A 181
None
1.05A 1zzuA-4q38A:
undetectable
1zzuA-4q38A:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3C_A_PNXA1435_1
(CHITINASE)
4q38 PUTATIVE
UNCHARACTERIZED
PROTEIN TCP24

(Actinoplanes
teichomyceticus)
4 / 6 TRP A 260
GLY A 194
PHE A 181
SER A 182
TEC  A 404 (-4.0A)
None
None
None
1.19A 2a3cA-4q38A:
undetectable
2a3cA-4q38A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3C_B_PNXB2434_1
(CHITINASE)
4q38 PUTATIVE
UNCHARACTERIZED
PROTEIN TCP24

(Actinoplanes
teichomyceticus)
4 / 6 TRP A 260
GLY A 194
PHE A 181
SER A 182
TEC  A 404 (-4.0A)
None
None
None
1.22A 2a3cB-4q38A:
undetectable
2a3cB-4q38A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_A_1FLA2003_1
(SERUM ALBUMIN)
4q38 PUTATIVE
UNCHARACTERIZED
PROTEIN TCP24

(Actinoplanes
teichomyceticus)
5 / 9 LEU A  99
PHE A 110
LEU A  12
LEU A  20
ALA A  70
None
1.20A 2bxeA-4q38A:
undetectable
2bxeA-4q38A:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXG_A_IBPA2002_1
(SERUM ALBUMIN)
4q38 PUTATIVE
UNCHARACTERIZED
PROTEIN TCP24

(Actinoplanes
teichomyceticus)
4 / 8 ARG A 151
ALA A  55
GLU A  57
VAL A 112
None
0.79A 2bxgA-4q38A:
undetectable
2bxgA-4q38A:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXP_A_P1ZA3001_1
(SERUM ALBUMIN)
4q38 PUTATIVE
UNCHARACTERIZED
PROTEIN TCP24

(Actinoplanes
teichomyceticus)
5 / 12 LEU A  99
PHE A 110
LEU A  12
LEU A  20
ALA A  70
None
1.21A 2bxpA-4q38A:
undetectable
2bxpA-4q38A:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_C_VIAC903_2
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)
4q38 PUTATIVE
UNCHARACTERIZED
PROTEIN TCP24

(Actinoplanes
teichomyceticus)
3 / 3 ASN A 286
ILE A 149
MET A 161
None
None
TEC  A 404 (-4.3A)
0.62A 2h42C-4q38A:
undetectable
2h42C-4q38A:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA4_A_ACTA544_0
(ACETYLCHOLINESTERASE)
4q38 PUTATIVE
UNCHARACTERIZED
PROTEIN TCP24

(Actinoplanes
teichomyceticus)
4 / 8 GLY A 104
GLY A 103
ALA A 106
ALA A 107
None
0.59A 2ha4A-4q38A:
undetectable
2ha4A-4q38A:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA4_B_ACTB601_0
(ACETYLCHOLINESTERASE)
4q38 PUTATIVE
UNCHARACTERIZED
PROTEIN TCP24

(Actinoplanes
teichomyceticus)
4 / 7 GLY A 104
GLY A 103
ALA A 106
ALA A 107
None
0.60A 2ha4B-4q38A:
undetectable
2ha4B-4q38A:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADS_A_IMNA2_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)
4q38 PUTATIVE
UNCHARACTERIZED
PROTEIN TCP24

(Actinoplanes
teichomyceticus)
5 / 12 HIS A  79
LEU A  35
LEU A  45
PHE A 115
LEU A 169
None
1.47A 3adsA-4q38A:
undetectable
3adsA-4q38A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L2V_A_RLTA397_1
(INTEGRASE)
4q38 PUTATIVE
UNCHARACTERIZED
PROTEIN TCP24

(Actinoplanes
teichomyceticus)
4 / 7 ASP A 291
PRO A 289
GLN A 288
GLU A 292
None
1.17A 3l2vA-4q38A:
undetectable
3l2vA-4q38A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_A_CELA682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
4q38 PUTATIVE
UNCHARACTERIZED
PROTEIN TCP24

(Actinoplanes
teichomyceticus)
5 / 12 TYR A 209
LEU A 204
ALA A 216
GLY A 234
SER A 236
None
COA  A 403 (-4.6A)
None
TEC  A 404 ( 3.9A)
COA  A 403 (-3.1A)
0.98A 3ln1A-4q38A:
undetectable
3ln1A-4q38A:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_A_CELA682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
4q38 PUTATIVE
UNCHARACTERIZED
PROTEIN TCP24

(Actinoplanes
teichomyceticus)
5 / 12 VAL A 197
TYR A 209
LEU A 204
ALA A 216
GLY A 234
TEC  A 404 ( 4.2A)
None
COA  A 403 (-4.6A)
None
TEC  A 404 ( 3.9A)
0.89A 3ln1A-4q38A:
undetectable
3ln1A-4q38A:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_B_CELB682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
4q38 PUTATIVE
UNCHARACTERIZED
PROTEIN TCP24

(Actinoplanes
teichomyceticus)
5 / 12 TYR A 209
LEU A 204
ALA A 216
GLY A 234
SER A 236
None
COA  A 403 (-4.6A)
None
TEC  A 404 ( 3.9A)
COA  A 403 (-3.1A)
1.00A 3ln1B-4q38A:
undetectable
3ln1B-4q38A:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_B_CELB682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
4q38 PUTATIVE
UNCHARACTERIZED
PROTEIN TCP24

(Actinoplanes
teichomyceticus)
5 / 12 VAL A 197
TYR A 209
LEU A 204
ALA A 216
GLY A 234
TEC  A 404 ( 4.2A)
None
COA  A 403 (-4.6A)
None
TEC  A 404 ( 3.9A)
0.91A 3ln1B-4q38A:
undetectable
3ln1B-4q38A:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_C_CELC682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
4q38 PUTATIVE
UNCHARACTERIZED
PROTEIN TCP24

(Actinoplanes
teichomyceticus)
5 / 12 TYR A 209
LEU A 204
ALA A 216
GLY A 234
SER A 236
None
COA  A 403 (-4.6A)
None
TEC  A 404 ( 3.9A)
COA  A 403 (-3.1A)
0.98A 3ln1C-4q38A:
undetectable
3ln1C-4q38A:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_C_CELC682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
4q38 PUTATIVE
UNCHARACTERIZED
PROTEIN TCP24

(Actinoplanes
teichomyceticus)
5 / 12 VAL A 197
TYR A 209
LEU A 204
ALA A 216
GLY A 234
TEC  A 404 ( 4.2A)
None
COA  A 403 (-4.6A)
None
TEC  A 404 ( 3.9A)
0.89A 3ln1C-4q38A:
undetectable
3ln1C-4q38A:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_D_CELD682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
4q38 PUTATIVE
UNCHARACTERIZED
PROTEIN TCP24

(Actinoplanes
teichomyceticus)
5 / 12 VAL A 197
TYR A 209
LEU A 204
ALA A 216
GLY A 234
TEC  A 404 ( 4.2A)
None
COA  A 403 (-4.6A)
None
TEC  A 404 ( 3.9A)
0.90A 3ln1D-4q38A:
undetectable
3ln1D-4q38A:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N62_B_MTLB870_0
(NITRIC OXIDE
SYNTHASE)
4q38 PUTATIVE
UNCHARACTERIZED
PROTEIN TCP24

(Actinoplanes
teichomyceticus)
4 / 8 SER A 212
ARG A 215
GLN A 180
PHE A 181
None
1.17A 3n62B-4q38A:
undetectable
3n62B-4q38A:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OWX_A_XRAA233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])
4q38 PUTATIVE
UNCHARACTERIZED
PROTEIN TCP24

(Actinoplanes
teichomyceticus)
5 / 9 GLY A 157
GLY A 158
ASN A 160
GLU A  57
ILE A  58
None
1.36A 3owxA-4q38A:
undetectable
3owxA-4q38A:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B3Q_A_NVPA999_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)
4q38 PUTATIVE
UNCHARACTERIZED
PROTEIN TCP24

(Actinoplanes
teichomyceticus)
4 / 7 LEU A  45
VAL A 119
TYR A 113
LEU A 143
None
0.90A 4b3qA-4q38A:
undetectable
4b3qA-4q38A:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_A_NCTA501_1
(CYTOCHROME P450 2A6)
4q38 PUTATIVE
UNCHARACTERIZED
PROTEIN TCP24

(Actinoplanes
teichomyceticus)
4 / 7 PHE A 224
GLY A 171
ILE A 131
PHE A 219
None
0.81A 4ejjA-4q38A:
undetectable
4ejjA-4q38A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_D_CLQD303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])
4q38 PUTATIVE
UNCHARACTERIZED
PROTEIN TCP24

(Actinoplanes
teichomyceticus)
4 / 6 GLY A 157
GLY A 158
GLU A  57
ILE A  58
None
0.89A 4fglD-4q38A:
undetectable
4fglD-4q38A:
21.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MFL_B_GCSB502_1
(PUTATIVE
UNCHARACTERIZED
PROTEIN TCP24
TEICOPLANIN
PSEUDOAGLYCONE)
4q38 PUTATIVE
UNCHARACTERIZED
PROTEIN TCP24

(Actinoplanes
teichomyceticus)
5 / 6 GLN A 142
MET A 161
TRP A 163
TRP A 164
PHE A 281
TEC  A 404 ( 4.0A)
TEC  A 404 (-4.3A)
TEC  A 404 (-4.6A)
TEC  A 404 (-3.7A)
COA  A 403 (-3.4A)
0.66A 4mflA-4q38A:
51.3
4mflA-4q38A:
97.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MFP_B_GCSB503_1
(PUTATIVE
UNCHARACTERIZED
PROTEIN TCP24
TEICOPLANIN
PSEUDOAGLYCONE)
4q38 PUTATIVE
UNCHARACTERIZED
PROTEIN TCP24

(Actinoplanes
teichomyceticus)
5 / 5 GLN A 142
MET A 161
TRP A 163
TRP A 164
PHE A 281
TEC  A 404 ( 4.0A)
TEC  A 404 (-4.3A)
TEC  A 404 (-4.6A)
TEC  A 404 (-3.7A)
COA  A 403 (-3.4A)
0.34A 4mfpA-4q38A:
50.5
4mfpA-4q38A:
97.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MFQ_B_GCSB503_1
(PUTATIVE
UNCHARACTERIZED
PROTEIN TCP24
TEICOPLANIN
PSEUDOAGLYCONE)
4q38 PUTATIVE
UNCHARACTERIZED
PROTEIN TCP24

(Actinoplanes
teichomyceticus)
5 / 6 GLN A 142
MET A 161
TRP A 163
TRP A 164
PHE A 281
TEC  A 404 ( 4.0A)
TEC  A 404 (-4.3A)
TEC  A 404 (-4.6A)
TEC  A 404 (-3.7A)
COA  A 403 (-3.4A)
0.73A 4mfqA-4q38A:
50.8
4mfqA-4q38A:
97.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O0W_A_ADNA501_1
(AURORA KINASE A)
4q38 PUTATIVE
UNCHARACTERIZED
PROTEIN TCP24

(Actinoplanes
teichomyceticus)
5 / 6 LEU A  10
GLY A  11
ALA A  70
THR A  16
LEU A  20
None
0.91A 4o0wA-4q38A:
undetectable
4o0wA-4q38A:
22.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4Q36_A_GCSA404_1
(PUTATIVE
UNCHARACTERIZED
PROTEIN TCP24)
4q38 PUTATIVE
UNCHARACTERIZED
PROTEIN TCP24

(Actinoplanes
teichomyceticus)
5 / 5 MET A 161
TRP A 163
TRP A 164
HIS A 196
PHE A 281
TEC  A 404 (-4.3A)
TEC  A 404 (-4.6A)
TEC  A 404 (-3.7A)
TEC  A 404 (-4.1A)
COA  A 403 (-3.4A)
0.13A 4q36A-4q38A:
50.9
4q36A-4q38A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R82_A_ACTA205_0
(OXIDOREDUCTASE)
4q38 PUTATIVE
UNCHARACTERIZED
PROTEIN TCP24

(Actinoplanes
teichomyceticus)
4 / 5 GLY A  87
ARG A 129
GLU A 226
PHE A 224
None
1.22A 4r82A-4q38A:
undetectable
4r82B-4q38A:
undetectable
4r82A-4q38A:
21.04
4r82B-4q38A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZJ_F_AZ1F2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR-DAR)
4q38 PUTATIVE
UNCHARACTERIZED
PROTEIN TCP24

(Actinoplanes
teichomyceticus)
5 / 7 GLY A 234
SER A 235
GLY A 318
VAL A 320
LEU A 262
TEC  A 404 ( 3.9A)
None
None
None
None
1.28A 5izjB-4q38A:
undetectable
5izjB-4q38A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JW1_A_CELA602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
4q38 PUTATIVE
UNCHARACTERIZED
PROTEIN TCP24

(Actinoplanes
teichomyceticus)
6 / 12 VAL A 197
TYR A 209
LEU A 204
ALA A 216
GLY A 234
SER A 236
TEC  A 404 ( 4.2A)
None
COA  A 403 (-4.6A)
None
TEC  A 404 ( 3.9A)
COA  A 403 (-3.1A)
1.22A 5jw1A-4q38A:
undetectable
5jw1A-4q38A:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G2P_A_TRPA502_0
(FLAVIN-DEPENDENT
L-TRYPTOPHAN OXIDASE
VIOA)
4q38 PUTATIVE
UNCHARACTERIZED
PROTEIN TCP24

(Actinoplanes
teichomyceticus)
4 / 7 TYR A 113
LEU A 143
TYR A 109
VAL A  50
None
1.33A 6g2pA-4q38A:
undetectable
6g2pA-4q38A:
22.12