SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4q3i'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG4_A_SAMA500_1
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 4q3i OSSERK2 D128N
(Oryza
sativa) 		4 / 8 GLU A 174
SER A 126
ILE A 169
LEU A 148
 None
 0.93A 1jg4A-4q3iA:
undetectable		 1jg4A-4q3iA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN6_A_T44A1370_1
(THYROXINE-BINDING
GLOBULIN)		 4q3i OSSERK2 D128N
(Oryza
sativa) 		5 / 10 LEU A 148
LEU A 142
LEU A 153
LEU A 127
ARG A 152
 None
 1.16A 2xn6A-4q3iA:
undetectable
2xn6B-4q3iA:
undetectable		 2xn6A-4q3iA:
22.60
2xn6B-4q3iA:
8.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CJT_G_SAMG302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 4q3i OSSERK2 D128N
(Oryza
sativa) 		5 / 12 VAL A  91
LEU A  94
ILE A 138
LEU A 127
LEU A 151
 None
 1.10A 3cjtG-4q3iA:
undetectable		 3cjtG-4q3iA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CJT_K_SAMK302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 4q3i OSSERK2 D128N
(Oryza
sativa) 		5 / 12 VAL A  91
LEU A  94
ILE A 138
LEU A 127
LEU A 151
 None
 1.13A 3cjtK-4q3iA:
undetectable		 3cjtK-4q3iA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_D_TOPD200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 4q3i OSSERK2 D128N
(Oryza
sativa) 		5 / 9 LEU A 177
VAL A 185
ILE A 199
LEU A 220
PHE A 190
 None
 1.29A 3fl9D-4q3iA:
undetectable		 3fl9D-4q3iA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		 4q3i OSSERK2 D128N
(Oryza
sativa) 		4 / 7 LEU A  52
GLN A  93
LEU A 121
LEU A 105
 None
 0.92A 3g8iA-4q3iA:
undetectable		 3g8iA-4q3iA:
25.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_B_SAMB302_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 4q3i OSSERK2 D128N
(Oryza
sativa) 		4 / 5 SER A 209
ASP A 187
ASP A 191
ILE A 189
 None
 1.28A 3uj7B-4q3iA:
undetectable		 3uj7B-4q3iA:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_F_W9TF512_1
(HEMOLYTIC LECTIN
CEL-III)		 4q3i OSSERK2 D128N
(Oryza
sativa) 		4 / 6 THR A 167
ASN A 168
GLY A 143
ILE A 138
 None
 1.02A 3w9tF-4q3iA:
undetectable		 3w9tF-4q3iA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MWY_A_YNUA1101_0
(MINERALOCORTICOID
RECEPTOR)		 4q3i OSSERK2 D128N
(Oryza
sativa) 		5 / 12 LEU A 129
LEU A 153
ALA A 176
LEU A 166
LEU A 148
 None
 1.11A 5mwyA-4q3iA:
undetectable		 5mwyA-4q3iA:
23.64